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    METHODS OF PREPARING POLYELECTROLYTE COMPLEX NANOPARTICLES
    1.
    发明申请
    METHODS OF PREPARING POLYELECTROLYTE COMPLEX NANOPARTICLES 审中-公开
    制备聚电解复合纳米粒子的方法

    公开(公告)号：US20170042829A1

    公开(公告)日：2017-02-16

    申请号：US15221189

    申请日：2016-07-27

    申请人： THE JOHNS HOPKINS UNIVERSITY

    发明人： HAI-QUAN MAO ,  JOSE LUIS SANTOS ,  YONG REN ,  JOHN-MICHAEL WILLIFORD

    IPC分类号： A61K9/51

    CPC分类号： A61K9/5192 ,  A61K9/5115 ,  A61K9/5146 ,  A61K9/5161 ,  A61K9/5169 ,  A61K47/61 ,  A61K47/6455

    摘要： The presently disclosed subject matter provides methods for continuously generating uniform polyelectrolyte complex (PEC) nanoparticles comprising: flowing a first stream comprising one or more water-soluble polycationic polymers at a first variable flow rate into a confined chamber; flowing a second stream comprising one or more water-soluble polyanionic polymers at a second variable flow rate into the confined chamber; and impinging the first stream and the second stream in the confined chamber until the Reynolds number is from about 1,000 to about 20,000, thereby causing the one or more water-soluble polycationic polymers and the one or more water-soluble polyanionic polymers to undergo a polyelectrolyte complexation process that continuously generates PEC nanoparticles. Compositions produced from the presently disclosed methods and a device for producing the compositions are also disclosed.

    摘要翻译： 目前公开的主题提供了连续生成均匀聚电解质复合物（PEC）纳米颗粒的方法，其包括：使包含一种或多种水溶性聚阳离子聚合物的第一流以第一可变流速流动到约束室中; 将包含一种或多种水溶性聚阴离子聚合物的第二流以第二可变流速流入限制室; 并且在密闭室中冲击第一流和第二流，直到雷诺数为约1,000至约20,000，从而使一种或多种水溶性聚阳离子聚合物和一种或多种水溶性聚阴离子聚合物经历聚电解质 连续生成PEC纳米粒子的络合过程。 还公开了由目前公开的方法制备的组合物和用于制备组合物的装置。

    COMPOSITIONS OF NUCLEIC ACID-CONTAINING NANOPARTICLES FOR IN VIVO DELIVERY
    3.
    发明申请
    COMPOSITIONS OF NUCLEIC ACID-CONTAINING NANOPARTICLES FOR IN VIVO DELIVERY 审中-公开
    含活性纳米粒子在体内分泌物中的组成

    公开(公告)号：US20160331845A1

    公开(公告)日：2016-11-17

    申请号：US15154143

    申请日：2016-05-13

    申请人： THE JOHNS HOPKINS UNIVERSITY

    发明人： HAI-QUAN MAO ,  JOHN MICHAEL WILLIFORD ,  MAANI ARCHANG ,  IL MINN ,  YONG REN ,  JOSE LUIS SANTOS ,  MARTIN G. POMPER

    IPC分类号： A61K48/00 ,  A61K47/48 ,  A61K45/06 ,  A61K51/04

    CPC分类号： A61K48/0041 ,  A61K45/06 ,  A61K47/59 ,  A61K47/60 ,  A61K47/62 ,  A61K47/64 ,  A61K47/6803 ,  A61K47/6935 ,  C12N15/88 ,  C12N2810/855 ,  C12N2810/856

    摘要： Compositions comprising a polymeric micellar nanoparticle composition comprising a block or graft copolymer comprising at least one polycationic polymer and at least one polyethylene glycol (PEG) polymer having an average molecular weight less than 1 kDa, and at least one nucleic acid, wherein the graft or block copolymer and at least one nucleic acid are complexed and condensed into a shaped micellar nanoparticle that is stable in biological media are disclosed. The presently disclosed subject matter also provides a method for preparing the presently disclosed polymeric micellar nanoparticle compositions, a method for targeting at least one metastatic cancer cell in a subject, and a method for treating a disease or condition using the presently disclosed polymeric micellar nanoparticle compositions.

    摘要翻译： 包含聚合物胶束纳米颗粒组合物的组合物，其包含包含至少一种聚阳离子聚合物和至少一种平均分子量小于1kDa的聚乙二醇（PEG）聚合物的嵌段或接枝共聚物和至少一种核酸，其中所述移植物或 嵌段共聚物和至少一种核酸被络合并缩合成在生物培养基中稳定的成形胶束纳米颗粒。 目前公开的主题还提供了制备本发明公开的高分子胶束纳米颗粒组合物的方法，靶向受试者中至少一种转移性癌细胞的方法，以及使用本发明公开的高分子胶束纳米颗粒组合物治疗疾病或病症的方法 。