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公开(公告)号：US09833423B2
公开(公告)日：2017-12-05
申请号：US15098972
申请日：2016-04-14
申请人： KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY , KATHOLIEKE UNIVERSITEIT LEUVEN K.U. LEUVEN R & D
发明人： Young Sik Jung , Chong Kgo Lee , Ihl Young Choi , Hae Soo Kim , Phil Ho Kim , Soo Bong Han , Johan Neyts , Hendrik Jan Thibaut
IPC分类号： A61K31/122 , A61K31/435 , C07D221/04 , C07C49/747 , C07C271/24 , C07C271/44 , C07C271/64 , C07C275/26 , C07C275/64 , C07C205/45 , C07C323/22 , C07C225/20 , C07C225/22 , C07C233/32 , C07C233/33 , C07C233/41 , C07C233/43 , C07C233/61 , C07C233/76 , C07C247/14 , C07C69/16 , C07C69/18 , C07C69/28 , C07C69/54 , C07C69/618 , C07C69/63 , C07C69/738 , C07C69/78 , C07C49/753 , C07D215/20 , C07D213/65 , C07C45/00 , C07C67/00 , C07C69/12 , C07C69/22 , C07C69/736 , C07C269/00 , C07C49/755 , C07C67/08 , C07C231/02 , C07C271/12
CPC分类号： A61K31/122 , A61K31/435 , C07C45/00 , C07C49/747 , C07C49/753 , C07C49/755 , C07C67/00 , C07C67/08 , C07C69/12 , C07C69/16 , C07C69/18 , C07C69/22 , C07C69/28 , C07C69/54 , C07C69/618 , C07C69/63 , C07C69/736 , C07C69/738 , C07C69/78 , C07C205/45 , C07C225/20 , C07C225/22 , C07C231/02 , C07C233/32 , C07C233/33 , C07C233/41 , C07C233/43 , C07C233/61 , C07C233/76 , C07C247/14 , C07C269/00 , C07C271/12 , C07C271/24 , C07C271/44 , C07C271/64 , C07C275/26 , C07C275/64 , C07C323/22 , C07C2601/02 , C07C2602/08 , C07D213/65 , C07D215/20 , C07D221/04
摘要： Disclosed are 1,3-Dioxoindene derivatives, pharmaceutically acceptable salts thereof or enantiomers, a preparation method thereof, and a pharmaceutical composition for the prevention or treatment of viral diseases, comprising the same as an active ingredient. The 1,3-Dioxoindene derivatives have excellent inhibitory activity against picornaviruses including coxsackie-, entero-, echo-, Polio-, and rhinoviruses, as well as exhibiting low cytotoxicity, so that they can be useful as an active ingredient of a pharmaceutical composition for the prevention or treatment of viral diseases including poliomyelitis, paralysis, acute hemorrhagic conjunctivitis, viral meningitis, hand-foot-and-mouth disease, vesicular disease, hepatitis A, myositis, myocarditis, pancreatitis, diabetes, epidemic myalgia, encephalitis, cold, herpangina, foot-and-mouth disease, asthma, chronic obstructive pulmonary disease, pneumonia, sinusitis or otitis media.
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公开(公告)号：US20170174611A1
公开(公告)日：2017-06-22
申请号：US15432593
申请日：2017-02-14
发明人： PENG CAO , Jianxin PU , Xiaoyan SUN , Handong SUN , Weiguang WANG , Jiao CHEN , Xueting CAI , Xue DU
CPC分类号： C07C69/21 , A61K36/00 , A61K36/53 , A61K2236/00 , C07C69/12 , C07C2103/86 , C07C2603/86
摘要： A compound of Formula I or pharmaceutically acceptable salt thereof and its preparation method and applications, the new structure of the compound of formula I has not been reported in literature. It is isolated from Isodon forrestii var. forrestii and can be a compound served as Trx1 selective inhibitor. The present invention further discloses a pharmaceutical composition, preparation of the compound ofFormula I and its applications in preparing medicines for preventing or treating cancer. Iso A of the present invention has the advantages of low toxicity, high safety and strong pharmacological effect, which suggests a potential prospect in pharmaceutical applications.
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公开(公告)号：US20170092866A1
公开(公告)日：2017-03-30
申请号：US15312448
申请日：2015-05-26
申请人： Merck Patent GmbH , Nano-C, Inc.
CPC分类号： H01L51/0047 , C07C35/44 , C07C69/12 , C07C69/157 , C07C69/16 , C07C2604/00 , H01L35/24 , H01L51/0036 , H01L51/0043 , H01L51/4253 , Y02E10/549
摘要： The invention relates to fullerene derivatives of formula I, to mixtures and formulations containing them, to the use of the fullerene derivatives, mixtures and formulations as organic semiconductors in, or for the preparation of electronic devices, especially organic photovoltaic (OPV) devices and organic photodetectors (OPD), and to electronic devices comprising, or being prepared from, these fullerene derivatives, mixtures or formulations.
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4.发明申请1,3-DI-OXO-INDENE DERIVATIVE, PHARMACEUTICALLY ACCEPTABLE SALT OR OPTICAL ISOMER THEREOF, PREPARATION METHOD THEREOF, AND PHARMACEUTICAL COMPOSITION CONTAINING SAME AS AN ANTIVIRAL, ACTIVE INGREDIENT 审中-公开1,3-DI-OXO-INDENE衍生物，药学上可接受的盐或光学异构体，其制备方法以及含有作为抗病毒活性成分的药物组合物公开(公告)号：US20160272564A1
公开(公告)日：2016-09-22
申请号：US15098972
申请日：2016-04-14
申请人： KOREA RESEARCH INSTTITUTE OF CHEMICAL TECHNOLOGY , KATHOLIEKE UNIVERSITEIT LEUVEN K.U. LEUVEN R & D
发明人： Young Sik JUNG , Chong Kgo LEE , Ihl Young CHOI , Hae Soo KIM , Phil Ho KIM , Soo Bong HAN , Johan NEYTS , Hendrik Jan Thibaut
IPC分类号： C07C49/755 , C07C231/02 , C07C69/738 , C07C69/16 , C07C233/61 , C07C323/22 , C07C271/24 , C07C275/26 , C07C205/45 , C07C275/64 , C07C233/43 , C07C233/33 , C07C233/76 , C07D213/65 , C07C49/747 , C07D215/20 , C07C271/12 , C07D221/04 , C07C247/14 , C07C67/08
CPC分类号： A61K31/122 , A61K31/435 , C07C45/00 , C07C49/747 , C07C49/753 , C07C49/755 , C07C67/00 , C07C67/08 , C07C69/12 , C07C69/16 , C07C69/18 , C07C69/22 , C07C69/28 , C07C69/54 , C07C69/618 , C07C69/63 , C07C69/736 , C07C69/738 , C07C69/78 , C07C205/45 , C07C225/20 , C07C225/22 , C07C231/02 , C07C233/32 , C07C233/33 , C07C233/41 , C07C233/43 , C07C233/61 , C07C233/76 , C07C247/14 , C07C269/00 , C07C271/12 , C07C271/24 , C07C271/44 , C07C271/64 , C07C275/26 , C07C275/64 , C07C323/22 , C07C2601/02 , C07C2602/08 , C07D213/65 , C07D215/20 , C07D221/04
摘要： Disclosed are 1,3-Dioxoindene derivatives, pharmaceutically acceptable salts thereof or enantiomers, a preparation method thereof, and a pharmaceutical composition for the prevention or treatment of viral diseases, comprising the same as an active ingredient. The 1,3-Dioxoindene derivatives have excellent inhibitory activity against picornaviruses including coxsackie-, entero-, echo-, Polio-, and rhinoviruses, as well as exhibiting low cytotoxicity, so that they can be useful as an active ingredient of a pharmaceutical composition for the prevention or treatment of viral diseases including poliomyelitis, paralysis, acute hemorrhagic conjunctivitis, viral meningitis, hand-foot-and-mouth disease, vesicular disease, hapatitis A, myositis, myocarditis, pancreatitis, diabetes, epidemic myalgia, encephalitis, cold, herpangina, foot-and-mouth disease, asthma, chronic obstructive pulmonary disease, pneumonia, sinusitis or otitis media.
摘要翻译： 公开了1,3-二氧代茚衍生物，其药学上可接受的盐或对映异构体，其制备方法和用于预防或治疗病毒性疾病的药物组合物，其包含其作为活性成分。 1,3-二氧代茚衍生物对包括柯萨奇，肠，回波，脊髓灰质炎和鼻病毒在内的小核糖核酸病毒具有优异的抑制活性，并且具有低的细胞毒性，因此它们可用作药物组合物的活性成分 用于预防或治疗包括脊髓灰质炎，麻痹，急性出血性结膜炎，病毒性脑膜炎，手足口病，囊泡病，甲型肝炎，肌炎，心肌炎，胰腺炎，糖尿病，流行性肌痛，脑炎，感冒， 麻疹，口蹄疫，哮喘，慢性阻塞性肺病，肺炎，鼻窦炎或中耳炎。
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公开(公告)号：US09242917B2
公开(公告)日：2016-01-26
申请号：US14239389
申请日：2012-08-16
申请人： Gregory L Beutner , Robert M Wenslow, Jr. , Eric J Choi , Clinton Scott Shultz , Jeremy Scott , Juan D Arredondo , Laura Artino
发明人： Gregory L Beutner , Robert M Wenslow, Jr. , Eric J Choi , Clinton Scott Shultz , Jeremy Scott , Juan D Arredondo , Laura Artino
IPC分类号： C07K5/08 , C07C35/04 , C07K5/083 , C07D403/12 , C07D498/16 , C07K5/12 , C07C67/14 , C07C69/013 , C07C69/12 , C07C269/04 , C07C271/34 , A61K38/00
CPC分类号： C07C35/04 , A61K38/00 , C07C67/14 , C07C69/013 , C07C69/12 , C07C269/04 , C07C271/34 , C07D403/12 , C07D498/16 , C07K5/0808 , C07K5/126
摘要： The present invention relates to different forms of a HCV inhibitory compound.
摘要翻译： 本发明涉及不同形式的HCV抑制化合物。
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公开(公告)号：US20140243519A1
公开(公告)日：2014-08-28
申请号：US14239391
申请日：2012-08-16
申请人： Nobuyoshi Yasuda , Jeffrey T. Kuethe , Guy Humphrey , Gregory L. Beutner , Yong-Li Zhong , Edward Cleator , Carl Baxter
发明人： Nobuyoshi Yasuda , Jeffrey T. Kuethe , Guy Humphrey , Gregory L. Beutner , Yong-Li Zhong , Edward Cleator , Carl Baxter
IPC分类号： C07D498/16 , C07D403/12 , C07C269/04 , C07C271/34 , C07C69/013 , C07C67/14 , C07C35/04 , C07C69/12
CPC分类号： C07C35/04 , A61K38/00 , C07C67/14 , C07C69/013 , C07C69/12 , C07C269/04 , C07C271/34 , C07D403/12 , C07D498/16 , C07K5/0808 , C07K5/126
摘要： The present invention includes compounds useful as intermediates in the preparation of macrolactams, methods for preparing the intermediates, and methods for preparing macrolactams. One use of the methods and intermediates described herein is in the production of macrolactam compounds able to inhibit HCV NS3 protease activity. HCV NS3 inhibitory compounds have therapeutic and research applica
摘要翻译： 本发明包括可用作制备大内酰胺的中间体的化合物，制备中间体的方法和制备大新戊酰胺的方法。 本文描述的方法和中间体的一个用途是制备能够抑制HCV NS3蛋白酶活性的大环内酰胺化合物。 HCV NS3抑制化合物具有治疗和研究应用
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公开(公告)号：US20140200343A1
公开(公告)日：2014-07-17
申请号：US14239393
申请日：2012-08-16
申请人： Feng Xu , Guy Humphrey , Tao Pei , Zhiguo Jake Song , Tao Wang , Laura Artino
发明人： Feng Xu , Guy Humphrey , Tao Pei , Zhiguo Jake Song , Tao Wang , Laura Artino
IPC分类号： C07D498/16 , C07D403/12
CPC分类号： C07C35/04 , A61K38/00 , C07C67/14 , C07C69/013 , C07C69/12 , C07C269/04 , C07C271/34 , C07D403/12 , C07D498/16 , C07K5/0808 , C07K5/126
摘要： The present invention includes compounds useful as intermediates in the preparation of macrolactams, methods for preparing the intermediates, and methods for preparing macrolactams from the intermediates. One use of the methods and intermediates described herein is in the production of macrolactam compounds able to inhibit HCV NS3 protease activity. HCV NS3 inhibitory compounds have therapeutic and research applications.
摘要翻译： 本发明包括可用作制备大新戊酰胺的中间体的化合物，制备中间体的方法和从中间体制备大环内酯的方法。 本文描述的方法和中间体的一个用途是制备能够抑制HCV NS3蛋白酶活性的大环内酰胺化合物。 HCV NS3抑制化合物具有治疗和研究应用。
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公开(公告)号：US20140162996A1
公开(公告)日：2014-06-12
申请号：US13953013
申请日：2013-07-29
申请人： CITY OF HOPE
发明人： Samuel RAHBAR , James L. FIGAROLA , Christopher LINCOLN , David HORNE , Rachael MOONEY , Monika POLEWSKI , George SOMLO , Lixin YANG
IPC分类号： C07D239/42 , A61K31/222 , C07C275/30 , A61K31/17 , A61K31/197 , A61K45/06 , A61K31/397 , C07D213/75 , A61K31/44 , A61K31/505 , A61K31/192 , C07C69/12 , C07D229/00
CPC分类号： C07D239/42 , A61K31/17 , A61K31/192 , A61K31/197 , A61K31/222 , A61K31/397 , A61K31/44 , A61K31/505 , A61K45/06 , C07C69/12 , C07C275/30 , C07C275/34 , C07C275/42 , C07C2601/14 , C07D213/75 , C07D229/00
摘要： One aspect of the disclosure relates to derivatives of aryl and heterocyclic ureido aryl and heterocyclic carboxamido isobutyric acids, dichlorophenyl urea, curcumin, and 1,3-diazetidine-2,4-dione, and pharmaceutical compositions thereof. The derivatives disclosed herein can modulate development of adipocytes and various cancer cells, including resistant cancer cells and cancer stem cells. Another aspect of the disclosure relates to the use of the derivatives and pharmaceutical compositions disclosed herein in treatment of obesity and various cancers.
摘要翻译： 本公开的一个方面涉及芳基和杂环脲基芳基和杂环羧酰氨基异丁酸，二氯苯基脲，姜黄素和1,3-二氮杂环丁烷-2,4-二酮的衍生物及其药物组合物。 本文公开的衍生物可以调节脂肪细胞和各种癌细胞的发育，包括抗性癌细胞和癌干细胞。 本公开的另一方面涉及本文公开的衍生物和药物组合物在治疗肥胖症和各种癌症中的用途。
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公开(公告)号：US3418360A
公开(公告)日：1968-12-24
申请号：US41827064
申请日：1964-12-14
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10.发明授权公开(公告)号：US09902684B2
公开(公告)日：2018-02-27
申请号：US15432593
申请日：2017-02-14
发明人： Peng Cao , Jianxin Pu , Xiaoyan Sun , Handong Sun , Weiguang Wang , Jiao Chen , Xueting Cai , Xue Du
IPC分类号： A61K31/222 , C07C69/12 , C07C69/21 , A61K36/00
CPC分类号： C07C69/21 , A61K36/00 , A61K36/53 , A61K2236/00 , C07C69/12 , C07C2103/86 , C07C2603/86
摘要： A compound of Formula I or pharmaceutically acceptable salt thereof and its preparation method and applications, the new structure of the compound of formula I has not been reported in literature. It is isolated from Isodon forrestii var. forrestii and can be a compound served as Trx1 selective inhibitor. The present invention further discloses a pharmaceutical composition, preparation of the compound of Formula I and its applications in preparing medicines for preventing or treating cancer. Iso A of the present invention has the advantages of low toxicity, high safety and strong pharmacological effect, which suggests a potential prospect in pharmaceutical applications.
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