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    PROCESS FOR PRODUCING OPTICALLY ACTIVE ALIPHATIC FLUOROALCOHOL
    6.
    发明申请
    PROCESS FOR PRODUCING OPTICALLY ACTIVE ALIPHATIC FLUOROALCOHOL 有权
    生产光学活性脂肪醇的方法

    公开(公告)号：US20110319671A1

    公开(公告)日：2011-12-29

    申请号：US13170347

    申请日：2011-06-28

    Applicant: Takeaki Katayama ,  Toshihide Takemoto ,  Kunihiko Murata

    Inventor： Takeaki Katayama ,  Toshihide Takemoto ,  Kunihiko Murata

    IPC: C07C29/143

    CPC classification number: C07C29/143 ,  C07B2200/07 ,  C07C31/38

    Abstract: The problem to be resolved by the present invention is to provide a method for efficiently synthesizing optically active lower aliphatic alcohols that have difficulty in separation from organic solvents, without using a special reactor.The present invention relates to a method for producing an optically active aliphatic alcohol having a fluorine atom at α position, wherein an optically active alcohol is produced by reacting an aliphatic ketone having a fluorine atom at α position in water using a formate, under the presence of an asymmetric catalyst represented by general formula (1) and an acid.

    Abstract translation: 本发明要解决的问题是提供一种高效合成难以与有机溶剂分离的光学活性低级脂族醇的方法，而不使用特殊的反应器。 本发明涉及一种在α位具有氟原子的光学活性脂肪醇的制造方法，其特征在于，在甲酸盐存在下，使甲酸酯在水中的α位置具有氟原子的脂肪族酮， 的由通式（1）表示的不对称催化剂和酸。

    Purification of 1,1,1,3,3,3-hexafluoroisopropanol
    7.
    发明授权
    Purification of 1,1,1,3,3,3-hexafluoroisopropanol 失效
    1,1,1,3,3,3-六氟异丙醇的纯化

    公开(公告)号：US07659433B2

    公开(公告)日：2010-02-09

    申请号：US10599472

    申请日：2005-02-04

    Applicant: Paul Mazzell, Jr. ,  Joel Swinson ,  Barry Jones ,  Daniel Graham

    Inventor： Paul Mazzell, Jr. ,  Joel Swinson ,  Barry Jones ,  Daniel Graham

    IPC: C07C29/145 ,  C07C29/82 ,  C07C29/80

    CPC classification number: C07C29/145 ,  C07C29/76 ,  C07C29/80 ,  C07C31/38

    Abstract: 1,1,1,3,3,3-Hexafluoroisopropanol (HFIP) substantially free of 1,1,1-trifluoroacetone (TFA) can be separated from a mixture containing both compounds by A) catalytic reduction with hydrogen followed by fractional distillation; B) cooling to a temperature at which HFIP freezes and TFA remains liquid; C) forming a high boiling complex comprising HF and TFA followed by fractional distillation; or D) producing HF-free conditions to yield a HFIP/TFA azeotrope followed by fractional distillation. It is emphasized that this abstract is provided to comply with the rules requiring an abstract, which will allow a searcher or other reader to quickly ascertain the subject matter of the technical disclosure. It is submitted with the understanding that it will not be used to interpret or limit the scope or meaning of the claims. 37 CFR § 1.72(b).

    Abstract translation: 基本上不含1,1,1-三氟丙酮（TFA）的1,1,1,3,3,3-六氟异丙醇（HFIP）可以从含有这两种化合物的混合物中分离出来，A）用氢气催化还原，然后分馏; B）冷却至HFIP冻结的温度，TFA保持液态; C）形成包含HF和TFA的高沸点络合物，然后分馏; 或D）产生无HF条件以产生HFIP / TFA共沸物，随后进行分馏。 要强调的是，该摘要被提供以符合要求摘要的规则，这将允许搜索者或其他读者快速确定技术公开的主题。 提交它的理解是，它不会用于解释或限制权利要求的范围或含义。 37 CFR§1.72（b）。

    Asymmetric hydrogenation of 1,1,1-trifluoroacetone
    8.
    发明授权
    Asymmetric hydrogenation of 1,1,1-trifluoroacetone 有权
    1,1,1-三氟丙酮的不对称氢化

    公开(公告)号：US07504544B2

    公开(公告)日：2009-03-17

    申请号：US11879644

    申请日：2007-07-18

    Applicant: Kurt Puentener ,  Pius Waldmeier

    Inventor： Kurt Puentener ,  Pius Waldmeier

    IPC: C07C29/14

    CPC classification number: C07C29/145 ,  C07B2200/07 ,  C07C31/38

    Abstract: The invention relates to the preparation of enantiomerically pure (S)-1,1,1-trifluoro-2-propanol by asymmetric hydrogenation of 1,1,1-trifluoroacetone which process comprises hydrogenating 1,1,1-trifluoroacetone in the presence of a ruthenium phosphine complex catalyst represented by formula Ru(E)(E′)(L)(A) wherein E, E′ are both chloro or E is hydrogen and E′ is BH4; L is a chiral diphosphine ligand; and A is an optionally chiral diamine wherein hydrogenation occurs in the presence of a weak base, with or without an additive, when E and E′ are both chloro or b) in the absence of a base and an additive when E and E′ are hydrogen and BH4.

    Abstract translation: 本发明涉及通过1,1,1-三氟丙酮的不对称氢化制备对映异构纯的（S）-1,1,1-三氟-2-丙醇，该方法包括在存在下氢化1,1,1-三氟丙酮 由式<β在线式描述=“在线式”中的钌膦配合物催化剂结束=“铅”→Ru（E）（E'）（L）（A） 其中E，E'均为氯或E为氢，E'为BH4;式为“In-Line Formulas”end =“tail” L是手性二膦配体; 并且A是任选的手性二胺，其中当E和E'都是氯时，或在不存在碱和添加剂的情况下，当E和E'都是氯时，或b）当E和E'是 氢和BH4。

    Process for recovery of 1,1,1,3,3,3-hexafluoroisopropanol from the waste stream of sevoflurane synthesis
    9.
    发明授权
    Process for recovery of 1,1,1,3,3,3-hexafluoroisopropanol from the waste stream of sevoflurane synthesis 有权
    从七氟醚合成废液中回收1,1,1,3,3,3-六氟异丙醇的方法

    公开(公告)号：US07375254B2

    公开(公告)日：2008-05-20

    申请号：US11135430

    申请日：2005-05-24

    Applicant: Leonid A. Rozov ,  Ralph A. Lessor

    Inventor： Leonid A. Rozov ,  Ralph A. Lessor

    IPC: C07C31/34 ,  C07C41/22

    CPC classification number: C07C29/124 ,  C07C29/10 ,  C07C41/22 ,  C07C43/123 ,  C07C31/38

    Abstract: Provided is a process of obtaining 1,1,1,3,3,3-hexafluoro-2-propanol (“HFIP”) from a composition comprising an HFIP hydrolyzable precursor. The HFIP hydrolyzable precursor is a compound, other than sevoflurane itself, that has an intact 1,1,1,3,3,3-hexafluoroisopropoxy moiety[(CF3)2CHO—], and contains one or more moieties susceptible to acidic hydrolysis, such that HFIP is released upon such treatment. The process is useful, among other things, for recovering HFIP from waste streams associated with the synthesis of the inhalation anesthetic, fluoromethyl 2,2,2-trifluoro-1-(trifluoromethyl)ethyl ether (“sevoflurane”). The process includes heating the composition with a strong protic acid to a temperature effective to hydrolyze at least some of the HFIP hydrolyzable precursor to HFIP, and then isolating the HFIP from the heated composition.

    Abstract translation: 提供了从包含HFIP可水解前体的组合物获得1,1,1,3,3,3-六氟-2-丙醇（“HFIP”）的方法。 HFIP可水解前体是除七氟烷本身以外的化合物，其具有完整的1,1,1,3,3,3-六氟异丙氧基部分[（CF 3）2） > CHO-]，并含有一个或多个对酸性水解敏感的部分，使得在这种处理时释放HFIP。 该方法尤其用于从与合成吸入麻醉剂氟甲基2,2,2-三氟-1-（三氟甲基）乙醚（“七氟烷”）相关的废物流中回收HFIP。 该方法包括用强质子酸将组合物加热至有效水解至少一些HFIP可水解前体至HFIP的温度，然后将HFIP与加热的组合物分离。

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