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    Gold complexes for use in the treatment of cancer
    4.
    发明授权
    Gold complexes for use in the treatment of cancer 有权
    用于治疗癌症的金配合物

    公开(公告)号：US09346832B2

    公开(公告)日：2016-05-24

    申请号：US13704894

    申请日：2011-06-14

    申请人： Orde Quentin Munro ,  Kate Julie Akerman ,  Piers Akerman

    发明人： Orde Quentin Munro ,  Kate Julie Akerman ,  Piers Akerman

    IPC分类号： C07F1/12 ,  A61K31/28 ,  C01G7/00 ,  C07C209/16 ,  C07C213/02 ,  C07D401/12 ,  C07D487/22 ,  C07C209/68 ,  C07C209/86 ,  C07C213/06 ,  C07D207/335

    CPC分类号： C07F1/12 ,  C01G7/00 ,  C07C209/16 ,  C07C209/68 ,  C07C209/86 ,  C07C213/02 ,  C07C213/06 ,  C07D207/335 ,  C07D401/12 ,  C07D487/22 ,  C07C211/15 ,  C07C217/42

    摘要： The invention provides compounds of the Formula (I), in which W is independently selected from W1, W2, W3, W4, W5, or W represents a pair of substituents independently selected from H, alkyl, aryl or amide in which the amide is optionally part of a linking chain, and the Zn—Zn′ bonds (n=4-17; n′=n+1) are optionally of any whole or partial bond order, Y is Y1 or Y represents a pair of substituents independently selected from H, C1-C6 alkyl, Z5 or Z6 aryl, or Y is optionally a bridging structure that may comprise one or more C1-C6 amide, C1-C6 ether, or C1-C6 ester groups, R—R39 are independently selected from no substituent, a lone pair of electrons, H, halogen, C5-C6 aryl, C1-C12 alkyl, amine, C1-C6 alkylamine, C1-C6 amide, nitro, cyano, carboxyl, C1-C6 ester, phosphane, thiol, C1-C6 thioether, OR40, and suitable pairs of adjacent R groups (R—R39) may optionally together form part of a C5 or C6 aryl ring, a Z5 or Z6 ring, R40 is independently selected from H, C1-C6 alkyl, Z5 or Z6 aryl, C1-C6 ester, poly(—C2O—), amine, and C1-C6 alkylamine, Z—Z24 are independently selected from C, N, P, O, and S, and X− is a pharmaceutically acceptable anion, for the treatment of cancer.

    摘要翻译： 本发明提供式（I）化合物，其中W独立地选自W 1，W 2，W 3，W 4，W 5或W表示独立地选自H，烷基，芳基或酰胺的一对取代基，其中酰胺是 任选地部分连接链，Zn-Zn'键（n = 4-17; n'= n + 1）任选地具有任何全部或部分键合顺序，Y是Y1或Y表示独立选择的一对取代基 由H，C 1 -C 6烷基，Z 5或Z 6芳基，或Y任选是可以包含一个或多个C 1 -C 6酰胺，C 1 -C 6醚或C 1 -C 6酯基团的桥连结构，R-R 39独立地选自 无取代基，孤对电子，H，卤素，C5-C6芳基，C1-C12烷基，胺，C1-C6烷基胺，C1-C6酰胺，硝基，氰基，羧基，C1-C6酯， C1-C6硫醚，OR40和适当的相邻R基团（R-R39）可以任选地一起形成C5或C6芳基环，Z5或Z6环的一部分，R40独立地选自H，C1-C6烷基， Z5 或Z6芳基，C1-C6酯，聚（-C2O-），胺和C1-C6烷基胺，Z-Z24独立地选自C，N，P，O和S，X-是药学上可接受的阴离子 ，用于治疗癌症。

    CONCENTRATE QUALITY IN THE ENRICHMENT OF UG-2 PLATINUM ORE
    5.
    发明申请
    CONCENTRATE QUALITY IN THE ENRICHMENT OF UG-2 PLATINUM ORE 审中-公开
    浓缩UG-2铂金的浓度

    公开(公告)号：US20110229384A1

    公开(公告)日：2011-09-22

    申请号：US13047156

    申请日：2011-03-14

    申请人： Alexej MICHAILOVSKI ,  Imme Domke ,  Frank Bozich ,  David F. Blackwood

    发明人： Alexej MICHAILOVSKI ,  Imme Domke ,  Frank Bozich ,  David F. Blackwood

    IPC分类号： C01G55/00 ,  C01G7/00

    CPC分类号： C01G7/00 ,  C01G55/00

    摘要： The present invention relates to a process for separating at least one first substance from a mixture comprising this at least one first substance and at least one second substance, comprising the steps of (A) bringing the mixture comprising at least one first substance and at least one second substance into contact with at least one surface-active substance, (B) if required, addition of at least one dispersing medium to the mixture obtained in step (A) in order to obtain a dispersion, and (C) separation of the adduct of at least one first substance and at least one surface-active substance from the dispersion from step (A) or (B), for example by means of flotation, at least one additive which is either a monomolecular compound comprising amino and carboxyl groups or derivatives thereof or a polymeric compound obtainable by reaction of alkylene oxides and/or aziridines, or mixtures thereof, being added to the mixture comprising at least one first substance and at least one second substance.

    摘要翻译： 本发明涉及从包含该至少一种第一物质和至少一种第二物质的混合物中分离出至少一种第一物质的方法，该方法包括以下步骤：（A）将混合物包含至少一种第一物质和至少 一种第二物质与至少一种表面活性物质接触，（B）如果需要，在步骤（A）中获得的混合物中加入至少一种分散介质以获得分散体，和（C）分离 至少一种第一物质和来自步骤（A）或（B）的分散体的至少一种表面活性物质的加合物，例如通过浮选，至少一种作为包含氨基和羧基的单分子化合物的添加剂 或其衍生物或通过环氧烷和/或氮丙啶或其混合物的反应获得的聚合物，其被加入到包含至少一种第一物质和至少一种第二物质的混合物中 ance。

    METHOD OF PRODUCING INORGANIC NANOPARTICLES
    6.
    发明申请
    METHOD OF PRODUCING INORGANIC NANOPARTICLES 审中-公开
    生产无机纳米粒子的方法

    公开(公告)号：US20100206720A1

    公开(公告)日：2010-08-19

    申请号：US12470918

    申请日：2009-05-22

    申请人： Kuan-Jiuh Lin ,  Chuen-Yuan Hsu

    发明人： Kuan-Jiuh Lin ,  Chuen-Yuan Hsu

    IPC分类号： C23C14/32 ,  C23C14/00

    CPC分类号： C23C14/5826 ,  B22F2998/00 ,  B22F2999/00 ,  B82Y30/00 ,  B82Y40/00 ,  C01G3/02 ,  C01G5/00 ,  C01G7/00 ,  C01G53/04 ,  C01P2004/03 ,  C01P2004/64 ,  B22F3/003 ,  B22F1/0018 ,  B22F9/14 ,  B22F2202/13

    摘要： A method of producing inorganic nanoparticles includes: (a) providing a layered structure including a substrate and an inorganic layer; (b) disposing the layered structure in a vacuum chamber, vacuuming the vacuum chamber, and introducing a gas into the vacuum chamber; and (c) applying microwave energy to the gas to produce a microwave plasma of the gas within the vacuum chamber so that the inorganic layer is acted by the microwave plasma and formed into a plurality of inorganic nanoparticles on the substrate. A system for producing the nanoparticles is also disclosed.

    摘要翻译： 制备无机纳米颗粒的方法包括：（a）提供包括基材和无机层的层状结构; （b）将层状结构设置在真空室中，抽真空室，并将气体引入真空室; 和（c）向所述气体施加微波能量以产生所述真空室内的所述气体的微波等离子体，使得所述无机层由所述微波等离子体起作用并在所述基板上形成多个无机纳米颗粒。 还公开了一种用于生产纳米颗粒的系统。

    CONFORMAL MULTIFUNCTIONAL COATINGS
    7.
    发明申请
    CONFORMAL MULTIFUNCTIONAL COATINGS 审中-公开
    一致的多功能涂料

    公开(公告)号：US20090104434A1

    公开(公告)日：2009-04-23

    申请号：US12253314

    申请日：2008-10-17

    申请人： Jennifer Hoyt Lalli

    发明人： Jennifer Hoyt Lalli

    IPC分类号： B32B5/16

    CPC分类号： C01G7/00 ,  B82Y30/00 ,  C01P2004/62 ,  C01P2004/64 ,  Y10T428/25

    摘要： A device includes a substrate having an outer surface and a nano-particle coating on the outer surface. In particular, the nano-particle coating is substantially a molecular monolayer of a plurality of nano-particles. Furthermore, a composite material may be constructed that includes a base material having one or more ingredients and a filler material. In particular, the filler material is made up of a plurality of particulates which, themselves, include a substrate having an outer surface and a nano-particle coating on the outer surface.

    摘要翻译： 一种器件包括在外表面上具有外表面和纳米颗粒涂层的衬底。 特别地，纳米颗粒涂层基本上是多个纳米颗粒的分子单层。 此外，可以构造复合材料，其包括具有一种或多种成分的基材和填料。 特别地，填充材料由多个微粒构成，其本身包括在外表面上具有外表面和纳米颗粒涂层的基底。

    Preparation of transition metal nanoparticles and surfaces modified with (CO) polymers synthesized by RAFT
    9.
    发明授权
    Preparation of transition metal nanoparticles and surfaces modified with (CO) polymers synthesized by RAFT 失效
    制备用RAFT合成的（CO）聚合物改性的过渡金属纳米粒子和表面

    公开(公告)号：US07417096B2

    公开(公告)日：2008-08-26

    申请号：US11586126

    申请日：2006-10-25

    申请人： Charles L. McCormick, III ,  Andrew B. Lowe ,  Brent S. Sumerlin

    发明人： Charles L. McCormick, III ,  Andrew B. Lowe ,  Brent S. Sumerlin

    IPC分类号： C08F214/06

    CPC分类号： B82Y30/00 ,  C01G5/00 ,  C01G7/00 ,  C01G55/00 ,  C01P2004/64 ,  C08F2/38 ,  C08F2/44 ,  C08F4/00 ,  C09C3/10 ,  Y10T428/31

    摘要： A new, facile, general one-phase method of generating thiol-functionalized transition metal nanoparticles and surface modified by (co)polymers synthesized by the RAFT method is described. The method includes the steps of forming a (co)polymer in aqueous solution using the RAFT methodology, forming a collidal transition metal precursor solution from an appropriate transition metal; adding the metal precursor solution or surface to the (co)polymer solution, adding a reducing agent into the solution to reduce the metal colloid in situ to produce the stabilized nanoparticles or surface, and isolating the stabilized nanoparticles or surface in a manner such that aggregation is minimized. The functionalized surfaces generated using these methods can further undergo planar surface modifications, such as fuctionalization with a variety of different chemical groups, expanding their utility and application.

    摘要翻译： 描述了通过RAFT方法合成的由（共）聚合物生成巯基官能化的过渡金属纳米颗粒和表面改性的新的，简单的通用单相方法。 该方法包括使用RAFT方法在水溶液中形成（共）聚合物的步骤，从合适的过渡金属形成碰撞过渡金属前体溶液; 将金属前体溶液或表面添加到（共）聚合物溶液中，向溶液中加入还原剂以原位还原金属胶体以产生稳定的纳米颗粒或表面，并以这样的方式分离稳定的纳米颗粒或表面，使得聚集 被最小化。 使用这些方法产生的官能化表面可以进一步进行平面表面修饰，例如用各种不同化学基团进行功能​​化，扩展其实用性和应用。