公开(公告)号：US20170071535A1

公开(公告)日：2017-03-16

申请号：US15342262

申请日：2016-11-03

Applicant: ARkival Technology Corp.

Inventor： Ronald D. Weiss

IPC: A61B5/00 ,  B03C1/025 ,  A61K49/18 ,  B03C1/30 ,  A61B5/05 ,  A61B5/055

CPC classification number: A61B5/4839 ,  A61B5/0035 ,  A61B5/0515 ,  A61B5/055 ,  A61B5/7246 ,  A61B2562/0285 ,  A61K49/0002 ,  A61K49/1818 ,  B03C1/025 ,  B03C1/30 ,  B03C2201/18 ,  B03C2201/26

Abstract: The invention features an apparatus for producing a fluid stream having plurality of nanoparticles in the fluid stream. The apparatus includes a source configured to provide a fluid stream having a first randomly sized distribution of a plurality of nanoparticles; a flow control zone configured to receive the fluid stream from the source and to control the fluid stream to produce a controlled fluid stream having a selected flow rate; a separation zone configured to receive and to separate the selectively controlled fluid stream into at least one separated fluid stream having a non-randomly sized distribution of nanoparticles; and a collection zone capable of receiving the separated fluid stream according to at least one non-random sized distribution of nanoparticles to produce at least one collected stream. The apparatus is configured for a continuous flow of the fluid stream. A size of a nanoparticle can be related to an intrinsic core diameter, a hydrodynamic diameter, and a combination of intrinsic core diameter and hydrodynamic diameter measurements. The nanoparticles can include non-magnetic nanoparticles, partially magnetic nanoparticles, magnetic nanoparticles, superparamagnetic nanoparticles, and a combination of at least two different nanoparticle types. The invention also features methods for producing said fluid streams. The invention further features apparatus and methods for cancer confirmation and targeted therapeutic drug development.

Abstract translation: 本发明的特征在于一种用于在流体流中产生具有多个纳米颗粒的流体流的装置。 该装置包括：源，其配置成提供具有多个纳米颗粒的第一随机大小分布的流体流; 流动控制区域，其被配置为从所述源接收流体流并且控制所述流体流以产生具有选定流量的受控流体流; 分离区，被配置为接收并且将选择性控制的流体流分离成具有非随机大小的纳米颗粒分布的至少一个分离的流体流; 以及能够根据至少一个非随机大小的纳米颗粒分布接收分离的流体流以产生至少一个收集的流的收集区。 该装置构造成用于流体流的连续流动。 纳米颗粒的尺寸可以与本征芯直径，流体动力学直径以及本征芯直径和流体动力学直径测量的组合有关。 纳米颗粒可以包括非磁性纳米颗粒，部分磁性纳米颗粒，磁性纳米颗粒，超顺磁性纳米颗粒，以及至​​少两种不同纳米颗粒类型的组合。 本发明还涉及生产所述流体流的方法。 本发明还涉及用于癌症确认和靶向治疗药物开发的装置和方法。

公开(公告)号：US20140367312A1

公开(公告)日：2014-12-18

申请号：US14355996

申请日：2012-08-06

Applicant: John Clarence Box ,  Vladimir Arkadievich Golovanevskiy

Inventor： John Clarence Box ,  Vladimir Arkadievich Golovanevskiy

IPC: B03C1/025 ,  B03C1/00 ,  B03C1/26

CPC classification number: B03C1/025 ,  B03C1/002 ,  B03C1/0335 ,  B03C1/035 ,  B03C1/26 ,  B03C2201/20

Abstract: The present disclosure provides an apparatus for sorting a particulate material. The apparatus comprises a receiving portion for receiving the particulate material having a particle size within a predetermined range of sizes. The apparatus also comprises a distributor for receiving the particulate material at an upper end thereof and having a sloped distribution surface along which, in use, the particulate material passes substantially by gravity. A surface area of the sloped distribution surface increases towards a lower end of the distributor to facilitate a monolayer feed stream of the particles exiting and falling from a lower end of the distributor distributed as a curtain-like stream of particles. The apparatus further comprises a magnetic element for generating a magnetic force that is directed such that the particles of the falling feed stream that exit the lower end of the distributor have pathways that depend on magnetic properties of the particles. The apparatus also comprises sorting portions for sorting the particles based on the pathways of the particles.

Abstract translation: 本公开提供了一种用于分选颗粒材料的设备。 该装置包括用于接收具有在预定尺寸范围内的粒度的颗粒材料的接收部分。 该设备还包括用于在其上端处接收颗粒材料并具有倾斜分布表面的分配器，在使用中，颗粒材料沿着该倾斜分布表面基本上通过重力通过。 倾斜分布表面的表面积朝向分配器的下端增加，以促进颗粒的单层进料流从分配器的下端排出并且作为帷幕状的颗粒分布分布。 该装置还包括用于产生磁力的磁性元件，该磁力被定向成使得离开分配器的下端的下降的进料流的颗粒具有取决于颗粒的磁性的通路。 该装置还包括基于颗粒的路径分选颗粒的分选部分。

公开(公告)号：US08469196B2

公开(公告)日：2013-06-25

申请号：US12500103

申请日：2009-07-09

Applicant: Stephen Birken

Inventor： Stephen Birken

IPC: B03C1/30

CPC classification number: B03C1/02 ,  B03C1/005 ,  B03C1/025 ,  B03C1/32 ,  C01G51/00 ,  C01G53/00 ,  C22B1/00 ,  C22B1/02 ,  C22B4/00 ,  C22B23/005 ,  C22B23/02

Abstract: Methods and apparatuses for separating metal values, such as nickel and nickel compounds, from mineral ores, including lateritic ores are disclosed. The method includes providing a mixture of particles (e.g., crushed and sized ore) that is composed of at least a first group of particles and a second group of particles. Group members have similar chemical composition, while particles belonging to different groups have dissimilar chemical compositions. The mixture of particles is concurrently, or generally concurrently, heated (using microwave/millimeter wave energy) and exposed to a reactant. The wave energy and the reactant act to increase the difference in either the magnetic susceptibility or other separation properties between the first and second group of particles. The mixture of particles is then passed through an appropriate separator to separate the particles of interest. Optional steps are disclosed for purifying selected particles. The reactant includes sulfur, sulfur compounds, halogens, or halogen compounds.

Abstract translation: 公开了从含矿物矿石，包括红土矿石中分离金属值的方法和装置，例如镍和镍化合物。 该方法包括提供由至少第一组颗粒和第二组颗粒组成的颗粒（例如粉碎和定尺寸矿石）的混合物。 组成员具有相似的化学成分，而属于不同组的颗粒具有不同的化学成分。 颗粒的混合物同时或通常同时加热（使用微波/毫米波能量）并暴露于反应物。 波能和反应物用于增加第一和第二组颗粒之间的磁化率或其他分离性能的差异。 然后将颗粒的混合物通过适当的分离器以分离感兴趣的颗粒。 公开了用于纯化所选粒子的可选步骤。 反应物包括硫，硫化合物，卤素或卤素化合物。

公开(公告)号：US06479176B2

公开(公告)日：2002-11-12

申请号：US09893686

申请日：2001-06-29

Applicant: Johna Leddy ,  Sudath Amarasinghe ,  Lois Anne Zook

Inventor： Johna Leddy ,  Sudath Amarasinghe ,  Lois Anne Zook

IPC: H01M490

CPC classification number: H01M4/8857 ,  B03C1/01 ,  B03C1/025 ,  B03C1/034 ,  B03C1/035 ,  B82Y25/00 ,  B82Y40/00 ,  C23C6/00 ,  C23C24/08 ,  C23C30/00 ,  C25B11/00 ,  C25D3/54 ,  G21F9/12 ,  H01F1/0027 ,  H01F1/0054 ,  H01F1/009 ,  H01F10/007 ,  H01F41/24 ,  H01F41/26 ,  H01F41/301 ,  H01M4/02 ,  H01M4/86 ,  H01M4/8605 ,  H01M4/8882 ,  H01M4/9083 ,  H01M4/926 ,  H01M8/04223 ,  H01M8/1004 ,  H01M8/1009 ,  H01M8/249 ,  H01M10/42 ,  H01M2300/0082 ,  Y10T428/32

Abstract: Magnetic composites exhibit distinct flux properties due to gradient interfaces. The composites can be used to improve fuel cells and batteries and effect transport and separation of different species of materials, for example, transition metal species such as lanthanides and actinides. A variety of devices can be made utilizing the composites including a separator, an electrode for channeling flux of magnetic species, an electrode for effecting electrolysis of magnetic species, a system for channeling electrolyte species, a system for separating particles with different magnetic susceptibilities, improved fuel cells, batteries, and oxygen concentrators. Some composites can be used to make a separator for distinguishing between two species of materials and a flux switch to regulate the flow of a chemical species. Some composites can control chemical species transport and distribution. Other composites enable ambient pressure fuel cells having enhanced performance and reduced weight to be produced. Still other composites enable rechargeable batteries to be made that have longer secondary cycle life and improved output power. Methods involving these composites provide distinct ways for these composites to be utilized.

Abstract translation: 由于梯度界面，磁性复合材料表现出不同的通量特性。 该复合材料可用于改善燃料电池和电池，并影响不同种类材料的输送和分离，例如过渡金属物质如镧系元素和锕系元素。 可以利用包括分离器，用于引导磁性物质通量的电极，用于实现磁性物质电解的电极，用于引导电解质物质的系统，用于分离具有不同磁化率的颗粒的系统的改进的复合材料来制备各种装置 燃料电池，电池和氧气浓缩器。 一些复合材料可用于制造用于区分两种材料的分离器和用于调节化学物质流动的通量开关。 一些复合材料可以控制化学物种的运输和分配。 其他复合材料能够产生具有增强性能和减轻重量的环境压力的燃料电池。 其他复合材料使得可再生电池具有更长的二次循环寿命和改善的输出功率。 涉及这些复合材料的方法为这些复合材料提供了不同的方法。

公开(公告)号：US20020012821A1

公开(公告)日：2002-01-31

申请号：US09893686

申请日：2001-06-29

Applicant: UNIVERSITY OF IOWA RESEARCH FOUNDATION

Inventor： Johna Leddy ,  Sudath Amarasinghe ,  Lois Anne Zook

IPC: H01M002/00 ,  H01M002/16 ,  H01M008/02 ,  B01D035/06 ,  B03C001/02 ,  C02F001/48 ,  C25C007/04 ,  B01D061/00 ,  C25D017/00 ,  G01N027/403

CPC classification number: H01M4/8857 ,  B03C1/01 ,  B03C1/025 ,  B03C1/034 ,  B03C1/035 ,  B82Y25/00 ,  B82Y40/00 ,  C23C6/00 ,  C23C24/08 ,  C23C30/00 ,  C25B11/00 ,  C25D3/54 ,  G21F9/12 ,  H01F1/0027 ,  H01F1/0054 ,  H01F1/009 ,  H01F10/007 ,  H01F41/24 ,  H01F41/26 ,  H01F41/301 ,  H01M4/02 ,  H01M4/86 ,  H01M4/8605 ,  H01M4/8882 ,  H01M4/9083 ,  H01M4/926 ,  H01M8/04223 ,  H01M8/1004 ,  H01M8/1009 ,  H01M8/249 ,  H01M10/42 ,  H01M2300/0082 ,  Y10T428/32

Abstract: Magnetic composites exhibit distinct flux properties due to gradient interfaces. The composites can be used to improve fuel cells and batteries and effect transport and separation of different species of materials, for example, transition metal species such as lanthanides and actinides. A variety of devices can be made utilizing the composites including a separator, an electrode for channeling flux of magnetic species, an electrode for effecting electrolysis of magnetic species, a system for channeling electrolyte species, a system for separating particles with different magnetic susceptibilities, improved fuel cells, batteries, and oxygen concentrators. Some composites can be used to make a separator for distinguishing between two species of materials and a flux switch to regulate the flow of a chemical species. Some composites can control chemical species transport and distribution. Other composites enable ambient pressure fuel cells having enhanced performance and reduced weight to be produced. Still other composites enable rechargeable batteries to be made that have longer secondary cycle life and improved output power. Methods involving these composites provide distinct ways for these composites to be utilized.

公开(公告)号：US5993665A

公开(公告)日：1999-11-30

申请号：US867008

申请日：1997-06-02

Applicant: Leon W. M. M. Terstappen ,  Paul A. Liberti

Inventor： Leon W. M. M. Terstappen ,  Paul A. Liberti

IPC: B03C1/025 ,  B01D35/06 ,  B03C1/034 ,  B03C1/035 ,  G01N33/533 ,  G01N33/543 ,  B01D35/00

CPC classification number: B03C1/025 ,  B01L3/502 ,  B03C1/034 ,  B03C1/035 ,  G01N27/745 ,  G01N33/54326 ,  G01N33/54366 ,  B01L2400/043 ,  Y10T436/108331 ,  Y10T436/25375

Abstract: A method of quantitative analysis of microscopic biological specimens in a fluid medium is disclosed in which the specimens are rendered magnetically responsive by immunospecific binding with ferromagnetic colloid. A known quantity of magnetically-responsive marker particles are added to the fluid medium. The fluid medium is then subjected to a magnetic separation process, to collect the magnetic species from the fluid. The collected species are resuspended in a second fluid medium, and the relative quantities thereof are enumerated to determine the concentration of the desired biological specimen in the first fluid medium. The marker particles may comprise magnetic particles having a relatively large magnetic moment, a magnetic moment approximately equal to the magnetically-labelled biological speciment of interest, or both in order to compensate the determination for variations in immunospecific binding affinity and/or magnetic collection efficiency. The present method is useful for conducting hematological assays, such as red blood cell counts and related determinations. In the case of red blood cells, the specimens may be rendered magnetically responsive by reduction of the iron atoms present in hemoglobin. The enumeration step of the method may be conducted with such equipment as a flow cytometer, or by a novel optical scanning magnetic cell immobilization apparatus.

Abstract translation: 公开了一种流体介质中微观生物样本的定量分析方法，其中通过与铁磁性胶体的免疫特异性结合使样本呈现磁响应。 将已知量的磁响应标记颗粒添加到流体介质中。 然后对流体介质进行磁分离处理，以从流体中收集磁性物质。 将收集的物质重新悬浮在第二流体培养基中，并列举其相对量以确定第一流体培养基中所需生物样品的浓度。 标记颗粒可以包括具有相对大的磁矩，大约等于感兴趣的磁性标记的生物学物理学的磁矩或两者的磁性颗粒，以补偿免疫特异性结合亲和力和/或磁收集效率的变化的确定。 本方法可用于进行血液学测定，如红细胞计数和相关测定。 在红细胞的情况下，可以通过还原血红蛋白中存在的铁原子来使样品呈现磁响应性。 该方法的计数步骤可以用流式细胞仪等设备进行，也可以通过新的光学扫描磁性细胞固定装置进行。

公开(公告)号：US5876593A

公开(公告)日：1999-03-02

申请号：US931067

申请日：1997-09-15

Applicant: Paul A. Liberti ,  Yuzhou Wang

Inventor： Paul A. Liberti ,  Yuzhou Wang

IPC: B01D35/06 ,  B03C1/00 ,  B03C1/01 ,  B03C1/025 ,  B03C1/032 ,  B03C1/033 ,  B03C1/034 ,  B03C1/035 ,  B03C1/28 ,  C12M3/00 ,  G01N33/483 ,  G01N33/543 ,  G01N33/569 ,  G01N35/00 ,  G01N35/02

CPC classification number: B03C1/002 ,  B03C1/01 ,  B03C1/025 ,  B03C1/032 ,  B03C1/0332 ,  B03C1/034 ,  B03C1/035 ,  C12M47/04 ,  G01N33/54326 ,  G01N33/56972 ,  G01N35/026 ,  G01N2333/70589 ,  G01N35/0098 ,  Y10T436/108331 ,  Y10T436/25375

Abstract: Biological entities such as cells, microbes, or components thereof are labeled with a magnetic colloid containing microscopic magnetic particles. The magnetic particles have a coating capable of biospecific or non-specific binding with the entities. An immobilization apparatus includes a non-magnetic vessel having a ferromagnetic collection structure for attracting the entities toward a collection surface upon which the magnetically labeled entities are immobilized subsequent to placement of the vessel on a support between two magnets. The ferromagnetic collection structure preferably has a sharp edge or high curvature for intensifying the magnetic field and for collecting the entities in a monolayer. The vessel includes an un-obstructed observation path so that immobilized entities may be observed and/or manipulated. The ferromagnetic collection structure may be arranged in various two dimensional patterns to provide a desired collection configuration. The apparatus may further have inlet and outlet ports for allowing a flow of liquid reagent through the vessel for washing or straining the immobilized entities. The support can be translated so that a shoulder on the collection structure concentrates the collected entities by movement of the shoulder in a transverse direction relative to the magnetic field.

Abstract translation: PCT No.PCT / US93 / 11087 Sec。 371日期1995年04月24日 102（e）1995年4月24日PCT PCT 1997年9月15日PCT公布。 公开号WO94 / 11078 日期1994年5月26日生物实体如细胞，微生物或其组分用含有微观磁性颗粒的磁性胶体标记。 磁性颗粒具有能够与实体进行生物特异性或非特异性结合的涂层。 固定装置包括具有铁磁收集结构的非磁性容器，用于在将容器放置在两个磁体之间的支撑件上时，将实体吸引到收集表面，在该收集表面上磁性标记的实体被固定。 铁磁收集结构优选地具有尖锐的边缘或高曲率，用于增强磁场和用于在单层中收集实体。 容器包括未阻挡的观察路径，使得可以观察和/或操纵固定的实体。 铁磁收集结构可以以各种二维图案布置以提供期望的收集配置。 该装置还可以具有用于允许液体试剂流过容器的入口和出口，用于洗涤或使固定的实体变窄。 支撑件可以平移，使得收集结构上的肩部通过肩部相对于磁场的横向方向的移动来集中收集的实体。

公开(公告)号：US5786040A

公开(公告)日：1998-07-28

申请号：US626082

申请日：1996-04-01

Applicant: Johna Leddy ,  Sudath Amarasinghe

Inventor： Johna Leddy ,  Sudath Amarasinghe

IPC: B03C1/01 ,  B03C1/025 ,  B03C1/034 ,  B03C1/035 ,  C23C6/00 ,  C23C24/08 ,  C23C30/00 ,  C25B11/00 ,  C25D3/54 ,  G21F9/12 ,  H01F1/00 ,  H01F10/00 ,  H01F41/24 ,  H01F41/26 ,  H01F41/30 ,  H01M4/02 ,  H01M4/86 ,  H01M4/88 ,  H01M4/90 ,  H01M4/92 ,  H01M8/00 ,  H01M8/04 ,  H01M8/10 ,  H01M8/24 ,  H01M10/42 ,  B05D1/00

CPC classification number: H01M4/8857 ,  B03C1/01 ,  B03C1/025 ,  B03C1/034 ,  B03C1/035 ,  B82Y25/00 ,  B82Y40/00 ,  C23C24/08 ,  C23C30/00 ,  C23C6/00 ,  C25B11/00 ,  C25D3/54 ,  G21F9/12 ,  H01F1/0027 ,  H01F1/009 ,  H01F10/007 ,  H01F41/24 ,  H01F41/26 ,  H01F41/301 ,  H01M10/42 ,  H01M4/02 ,  H01M4/86 ,  H01M4/8605 ,  H01M4/9083 ,  H01M4/926 ,  H01M8/04223 ,  H01M8/1004 ,  H01M8/1009 ,  H01F1/0054 ,  H01M2300/0082 ,  H01M4/8882 ,  H01M8/249 ,  Y10T428/32

Abstract: A method for coating a surface with a magnetic composite material exhibiting distinct flux properties due to gradient interfaces within the composite. Surfaces coated with such a composite can be used to improve fuel cells and to effect improved transport and separation of different species of materials. A wide variety of devices can incorporate such composite-coated surfaces, including separators, fuel cells, electrochemical cells, and electrodes for channeling flux of, or for effecting electrolysis of, magnetic species.

公开(公告)号：US5711871A

公开(公告)日：1998-01-27

申请号：US487277

申请日：1995-06-07

Applicant: Stefan Miltenyi

Inventor： Stefan Miltenyi

IPC: A61M1/36 ,  B01D35/06 ,  B03C1/00 ,  B03C1/025 ,  G01N1/34 ,  G01N33/543

CPC classification number: B03C1/002 ,  A61M1/3618 ,  A61M1/362 ,  B01D35/06 ,  B03C1/025 ,  G01N33/54326 ,  A61M1/36 ,  G01N1/34 ,  Y10S436/806

Abstract: Improved magnetic separation devices for magnetic separation procedures are provided. The improved separation devices contain matrices which provide uniform pores or channels that reduce the entrapment of air or non-target substances, and decrease the loss of target substances due to mechanical disruption. Target cells, from various systems and organs, or other target biological substances are labeled in conjunction with a suitable specific binding member, and isolated using the devices and methods of the present invention. In its simplest form, the cell separation system of the present invention has two main components: a magnetic separator and a cell separation reagent. A more complex separation device includes fluid passages, collection and storage containers and the separation column. The fluid circuitry can be constructed with integrated valves, or the valves may be applied externally to the fluid pathways.

Abstract translation: 提供了用于磁分离程序的改进的磁分离装置。 改进的分离装置包含提供均匀的孔或通道的基质，其减少空气或非目标物质的捕获，并减少由于机械破坏导致的目标物质的损失。 来自各种系统和器官的靶细胞或其它目标生物物质与合适的特异性结合成员一起标记，并使用本发明的装置和方法进行分离。 在其最简单的形式中，本发明的细胞分离系统具有两个主要成分：磁选机和细胞分离试剂。 更复杂的分离装置包括流体通道，收集和储存容器以及分离塔。 流体回路可以用集成阀构成，或者阀可以在流体路径的外部施加。

公开(公告)号：US5356015A

公开(公告)日：1994-10-18

申请号：US887499

申请日：1992-05-26

Applicant: Cornelis W. Notebaart ,  Frank P. Van Der Meer

Inventor： Cornelis W. Notebaart ,  Frank P. Van Der Meer

IPC: B03C1/025 ,  B03C1/029 ,  B03C1/00

CPC classification number: B03C1/029 ,  B03C1/025

Abstract: In a process for separating relatively magnetic mineral particles P.sub.m having magnetic susceptibilities .chi..sub.m, with .chi..sub.m >0 from relatively non-magnetic particles P.sub.n, having magnetic susceptibilities .chi..sub.n, with .chi..sub.m >.chi..sub.n, all the particles are suspended in a liquid stream, which is supplied to a separating container. The container is provided with an inlet and an outlet and forms a passageway for the stream therebetween. Furthermore an arrangement of magnetizable matrix elements provided in the passageway is magnetized. The supplying and magnetizing are conditioned in such a way, that depositions of particles are obtained predominantly upon the downstream side of the elements. From all the particles magnetic particles P.sub.m are captured to an effective amount upon the downstream side, thereby resulting in a high grade deposition.

Abstract translation: 在具有磁化率chi m的相对磁性矿物颗粒Pm的相对磁性矿物颗粒Pm的过程中，具有磁化率chi n，具有奇偶性的相对非磁性颗粒Pn，其中所有颗粒悬浮在液体中 流，其被供应到分离容器。 容器设置有入口和出口，并形成用于其间的流的通道。 此外，设置在通道中的可磁化矩阵元件的布置被磁化。 以这种方式调节供给和磁化，主要是在元件的下游侧获得颗粒的沉积。 从所有的粒子磁性粒子Pm被捕获到有效量在下游侧，从而导致高等级的沉积。