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1.发明公开公开(公告)号：US20240219392A1
公开(公告)日：2024-07-04
申请号：US18596432
申请日：2024-03-05
发明人： Stefan Miltenyi , Winfried Schimmelpfennig , Holger Lantow , Niklas Elmar Neuschaefer , Martin Biehl , Eiad Kabaha , Juergen Schulz
IPC分类号： G01N33/58 , A61M1/02 , A61M1/36 , B01D15/38 , B01D21/26 , B01L3/00 , B03C1/00 , B03C1/027 , B03C1/032 , B03C1/033 , B03C1/034 , B03C1/28 , B04B1/12 , B04B5/00 , B04B5/04 , B04B5/10 , B04B7/08 , B04B13/00 , C12M1/00 , C12M1/26 , C12M1/36 , C12N5/00 , C12N5/077 , C12N5/0783 , C12N5/0789 , G01N35/00
CPC分类号： G01N33/58 , A61M1/0209 , A61M1/3618 , A61M1/3633 , A61M1/3679 , A61M1/3692 , A61M1/3693 , A61M1/3696 , B01D15/3809 , B01D15/3885 , B01D21/26 , B03C1/002 , B03C1/027 , B03C1/032 , B03C1/0332 , B03C1/0335 , B03C1/034 , B03C1/288 , B04B1/12 , B04B5/00 , B04B5/04 , B04B5/0442 , B04B5/10 , B04B7/08 , B04B13/00 , C12M23/28 , C12M33/10 , C12M41/48 , C12M47/04 , C12N5/0018 , C12N5/0636 , C12N5/0646 , C12N5/0647 , C12N5/0669 , G01N35/0098 , A61M1/3623 , A61M2202/0071 , A61M2202/0413 , A61M2202/0427 , A61M2202/10 , B01D21/262 , B01L3/5021 , B03C2201/18 , B03C2201/26 , B04B2005/0464 , B04B2013/006 , C12N2500/34 , C12N2501/998 , G01N2333/70596
摘要： The invention relates to a system, comprising: a) a sample processing unit, comprising an input port and an output port coupled to a rotating container having at least one sample chamber, the sample processing unit configured provide a first processing step to a sample or to rotate the container so as to apply a centrifugal force to a sample deposited in the chamber and separate at least a first component and a second component of the deposited sample; and b) a sample separation unit coupled to the output port of the sample processing unit, the cell separation unit comprising separation column holder, a pump and a plurality of valves configured to at least partially control fluid flow through a fluid circuitry and a separation column positioned in the holder, the separation column configured to separate labeled and unlabeled components of sample flowed through the column.
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公开(公告)号：US11499977B2
公开(公告)日：2022-11-15
申请号：US17725388
申请日：2022-04-20
发明人： Stefan Miltenyi , Winfried Schimmelpfennig , Holger Lantow , Niklas Elmar Neuschaefer , Martin Biehl , Eiad Kabaha , Juergen Schulz
IPC分类号： C12M3/00 , B01L3/00 , G01N33/58 , A61M1/36 , B03C1/28 , B04B5/04 , B04B13/00 , B03C1/032 , B03C1/00 , B03C1/027 , B03C1/033 , B03C1/034 , A61M1/02 , G01N35/00 , C12N5/00 , C12M1/26 , C12M1/00 , B01D21/26 , B04B5/00 , B04B5/10 , B04B1/12 , B04B7/08 , B01D15/38 , C12N5/0789 , C12N5/077 , C12N5/0783 , C12M1/36
摘要： The invention relates to a system, comprising: a) a sample processing unit, comprising an input port and an output port coupled to a rotating container having at least one sample chamber, the sample processing unit configured provide a first processing step to a sample or to rotate the container so as to apply a centrifugal force to a sample deposited in the chamber and separate at least a first component and a second component of the deposited sample; and b) a sample separation unit coupled to the output port of the sample processing unit, the cell separation unit comprising separation column holder (42), a pump (64) and a plurality of valves (1-11) configured to at least partially control fluid flow through a fluid circuitry and a separation column (40) positioned in the holder, the separation column configured to separate labeled and unlabeled components of sample flowed through the column.
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公开(公告)号：US20200030817A1
公开(公告)日：2020-01-30
申请号：US16337069
申请日：2017-09-28
摘要： The invention relates to a magnetic matrix for high intensity magnetic separator which is fed with a pulp containing magnetic and non-magnetic particles, the magnetic matrix (8) comprising a series of grooved metal plates (7) on both sides thereof, the grooved plates being arranged in rows parallel to and spaced apart from each other from the same spacing (6) within a housing, each face of each metal grooved plate (7) having the ridges aligned with the valleys of the face facing it of the grooved plate (7), and a corrugated expanded sheet (12) is disposed at each spacing (6) between adjacent grooved plates (7), with corrugations of the corrugated expanded sheets (12) accompanying the ridge-valley alignments of the respective grooved plates (7).
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公开(公告)号：US10449550B2
公开(公告)日：2019-10-22
申请号：US15317505
申请日：2015-06-09
发明人： Tatsuya Oki , Tomohiro Noguchi , Taeko Hazumi
摘要： The present invention provides a sorting device and a sorting method for sorting a magnetically attractable substance and a non-magnetically attractable substance from a sorting target using a high gradient magnetic separator.
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公开(公告)号：US09884326B2
公开(公告)日：2018-02-06
申请号：US14900795
申请日：2014-06-30
发明人： Tatsuya Oki , Taeko Hazumi , Tomohiro Noguchi
CPC分类号： B03C1/02 , B03C1/032 , B03C1/0335 , B03C1/034 , B03C1/288
摘要： To provide matrix for magnetic separator capable of sorting magnetic and non-magnetic particles highly accurately and efficiently and enabling previous simulative recognition of correct magnetic force distribution in matrix space, and magnetic separator.Matrix for magnetic separator of present invention includes: entirely approximately wavelike plate-shaped magnetic walls each having orderly structure of wave-shaped bent sections continuously repeatedly formed in wave advancing direction and each having wave height h of ≦1 mm and approximately inverted V- or U-shape; and entirely approximately box-shaped housing part housing magnetic walls and having in opposite surfaces, introducing and discharging parts through which sorting target fluid containing magnetically-attractable substance magnetically-attractable to magnetic walls is passed thereinto/therefrom, magnetic walls arranged in juxtaposition such that convex shapes of wave-shaped bent sections in one magnetic wall face concave shapes thereof in another magnetic wall adjacent to one magnetic wall with constant interval therebetween.
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公开(公告)号：US09463470B2
公开(公告)日：2016-10-11
申请号：US14001590
申请日：2012-02-28
申请人： Kazuki Murahashi , Kentarou Morita , Yuzuru Kato , Atsushi Murata
发明人： Kazuki Murahashi , Kentarou Morita , Yuzuru Kato , Atsushi Murata
CPC分类号： B03C1/034 , B03C1/0332 , B03C1/288 , B03C2201/18
摘要： Means for Solving the ProblemAccording to an aspect of the present invention, there is provided a magnetic-separation filter device that removes contaminants of fine ferromagnetic particles from a fluid containing such contaminants, comprising: a substantially cylindrical housing; two partition plates that are disposed in an inside of the housing so as to extend in a vertical direction of the housing, dividing the inside of the housing by being disposed in parallel to each other;a filter medium that includes a fine amorphous-alloy wire bundle filled in a first region defined by the housing and the two partition plates; andplural permanent magnets that are provided on both sides of the first region outside the housing, wherein the contaminants of fine ferromagnetic particles are adsorbed on the filter media by flowing the fluid containing such contaminants through the first region in which the magnetic field has been formed by these plural permanent magnets.
摘要翻译： 设置在壳体外部的第一区域的两侧的多个永久磁铁，其中通过使含有这些污染物的流体流过形成有磁场的第一区域，将精细铁磁颗粒的污染物吸附在过滤介质上 这些多个永久磁铁。
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7.发明授权
公开(公告)号：US6020210A
公开(公告)日：2000-02-01
申请号：US377774
申请日：1995-01-23
申请人： Stefan Miltenyi
发明人： Stefan Miltenyi
IPC分类号： B03C1/00 , B03C1/01 , B03C1/033 , B03C1/034 , G01N33/543 , G01N33/553 , G01N33/48 , G01N33/567 , A61L3/00
CPC分类号： G01N33/5434 , B03C1/002 , B03C1/01 , B03C1/0332 , B03C1/034 , G01N2400/22 , G01N2446/20 , G01N2446/30 , G01N2446/90 , Y10S436/807 , Y10S436/824
摘要： Improvements in the existing procedures and materials for conduct of high gradient magnetic separation (HGMS) are disclosed. The use of plastic coated matrices especially small spheres or balls which form superior magnetic gradient-intensifying supports are disclosed, along with improved methods and apparatus to conduct HGMS. The selection of small spheres in combination with the coating provides for uniform matrices of high stability.
摘要翻译： 公开了用于进行高梯度磁选（HGMS）的现有程序和材料的改进。 公开了使用形成优异的磁梯度增强载体的塑料涂层基质，特别是小球或球，以及改进的用于进行HGMS的方法和装置。 与涂层组合的小球的选择提供了高稳定性的均匀基质。
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公开(公告)号：US06001248A
公开(公告)日：1999-12-14
申请号：US486570
申请日：1995-06-07
申请人： Johna Leddy , Sudath Amarasinghe , Lois Anne Zook
发明人： Johna Leddy , Sudath Amarasinghe , Lois Anne Zook
IPC分类号： B03C1/01 , B03C1/025 , B03C1/034 , B03C1/035 , C23C6/00 , C23C24/08 , C23C30/00 , C25B11/00 , C25D3/54 , G21F9/12 , H01F1/00 , H01F10/00 , H01F41/24 , H01F41/26 , H01F41/30 , H01M4/02 , H01M4/86 , H01M4/88 , H01M4/90 , H01M4/92 , H01M8/00 , H01M8/04 , H01M8/10 , H01M8/24 , H01M10/42 , B01D35/06
CPC分类号： H01M4/8857 , B03C1/01 , B03C1/025 , B03C1/034 , B03C1/035 , B82Y25/00 , B82Y40/00 , C23C24/08 , C23C30/00 , C23C6/00 , C25B11/00 , C25D3/54 , G21F9/12 , H01F1/0027 , H01F1/009 , H01F10/007 , H01F41/24 , H01F41/26 , H01F41/301 , H01M10/42 , H01M4/02 , H01M4/86 , H01M4/8605 , H01M4/9083 , H01M4/926 , H01M8/04223 , H01M8/1004 , H01M8/1009 , H01F1/0054 , H01M2300/0082 , H01M4/8882 , H01M8/249 , Y10T428/32
摘要： Magnetic composites exhibit distinct flux properties due to gradient interfaces. The composites can be used to improve fuel cells and batteries and effect transport and separation of different species of materials, for example, transition metal species such as lanthanides and actinides. A variety of devices can be made utilizing the composites including a separator, an electrode for channeling flux of magnetic species, an electrode for effecting electrolysis of magnetic species, a system for channeling electrolyte species, a system for separating particles with different magnetic susceptibilities, improved fuel cells, batteries, and oxygen concentrators. Some composites can be used to make a separator for distinguishing between two species of materials and a flux switch to regulate the flow of a chemical species. Some composites can control chemical species transport and distribution. Other composites enable ambient pressure fuel cells having enhanced performance and reduced weight to be produced. Still other composites enable rechargeable batteries to be made that have longer secondary cycle life and improved output power. Methods involving these composites provide distinct ways for these composites to be utilized.
摘要翻译： 由于梯度界面，磁性复合材料表现出不同的通量特性。 该复合材料可用于改善燃料电池和电池，并影响不同种类材料的输送和分离，例如过渡金属物质如镧系元素和锕系元素。 可以利用包括分离器，用于引导磁性物质通量的电极，用于实现磁性物质电解的电极，用于引导电解质物质的系统，用于分离具有不同磁化率的颗粒的系统的改进的复合材料来制备各种装置 燃料电池，电池和氧气浓缩器。 一些复合材料可用于制造用于区分两种材料的分离器和用于调节化学物质流动的通量开关。 一些复合材料可以控制化学物种的运输和分配。 其他复合材料能够产生具有增强性能和减轻重量的环境压力的燃料电池。 其他复合材料使得可再生电池具有更长的二次循环寿命和改善的输出功率。 涉及这些复合材料的方法为这些复合材料提供了不同的方法。
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公开(公告)号：US5622831A
公开(公告)日：1997-04-22
申请号：US482652
申请日：1995-06-07
申请人： Paul A. Liberti , Yozhou Wang
发明人： Paul A. Liberti , Yozhou Wang
IPC分类号： B03C1/033 , B03C1/034 , B03C1/035 , C12M3/00 , G01N33/543 , G01N33/569 , G01N35/00 , G01N35/02 , G01N33/567 , G01N33/553
CPC分类号： G01N35/026 , B03C1/0332 , B03C1/034 , B03C1/035 , C12M47/04 , G01N33/54326 , G01N33/56972 , G01N2333/70589 , G01N35/0098 , Y10S436/806 , Y10S436/807 , Y10S436/824 , Y10T436/117497
摘要： Methods and devices are disclosed which are useful for collecting magnetic materials in either internally or externally generated magnetic gradient fields, followed by resuspension into solution with a simple manipulation of the magnetic device. The methods provide for removal of excess reagent, washing of magnetic material, and resuspension for analysis, among other uses. The methods are applicable to all types of biological material that are susceptible to magnetic labelling, including, for example, cells, viruses, proteins, hormones, and receptor-ligand complexes. Several devices are disclosed to take advantage of the method for cellular and immunoassay applications, including both internal and external devices. Both flow-through and static separators are disclosed.
摘要翻译： 公开了用于在内部或外部产生的磁梯度场中收集磁性材料的方法和装置，随后通过简单地操纵磁性装置将其重新悬浮到溶液中。 除了其他用途之外，该方法提供去除过量试剂，洗涤磁性材料和再悬浮以用于分析。 该方法适用于易受磁性标记影响的所有类型的生物材料，包括例如细胞，病毒，蛋白质，激素和受体 - 配体复合物。 公开了若干设备以利用蜂窝和免疫测定应用的方法，包括内部和外部设备。 公开了流通式和静态分离器。
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公开(公告)号：US5122269A
公开(公告)日：1992-06-16
申请号：US615607
申请日：1990-11-19
IPC分类号： B03C1/034
CPC分类号： B03C1/034
摘要： A bar filter is disclosed which is fit for use in an apparatus for removing phosphates from waste water. Thereto phosphates are chemically bound to magnetic material, like magnetite, and subsequently the liquid containing the suspended particles is fed through a filter according to the present invention. The magnetic particles adhere to the bars of the magnetic filter so that the filter gradually fills with the particles. According to the present invention, the configuration of the bars of the filter is such that the gradient of the magnetic field is substantially constant, leading to an even filling of the filter, so that the frequency of flushing the filter to empty it is limited as far as possible. Preferably the density of the bars is a plane perpendicular to the bars is constant.
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