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1.发明公开公开(公告)号：US20240219392A1
公开(公告)日：2024-07-04
申请号：US18596432
申请日：2024-03-05
发明人： Stefan Miltenyi , Winfried Schimmelpfennig , Holger Lantow , Niklas Elmar Neuschaefer , Martin Biehl , Eiad Kabaha , Juergen Schulz
IPC分类号： G01N33/58 , A61M1/02 , A61M1/36 , B01D15/38 , B01D21/26 , B01L3/00 , B03C1/00 , B03C1/027 , B03C1/032 , B03C1/033 , B03C1/034 , B03C1/28 , B04B1/12 , B04B5/00 , B04B5/04 , B04B5/10 , B04B7/08 , B04B13/00 , C12M1/00 , C12M1/26 , C12M1/36 , C12N5/00 , C12N5/077 , C12N5/0783 , C12N5/0789 , G01N35/00
CPC分类号： G01N33/58 , A61M1/0209 , A61M1/3618 , A61M1/3633 , A61M1/3679 , A61M1/3692 , A61M1/3693 , A61M1/3696 , B01D15/3809 , B01D15/3885 , B01D21/26 , B03C1/002 , B03C1/027 , B03C1/032 , B03C1/0332 , B03C1/0335 , B03C1/034 , B03C1/288 , B04B1/12 , B04B5/00 , B04B5/04 , B04B5/0442 , B04B5/10 , B04B7/08 , B04B13/00 , C12M23/28 , C12M33/10 , C12M41/48 , C12M47/04 , C12N5/0018 , C12N5/0636 , C12N5/0646 , C12N5/0647 , C12N5/0669 , G01N35/0098 , A61M1/3623 , A61M2202/0071 , A61M2202/0413 , A61M2202/0427 , A61M2202/10 , B01D21/262 , B01L3/5021 , B03C2201/18 , B03C2201/26 , B04B2005/0464 , B04B2013/006 , C12N2500/34 , C12N2501/998 , G01N2333/70596
摘要： The invention relates to a system, comprising: a) a sample processing unit, comprising an input port and an output port coupled to a rotating container having at least one sample chamber, the sample processing unit configured provide a first processing step to a sample or to rotate the container so as to apply a centrifugal force to a sample deposited in the chamber and separate at least a first component and a second component of the deposited sample; and b) a sample separation unit coupled to the output port of the sample processing unit, the cell separation unit comprising separation column holder, a pump and a plurality of valves configured to at least partially control fluid flow through a fluid circuitry and a separation column positioned in the holder, the separation column configured to separate labeled and unlabeled components of sample flowed through the column.
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公开(公告)号：US11499977B2
公开(公告)日：2022-11-15
申请号：US17725388
申请日：2022-04-20
发明人： Stefan Miltenyi , Winfried Schimmelpfennig , Holger Lantow , Niklas Elmar Neuschaefer , Martin Biehl , Eiad Kabaha , Juergen Schulz
IPC分类号： C12M3/00 , B01L3/00 , G01N33/58 , A61M1/36 , B03C1/28 , B04B5/04 , B04B13/00 , B03C1/032 , B03C1/00 , B03C1/027 , B03C1/033 , B03C1/034 , A61M1/02 , G01N35/00 , C12N5/00 , C12M1/26 , C12M1/00 , B01D21/26 , B04B5/00 , B04B5/10 , B04B1/12 , B04B7/08 , B01D15/38 , C12N5/0789 , C12N5/077 , C12N5/0783 , C12M1/36
摘要： The invention relates to a system, comprising: a) a sample processing unit, comprising an input port and an output port coupled to a rotating container having at least one sample chamber, the sample processing unit configured provide a first processing step to a sample or to rotate the container so as to apply a centrifugal force to a sample deposited in the chamber and separate at least a first component and a second component of the deposited sample; and b) a sample separation unit coupled to the output port of the sample processing unit, the cell separation unit comprising separation column holder (42), a pump (64) and a plurality of valves (1-11) configured to at least partially control fluid flow through a fluid circuitry and a separation column (40) positioned in the holder, the separation column configured to separate labeled and unlabeled components of sample flowed through the column.
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公开(公告)号：US20230176062A1
公开(公告)日：2023-06-08
申请号：US18083279
申请日：2022-12-16
发明人： Stefan Miltenyi , Winfried Schimmelpfennig , Holger Lantow , Niklas Elmar Neuschaefer , Martin Biehl , Eiad Kabaha , Juergen Schulz
IPC分类号： G01N33/58 , A61M1/36 , B03C1/28 , B04B5/04 , B04B13/00 , B03C1/032 , B03C1/00 , B03C1/027 , B03C1/033 , B03C1/034 , A61M1/02 , G01N35/00 , C12N5/00 , C12M1/26 , C12M1/00 , B01D21/26 , B04B5/00 , B04B5/10 , B04B1/12 , B04B7/08 , B01D15/38 , C12N5/0789 , C12N5/077 , C12N5/0783 , C12M1/36
CPC分类号： G01N33/58 , A61M1/0209 , A61M1/3618 , A61M1/3633 , A61M1/3679 , A61M1/3692 , A61M1/3693 , A61M1/3696 , B01D15/3809 , B01D15/3885 , B01D21/26 , B03C1/002 , B03C1/027 , B03C1/032 , B03C1/034 , B03C1/288 , B03C1/0332 , B03C1/0335 , B04B1/12 , B04B5/00 , B04B5/04 , B04B5/10 , B04B5/0442 , B04B7/08 , B04B13/00 , C12M23/28 , C12M33/10 , C12M41/48 , C12M47/04 , C12N5/0018 , C12N5/0636 , C12N5/0646 , C12N5/0647 , C12N5/0669 , G01N35/0098 , B01L3/5021 , B03C2201/18 , B03C2201/26
摘要： The invention relates to a system, comprising: a) a sample processing unit, comprising an input port and an output port coupled to a rotating container having at least one sample chamber, the sample processing unit configured provide a first processing step to a sample or to rotate the container so as to apply a centrifugal force to a sample deposited in the chamber and separate at least a first component and a second component of the deposited sample; and b) a sample separation unit coupled to the output port of the sample processing unit, the cell separation unit comprising separation column holder (42), a pump (64) and a plurality of valves (1-11) configured to at least partially control fluid flow through a fluid circuitry and a separation column (40) positioned in the holder, the separation column configured to separate labeled and unlabeled components of sample flowed through the column.
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4.发明授权公开(公告)号：US11531031B2
公开(公告)日：2022-12-20
申请号：US17725509
申请日：2022-04-20
发明人： Stefan Miltenyi , Winfried Schimmelpfennig , Holger Lantow , Niklas Elmar Neuschaefer , Martin Biehl , Eiad Kabaha , Juergen Schulz
IPC分类号： C12M3/00 , B01L3/00 , G01N33/58 , A61M1/36 , B03C1/28 , B04B5/04 , B04B13/00 , B03C1/032 , B03C1/00 , B03C1/027 , B03C1/033 , B03C1/034 , A61M1/02 , G01N35/00 , C12N5/00 , C12M1/26 , C12M1/00 , B01D21/26 , B04B5/00 , B04B5/10 , B04B1/12 , B04B7/08 , B01D15/38 , C12N5/0789 , C12N5/077 , C12N5/0783 , C12M1/36
摘要： The invention relates to a system, comprising: a) a sample processing unit, comprising an input port and an output port coupled to a rotating container having at least one sample chamber, the sample processing unit configured provide a first processing step to a sample or to rotate the container so as to apply a centrifugal force to a sample deposited in the chamber and separate at least a first component and a second component of the deposited sample; and b) a sample separation unit coupled to the output port of the sample processing unit, the cell separation unit comprising separation column holder (42), a pump (64) and a plurality of valves (1-11) configured to at least partially control fluid flow through a fluid circuitry and a separation column (40) positioned in the holder, the separation column configured to separate labeled and unlabeled components of sample flowed through the column.
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公开(公告)号：US11933787B2
公开(公告)日：2024-03-19
申请号：US18083279
申请日：2022-12-16
发明人： Stefan Miltenyi , Winfried Schimmelpfennig , Holger Lantow , Niklas Elmar Neuschaefer , Martin Biehl , Eiad Kabaha , Juergen Schulz
IPC分类号： C12M3/00 , A61M1/02 , A61M1/36 , B01D15/38 , B01D21/26 , B01L3/00 , B03C1/00 , B03C1/027 , B03C1/032 , B03C1/033 , B03C1/034 , B03C1/28 , B04B1/12 , B04B5/00 , B04B5/04 , B04B5/10 , B04B7/08 , B04B13/00 , C12M1/00 , C12M1/26 , C12M1/36 , C12N5/00 , C12N5/077 , C12N5/0783 , C12N5/0789 , G01N33/00 , G01N33/58 , G01N35/00
CPC分类号： G01N33/58 , A61M1/0209 , A61M1/3618 , A61M1/3633 , A61M1/3679 , A61M1/3692 , A61M1/3693 , A61M1/3696 , B01D15/3809 , B01D15/3885 , B01D21/26 , B03C1/002 , B03C1/027 , B03C1/032 , B03C1/0332 , B03C1/0335 , B03C1/034 , B03C1/288 , B04B1/12 , B04B5/00 , B04B5/04 , B04B5/0442 , B04B5/10 , B04B7/08 , B04B13/00 , C12M23/28 , C12M33/10 , C12M41/48 , C12M47/04 , C12N5/0018 , C12N5/0636 , C12N5/0646 , C12N5/0647 , C12N5/0669 , G01N35/0098 , A61M1/3623 , A61M2202/0071 , A61M2202/0413 , A61M2202/0427 , A61M2202/10 , B01D21/262 , B01L3/5021 , B03C2201/18 , B03C2201/26 , B04B2005/0464 , B04B2013/006 , C12N2500/34 , C12N2501/998 , G01N2333/70596
摘要： The invention relates to a system, comprising: a) a sample processing unit, comprising an input port and an output port coupled to a rotating container having at least one sample chamber, the sample processing unit configured provide a first processing step to a sample or to rotate the container so as to apply a centrifugal force to a sample deposited in the chamber and separate at least a first component and a second component of the deposited sample; and b) a sample separation unit coupled to the output port of the sample processing unit, the cell separation unit comprising separation column holder (42), a pump (64) and a plurality of valves (1-11) configured to at least partially control fluid flow through a fluid circuitry and a separation column (40) positioned in the holder, the separation column configured to separate labeled and unlabeled components of sample flowed through the column.
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公开(公告)号：US20200292552A1
公开(公告)日：2020-09-17
申请号：US16889471
申请日：2020-06-01
发明人： Stefan Miltenyi , Winfried Schimmelpfennig , Holger Lantow , Niklas Elmar Neuschaefer , Martin Biehl , Eiad Kabaha , Juergen Schulz
IPC分类号： G01N33/58 , A61M1/36 , B03C1/28 , B04B5/04 , B04B13/00 , B03C1/032 , B03C1/00 , B03C1/027 , B03C1/033 , B03C1/034 , A61M1/02 , G01N35/00 , C12N5/00 , C12M1/26 , C12M1/00 , B01D21/26 , B04B5/00 , B04B5/10 , B04B1/12 , B04B7/08 , B01D15/38 , C12N5/0789 , C12N5/077 , C12N5/0783 , C12M1/36
摘要： The invention relates to a system, comprising: a) a sample processing unit, comprising an input port and an output port coupled to a rotating container having at least one sample chamber, the sample processing unit configured provide a first processing step to a sample or to rotate the container so as to apply a centrifugal force to a sample deposited in the chamber and separate at least a first component and a second component of the deposited sample; and b) a sample separation unit coupled to the output port of the sample processing unit, the cell separation unit comprising separation column holder (42), a pump (64) and a plurality of valves (1-11) configured to at least partially control fluid flow through a fluid circuitry and a separation column (40) positioned in the holder, the separation column configured to separate labeled and unlabeled components of sample flowed through the column.
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公开(公告)号：US11499976B2
公开(公告)日：2022-11-15
申请号：US16889471
申请日：2020-06-01
发明人： Stefan Miltenyi , Winfried Schimmelpfennig , Holger Lantow , Niklas Elmar Neuschaefer , Martin Biehl , Eiad Kabaha , Juergen Schulz
IPC分类号： C12M3/00 , B01L3/00 , G01N33/58 , A61M1/36 , B03C1/28 , B04B5/04 , B04B13/00 , B03C1/032 , B03C1/00 , B03C1/027 , B03C1/033 , B03C1/034 , A61M1/02 , G01N35/00 , C12N5/00 , C12M1/26 , C12M1/00 , B01D21/26 , B04B5/00 , B04B5/10 , B04B1/12 , B04B7/08 , B01D15/38 , C12N5/0789 , C12N5/077 , C12N5/0783 , C12M1/36
摘要： The invention relates to a system, comprising: a) a sample processing unit, comprising an input port and an output port coupled to a rotating container having at least one sample chamber, the sample processing unit configured provide a first processing step to a sample or to rotate the container so as to apply a centrifugal force to a sample deposited in the chamber and separate at least a first component and a second component of the deposited sample; and b) a sample separation unit coupled to the output port of the sample processing unit, the cell separation unit comprising separation column holder (42), a pump (64) and a plurality of valves (1-11) configured to at least partially control fluid flow through a fluid circuitry and a separation column (40) positioned in the holder, the separation column configured to separate labeled and unlabeled components of sample flowed through the column.
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8.发明申请公开(公告)号：US20220326248A1
公开(公告)日：2022-10-13
申请号：US17725509
申请日：2022-04-20
发明人： Stefan Miltenyi , Winfried Schimmelpfennig , Holger Lantow , Niklas Elmar Neuschaefer , Martin Biehl , Eiad Kabaha , Juergen Schulz
IPC分类号： G01N33/58 , A61M1/36 , B03C1/28 , B04B5/04 , B04B13/00 , B03C1/032 , B03C1/00 , B03C1/027 , B03C1/033 , B03C1/034 , A61M1/02 , G01N35/00 , C12N5/00 , C12M1/26 , C12M1/00 , B01D21/26 , B04B5/00 , B04B5/10 , B04B1/12 , B04B7/08 , B01D15/38 , C12N5/0789 , C12N5/077 , C12N5/0783 , C12M1/36
摘要： The invention relates to a system, comprising: a) a sample processing unit, comprising an input port and an output port coupled to a rotating container having at least one sample chamber, the sample processing unit configured provide a first processing step to a sample or to rotate the container so as to apply a centrifugal force to a sample deposited in the chamber and separate at least a first component and a second component of the deposited sample; and b) a sample separation unit coupled to the output port of the sample processing unit, the cell separation unit comprising separation column holder (42), a pump (64) and a plurality of valves (1-11) configured to at least partially control fluid flow through a fluid circuitry and a separation column (40) positioned in the holder, the separation column configured to separate labeled and unlabeled components of sample flowed through the column.
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