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    System and method for biological applications using pre-determined sized nanoparticles
    1.
    发明授权
    System and method for biological applications using pre-determined sized nanoparticles 有权
    使用预定尺寸的纳米颗粒的生物应用的系统和方法

    公开(公告)号：US09510767B2

    公开(公告)日：2016-12-06

    申请号：US14832319

    申请日：2015-08-21

    Applicant: ARkival Technology Corp.

    Inventor： Ronald D. Weiss

    IPC: A61B5/05 ,  A61K49/00 ,  A61K49/18 ,  A61B5/055 ,  A61B5/00 ,  B03C1/30

    CPC classification number: A61B5/4839 ,  A61B5/0035 ,  A61B5/0515 ,  A61B5/055 ,  A61B5/7246 ,  A61B2562/0285 ,  A61K49/0002 ,  A61K49/1818 ,  B03C1/025 ,  B03C1/30 ,  B03C2201/18 ,  B03C2201/26

    Abstract: The invention features an apparatus for producing a fluid stream having plurality of nanoparticles in the fluid stream. The apparatus includes a source configured to provide a fluid stream having a first randomly sized distribution of a plurality of nanoparticles; a flow control zone configured to receive the fluid stream from the source and to control the fluid stream to produce a controlled fluid stream having a selected flow rate; a separation zone configured to receive and to separate the selectively controlled fluid stream into at least one separated fluid stream having a non-randomly sized distribution of nanoparticles; and a collection zone capable of receiving the separated fluid stream according to at least one non-random sized distribution of nanoparticles to produce at least one collected stream. The apparatus is configured for a continuous flow of the fluid stream. A size of a nanoparticle can be related to an intrinsic core diameter, a hydrodynamic diameter, and a combination of intrinsic core diameter and hydrodynamic diameter measurements. The nanoparticles can include non-magnetic nanoparticles, partially magnetic nanoparticles, magnetic nanoparticles, superparamagnetic nanoparticles, and a combination of at least two different nanoparticle types. The invention also features methods for producing said fluid streams. The invention further features apparatus and methods for cancer confirmation and targeted therapeutic drug development.

    Abstract translation: 本发明的特征在于一种用于在流体流中产生具有多个纳米颗粒的流体流的装置。 该装置包括：源，其配置成提供具有多个纳米颗粒的第一随机大小分布的流体流; 流动控制区域，其被配置为从所述源接收流体流并且控制所述流体流以产生具有选定流量的受控流体流; 分离区，被配置为接收并且将选择性控制的流体流分离成具有非随机大小的纳米颗粒分布的至少一个分离的流体流; 以及能够根据至少一个非随机大小的纳米颗粒分布接收分离的流体流以产生至少一个收集的流的收集区。 该装置构造成用于流体流的连续流动。 纳米颗粒的尺寸可以与本征芯直径，流体动力学直径以及本征芯直径和流体动力学直径测量的组合有关。 纳米颗粒可以包括非磁性纳米颗粒，部分磁性纳米颗粒，磁性纳米颗粒，超顺磁性纳米颗粒，以及至​​少两种不同纳米颗粒类型的组合。 本发明还涉及生产所述流体流的方法。 本发明还涉及用于癌症确认和靶向治疗药物开发的装置和方法。

    System and method for biological applications using pre-determined sized nanoparticles
    3.
    发明授权
    System and method for biological applications using pre-determined sized nanoparticles 有权

    公开(公告)号：US09980675B2

    公开(公告)日：2018-05-29

    申请号：US15342262

    申请日：2016-11-03

    Applicant: ARkival Technology Corp.

    Inventor： Ronald D. Weiss

    IPC: A61B5/055 ,  A61B5/00 ,  A61B5/05 ,  A61K49/00 ,  A61K49/18 ,  B03C1/30 ,  B03C1/025

    CPC classification number: A61B5/4839 ,  A61B5/0035 ,  A61B5/0515 ,  A61B5/055 ,  A61B5/7246 ,  A61B2562/0285 ,  A61K49/0002 ,  A61K49/1818 ,  B03C1/025 ,  B03C1/30 ,  B03C2201/18 ,  B03C2201/26

    Abstract: The invention features an apparatus for producing a fluid stream having plurality of nanoparticles in the fluid stream. The apparatus includes a source configured to provide a fluid stream having a first randomly sized distribution of a plurality of nanoparticles; a flow control zone configured to receive the fluid stream from the source and to control the fluid stream to produce a controlled fluid stream having a selected flow rate; a separation zone configured to receive and to separate the selectively controlled fluid stream into at least one separated fluid stream having a non-randomly sized distribution of nanoparticles; and a collection zone capable of receiving the separated fluid stream according to at least one non-random sized distribution of nanoparticles to produce at least one collected stream. The apparatus is configured for a continuous flow of the fluid stream. A size of a nanoparticle can be related to an intrinsic core diameter, a hydrodynamic diameter, and a combination of intrinsic core diameter and hydrodynamic diameter measurements. The nanoparticles can include non-magnetic nanoparticles, partially magnetic nanoparticles, magnetic nanoparticles, superparamagnetic nanoparticles, and a combination of at least two different nanoparticle types. The invention also features methods for producing said fluid streams. The invention further features apparatus and methods for cancer confirmation and targeted therapeutic drug development.

    SYSTEM AND METHOD FOR BIOLOGICAL APPLICATIONS USING PRE-DETERMINED SIZED NANOPARTICLES
    4.
    发明申请
    SYSTEM AND METHOD FOR BIOLOGICAL APPLICATIONS USING PRE-DETERMINED SIZED NANOPARTICLES 有权
    使用预先确定的尺寸纳米颗粒的生物应用的系统和方法

    公开(公告)号：US20160051165A1

    公开(公告)日：2016-02-25

    申请号：US14832319

    申请日：2015-08-21

    Applicant: ARkival Technology Corp.

    Inventor： Ronald D. Weiss

    IPC: A61B5/05 ,  A61B5/00 ,  B03C1/04 ,  A61B5/055 ,  A61K49/00 ,  A61K49/18

    CPC classification number: A61B5/4839 ,  A61B5/0035 ,  A61B5/0515 ,  A61B5/055 ,  A61B5/7246 ,  A61B2562/0285 ,  A61K49/0002 ,  A61K49/1818 ,  B03C1/025 ,  B03C1/30 ,  B03C2201/18 ,  B03C2201/26

    Abstract: The invention features an apparatus for producing a fluid stream having plurality of nanoparticles in the fluid stream. The apparatus includes a source configured to provide a fluid stream having a first randomly sized distribution of a plurality of nanoparticles; a flow control zone configured to receive the fluid stream from the source and to control the fluid stream to produce a controlled fluid stream having a selected flow rate; a separation zone configured to receive and to separate the selectively controlled fluid stream into at least one separated fluid stream having a non-randomly sized distribution of nanoparticles; and a collection zone capable of receiving the separated fluid stream according to at least one non-random sized distribution of nanoparticles to produce at least one collected stream. The apparatus is configured for a continuous flow of the fluid stream. A size of a nanoparticle can be related to an intrinsic core diameter, a hydrodynamic diameter, and a combination of intrinsic core diameter and hydrodynamic diameter measurements. The nanoparticles can include non-magnetic nanoparticles, partially magnetic nanoparticles, magnetic nanoparticles, superparamagnetic nanoparticles, and a combination of at least two different nanoparticle types. The invention also features methods for producing said fluid streams. The invention further features apparatus and methods for cancer confirmation and targeted therapeutic drug development.

    Abstract translation: 本发明的特征在于一种用于在流体流中产生具有多个纳米颗粒的流体流的装置。 该装置包括：源，其配置成提供具有多个纳米颗粒的第一随机大小分布的流体流; 流动控制区域，其被配置为从所述源接收流体流并且控制所述流体流以产生具有选定流量的受控流体流; 分离区，被配置为接收并且将选择性控制的流体流分离成具有非随机大小的纳米颗粒分布的至少一个分离的流体流; 以及能够根据至少一个非随机大小的纳米颗粒分布接收分离的流体流以产生至少一个收集的流的收集区。 该装置构造成用于流体流的连续流动。 纳米颗粒的尺寸可以与本征芯直径，流体动力学直径以及本征芯直径和流体动力学直径测量的组合有关。 纳米颗粒可以包括非磁性纳米颗粒，部分磁性纳米颗粒，磁性纳米颗粒，超顺磁性纳米颗粒，以及至​​少两种不同纳米颗粒类型的组合。 本发明还涉及生产所述流体流的方法。 本发明还涉及用于癌症确认和靶向治疗药物开发的装置和方法。

    SYSTEM AND METHOD FOR BIOLOGICAL APPLICATIONS USING PRE-DETERMINED SIZED NANOPARTICLES
    5.
    发明申请
    SYSTEM AND METHOD FOR BIOLOGICAL APPLICATIONS USING PRE-DETERMINED SIZED NANOPARTICLES 有权
    使用预先确定的尺寸纳米颗粒的生物应用的系统和方法

    公开(公告)号：US20170071535A1

    公开(公告)日：2017-03-16

    申请号：US15342262

    申请日：2016-11-03

    Applicant: ARkival Technology Corp.

    Inventor： Ronald D. Weiss

    IPC: A61B5/00 ,  B03C1/025 ,  A61K49/18 ,  B03C1/30 ,  A61B5/05 ,  A61B5/055

    CPC classification number: A61B5/4839 ,  A61B5/0035 ,  A61B5/0515 ,  A61B5/055 ,  A61B5/7246 ,  A61B2562/0285 ,  A61K49/0002 ,  A61K49/1818 ,  B03C1/025 ,  B03C1/30 ,  B03C2201/18 ,  B03C2201/26

    Abstract: The invention features an apparatus for producing a fluid stream having plurality of nanoparticles in the fluid stream. The apparatus includes a source configured to provide a fluid stream having a first randomly sized distribution of a plurality of nanoparticles; a flow control zone configured to receive the fluid stream from the source and to control the fluid stream to produce a controlled fluid stream having a selected flow rate; a separation zone configured to receive and to separate the selectively controlled fluid stream into at least one separated fluid stream having a non-randomly sized distribution of nanoparticles; and a collection zone capable of receiving the separated fluid stream according to at least one non-random sized distribution of nanoparticles to produce at least one collected stream. The apparatus is configured for a continuous flow of the fluid stream. A size of a nanoparticle can be related to an intrinsic core diameter, a hydrodynamic diameter, and a combination of intrinsic core diameter and hydrodynamic diameter measurements. The nanoparticles can include non-magnetic nanoparticles, partially magnetic nanoparticles, magnetic nanoparticles, superparamagnetic nanoparticles, and a combination of at least two different nanoparticle types. The invention also features methods for producing said fluid streams. The invention further features apparatus and methods for cancer confirmation and targeted therapeutic drug development.

    Abstract translation: 本发明的特征在于一种用于在流体流中产生具有多个纳米颗粒的流体流的装置。 该装置包括：源，其配置成提供具有多个纳米颗粒的第一随机大小分布的流体流; 流动控制区域，其被配置为从所述源接收流体流并且控制所述流体流以产生具有选定流量的受控流体流; 分离区，被配置为接收并且将选择性控制的流体流分离成具有非随机大小的纳米颗粒分布的至少一个分离的流体流; 以及能够根据至少一个非随机大小的纳米颗粒分布接收分离的流体流以产生至少一个收集的流的收集区。 该装置构造成用于流体流的连续流动。 纳米颗粒的尺寸可以与本征芯直径，流体动力学直径以及本征芯直径和流体动力学直径测量的组合有关。 纳米颗粒可以包括非磁性纳米颗粒，部分磁性纳米颗粒，磁性纳米颗粒，超顺磁性纳米颗粒，以及至​​少两种不同纳米颗粒类型的组合。 本发明还涉及生产所述流体流的方法。 本发明还涉及用于癌症确认和靶向治疗药物开发的装置和方法。

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