公开(公告)号：US09416430B2

公开(公告)日：2016-08-16

申请号：US13984106

申请日：2012-02-27

申请人： Graham Guest

发明人： Graham Guest

IPC分类号： F27D27/00 ,  C21C5/52 ,  B01F13/08 ,  F27B3/02 ,  F27B3/04 ,  F27B3/10 ,  F27B3/19 ,  C21C7/00 ,  F27D3/14 ,  F27D11/06 ,  F27D3/00

CPC分类号： C21C5/5241 ,  B01F13/0809 ,  C21C5/5211 ,  C21C5/5247 ,  C21C5/527 ,  C21C7/00 ,  F27B3/02 ,  F27B3/045 ,  F27B3/10 ,  F27B3/19 ,  F27D3/14 ,  F27D11/06 ,  F27D27/00 ,  F27D2003/004

摘要： The apparatus includes a furnace having a furnace chamber (14), a port (16) in fluid communication with the furnace chamber having an inclined lower wall (18), and a bi-directional induction unit (24) mounted to the inclined lower wall for inducing flow in molten material in the port. A retractable channel plate assembly (26) is selectively positionable in the port to define an extraction flow channel (28) for the molten material between the channel plate assembly and the inclined lower wall. A drive arrangement (64) moves the channel plate assembly into and out of the port and the control of a control system (74) which includes a sensor system (78) for measuring the level of the molten material in the port and a feedback system for providing information regarding the position of the channel plate assembly. A method of operating the apparatus is also disclosed.

摘要翻译： 该装置包括具有炉室（14）的炉子，与炉室流体连通的具有倾斜下壁（18）的端口（16）和安装在倾斜下壁上的双向感应单元（24） 用于在端口中的熔融材料中引起流动。 可缩回通道板组件（26）可选择性地定位在端口中，以限定用于在通道板组件和倾斜下壁之间的熔融材料的提取流动通道（28）。 驱动装置（64）将通道板组件移入和移出端口以及控制系统（74）的控制，控制系统（74）包括用于测量端口中的熔融材料的水平的传感器系统（78）和反馈系统 用于提供关于通道板组件的位置的信息。 还公开了一种操作该装置的方法。

公开(公告)号：US20150056611A1

公开(公告)日：2015-02-26

申请号：US14537153

申请日：2014-11-10

申请人： Spinomix S.A.

发明人： Amar Rida

IPC分类号： B01F13/08 ,  B01F13/00 ,  B01F3/12

CPC分类号： B01F13/0809 ,  B01F3/1207 ,  B01F3/1235 ,  B01F13/0077 ,  B01F2215/0037 ,  C12N15/1013 ,  G01N35/0098

摘要： A method of mixing magnetic particles (3) in a reaction chamber (2) that is part of a microfluidic device and that contains the said particles in suspension, comprises the steps: (a) providing an electromagnetic means (1,1′,6,7) to generate magnetic field sequences having polarity and intensity that vary in time and a magnetic field gradient that covers the whole space of the said reaction chamber (2); (b) applying a first magnetic field sequence to separate or confine the particles (3) so the particles occupy a sub-volume in the volume of the reaction chamber (2); (c) injecting a defined volume of the said reagent in the reaction chamber; and (d) applying a second magnetic field sequence to leads the particles (3) to be homogenously distributed and dynamically moving over a substantial portion of the whole reaction chamber volume.

摘要翻译： 在作为微流体装置的一部分并且包含所述悬浮液的颗粒的反应室（2）中混合磁性颗粒（3）的方法包括以下步骤：（a）提供电磁装置（1,1'，6 ，7）产生具有时间上变化的极性和强度的磁场序列和覆盖所述反应室（2）的整个空间的磁场梯度; （b）施加第一磁场序列以分离或限制颗粒（3），使得颗粒占据反应室（2）的体积中的子体积; （c）将限定体积的所述试剂注入反应室中; 和（d）施加第二磁场序列以使颗粒（3）均匀分布并在整个反应室体积的大部分上动态移动。

公开(公告)号：US20140251887A1

公开(公告)日：2014-09-11

申请号：US14047888

申请日：2013-10-07

申请人： SIGRIS RESEARCH, INC.

发明人： Iqbal W. Siddiqi

IPC分类号： B03C1/12

CPC分类号： B03C1/12 ,  B01F13/0809 ,  B01F13/1013 ,  B01F13/1022 ,  B01L9/523 ,  B03C1/01 ,  B03C1/14 ,  B03C1/24 ,  B03C1/288 ,  G01N35/0098 ,  Y10T436/25 ,  Y10T436/25375

摘要： An apparatus for mixing and separating magnetic particles in a liquid comprises a holder having a plurality of apertures configured as an array of rows and columns and a plurality of containers capable of receiving liquid containing magnetic particles, each container being sized to be placed in one of the apertures; plural magnets capable of being moved relative to the containers between a first position and a second position to change the position of the magnets and magnetic particles in the container; and a drive mechanism for moving the magnets between positions at a sufficiently high speed that the particles do not settle down due to gravitational forces during motion between the first and second positions.

摘要翻译： 用于混合和分离液体中的磁性颗粒的装置包括具有多个孔的构造为行和列的阵列的保持器，以及能够接收含有磁性颗粒的液体的多个容器，每个容器的尺寸设置成 孔; 能够在第一位置和第二位置之间相对于容器移动的多个磁体，以改变容器中的磁体和磁性颗粒的位置; 以及用于在足够高的速度的位置之间移动磁体的驱动机构，使得由于在第一和第二位置之间运动期间的重力，颗粒不会沉降。

公开(公告)号：US20140158600A1

公开(公告)日：2014-06-12

申请号：US14182804

申请日：2014-02-18

申请人： Drexel University

发明人： Benjamin B. Yellen ,  Gennady Friedman

IPC分类号： B03C1/02

CPC分类号： B03C1/02 ,  B01F13/0809 ,  B03C1/288 ,  B03C1/30 ,  B03C1/32 ,  B03C2201/18

摘要： One aspect of the invention provides a device for sorting non-magnetic particles. The device includes: (a) a fluid holding chamber comprising an inner and outer surface; (b) a fluid in contact with the inner surface of the fluid holding chamber, said fluid containing a dispersion of magnetic particles and at least two sets of non-magnetic particles; and (c) at least two sources of magnetic fields positioned in close proximity to, or inside of, the fluid holding chamber. The at least two sources of magnetic fields produce a changeable pattern of magnetic field minima and maxima regions thereby causing said non-magnetic particles in the fluid to be transported towards the magnetic field minima regions by magnetic force. At least one of said sources of magnetic fields comprises an array of magnetizable features on a micrometer or nanometer length scale.

摘要翻译： 本发明的一个方面提供一种用于分选非磁性颗粒的装置。 该装置包括：（a）流体保持室，其包括内表面和外表面; （b）与流体保持室的内表面接触的流体，所述流体包含磁性颗粒和至少两组非磁性颗粒的分散体; 和（c）至少两个定位在流体保持室附近或内部的磁场源。 所述至少两个磁场源产生磁场最小值和最大值区域的可变图案，从而使流体中的所述非磁性颗粒通过磁力被传送到磁场最小区域。 所述磁场源中的至少一个包括千分尺或纳米长度刻度上的可磁化特征阵列。

公开(公告)号：US08608370B1

公开(公告)日：2013-12-17

申请号：US12753317

申请日：2010-04-02

申请人： Oleg S. Fishman ,  Mike Maochang Cao

发明人： Oleg S. Fishman ,  Mike Maochang Cao

IPC分类号： B01F13/08 ,  C21C7/00

CPC分类号： C21C5/5241 ,  B01F13/0809 ,  C30B15/305 ,  F27D27/00 ,  Y02P10/253

摘要： Apparatus for, and method of, containing, transferring and electromagnetically stirring an electrically conductive fluid is provided. A vessel is formed from spaced-apart annular structural elements, or hoops, that are bound together by a high-temperature electrical insulating material, which also forms the interior surface of the vessel. Reinforcing members are embedded in the high-temperature electrical insulating material and passed through the hoops. The vessel is disposed within an electrical stator having multiple electrical poles. Each pole is wound with a separate coil. Current can be supplied to each coil winding, with a suitable phase shift between currents to all coil windings, to achieve an electromagnetically induced stirring and heating of the electrically conductive fluid. The vessel may be removably disposed in the electrical stator so that the vessel can be transported to and from the electrical stator for induced stirring.

摘要翻译： 提供了用于传导流体的设备和方法，包含，转移和电磁搅拌。 容器由间隔开的环形结构元件或箍构成，其通过也形成容器内表面的高温电绝缘材料结合在一起。 加强构件嵌入高温电绝缘材料中并通过箍。 容器设置在具有多个电极的电定子内。 每个杆用一个单独的线圈缠绕。 可以向每个线圈绕组提供电流，在所有线圈绕组的电流之间具有合适的相移，以实现对导电流体的电磁感应搅拌和加热。 容器可以可拆卸地设置在电子定子中，使得容器可以被输送到电子定子以及用于诱导搅拌。

公开(公告)号：US20110312531A1

公开(公告)日：2011-12-22

申请号：US13181903

申请日：2011-07-13

申请人： Alice A. Jacobs ,  Vineet Gupta ,  Boris Nikolic

发明人： Alice A. Jacobs ,  Vineet Gupta ,  Boris Nikolic

IPC分类号： C40B30/04

CPC分类号： B01F13/0088 ,  B01F13/08 ,  B01F13/0809 ,  B01J19/0046 ,  B01J2219/00315 ,  B01J2219/00317 ,  B01J2219/00481 ,  B01J2219/00497 ,  B01J2219/00509 ,  B01J2219/00511 ,  B01J2219/00527 ,  B01J2219/00547 ,  B01J2219/00585 ,  B01J2219/00596 ,  B01J2219/00605 ,  B01J2219/0061 ,  B01J2219/00612 ,  B01J2219/00619 ,  B01J2219/00621 ,  B01J2219/00626 ,  B01J2219/0063 ,  B01J2219/00637 ,  B01J2219/00644 ,  B01J2219/00659 ,  B01J2219/00662 ,  B01J2219/00664 ,  B01J2219/00677 ,  B01J2219/00689 ,  B01J2219/00702 ,  B01J2219/0072 ,  B01J2219/00722 ,  B01J2219/00725 ,  B01J2219/00731 ,  B01J2219/0074 ,  B01J2219/00745 ,  B01L3/5027 ,  B01L3/5085 ,  B01L3/50857 ,  B01L2300/021 ,  B01L2300/0636 ,  B01L2300/069 ,  B01L2300/0819 ,  B01L2300/0864 ,  B82Y30/00 ,  C12Q1/6837 ,  C40B40/06 ,  C40B40/10 ,  C40B40/12 ,  C40B40/18 ,  C40B60/14 ,  C40B70/00 ,  G01N33/53 ,  G01N33/543 ,  G01N33/54366 ,  G01N33/6803 ,  G01N33/6845

摘要： The invention relates to the clinically intelligent design of diagnostic devices (such as microarrays) and methods of making and using such devices in differential diagnoses of specific clinical symptoms or sets of symptoms. In one aspect, the devices include various probes used to perform parallel screening of a number of analytes. The probes are clustered on the devices based on known clinical presentations of symptoms associated with specific diseases and disorders.

摘要翻译： 本发明涉及诊断装置（例如微阵列）的临床智能设计以及制造和使用这些装置在特定临床症状或症状组的鉴别诊断中的方法。 在一个方面，所述装置包括用于执行多个分析物的并行筛选的各种探针。 基于与特定疾病和病症相关的症状的已知临床表现，将探针聚集在装置上。

公开(公告)号：US07972556B2

公开(公告)日：2011-07-05

申请号：US11997363

申请日：2006-08-09

申请人： Hideo Araseki ,  Hirofumi Kasahara

发明人： Hideo Araseki ,  Hirofumi Kasahara

IPC分类号： C21C7/00

CPC分类号： B01F13/0809 ,  B22D11/115 ,  F27D27/00

摘要： An electromagnetic stirring apparatus includes a vessel (2) for containing an electroconductive material in a molten state, such as a molten metal (1); an axially traveling magnetic field generating coil (3) for generating magnetic line of force (15) in an axial direction of the vessel (2) towards the molten metal (1) contained in the vessel (2) from an outside of the vessel (2); and a strip-shaped magnetic plate (4) disposed between the coil (3) and the vessel (2). Portions (11) where an axial electromagnetic force is generated in the molten metal contained in the vessel by the coil (3), and portions (10) into which a magnetic field is prevented by the magnetic plate (4) from locally entering, are formed in the vessel (2), whereby a circumferential pressure gradient is generated. Only with the axially traveling magnetic field generating coil (3), streams formed by convolution of axial motion and rotary motion are generated in the molten metal (1) in accordance with the axial electromagnetic force and the circumferential pressure gradient, thereby to perform stirring of the molten metal (1).

摘要翻译： 电磁搅拌装置包括用于容纳熔融状态的导电材料的容器（2），例如熔融金属（1）; 轴向移动的磁场产生线圈（3），用于从所述容器（2）的外部朝向所述容器（2）中所包含的熔融金属（1）沿所述容器（2）的轴向方向产生力线（15） 2）; 以及设置在线圈（3）和容器（2）之间的条形磁板（4）。 通过线圈（3）容纳在容器中的熔融金属中产生轴向电磁力的部分（11）以及被磁板（4）防止局部进入的磁场的部分（10）是 形成在容器（2）中，由此产生周向压力梯度。 仅在轴向移动的磁场产生线圈（3）中，根据轴向电磁力和周向压力梯度，在熔融金属（1）中产生通过轴向运动和旋转运动的卷积形成的流，从而进行搅拌 熔融金属（1）。

公开(公告)号：US20100148411A1

公开(公告)日：2010-06-17

申请号：US11997363

申请日：2006-08-09

申请人： Hideo Araseki ,  Hirofumi Kasahara

发明人： Hideo Araseki ,  Hirofumi Kasahara

IPC分类号： C21C7/00 ,  B01F13/08

CPC分类号： B01F13/0809 ,  B22D11/115 ,  F27D27/00

摘要： An electromagnetic stirring apparatus includes a vessel (2) for containing an electroconductive material in a molten state, such as a molten metal (1); an axially traveling magnetic field generating coil (3) for generating magnetic line of force (15) in an axial direction of the vessel (2) towards the molten metal (1) contained in the vessel (2) from an outside of the vessel (2); and a strip-shaped magnetic plate (4) disposed between the coil (3) and the vessel (2). Portions (11) where an axial electromagnetic force is generated in the molten metal contained in the vessel by the coil (3), and portions (10) into which a magnetic field is prevented by the magnetic plate (4) from locally entering, are formed in the vessel (2), whereby a circumferential pressure gradient is generated. Only with the axially traveling magnetic field generating coil (3), streams formed by convolution of axial motion and rotary motion are generated in the molten metal (1) in accordance with the axial electromagnetic force and the circumferential pressure gradient, thereby to perform stirring of the molten metal (1).

摘要翻译： 电磁搅拌装置包括用于容纳熔融状态的导电材料的容器（2），例如熔融金属（1）; 轴向移动的磁场产生线圈（3），用于从所述容器（2）的外部朝向所述容器（2）中所包含的熔融金属（1）沿所述容器（2）的轴向方向产生力线（15） 2）; 以及设置在线圈（3）和容器（2）之间的条形磁板（4）。 通过线圈（3）容纳在容器中的熔融金属中产生轴向电磁力的部分（11）以及被磁板（4）防止局部进入的磁场的部分（10）是 形成在容器（2）中，由此产生周向压力梯度。 仅在轴向移动的磁场产生线圈（3）中，根据轴向电磁力和周向压力梯度，在熔融金属（1）中产生通过轴向运动和旋转运动的卷积形成的流，从而进行 熔融金属（1）。

公开(公告)号：US20090325822A1

公开(公告)日：2009-12-31

申请号：US12296524

申请日：2007-04-11

申请人： Rudolf Heer ,  Christa Noehammer ,  Joerg Schotter ,  Moritz Eggeling ,  Rudolf Pichler ,  Markus Mansfeld

发明人： Rudolf Heer ,  Christa Noehammer ,  Joerg Schotter ,  Moritz Eggeling ,  Rudolf Pichler ,  Markus Mansfeld

IPC分类号： C40B60/00

CPC分类号： B01F13/0809 ,  B01F13/0059 ,  B01L3/5027

摘要： An apparatus for enhancing the contact frequency between two reactants capable of binding to one another, preferably between an analyzer molecule and an analyte molecule, especially for enhancing the binding effectiveness in bioanalysis arrays with the aid of micro- or nanomagnetic particles (75) set in motion in a controlled manner in the fluid reaction medium by means of magnetic fields generated by variably feedable electromagnets (3, 2, 20) arranged on both sides of the reaction fluid film. On one side of a reaction fluid film, especially of a microscope slide (4) comprising the reactants (63), the reaction liquid (70) comprising the reactants (73) and preferably a glass plate (5) covering the microbioanalysis array (6), is arranged close to a two-dimensional matrix (20) having a multitude of miniature or millimagnetic coils (2) feedable individually with magnetization current of variable strength and/or voltage as a function of time—corresponding to a time-dependent variable magnetization pattern desired in each case—and, on the other side of the reaction vessel, especially the microscope slide (4) with the (micro)bioanalysis array (6), in whose vicinity is positioned only one magnetic coil (3) likewise feedable with variable magnetization current and whose magnetic field permeates the entire reaction vessel, especially the microbioanalysis array (6).

摘要翻译： 一种用于增强能够彼此结合的两种反应物之间的接触频率的装置，优选在分析器分子和分析物分子之间，特别是借助于设置在微生物或纳米磁性颗粒中的增强生物分析阵列的结合效果 通过设置在反应流体膜两侧的可变输入电磁体（3,2,20）产生的磁场，在流体反应介质中以受控的方式运动。 在反应流体膜的一侧，特别是包含反应物（63）的显微镜载片（4）的一侧，包含反应物（73）的反应液（70）和优选覆盖微生物分析阵列（6）的玻璃板（5） ）布置成靠近二维矩阵（20），该二维矩阵（20）具有多个微型或微电磁线圈（2），该二维矩阵能够单独地馈送作为时间的函数的可变强度和/或电压的磁化电流 - 对应于时间因变量 在每种情况下都需要磁化图案，并且在反应容器的另一侧，特别是具有（微）生物分析阵列（6）的显微镜载玻片（4），其附近仅定位一个电磁线圈（3），同样可进给 具有可变的磁化电流并且其磁场渗透整个反应容器，特别是微量分析阵列（6）。

公开(公告)号：US20090211956A1

公开(公告)日：2009-08-27

申请号：US12387158

申请日：2009-04-29

申请人： Iqbal Waheed Siddiqi

发明人： Iqbal Waheed Siddiqi

IPC分类号： B03C1/06

CPC分类号： B03C1/12 ,  B01F13/0809 ,  B01F13/1013 ,  B01F13/1022 ,  B01L9/523 ,  B03C1/01 ,  B03C1/14 ,  B03C1/24 ,  B03C1/288 ,  G01N35/0098 ,  Y10T436/25 ,  Y10T436/25375

摘要： An apparatus for mixing and separating magnetic particles in a liquid comprises a holder having a plurality of apertures configured as an array of rows and columns and a plurality of containers capable of receiving liquid containing magnetic particles, each container being sized to be placed in one of the apertures; plural magnets capable of being moved relative to the containers between a first position and a second position to change the position of the magnets and magnetic particles in the container; and a drive mechanism for moving the magnets between positions at a sufficiently high speed that the particles do not settle down due to gravitational forces during motion between the first and second positions.

摘要翻译： 用于混合和分离液体中的磁性颗粒的装置包括具有多个孔的构造为行和列的阵列的保持器，以及能够接收含有磁性颗粒的液体的多个容器，每个容器的尺寸设置成 孔; 能够在第一位置和第二位置之间相对于容器移动的多个磁体，以改变容器中的磁体和磁性颗粒的位置; 以及用于在足够高的速度的位置之间移动磁体的驱动机构，使得由于在第一和第二位置之间运动期间的重力，颗粒不会沉降。