公开(公告)号：US11944717B2

公开(公告)日：2024-04-02

申请号：US17477947

申请日：2021-09-17

申请人： Tulavi Therapeutics, Inc. ,  Incept, LLC

发明人： Corinne Bright ,  Yong Ren ,  Kenneth M. Martin ,  Farhad Khosravi ,  Amarpreet S. Sawhney

IPC分类号： A61B17/11 ,  A61B17/00 ,  A61F2/00 ,  A61F2/02 ,  A61K9/00 ,  A61L27/18 ,  A61L27/26 ,  A61L27/52 ,  A61L31/14

CPC分类号： A61L27/26 ,  A61B17/1128 ,  A61F2/00 ,  A61F2/02 ,  A61K9/0004 ,  A61L27/18 ,  A61L27/52 ,  A61L31/14 ,  A61B2017/00526 ,  A61F2210/00 ,  A61F2210/008 ,  A61F2240/00 ,  A61F2240/001 ,  A61F2250/00 ,  A61L2400/06 ,  A61L2430/32

摘要： Disclosed are methods, devices and materials for the in situ formation of a nerve cap and/or a nerve wrap to inhibit neuroma formation following planned or traumatic nerve injury. The method includes the steps of identifying a severed end of a nerve, and positioning the severed end into a cavity defined by a form. A transformable media is introduced into the form cavity to surround the severed end. The media is permitted to undergo a transformation from a first, relatively flowable state to a second, relatively non flowable state to form a protective barrier surrounding the severed end. The media may be a hydrogel, and the transformation may produce a synthetic crosslinked hydrogel protective barrier. The media may include at least one anti-regeneration agent to inhibit nerve regrowth.

公开(公告)号：US20120209382A1

公开(公告)日：2012-08-16

申请号：US13383008

申请日：2010-07-12

申请人： Peter Forsell

发明人： Peter Forsell

IPC分类号： A61F2/08

CPC分类号： A61F2/30756 ,  A61B17/1604 ,  A61B17/1637 ,  A61B17/1664 ,  A61B17/1666 ,  A61B17/1668 ,  A61B17/562 ,  A61B17/74 ,  A61B17/86 ,  A61B17/8805 ,  A61B18/04 ,  A61B2018/046 ,  A61F2/30 ,  A61F2/30721 ,  A61F2/30942 ,  A61F2/32 ,  A61F2/34 ,  A61F2/36 ,  A61F2/3601 ,  A61F2/3603 ,  A61F2/3859 ,  A61F2/389 ,  A61F2/46 ,  A61F2/4618 ,  A61F2002/30065 ,  A61F2002/30471 ,  A61F2002/30507 ,  A61F2002/30558 ,  A61F2002/30563 ,  A61F2002/30565 ,  A61F2002/30579 ,  A61F2002/30583 ,  A61F2002/30668 ,  A61F2002/3067 ,  A61F2002/30672 ,  A61F2002/30673 ,  A61F2002/30675 ,  A61F2002/30754 ,  A61F2002/30757 ,  A61F2002/30759 ,  A61F2002/30878 ,  A61F2002/30886 ,  A61F2002/3241 ,  A61F2002/3483 ,  A61F2002/3496 ,  A61F2002/3615 ,  A61F2002/3631 ,  A61F2002/4631 ,  A61F2002/4635 ,  A61F2002/4655 ,  A61F2002/4677 ,  A61F2002/482 ,  A61F2002/485 ,  A61F2250/00 ,  A61L27/16 ,  A61L31/042 ,  A61L31/044 ,  A61L31/046 ,  A61L31/148 ,  A61L2300/406 ,  A61L2400/06 ,  A61L2430/24 ,  A61M5/14276 ,  A61M2005/14284

摘要： An implantable medical device for implantation in a mammal joint having at least two contacting surfaces is provided. The medical device comprises; an artificial contacting surface adapted to replace at least the surface of at least one of the mammal's joint contacting surfaces, wherein the artificial contacting surface is adapted to be lubricated, when implanted in said joint. Furthermore the medical device comprises at least one inlet adapted to receive a lubricating fluid from a reservoir, at least one channel at least partly integrated in the artificial contacting surface in connection with the at least one inlet for distributing the lubricating fluid to the surface of the artificial contacting surface. The medical device could be adapted to be operable by an operation device to receive the distributed lubricated fluid from a reservoir.

摘要翻译： 提供了用于植入具有至少两个接触表面的哺乳动物关节中的可植入医疗装置。 医疗器械包括： 人造接触表面，其适于替代至少哺乳动物的关节接触表面中的至少一个的表面，其中人造接触表面适于在植入所述关节时被润滑。 此外，医疗装置包括至少一个入口，其适于从容器接收润滑流体，至少一个通道，至少部分地与至少一个入口结合在人造接触表面中，用于将润滑流体分配到 人工接触面。 医疗装置可以适于由操作装置操作以从储存器接收分布式润滑的流体。

公开(公告)号：US11890393B2

公开(公告)日：2024-02-06

申请号：US17138703

申请日：2020-12-30

申请人： Tulavi Therapeutics, Inc. ,  Incept, LLC

发明人： Corinne Bright ,  Yong Ren ,  Kenneth M. Martin ,  Farhad Khosravi ,  Amarpreet S. Sawhney

IPC分类号： A61B17/11 ,  A61F2/00 ,  A61F2/02 ,  A61K9/00 ,  A61L27/52 ,  A61L31/14 ,  A61B17/00 ,  A61L27/26 ,  A61L27/18

CPC分类号： A61L27/26 ,  A61B17/1128 ,  A61F2/00 ,  A61F2/02 ,  A61K9/0004 ,  A61L27/18 ,  A61L27/52 ,  A61L31/14 ,  A61B2017/00526 ,  A61F2210/00 ,  A61F2210/008 ,  A61F2240/00 ,  A61F2240/001 ,  A61F2250/00 ,  A61L2400/06 ,  A61L2430/32

摘要： Disclosed are methods, devices and materials for the in situ formation of a nerve cap to inhibit neuroma formation following planned or traumatic nerve injury. The method includes the steps of identifying a severed end of a nerve, and positioning the severed end into a cavity defined by a form. A transformable media is introduced into the form cavity to surround the severed end. The media is permitted to undergo a transformation from a first, relatively flowable state to a second, relatively non flowable state to form a protective barrier surrounding the severed end. The media may be a hydrogel, and the transformation may produce a synthetic crosslinked hydrogel protective barrier. The media may include at least one anti-regeneration agent to inhibit nerve regrowth.

公开(公告)号：US20180028320A1

公开(公告)日：2018-02-01

申请号：US15620338

申请日：2017-06-12

申请人： Peter Forsell

发明人： Peter Forsell

IPC分类号： A61F2/30 ,  A61B17/16 ,  A61F2/34 ,  A61F2/32 ,  A61L31/14 ,  A61L31/04 ,  A61L27/16 ,  A61F2/48 ,  A61F2/46 ,  A61F2/36 ,  A61F2/38 ,  A61B18/04 ,  A61B17/88 ,  A61B17/86 ,  A61B17/74 ,  A61B17/56 ,  A61M5/142

CPC分类号： A61F2/30756 ,  A61B17/1604 ,  A61B17/1617 ,  A61B17/1631 ,  A61B17/1637 ,  A61B17/1664 ,  A61B17/1666 ,  A61B17/1668 ,  A61B17/562 ,  A61B17/74 ,  A61B17/86 ,  A61B17/8805 ,  A61B17/8816 ,  A61B17/8822 ,  A61B17/8833 ,  A61B18/04 ,  A61B2017/8838 ,  A61B2018/046 ,  A61F2/30 ,  A61F2/30721 ,  A61F2/30728 ,  A61F2/30942 ,  A61F2/32 ,  A61F2/34 ,  A61F2/36 ,  A61F2/3601 ,  A61F2/3603 ,  A61F2/3607 ,  A61F2/3609 ,  A61F2/3859 ,  A61F2/389 ,  A61F2/46 ,  A61F2/4618 ,  A61F2002/30065 ,  A61F2002/302 ,  A61F2002/3038 ,  A61F2002/30387 ,  A61F2002/30469 ,  A61F2002/30471 ,  A61F2002/30492 ,  A61F2002/30495 ,  A61F2002/30497 ,  A61F2002/305 ,  A61F2002/30507 ,  A61F2002/30558 ,  A61F2002/30563 ,  A61F2002/30565 ,  A61F2002/30576 ,  A61F2002/30579 ,  A61F2002/30583 ,  A61F2002/30594 ,  A61F2002/30604 ,  A61F2002/30668 ,  A61F2002/3067 ,  A61F2002/30672 ,  A61F2002/30673 ,  A61F2002/30675 ,  A61F2002/30729 ,  A61F2002/30754 ,  A61F2002/30757 ,  A61F2002/30759 ,  A61F2002/30878 ,  A61F2002/30886 ,  A61F2002/30975 ,  A61F2002/3241 ,  A61F2002/3429 ,  A61F2002/347 ,  A61F2002/3483 ,  A61F2002/3496 ,  A61F2002/3605 ,  A61F2002/3615 ,  A61F2002/3631 ,  A61F2002/365 ,  A61F2002/4631 ,  A61F2002/4635 ,  A61F2002/4655 ,  A61F2002/4677 ,  A61F2002/482 ,  A61F2002/485 ,  A61F2240/002 ,  A61F2250/00 ,  A61F2310/00359 ,  A61L27/16 ,  A61L31/042 ,  A61L31/044 ,  A61L31/046 ,  A61L31/148 ,  A61L2300/406 ,  A61L2400/06 ,  A61L2430/24 ,  A61M5/14276 ,  A61M2005/14284

摘要： An implantable medical device, for implantation in a mammal knee joint, comprising an artificial contacting surface adapted to replace at least one contacting surface of the knee joint and to be lubricated when implanted in said joint. The medical device further comprises a reservoir comprising a movable wall portion defining the volume of the reservoir, at least one inlet adapted to receive a lubricating fluid from the reservoir, at least one channel at least partly integrated in said artificial contacting surface, wherein the channel is fluidly connected with said at least one inlet for distributing said lubricating fluid to the surface of said artificial contacting surface. The medical device further comprises an operation device adapted to non-invasively transport said lubricating fluid from said reservoir to said artificial contacting surface, and an implantable injection port for refilling said reservoir, wherein the movable wall portion is moved when the reservoir is refilled, such that the volume of the reservoir is increased.

公开(公告)号：US20160302931A1

公开(公告)日：2016-10-20

申请号：US15193184

申请日：2016-06-27

申请人： Peter Forsell

发明人： Peter Forsell

IPC分类号： A61F2/30 ,  A61B17/88 ,  A61B18/04 ,  A61L27/16 ,  A61F2/38 ,  A61F2/46 ,  A61L31/04 ,  A61L31/14 ,  A61B17/16 ,  A61F2/32

CPC分类号： A61F2/30756 ,  A61B17/1604 ,  A61B17/1637 ,  A61B17/1664 ,  A61B17/1666 ,  A61B17/1668 ,  A61B17/562 ,  A61B17/74 ,  A61B17/86 ,  A61B17/8805 ,  A61B18/04 ,  A61B2018/046 ,  A61F2/30 ,  A61F2/30721 ,  A61F2/30942 ,  A61F2/32 ,  A61F2/34 ,  A61F2/36 ,  A61F2/3601 ,  A61F2/3603 ,  A61F2/3859 ,  A61F2/389 ,  A61F2/46 ,  A61F2/4618 ,  A61F2002/30065 ,  A61F2002/30471 ,  A61F2002/30507 ,  A61F2002/30558 ,  A61F2002/30563 ,  A61F2002/30565 ,  A61F2002/30579 ,  A61F2002/30583 ,  A61F2002/30668 ,  A61F2002/3067 ,  A61F2002/30672 ,  A61F2002/30673 ,  A61F2002/30675 ,  A61F2002/30754 ,  A61F2002/30757 ,  A61F2002/30759 ,  A61F2002/30878 ,  A61F2002/30886 ,  A61F2002/3241 ,  A61F2002/3483 ,  A61F2002/3496 ,  A61F2002/3615 ,  A61F2002/3631 ,  A61F2002/4631 ,  A61F2002/4635 ,  A61F2002/4655 ,  A61F2002/4677 ,  A61F2002/482 ,  A61F2002/485 ,  A61F2250/00 ,  A61L27/16 ,  A61L31/042 ,  A61L31/044 ,  A61L31/046 ,  A61L31/148 ,  A61L2300/406 ,  A61L2400/06 ,  A61L2430/24 ,  A61M5/14276 ,  A61M2005/14284

摘要： A mould adapted to be introduced into a joint of a human patient for resurfacing at least one carrying contacting surface of said joint is provided. The mould is adapted to receive material for resurfacing at least one carrying contacting surface of said joint. The mould is further adapted to be resorbed by the human body or melt after having served its purpose.Further, a method of treating hip joint osteoarthritis in a human patient by providing an artificial hip joint surface using a mould is provided. The method comprises the steps of: said mould being placed inside of said hip joint, said mould being injected with a fluid adapted to harden, said fluid hardening inside of said hip joint, said mould being resorbed by the human body, and said hardened fluid serving as artificial hip joint surface

摘要翻译： 另外，提供了通过使用模具提供人造髋关节面来治疗人类患者的髋关节骨关节炎的方法。 该方法包括以下步骤：将所述模具放置在所述髋关节内部，所述模具注入适于硬化的流体，所述髋关节内部的所述流体硬化，所述模具被人体吸收，并且所述硬化流体 用作人造髋关节表面

公开(公告)号：US11957588B2

公开(公告)日：2024-04-16

申请号：US16159755

申请日：2018-10-15

申请人： Peter Forsell

发明人： Peter Forsell

IPC分类号： A61F2/30 ,  A61B17/16 ,  A61B17/56 ,  A61B17/88 ,  A61B18/04 ,  A61F2/28 ,  A61F2/32 ,  A61F2/34 ,  A61F2/46 ,  A61L27/20 ,  A61L27/22 ,  A61L27/24 ,  A61L27/58 ,  A61B17/74 ,  A61B17/86 ,  A61F2/36 ,  A61F2/38 ,  A61F2/48 ,  A61L27/16 ,  A61L31/04 ,  A61L31/14 ,  A61M5/142

CPC分类号： A61F2/30756 ,  A61B17/1666 ,  A61B17/1668 ,  A61B17/562 ,  A61B17/8802 ,  A61B17/8811 ,  A61B18/04 ,  A61F2/28 ,  A61F2/30 ,  A61F2/30721 ,  A61F2/32 ,  A61F2/34 ,  A61F2/4618 ,  A61L27/20 ,  A61L27/225 ,  A61L27/24 ,  A61L27/58 ,  A61B17/1604 ,  A61B17/1637 ,  A61B17/1664 ,  A61B17/74 ,  A61B17/86 ,  A61B17/8805 ,  A61B2018/046 ,  A61F2002/30032 ,  A61F2002/30065 ,  A61F2002/30471 ,  A61F2002/30507 ,  A61F2002/30558 ,  A61F2002/30563 ,  A61F2002/30565 ,  A61F2002/30579 ,  A61F2002/30583 ,  A61F2002/30655 ,  A61F2002/30668 ,  A61F2002/3067 ,  A61F2002/30672 ,  A61F2002/30673 ,  A61F2002/30675 ,  A61F2002/307 ,  A61F2/30723 ,  A61F2002/30754 ,  A61F2002/30757 ,  A61F2002/30759 ,  A61F2002/30878 ,  A61F2002/30886 ,  A61F2/30942 ,  A61F2002/3241 ,  A61F2002/3483 ,  A61F2/36 ,  A61F2/3601 ,  A61F2/3603 ,  A61F2002/3615 ,  A61F2002/3631 ,  A61F2/3859 ,  A61F2/389 ,  A61F2/46 ,  A61F2002/4627 ,  A61F2002/4628 ,  A61F2002/4631 ,  A61F2002/4635 ,  A61F2002/4655 ,  A61F2002/4677 ,  A61F2/482 ,  A61F2/484 ,  A61F2210/0071 ,  A61F2210/0085 ,  A61F2250/00 ,  A61L27/16 ,  A61L31/042 ,  A61L31/044 ,  A61L31/046 ,  A61L31/148 ,  A61L2300/254 ,  A61L2300/406 ,  A61L2400/06 ,  A61L2430/24 ,  A61M5/14276 ,  A61M2005/14284 ,  A61L27/20 ,  C08L5/08

摘要： A mould adapted to be introduced into a joint of a human patient for resurfacing at least one carrying contacting surface of said joint is provided. The mould is adapted to receive material for resurfacing at least one carrying contacting surface of said joint. The mould is further adapted to be resorbed by the human body or melt after having served its purpose.

公开(公告)号：US09675460B2

公开(公告)日：2017-06-13

申请号：US13383270

申请日：2010-07-12

申请人： Peter Forsell

发明人： Peter Forsell

IPC分类号： A61F2/34 ,  A61F2/30 ,  A61F2/32 ,  A61B17/16 ,  A61B17/56 ,  A61B17/74 ,  A61B17/86 ,  A61F2/36 ,  A61F2/46 ,  A61F2/48 ,  A61M5/142 ,  A61B17/88 ,  A61B18/04 ,  A61F2/38 ,  A61L27/16 ,  A61L31/04 ,  A61L31/14

CPC分类号： A61F2/30756 ,  A61B17/1604 ,  A61B17/1637 ,  A61B17/1664 ,  A61B17/1666 ,  A61B17/1668 ,  A61B17/562 ,  A61B17/74 ,  A61B17/86 ,  A61B17/8805 ,  A61B18/04 ,  A61B2018/046 ,  A61F2/30 ,  A61F2/30721 ,  A61F2/30942 ,  A61F2/32 ,  A61F2/34 ,  A61F2/36 ,  A61F2/3601 ,  A61F2/3603 ,  A61F2/3859 ,  A61F2/389 ,  A61F2/46 ,  A61F2/4618 ,  A61F2002/30065 ,  A61F2002/30471 ,  A61F2002/30507 ,  A61F2002/30558 ,  A61F2002/30563 ,  A61F2002/30565 ,  A61F2002/30579 ,  A61F2002/30583 ,  A61F2002/30668 ,  A61F2002/3067 ,  A61F2002/30672 ,  A61F2002/30673 ,  A61F2002/30675 ,  A61F2002/30754 ,  A61F2002/30757 ,  A61F2002/30759 ,  A61F2002/30878 ,  A61F2002/30886 ,  A61F2002/3241 ,  A61F2002/3483 ,  A61F2002/3496 ,  A61F2002/3615 ,  A61F2002/3631 ,  A61F2002/4631 ,  A61F2002/4635 ,  A61F2002/4655 ,  A61F2002/4677 ,  A61F2002/482 ,  A61F2002/485 ,  A61F2250/00 ,  A61L27/16 ,  A61L31/042 ,  A61L31/044 ,  A61L31/046 ,  A61L31/148 ,  A61L2300/406 ,  A61L2400/06 ,  A61L2430/24 ,  A61M5/14276 ,  A61M2005/14284

摘要： An implantable medical device for implantation in a mammal joint having at least two contacting surfaces is provided. The medical device comprises; an artificial contacting surface adapted to replace at least the surface of at least one of the mammal's joint contacting surfaces, wherein the artificial contacting surface is adapted to be lubricated, when implanted in said joint. Furthermore the medical device comprises at least one inlet adapted to receive a lubricating fluid from a reservoir, at least one channel at least partly integrated in the artificial contacting surface in connection with the at least one inlet for distributing the lubricating fluid to the surface of the artificial contacting surface. The medical device could be adapted to be operable by an operation device to receive the distributed lubricated fluid from a reservoir.

公开(公告)号：US20120116310A1

公开(公告)日：2012-05-10

申请号：US13383270

申请日：2010-07-12

申请人： Peter Forsell

发明人： Peter Forsell

IPC分类号： A61M5/142 ,  A61M5/00

CPC分类号： A61F2/30756 ,  A61B17/1604 ,  A61B17/1637 ,  A61B17/1664 ,  A61B17/1666 ,  A61B17/1668 ,  A61B17/562 ,  A61B17/74 ,  A61B17/86 ,  A61B17/8805 ,  A61B18/04 ,  A61B2018/046 ,  A61F2/30 ,  A61F2/30721 ,  A61F2/30942 ,  A61F2/32 ,  A61F2/34 ,  A61F2/36 ,  A61F2/3601 ,  A61F2/3603 ,  A61F2/3859 ,  A61F2/389 ,  A61F2/46 ,  A61F2/4618 ,  A61F2002/30065 ,  A61F2002/30471 ,  A61F2002/30507 ,  A61F2002/30558 ,  A61F2002/30563 ,  A61F2002/30565 ,  A61F2002/30579 ,  A61F2002/30583 ,  A61F2002/30668 ,  A61F2002/3067 ,  A61F2002/30672 ,  A61F2002/30673 ,  A61F2002/30675 ,  A61F2002/30754 ,  A61F2002/30757 ,  A61F2002/30759 ,  A61F2002/30878 ,  A61F2002/30886 ,  A61F2002/3241 ,  A61F2002/3483 ,  A61F2002/3496 ,  A61F2002/3615 ,  A61F2002/3631 ,  A61F2002/4631 ,  A61F2002/4635 ,  A61F2002/4655 ,  A61F2002/4677 ,  A61F2002/482 ,  A61F2002/485 ,  A61F2250/00 ,  A61L27/16 ,  A61L31/042 ,  A61L31/044 ,  A61L31/046 ,  A61L31/148 ,  A61L2300/406 ,  A61L2400/06 ,  A61L2430/24 ,  A61M5/14276 ,  A61M2005/14284

摘要： An implantable medical device for implantation in a mammal joint having at least two contacting surfaces is provided. The medical device comprises; an artificial contacting surface adapted to replace at least the surface of at least one of the mammal's joint contacting surfaces, wherein the artificial contacting surface is adapted to be lubricated, when implanted in said joint. Furthermore the medical device comprises at least one inlet adapted to receive a lubricating fluid from a reservoir, at least one channel at least partly integrated in the artificial contacting surface in connection with the at least one inlet for distributing the lubricating fluid to the surface of the artificial contacting surface. The medical device could be adapted to be operable by an operation device to receive the distributed lubricated fluid from a reservoir.

摘要翻译： 提供了用于植入具有至少两个接触表面的哺乳动物关节中的可植入医疗装置。 医疗器械包括： 人造接触表面，其适于替代至少哺乳动物的关节接触表面中的至少一个的表面，其中人造接触表面适于在植入所述关节时被润滑。 此外，医疗装置包括至少一个入口，其适于从容器接收润滑流体，至少一个通道，至少部分地与至少一个入口结合在人造接触表面中，用于将润滑流体分配到 人工接触面。 医疗装置可以适于由操作装置操作以从储存器接收分布式润滑的流体。

公开(公告)号：US20240238480A1

公开(公告)日：2024-07-18

申请号：US18617246

申请日：2024-03-26

申请人： Tulavi Therapeutics, Inc. ,  Incept, LLC

发明人： Corinne BRIGHT ,  Yong REN ,  Kenneth M. Martin

IPC分类号： A61L27/26 ,  A61B17/00 ,  A61B17/11 ,  A61F2/00 ,  A61F2/02 ,  A61K9/00 ,  A61L27/18 ,  A61L27/52 ,  A61L31/14

CPC分类号： A61L27/26 ,  A61B17/1128 ,  A61F2/00 ,  A61F2/02 ,  A61K9/0004 ,  A61L27/18 ,  A61L27/52 ,  A61L31/14 ,  A61B2017/00526 ,  A61F2210/00 ,  A61F2210/008 ,  A61F2240/00 ,  A61F2240/001 ,  A61F2250/00 ,  A61L2400/06 ,  A61L2430/32

摘要： Disclosed are methods, devices and materials for the in situ formation of a nerve cap and/or a nerve wrap to inhibit neuroma formation following planned or traumatic nerve injury. The method includes the steps of identifying a severed end of a nerve, and positioning the severed end into a cavity defined by a form. A transformable media is introduced into the form cavity to surround the severed end. The media is permitted to undergo a transformation from a first, relatively flowable state to a second, relatively non flowable state to form a protective barrier surrounding the severed end. The media may be a hydrogel, and the transformation may produce a synthetic crosslinked hydrogel protective barrier. The media may include at least one anti-regeneration agent to inhibit nerve regrowth.

公开(公告)号：US20160310280A1

公开(公告)日：2016-10-27

申请号：US15079867

申请日：2016-03-24

申请人： Osiris Therapeutics, Inc.

发明人： Alla Danilkovitch ,  Jinqiang Kuang ,  Steven Michael Sinclair

IPC分类号： A61F2/30 ,  A61F2/38 ,  A61L27/36

CPC分类号： A61F2/30756 ,  A61F2/3094 ,  A61F2/3872 ,  A61F2002/30006 ,  A61F2002/30047 ,  A61F2002/30807 ,  A61F2250/00 ,  A61F2310/00371 ,  A61L27/3604 ,  A61L27/3612 ,  A61L27/3654 ,  A61L27/3852 ,  A61L27/54 ,  A61L2300/414

摘要： Disclosed are compositions comprising a meniscal tissue. For example, disclosed are compositions comprising a meniscal tissue, wherein the meniscal tissue comprises one or more engineered channels. Disclosed are compositions comprising a meniscal tissue comprising viable cells native to the meniscal tissue and devitalized blood vessels. Disclosed are compositions comprising a previously cryopreserved meniscal tissue, wherein after cryopreservation and subsequent thawing the meniscal tissue comprises a) cells native to the meniscal tissue and greater than 30% of the cells are viable, b) extracellular matrix that is native to the meniscal tissue, c) one or more growth factors that are native to the meniscal tissue, and d) depleted amounts of one or more types of functional immunogenic cells. Also disclosed are methods of producing and using these compositions comprising meniscal tissue.

摘要翻译： 公开了包含半月板组织的组合物。 例如，所公开的是包含半月板组织的组合物，其中所述半月板组织包括一个或多个工程化通道。 公开的是包含半月板组织的组合物，其包含半月板组织天然的活细胞和失活的血管。 公开了包含先前低温保存的半月板组织的组合物，其中在冷冻保存和随后解冻之后，半月板组织包含a）半月板组织天然的细胞，并且大于30％的细胞是活的，b）对半月板组织是天然的细胞外基质 c）一种或多种对半月板组织天然的生长因子，和d）一种或多种类型的功能性免疫原性细胞的耗尽量。 还公开了生产和使用包含半月板组织的这些组合物的方法。