公开(公告)号：US20240238480A1

公开(公告)日：2024-07-18

申请号：US18617246

申请日：2024-03-26

申请人： Tulavi Therapeutics, Inc. ,  Incept, LLC

发明人： Corinne BRIGHT ,  Yong REN ,  Kenneth M. Martin

IPC分类号： A61L27/26 ,  A61B17/00 ,  A61B17/11 ,  A61F2/00 ,  A61F2/02 ,  A61K9/00 ,  A61L27/18 ,  A61L27/52 ,  A61L31/14

CPC分类号： A61L27/26 ,  A61B17/1128 ,  A61F2/00 ,  A61F2/02 ,  A61K9/0004 ,  A61L27/18 ,  A61L27/52 ,  A61L31/14 ,  A61B2017/00526 ,  A61F2210/00 ,  A61F2210/008 ,  A61F2240/00 ,  A61F2240/001 ,  A61F2250/00 ,  A61L2400/06 ,  A61L2430/32

摘要： Disclosed are methods, devices and materials for the in situ formation of a nerve cap and/or a nerve wrap to inhibit neuroma formation following planned or traumatic nerve injury. The method includes the steps of identifying a severed end of a nerve, and positioning the severed end into a cavity defined by a form. A transformable media is introduced into the form cavity to surround the severed end. The media is permitted to undergo a transformation from a first, relatively flowable state to a second, relatively non flowable state to form a protective barrier surrounding the severed end. The media may be a hydrogel, and the transformation may produce a synthetic crosslinked hydrogel protective barrier. The media may include at least one anti-regeneration agent to inhibit nerve regrowth.

公开(公告)号：US20210187160A1

公开(公告)日：2021-06-24

申请号：US17138703

申请日：2020-12-30

申请人： Tulavi Therapeutics, Inc. ,  Incept, LLC

发明人： Corinne BRIGHT ,  Yong REN ,  Kenneth M. MARTIN ,  Farhad KHOSRAVI ,  Amarpreet S. SAWHNEY

IPC分类号： A61L27/26 ,  A61L27/18 ,  A61L27/52

摘要： Disclosed are methods, devices and materials for the in situ formation of a nerve cap to inhibit neuroma formation following planned or traumatic nerve injury. The method includes the steps of identifying a severed end of a nerve, and positioning the severed end into a cavity defined by a form. A transformable media is introduced into the form cavity to surround the severed end. The media is permitted to undergo a transformation from a first, relatively flowable state to a second, relatively non flowable state to form a protective barrier surrounding the severed end. The media may be a hydrogel, and the transformation may produce a synthetic crosslinked hydrogel protective barrier. The media may include at least one anti-regeneration agent to inhibit nerve regrowth

公开(公告)号：US20210268271A1

公开(公告)日：2021-09-02

申请号：US17257266

申请日：2019-07-02

申请人： Tulavi Therapeutics, Inc.

发明人： Corinne BRIGHT

IPC分类号： A61N1/05 ,  A61N1/06 ,  A61K9/06 ,  A61K47/14 ,  A61K47/10 ,  A61K47/34

摘要： Methods, devices and systems are described for gel-based modulation of neural tissue, including prevention of nerve regeneration and neuroma formation. The gel can be delivered to selected target locations including the myenteric plexus.