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公开(公告)号：US11944717B2
公开(公告)日：2024-04-02
申请号：US17477947
申请日：2021-09-17
IPC分类号： A61B17/11 , A61B17/00 , A61F2/00 , A61F2/02 , A61K9/00 , A61L27/18 , A61L27/26 , A61L27/52 , A61L31/14
CPC分类号： A61L27/26 , A61B17/1128 , A61F2/00 , A61F2/02 , A61K9/0004 , A61L27/18 , A61L27/52 , A61L31/14 , A61B2017/00526 , A61F2210/00 , A61F2210/008 , A61F2240/00 , A61F2240/001 , A61F2250/00 , A61L2400/06 , A61L2430/32
摘要： Disclosed are methods, devices and materials for the in situ formation of a nerve cap and/or a nerve wrap to inhibit neuroma formation following planned or traumatic nerve injury. The method includes the steps of identifying a severed end of a nerve, and positioning the severed end into a cavity defined by a form. A transformable media is introduced into the form cavity to surround the severed end. The media is permitted to undergo a transformation from a first, relatively flowable state to a second, relatively non flowable state to form a protective barrier surrounding the severed end. The media may be a hydrogel, and the transformation may produce a synthetic crosslinked hydrogel protective barrier. The media may include at least one anti-regeneration agent to inhibit nerve regrowth.
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公开(公告)号：US20210361292A1
公开(公告)日：2021-11-25
申请号：US17388327
申请日：2021-07-29
发明人： Corinne Bright , Yong Ren , Ken Martin , Farhad Khosravi , Amarpreet S. Sawhney
摘要： Disclosed are methods, devices and materials for the in situ formation of an implant for treating a nerve. A treatment site on a nerve is positioned within a cavity defined by a form. A transformable media is introduced into the form cavity to surround the treatment site. The media is permitted to undergo a transformation from a first, relatively flowable state to a second, relatively non flowable state to form a protective barrier surrounding the treatment site. The implant may be a growth inhibiting nerve cap to inhibit neuroma formation following planned or traumatic nerve injury, a growth permissive conduit for facilitating reconnection of a severed nerve, or an anchor for stabilizing a pain management electrode with respect to a nerve. Access to the nerve treatment site may be open surgical or percutaneous.
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公开(公告)号：US12096941B2
公开(公告)日：2024-09-24
申请号：US17388327
申请日：2021-07-29
发明人： Corinne Bright , Yong Ren , Ken Martin , Farhad Khosravi , Amarpreet S. Sawhney
CPC分类号： A61B17/12181 , A61F2/0059 , A61F2/02 , A61F2/08 , A61L27/52
摘要： Disclosed are methods, devices and materials for the in situ formation of an implant for treating a nerve. A treatment site on a nerve is positioned within a cavity defined by a form. A transformable media is introduced into the form cavity to surround the treatment site. The media is permitted to undergo a transformation from a first, relatively flowable state to a second, relatively non flowable state to form a protective barrier surrounding the treatment site. The implant may be a growth inhibiting nerve cap to inhibit neuroma formation following planned or traumatic nerve injury, a growth permissive conduit for facilitating reconnection of a severed nerve, or an anchor for stabilizing a pain management electrode with respect to a nerve. Access to the nerve treatment site may be open surgical or percutaneous.
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公开(公告)号：US20220096711A1
公开(公告)日：2022-03-31
申请号：US17547583
申请日：2021-12-10
摘要： Disclosed are methods, devices and materials for the in situ formation of a nerve cap and/or a nerve wrap to inhibit neuroma formation following planned or traumatic nerve injury. The method includes the steps of identifying a severed end of a nerve, and positioning the severed end into a cavity defined by a form. A transformable media is introduced into the form cavity to surround the severed end. The media is permitted to undergo a transformation from a first, relatively flowable state to a second, relatively non flowable state to form a protective barrier surrounding the severed end. The media may be a hydrogel, and the transformation may produce a synthetic crosslinked hydrogel protective barrier. The media may include at least one anti-regeneration agent to inhibit nerve regrowth
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公开(公告)号：US20210315587A1
公开(公告)日：2021-10-14
申请号：US17148427
申请日：2021-01-13
发明人： Corinne Bright , Yong Ren , Ken Martin , Farhad Khosravi , Amarpreet S. Sawhney
摘要： Disclosed are methods, devices and materials for the in situ formation of an implant for treating a nerve. A treatment site on a nerve is positioned within a cavity defined by a form. A transformable media is introduced into the form cavity to surround the treatment site. The media is permitted to undergo a transformation from a first, relatively flowable state to a second, relatively non flowable state to form a protective barrier surrounding the treatment site. A hydrophilic characteristic of the media cooperates with a hydrophobic characteristic of the surface of the cavity to facilitate a rapid release of the implant from the cavity following the transformation. The implant may be a growth inhibiting nerve cap to inhibit neuroma formation following planned or traumatic nerve injury, a growth permissive conduit for facilitating reconnection of a severed nerve, or an anchor for stabilizing a pain management electrode with respect to a nerve. Access to the nerve treatment site may be open surgical or percutaneous.
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公开(公告)号：US11890393B2
公开(公告)日：2024-02-06
申请号：US17138703
申请日：2020-12-30
IPC分类号： A61B17/11 , A61F2/00 , A61F2/02 , A61K9/00 , A61L27/52 , A61L31/14 , A61B17/00 , A61L27/26 , A61L27/18
CPC分类号： A61L27/26 , A61B17/1128 , A61F2/00 , A61F2/02 , A61K9/0004 , A61L27/18 , A61L27/52 , A61L31/14 , A61B2017/00526 , A61F2210/00 , A61F2210/008 , A61F2240/00 , A61F2240/001 , A61F2250/00 , A61L2400/06 , A61L2430/32
摘要： Disclosed are methods, devices and materials for the in situ formation of a nerve cap to inhibit neuroma formation following planned or traumatic nerve injury. The method includes the steps of identifying a severed end of a nerve, and positioning the severed end into a cavity defined by a form. A transformable media is introduced into the form cavity to surround the severed end. The media is permitted to undergo a transformation from a first, relatively flowable state to a second, relatively non flowable state to form a protective barrier surrounding the severed end. The media may be a hydrogel, and the transformation may produce a synthetic crosslinked hydrogel protective barrier. The media may include at least one anti-regeneration agent to inhibit nerve regrowth.
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公开(公告)号：US20220054705A1
公开(公告)日：2022-02-24
申请号：US17477947
申请日：2021-09-17
摘要： Disclosed are methods, devices and materials for the in situ formation of a nerve cap and/or a nerve wrap to inhibit neuroma formation following planned or traumatic nerve injury. The method includes the steps of identifying a severed end of a nerve, and positioning the severed end into a cavity defined by a form. A transformable media is introduced into the form cavity to surround the severed end. The media is permitted to undergo a transformation from a first, relatively flowable state to a second, relatively non flowable state to form a protective barrier surrounding the severed end. The media may be a hydrogel, and the transformation may produce a synthetic crosslinked hydrogel protective barrier. The media may include at least one anti-regeneration agent to inhibit nerve regrowth
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公开(公告)号：US20240316085A1
公开(公告)日：2024-09-26
申请号：US18444468
申请日：2024-02-16
IPC分类号： A61K31/704 , A61K9/00 , A61K31/135 , A61K31/445 , A61N1/36
CPC分类号： A61K31/704 , A61K9/0019 , A61K31/135 , A61K31/445 , A61N1/36114
摘要： Methods, agents, and devices to treat medical conditions through local chemical neuromodulation of the autonomic nervous system are described. Drug formulations may be injected at or near ganglia, nerve plexi, ganglionated plexi, and nerves to treat different diseases. Target sites for the treatment of cardiac and other disease conditions may include extrinsic stellate (cervicothoracic) and cervical ganglia of the sympathetic chain, and intrinsic cardiac nerves and ganglionated plexi innervating the myocardium.
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公开(公告)号：US11446359B2
公开(公告)日：2022-09-20
申请号：US16275120
申请日：2019-02-13
发明人： Corinne Bright
IPC分类号： A01N43/00 , A01N43/46 , A61K31/55 , A61K38/21 , A61N5/02 , A61B18/14 , A61B90/30 , A61B17/34 , A61K45/06 , A61B8/12 , A61B18/18 , A61K31/4422 , A61K31/475 , A61K47/10 , A61K9/06 , A61K47/36 , A61K9/51 , A61K31/045 , A61K31/19 , A61K31/337 , A61N7/02 , A61L27/18 , A61L27/52 , A61L27/56 , A61L31/06 , A61L31/14 , A61P9/00 , A61P29/02 , A61P25/02 , A61B18/00 , A61B8/08 , A61N7/00
摘要： Methods, devices and systems are described for decreasing the activity of the sympathetic nervous innervation to and from the lungs and the vessels supplying the lungs to treat pulmonary medical conditions such as asthma. In one embodiment, the method may involve advancing an intravascular instrument to a target location in a blood vessel within the intercostal vasculature to ablate either or both the sympathetic afferent and efferent nerves lying within the paravertebral gutter including the visceral fibers that travel to the cardiothoracic cavity and abdominopelvic viscera and the T1 to T4/5 sympathetic chain. In another embodiment, an intravascular instrument may be advanced to the bronchial vessels to ablate either or both the sympathetic afferent and efferent nerves in and around the posterior pulmonary plexus. In one embodiment the ablative agent is a neurolytic agent delivered in a gel. This approach may be utilized to treat other cardiac and pulmonary diseases.
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公开(公告)号：US11246879B2
公开(公告)日：2022-02-15
申请号：US16076308
申请日：2017-02-09
IPC分类号： A61K31/704 , A61K31/445 , A61N1/36
摘要： Methods, agents, and devices to treat medical conditions through local chemical neuromodulation of the autonomic nervous system are described. Drug formulations may be injected at or near ganglia, nerve plexi, ganglionated plexi, and nerves to treat different diseases. Target sites for the treatment of cardiac and other disease conditions may include extrinsic stellate (cervicothoracic) and cervical ganglia of the sympathetic chain, and intrinsic cardiac nerves and ganglionated plexi innervating the myocardium.
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