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公开(公告)号：US12124097B1
公开(公告)日：2024-10-22
申请号：US17677651
申请日：2022-02-22
CPC分类号： G02B6/4427 , G02B6/3816 , B33Y80/00
摘要： Systems and methods for tethering a fiber optic cable to an apparatus such as an unmanned underwater vehicle (UUV) or remotely operated vehicle (ROV). The cable is a bare or tight-buffered optical fiber surrounded by a braided sheath, and is constructed so that loads experienced by the cable are not transferred from the sheath to the optical fiber. This construction enables the cable to have good tensile strength but be sufficiently lightweight so that a commercial fishing reel or any similarly scaled lightweight/portable winch system can be used, instead of large specialized deployment equipment. A tube is inserted between the sheath and the optical fiber a certain distance from the end of the cable, and then the cable and tube are inserted into a housing which attaches to the apparatus and potted using an epoxy resin.
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公开(公告)号：US20240285772A1
公开(公告)日：2024-08-29
申请号：US18106242
申请日：2023-02-06
IPC分类号： A61K47/54 , C07D213/61 , C07D213/64 , C07D213/68 , C07D213/71 , C07D213/76 , C07D235/24 , C07D235/28 , C07D237/12 , C07D239/30 , C07D277/62
CPC分类号： A61K47/545 , C07D213/61 , C07D213/64 , C07D213/68 , C07D213/71 , C07D213/76 , C07D235/24 , C07D235/28 , C07D237/12 , C07D239/30 , C07D277/62
摘要： Disclosed are pnictogen-containing heterocyclic compounds of Formula (I)
Each of R1, the heterocyclic ring H, A+, LG, and X− is defined herein. Also provided are methods of modifying a substrate using such a compound, conjugated biomolecules thus modified, and pharmaceutical compositions containing one of the conjugated biomolecules.-
公开(公告)号：US11958739B2
公开(公告)日：2024-04-16
申请号：US17188985
申请日：2021-03-01
IPC分类号： B81C1/00
CPC分类号： B81C1/00547 , B81C1/00071 , B81C2201/0133 , B81C2201/0145
摘要： The present invention provides a simple method for ablating a protective thin film on a bulk surface and roughening the underlying bulk. In an embodiment, silicon nitride thin films, which are useful as etch-stop masks in micro- and nano-fabrication, is removed from a silicon wafer's surface using a hand-held “flameless” Tesla-coil lighter. Vias created by a spatially localized electron beam from the lighter allow a practitioner to perform micro- and nano-fabrication without the conventional steps of needing a photoresist and photolithography. Patterning could be achieved with a hard mask or rastering of the spatially confined discharge, offering—with low barriers to rapid use—particular capabilities that might otherwise be out of reach to researchers without access to conventional, instrumentation-intensive micro- and nano-fabrication workflows.
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公开(公告)号：US11857509B2
公开(公告)日：2024-01-02
申请号：US16717577
申请日：2019-12-17
IPC分类号： A61K9/127 , A61K47/69 , A61K31/20 , A61K31/337 , A61K31/704 , A61K31/7105 , A61K31/711 , A61P35/00 , A61K31/713
CPC分类号： A61K9/1271 , A61K9/127 , A61K31/20 , A61K31/337 , A61K31/704 , A61K31/711 , A61K31/713 , A61K31/7105 , A61K47/6911 , A61P35/00
摘要： The present application relates to compositions comprising and methods of using a liposome comprising a pHLIP polypeptide, wherein a lipid bilayer of the liposome is substantially free of the pHLIP polypeptide.
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公开(公告)号：US20230384261A1
公开(公告)日：2023-11-30
申请号：US18121505
申请日：2023-03-14
发明人： Jason R Dwyer , James Hagan , Grace G.D. Han , Alejandra Gonzalez
IPC分类号： G01N27/447 , G01N33/487 , B82Y15/00
CPC分类号： G01N27/44791 , G01N33/48721 , B82Y15/00
摘要： Disclosed herein is the fabrication of a photo-regulated nanopore by covalently linking a photoswitch to the interior of a silicon-based membrane and related methods of translocating an analyte and distinguishing molecule types through such a nanopore.
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公开(公告)号：US11662298B1
公开(公告)日：2023-05-30
申请号：US17079027
申请日：2020-10-23
CPC分类号： G01N17/002 , G01N33/44
摘要： An accelerated life testing (ALT) system for the pressurization of corrosive media, such as seawater, at high pressures and at elevated temperatures (up to about 70° C.) for extended periods of time. The interior of a pressure vessel is coated in an inert ceramic/epoxy coating that provides adequate corrosion protection from the corrosive media. A fabric reinforced nitrile diaphragm separates the corrosive media from hydraulic actuating media, such as oil. The hydraulic actuating media is pressurized, which deforms the diaphragm into the corrosive media, thereby increasing the pressure. The diaphragm and supplementary flouroelastomer seals isolate the corrosive media from pressure generating, monitoring, and safety equipment. The temperature of the entire vessel and contents is maintained by complete immersion in a heated, filtered water bath. The system is particularly useful for ALT experiments on components intended for sea floor and long term deep ocean environment operations at about 6000 psi (41.4 MPa).
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公开(公告)号：US11300542B2
公开(公告)日：2022-04-12
申请号：US16804787
申请日：2020-02-28
IPC分类号： H01J49/00 , G01N27/622 , H01J49/04 , H01J49/02
摘要： The present disclosure describes an improved sample preparation technique and adapter device for the removal of trace materials from swabs and delivery of the trace materials into a mass spectrometer (MS) or an ion mobility spectrometer (IMS). The adapter device and technique aids the delivery of the analyte into the instrument inlet and concurrently serves as an ionization source. The technique includes the steps of positioning or shaping the swab so that a pointed analyte release corner or tip is directed toward the inlet of the MS or IMS, adding a solvent to the swab and charging the swab to create an ionized analyte spray pointed at or positioned within the inlet of the detection instrument.
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8.发明公开公开(公告)号：US20240343859A1
公开(公告)日：2024-10-17
申请号：US18628340
申请日：2024-04-05
摘要： Embodiments of the present invention comprises one or more of an article composed of a copolymer, a copolymer made from a process, and a process for the preparation of a copolymer composition by metal free enzyme ring-opening polymerization of a monomer composition comprising i) an ethylene brassylate monomer; ii) a 1-4 dioxan-2-one (DO); iii) lipase B from Candida antarctica (Novozyme® 435) and at an elevated temperature, processing the monomer reactants i) and ii) to a copolymer via ring-opening polymerization under solvent-free conditions and a nitrogen atmosphere in the absence of a metal and the presence of the lipase to produce a random EB-co-DO copolymer.
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9.发明公开公开(公告)号：US20240148911A1
公开(公告)日：2024-05-09
申请号：US18349851
申请日：2023-07-10
IPC分类号： A61K49/00 , A61B5/00 , A61K49/04 , A61K49/22 , C07K14/00 , C07K19/00 , C09B69/10 , C09K11/06 , G01N33/58
CPC分类号： A61K49/0056 , A61B5/0082 , A61K49/0034 , A61K49/04 , A61K49/221 , A61K49/227 , C07K14/001 , C07K19/00 , C09B69/107 , C09K11/06 , G01N33/582 , A61B5/0071 , C09K2211/1466
摘要： The present subject matter provides compounds, compositions, and methods for identifying, monitoring, treating, and removing diseased tissue. Compounds, compositions, and methods for identifying, monitoring, and detecting circulating fluids such as blood are also provided.
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公开(公告)号：US11932558B1
公开(公告)日：2024-03-19
申请号：US17190248
申请日：2021-03-02
发明人： William B. Euler , Angela Thach , Lasanthi Sumathirathne , Benjamin B. Cromwell , Mara Dubnicka
IPC分类号： C02F1/461 , C02F1/467 , C02F101/34 , C02F101/38 , C25B1/04 , C25B1/27 , C25B3/07 , C25B3/26 , C25B11/095 , H10N30/857
CPC分类号： C02F1/46109 , C02F1/4672 , C25B1/04 , C25B1/27 , C25B3/07 , C25B3/26 , C25B11/095 , H10N30/857 , C02F2001/46133 , C02F2101/345 , C02F2101/38 , C02F2201/46115
摘要： A piezoelectric polymer used as a piezocatalyst, and methods of manufacture and use therefor. A preferred piezoelectric polymer is poly(vinylidene difluoride) (PVDF) due to its piezoelectric response and good flexibility. The polymer can be doped with a metal, metal salt, metal carbonyl, metal oxide such as ZnO, Co2O3, or TiO2, or ion such as Cr3+, Co2+, or Zn2+. The dopant can be chosen so that when the polymer is PVDF the dopant increases the amount of β-phase PVDF and/or γ-phase PVDF relative to α-phase PVDF, thereby increasing the piezocatalytic response of the polymer. The compound to be decomposed can be adsorbed on the surface of the piezoelectric polymer. Applications include wastewater treatment, CO2 capture and reduction, hydroformylation, water splitting, and ammonia synthesis.
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