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公开(公告)号：US20240287018A1
公开(公告)日：2024-08-29
申请号：US18438838
申请日：2024-02-12
申请人： Corsair Pharma, Inc.
发明人： Cyrus K. BECKER , Meenakshi S. VENKATRAMAN , Xiaoming ZHANG , Jürg R. Pfister , Gwenaella Rescourio
IPC分类号： C07D321/00 , A61K9/00 , A61K9/70 , A61K31/165 , A61K31/216 , A61K31/341 , A61K31/365 , A61K45/06 , C07C59/72 , C07C69/712 , C07C69/734 , C07C69/74 , C07C69/96 , C07C219/16 , C07C235/20 , C07D207/08 , C07D211/60 , C07D257/06 , C07D263/24 , C07D263/26 , C07D265/30 , C07D295/088 , C07D295/145 , C07D307/20 , C07D317/34 , C07D317/40 , C07D453/02
CPC分类号： C07D321/00 , A61K9/0014 , A61K9/7023 , A61K31/165 , A61K31/216 , A61K31/341 , A61K31/365 , A61K45/06 , C07C59/72 , C07C69/712 , C07C69/734 , C07C69/74 , C07C69/96 , C07C219/16 , C07C235/20 , C07D207/08 , C07D211/60 , C07D257/06 , C07D263/24 , C07D263/26 , C07D265/30 , C07D295/088 , C07D295/145 , C07D307/20 , C07D317/34 , C07D317/40 , C07D453/02 , C07C2601/02 , C07C2601/08 , C07C2601/14 , C07C2602/42 , C07C2603/14
摘要： Compounds represented by formulae I, II, III, and IV including pro-drugs for treprostinil and prostacyclin analogs. Uses include treatment of pulmonary hypertension (PH) or pulmonary arterial hypertension (PAH). The structures of the compounds can be adapted to the particular application for a suitable treatment dosage. Transdermal applications can be used.
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公开(公告)号：US20240124385A1
公开(公告)日：2024-04-18
申请号：US18516407
申请日：2023-11-21
申请人： CORSAIR PHARMA, INC.
IPC分类号： C07C69/734 , A61K9/70 , C07C53/136 , C07C59/11 , C07C59/13 , C07C69/28 , C07C69/675 , C07C69/68 , C07C69/708 , C07C69/712 , C07C69/74 , C07C69/75 , C07C69/96 , C07D305/08 , C07D307/24 , C07D307/30 , C07D309/08
CPC分类号： C07C69/734 , A61K9/7023 , C07C53/136 , C07C59/11 , C07C59/13 , C07C69/28 , C07C69/675 , C07C69/68 , C07C69/708 , C07C69/712 , C07C69/74 , C07C69/75 , C07C69/96 , C07D305/08 , C07D307/24 , C07D307/30 , C07D309/08 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2603/14
摘要： The present disclosure provides treprostinil derivatives that can act as prodrugs of treprostinil. The treprostinil derivatives can be used to treat any conditions responsive to treatment with treprostinil, including pulmonary hypertension, such as pulmonary arterial hypertension.
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公开(公告)号：US20210009501A1
公开(公告)日：2021-01-14
申请号：US16936256
申请日：2020-07-22
申请人： CORSAIR PHARMA, INC.
IPC分类号： C07C69/734 , C07C69/732 , C07C69/013 , C07C69/26 , C07C69/675 , C07C69/708 , C07C69/712 , C07C69/96 , C07D303/48 , A61K9/00 , A61K9/70 , A61K31/216 , A61K45/06
摘要： The present disclosure provides treprostinil derivatives that can act as prodrugs of treprostinil. The treprostinil derivatives can be used to treat any conditions responsive to treatment with treprostinil, including pulmonary hypertension, such as pulmonary arterial hypertension.
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公开(公告)号：US10752605B2
公开(公告)日：2020-08-25
申请号：US16417664
申请日：2019-05-21
申请人： CORSAIR PHARMA, INC.
IPC分类号： C07D313/00 , C07C69/712 , C07D317/40 , C07D321/00 , C07D257/06 , C07D263/24 , C07D265/30 , C07D295/088 , C07D211/60 , C07D295/145 , C07D307/20 , C07C219/16 , C07C235/20 , C07D453/02 , C07C59/54 , C07C69/734 , C07C235/34 , C07D207/08 , C07D263/26 , C07D317/34 , A61K9/70 , A61K31/165 , A61K31/216 , A61K31/335 , C07C59/31
摘要： Compounds represented by formulae I, II, III, and IV including pro-drugs for treprostinil and prostacyclin analogs. Uses include treatment of pulmonary hypertension (PH) or pulmonary arterial hypertension (PAH). The structures of the compounds can be adapted to the particular application for a suitable treatment dosage. Transdermal applications can be used.
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公开(公告)号：US10246403B2
公开(公告)日：2019-04-02
申请号：US15735546
申请日：2016-06-14
申请人： CORSAIR PHARMA, INC.
IPC分类号： C07C69/734 , C07C69/74 , C07C53/136 , C07C59/11 , C07C59/13 , A61K9/70 , C07D309/08 , C07C69/28 , C07C69/708 , C07C69/712 , C07D305/08 , C07C69/675 , C07C69/68 , C07C69/75 , C07C69/96 , C07D307/24
摘要： The present disclosure provides treprostinil derivatives that can act as prodrugs of treprostinil. The treprostinil derivatives can be used to treat any conditions responsive to treatment with treprostinil, including pulmonary hypertension, such as pulmonary arterial hypertension.
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公开(公告)号：US09845305B2
公开(公告)日：2017-12-19
申请号：US15296164
申请日：2016-10-18
申请人： Corsair Pharma Inc.
发明人： Cyrus K. Becker , Jürg R. Pfister , Gwenaella Rescourio , Meenakshi S. Venkatraman , Xiaoming Zhang
IPC分类号： C07D321/00 , C07D307/20 , C07D317/40 , C07C235/20 , A61K31/165 , C07C69/734 , A61K31/216 , A61K31/365 , A61K31/341 , A61K45/06 , A61K9/00 , C07D317/34 , C07C69/712 , C07C219/16 , C07D453/02 , C07D257/06 , C07D263/24 , C07D263/26 , C07D265/30 , C07D207/08 , C07D295/088 , C07D211/60 , C07D295/145 , C07C59/72 , C07C69/74 , C07C69/96 , A61K9/70
CPC分类号： C07D321/00 , A61K9/0014 , A61K9/7023 , A61K31/165 , A61K31/216 , A61K31/341 , A61K31/365 , A61K45/06 , C07C59/72 , C07C69/712 , C07C69/734 , C07C69/74 , C07C69/96 , C07C219/16 , C07C235/20 , C07C2601/02 , C07C2601/08 , C07C2601/14 , C07C2602/42 , C07C2603/14 , C07D207/08 , C07D211/60 , C07D257/06 , C07D263/24 , C07D263/26 , C07D265/30 , C07D295/088 , C07D295/145 , C07D307/20 , C07D317/34 , C07D317/40 , C07D453/02
摘要： Compounds represented by formulae I, II, III, and IV including pro-drugs for treprostinil and prostacyclin analogs. Uses include treatment of pulmonary hypertension (PH) or pulmonary arterial hypertension (PAH). The structures of the compounds can be adapted to the particular application for a suitable dosage. Transdermal applications can be used.
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公开(公告)号：US09643911B2
公开(公告)日：2017-05-09
申请号：US14829180
申请日：2015-08-18
申请人： CORSAIR PHARMA, INC.
IPC分类号： C07C69/28 , C07C69/68 , C07C69/75 , C07C69/675 , C07C69/96 , C07D309/08 , C07C69/708 , C07C69/712 , C07D305/08 , C07D307/30 , A61K9/70 , C07C59/13 , C07C53/136 , C07C69/74 , C07C59/11
CPC分类号： C07C69/74 , A61K9/7023 , C07C53/136 , C07C59/11 , C07C59/13 , C07C69/28 , C07C69/675 , C07C69/68 , C07C69/708 , C07C69/712 , C07C69/75 , C07C69/96 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2603/14 , C07D305/08 , C07D307/24 , C07D307/30 , C07D309/08
摘要： The present disclosure provides treprostinil derivatives that can act as prodrugs of treprostinil. The treprostinil derivatives can be used to treat any conditions responsive to treatment with treprostinil, including pulmonary hypertension, such as pulmonary arterial hypertension.
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公开(公告)号：US20240116847A1
公开(公告)日：2024-04-11
申请号：US18370574
申请日：2023-09-20
申请人： CORSAIR PHARMA, INC.
IPC分类号： C07C69/734 , A61K9/70 , C07C53/136 , C07C59/11 , C07C59/13 , C07C69/28 , C07C69/675 , C07C69/68 , C07C69/708 , C07C69/712 , C07C69/74 , C07C69/75 , C07C69/96 , C07D305/08 , C07D307/24 , C07D307/30 , C07D309/08
CPC分类号： C07C69/734 , A61K9/7023 , C07C53/136 , C07C59/11 , C07C59/13 , C07C69/28 , C07C69/675 , C07C69/68 , C07C69/708 , C07C69/712 , C07C69/74 , C07C69/75 , C07C69/96 , C07D305/08 , C07D307/24 , C07D307/30 , C07D309/08 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2603/14
摘要： The present disclosure provides treprostinil derivatives that can act as prodrugs of treprostinil. The treprostinil derivatives can be used to treat any conditions responsive to treatment with treprostinil, including pulmonary hypertension, such as pulmonary arterial hypertension.
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公开(公告)号：US20220055980A1
公开(公告)日：2022-02-24
申请号：US17207975
申请日：2021-03-22
申请人： CORSAIR PHARMA, INC.
IPC分类号： C07C69/734 , C07C69/74 , C07C53/136 , C07C59/11 , C07C59/13 , A61K9/70 , C07D309/08 , C07C69/708 , C07C69/712 , C07D305/08 , C07C69/675 , C07C69/68 , C07C69/75 , C07C69/96 , C07D307/24 , C07C69/28 , C07D307/30
摘要： The present disclosure provides treprostinil derivatives that can act as prodrugs of treprostinil. The treprostinil derivatives can be used to treat any conditions responsive to treatment with treprostinil, including pulmonary hypertension, such as pulmonary arterial hypertension.
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公开(公告)号：US20210355072A1
公开(公告)日：2021-11-18
申请号：US17245235
申请日：2021-04-30
申请人： CORSAIR PHARMA, INC.
IPC分类号： C07C69/734 , C07C69/74 , C07C53/136 , C07C59/11 , C07C59/13 , A61K9/70 , C07D309/08 , C07C69/708 , C07C69/712 , C07D305/08 , C07C69/675 , C07C69/68 , C07C69/75 , C07C69/96 , C07D307/24 , C07C69/28 , C07D307/30
摘要： The present disclosure provides treprostinil derivatives that can act as prodrugs of treprostinil. The treprostinil derivatives can be used to treat any conditions responsive to treatment with treprostinil, including pulmonary hypertension, such as pulmonary arterial hypertension.
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