-
公开(公告)号：US20210199624A1
公开(公告)日：2021-07-01
申请号：US17057361
申请日：2019-05-20
发明人： Martin Gilar , Thomas S. McDonald , Joseph D. Michienzi , Jeffrey Musacchio , Rachel Mumma , Keith Fadgen , Geoff C. Gerhardt
IPC分类号： G01N30/06 , G01N1/40 , G01N30/54 , G01N30/60 , B01J20/24 , B01J20/28 , B01J20/288 , B01J20/32 , B01D15/38 , B01D15/22 , B01D15/16
摘要： Sample preparation and separation can be performed using a sample cartridge (201). The cartridge includes a barrel (204) with a first and second end, a column segment (209) connected to the second end of the barrel, and a column (205) containing a sorbent material. The sorbent material includes particles that have antibodies attached to them to selectively retain analytes, proteins attached to them to retain certain classes of antibodies, or enzymes attached to them to perform specific modifications to certain classes of molecules. The column segment can be in thermal communication with a temperature control device in order to control the temperature of the column.
-
2.发明申请公开(公告)号：US20150346168A1
公开(公告)日：2015-12-03
申请号：US14822527
申请日：2015-08-10
CPC分类号： G01N30/34 , G01N30/32 , G01N2030/326 , G05D11/132
摘要： A solvent delivery subsystem for a chromatography device performs relatively low pressure, high flow mixing of solvents to form a gradient and subsequent high pressure, low flow delivery of the gradient to the separation column. The mixing of the gradient is independent and does not interfere with the gradient delivery. To form the gradient, the outputs of an aqueous pump and an organic pump are mixed to fill a storage capillary while a downstream point from the storage capillary is vented to atmosphere. After gradient formation, the vent to atmosphere is closed, the solvent delivery system rises to high pressure, and only the aqueous pump runs for gradient delivery. To maintain integrity of the fluid stream, the solvent delivery system uses feed forward compensation and controls at least one parameter selected from the group consisting of pressure and flow in the conduit means to follow a gradual ramp.
-
3.发明授权公开(公告)号：US10996204B2
公开(公告)日：2021-05-04
申请号：US15948653
申请日：2018-04-09
发明人： Joseph D. Michienzi , Joshua A. Shreve , Jason F. Hill , Abhijit Tarafder , Michael O. Fogwill , Keith Fadgen
摘要： Methods for transferring a carbon dioxide based separation procedure from a reference chromatographic system to a target chromatographic system involve alternative techniques for determining system pressure drops not attributable to the column. One technique involves leveraging experimental chromatography to develop a correction factor that is a function of at least one correction coefficient and at least one ratio of the differential analyte retention time to the retention time in the reference system. Another technique involves leveraging other experimental measurements of tubing pressure drops under various condition to develop a lookup table that can be used to identify likely tubing pressure drops in the target system. A third technique leverages knowledge of the separation procedure and the target system and the likely nature of the relevant flow to calculate tubing pressure drops in the target system.
-
公开(公告)号：US10465808B2
公开(公告)日：2019-11-05
申请号：US16323637
申请日：2017-08-07
IPC分类号： F16K15/14 , F04B53/10 , G01N30/02 , G01N30/20 , F16J15/3212
摘要： A check valve includes a first valve body having a chamber in which second and third valve bodies are located. The check valve also includes a spring-energized seal disposed in the chamber. The spring-energized seal includes a compliant seal body having an annular shape and a resilient member, such as a cantered spring or O-ring, disposed in a pocket of the seal body. The resilient member applies a force to portions of the seal body to prevent the passage of fluid from a valve inlet port to a valve outlet port unless the differential fluid exceeds the cracking pressure of the check valve.
-
5.发明申请公开(公告)号：US20180207549A1
公开(公告)日：2018-07-26
申请号：US15873280
申请日：2018-01-17
发明人： Xiangjin Song , James P. Murphy , Keith Fadgen , Wade P. Leveille , Joseph D. Michienzi , Jonathan L. Belanger , Moon Chul Jung , Abhijit Tarafder
CPC分类号： B01D15/14 , B01L3/545 , B01L9/00 , B01L2300/021 , B65D1/0223 , B65D23/14 , B65D2501/0081 , G01N30/26 , G01N30/80 , G01N35/00732
摘要： Solvent containers and solvent container trays for chromatography systems are described for providing control over solvent supply and waste collection. Designated solvent containers and exclusively designated solvent containers provide solvents for use by chromatography systems. Control over solvent supply is achieved by requiring matched container shape and container receiving position shape within the tray, and additionally or alternatively, through solvent container coding readable by the solvent tray and chromatography system which provide information about the solvent container to the chromatography system.
-
公开(公告)号：US09662595B2
公开(公告)日：2017-05-30
申请号：US13749929
申请日：2013-01-25
CPC分类号： B01D15/14 , B01D15/22 , G01N30/6004 , G01N30/6026 , G01N30/603 , G01N30/6039 , Y10T29/49826
摘要： A method for making a liquid-chromatography apparatus includes inserting two inner conduits into an intermediate tube, inserting the intermediate tube into an outer tube, forming a proximal seal between the intermediate tube and at least one of the inner conduits, and forming a distal seal between the intermediate tube and at least one of the inner conduits. A liquid-chromatography apparatus includes an outer tube, an intermediate tube disposed in the outer tube, two inner conduits disposed in the intermediate tube, a proximal seal between the intermediate tube and at least one of the inner conduits, and a distal seal between the intermediate tube and at least one of the inner conduits.
-
公开(公告)号：US11717770B2
公开(公告)日：2023-08-08
申请号：US17716367
申请日：2022-04-08
CPC分类号： B01D15/163 , G01N30/32 , G01N2030/324 , G01N2030/328
摘要： A variable fluidic restrictor of a liquid chromatography system including a stator body, the stator body include a plurality of fluidic channels located within the stator body, wherein each fluidic channel of the plurality of fluidic channels includes a restrictor element, wherein a flow of a fluid through the variable fluidic restrictor is selectively restricted based on a position of an external element coupled to the stator body is provided. Furthermore, an associated method is also provided.
-
公开(公告)号：US11325055B2
公开(公告)日：2022-05-10
申请号：US16545845
申请日：2019-08-20
摘要： A variable fluidic restrictor of a liquid chromatography system including a stator body, the stator body include a plurality of fluidic channels located within the stator body, wherein each fluidic channel of the plurality of fluidic channels includes a restrictor element, wherein a flow of a fluid through the variable fluidic restrictor is selectively restricted based on a position of an external element coupled to the stator body is provided. Furthermore, an associated method is also provided.
-
公开(公告)号：US20210199630A1
公开(公告)日：2021-07-01
申请号：US17057242
申请日：2019-05-20
发明人： Martin Gilar , Thomas S. McDonald , Joseph D. Michienzi , Jeffrey Musacchio , Rachel Mumma , Keith Fadgen , Geoff C. Gerhardt
摘要： Methods and devices for the washing, extraction, and separation of a sample in a disposable chromatography cartridge (201) comprising a barrel (204) and a column (205), and especially including reinforcement to the column permitting high-pressure separation.
-
10.发明授权公开(公告)号：US10953346B2
公开(公告)日：2021-03-23
申请号：US15873280
申请日：2018-01-17
发明人： Xiangjin Song , James P. Murphy , Keith Fadgen , Wade P. Leveille , Joseph D. Michienzi , Jonathan L. Belanger , Moon Chul Jung , Abhijit Tarafder
摘要： Solvent containers and solvent container trays for chromatography systems are described for providing control over solvent supply and waste collection. Designated solvent containers and exclusively designated solvent containers provide solvents for use by chromatography systems. Control over solvent supply is achieved by requiring matched container shape and container receiving position shape within the tray, and additionally or alternatively, through solvent container coding readable by the solvent tray and chromatography system which provide information about the solvent container to the chromatography system.
-
-
-
-
-
-
-
-
-
搜索结果
28 条记录 (耗时 0.017 秒)
