-
1.发明申请FLAME IONIZATION DETECTION FOR SUPERCRITICAL FLUID CHROMATOGRAPHY EMPLOYING A MATCHED SEPARATION COLUMN AND FLAME BURNER 有权用于超临界流体色谱的火焰离子检测采用匹配分离柱和火焰燃烧器公开(公告)号：US20150301000A1
公开(公告)日：2015-10-22
申请号：US14675865
申请日：2015-04-01
IPC分类号： G01N30/68
CPC分类号： G01N30/68
摘要： The present disclosure relates to flame based detection methods for compressed mobile phase chromatography. In particular, the present disclosure relates to the operation of a flame ionization detector for carbon dioxide based chromatography, such as supercritical fluid chromatography. The present disclosure includes a method of matching a chromatographic column with a flame ionization detector inner burner including providing a chromatographic column with an internal diameter, determining an optimal mobile phase flow rate for the chromatographic column, calculating an optimal inner diameter of the inner burner that combined with the internal diameter and flow rate of the column produces optimal detector performance, and providing a flame ionization detector inner burner having an inner diameter substantially equal to the calculated optimal inner diameter.
摘要翻译： 本公开涉及用于压缩流动相色谱法的基于火焰的检测方法。 特别地，本公开涉及用于二氧化碳基色谱的火焰离子化检测器的操作，例如超临界流体色谱法。 本公开内容包括将色谱柱与火焰离子化检测器内部燃烧器匹配的方法，包括提供具有内径的色谱柱，确定色谱柱的最佳流动相流速，计算内部燃烧器的最佳内径， 结合柱的内径和流速产生最佳的检测器性能，并提供具有基本上等于计算的最佳内径的内径的火焰离子化检测器内燃烧器。
-
2.发明申请公开(公告)号：US20150079691A1
公开(公告)日：2015-03-19
申请号：US14484350
申请日：2014-09-12
CPC分类号： G01N30/84 , G01N27/626 , G01N30/68 , G01N2030/8435
摘要： The present disclosure relates to an oxidizer, and related methods, for oxidizing polar modifiers in chromatographic mobile phases. The oxidizer enables the use of flame-based detection in chromatographic separations, such as carbon dioxide based chromatography, which employ polar modifiers, such as methanol. Upon exiting a chromatographic column, the mobile phase containing the polar modifier is flowed through an oxidizer that contains a catalyst to oxidize at least a portion of the polar modifier to a species that does not interfere with the function of the flame-based detector. The oxidizer allows for flame-based detection, such as flame ionization detection, in applications in which a polar modifier with a reduced form of carbon is used.
摘要翻译： 本公开内容涉及用于在色谱流动相中氧化极性改性剂的氧化剂和相关方法。 氧化剂使得能够在色谱分离中使用基于火焰的检测，例如使用极性改性剂如甲醇的基于二氧化碳的色谱法。 在离开色谱柱时，含有极性改性剂的流动相流过含有催化剂的氧化剂，以将至少一部分极性改性剂氧化成不干扰基于火焰的检测器的功能的物质。 在使用具有还原形式的碳的极性改性剂的应用中，氧化剂允许基于火焰的检测，例如火焰离子化检测。
-
公开(公告)号：US20150078962A1
公开(公告)日：2015-03-19
申请号：US14483389
申请日：2014-09-11
IPC分类号： G01N30/68
CPC分类号： G01N30/68 , G01N30/6095
摘要： The present disclosure relates to a microfluidic flame ionization detector for use in small scale separations, such as, for example, microfluidic gas chromatography and microfluidic carbon dioxide based fluid chromatography. In some arrangements, the microfluidic counter-current flame ionization detector employs a non-parallel arrangement for the introduction of combustion gases into the combustion chamber. In other arrangements, the detector housing is configured to incorporate at least one of the detector electrodes within the housing using electrically isolating fittings.
摘要翻译： 本公开内容涉及用于小规模分离的微流体火焰离子化检测器，例如微流体气相色谱法和基于微流体二氧化碳的流体色谱法。 在一些布置中，微流控逆流火焰离子化检测器采用非平行布置来将燃烧气体引入燃烧室。 在其他布置中，检测器壳体构造成使用电隔离配件将至少一个检测器电极并入外壳内。
-
4.发明授权公开(公告)号：US10953346B2
公开(公告)日：2021-03-23
申请号：US15873280
申请日：2018-01-17
发明人： Xiangjin Song , James P. Murphy , Keith Fadgen , Wade P. Leveille , Joseph D. Michienzi , Jonathan L. Belanger , Moon Chul Jung , Abhijit Tarafder
摘要： Solvent containers and solvent container trays for chromatography systems are described for providing control over solvent supply and waste collection. Designated solvent containers and exclusively designated solvent containers provide solvents for use by chromatography systems. Control over solvent supply is achieved by requiring matched container shape and container receiving position shape within the tray, and additionally or alternatively, through solvent container coding readable by the solvent tray and chromatography system which provide information about the solvent container to the chromatography system.
-
公开(公告)号：US20190111376A1
公开(公告)日：2019-04-18
申请号：US16157921
申请日：2018-10-11
IPC分类号： B01D53/02
摘要： The present disclosure relates to methodologies, systems, apparatus, kits, and microfluidic separation devices based on separation columns and restrictors that are matched and bundled together for distribution as a unit, where the mobile phase flow rate and post-column pressure are specified based on this combination of matched separation column and restrictor.
-
公开(公告)号：US10191020B2
公开(公告)日：2019-01-29
申请号：US14713439
申请日：2015-05-15
摘要： Burner assemblies are configured to deliver decompressed mobile phase of supercritical fluid chromatography systems to the flame of a flame-based detector while providing for improved optimization of analyte response as well as enhanced flame stability during operation.
-
公开(公告)号：US10151733B2
公开(公告)日：2018-12-11
申请号：US14484350
申请日：2014-09-12
摘要： The present disclosure relates to an oxidizer, and related methods, for oxidizing polar modifiers in chromatographic mobile phases. The oxidizer enables the use of flame-based detection in chromatographic separations, such as carbon dioxide based chromatography, which employ polar modifiers, such as methanol. Upon exiting a chromatographic column, the mobile phase containing the polar modifier is flowed through an oxidizer that contains a catalyst to oxidize at least a portion of the polar modifier to a species that does not interfere with the function of the flame-based detector. The oxidizer allows for flame-based detection, such as flame ionization detection, in applications in which a polar modifier with a reduced form of carbon is used.
-
公开(公告)号：US09625428B2
公开(公告)日：2017-04-18
申请号：US14507310
申请日：2014-10-06
CPC分类号： G01N30/38 , G01F1/76 , G01N1/28 , G01N30/68 , G01N33/0016 , G01N2001/002 , G01N2030/324 , Y02E20/328
摘要： Methods and apparatus for the modulation of flame gas stoichiometry to a flame-based detector for use in chromatographic separations are presented. As the total mass flow rate of mobile phase entering the flame-based detector changes (e.g., as a result of density programming in the separation), the mass flow rate of combustion gases to the detector are altered in proportion to the amount of mobile phase entering the detector. As a result, flame stability and sensitivity of the detector can be maintained by the methods and apparatus of the present disclosure.
-
9.发明申请ENHANCED SENSITIVITY OF DETECTION IN ELECTROSPRAY IONIZATION MASS SPECTROMETRY USING A POST-COLUMN MODIFIER AND A MICROFLUIDIC DEVICE 有权使用后柱改性剂和微流体装置的电喷雾离子质谱检测中增强的敏感性公开(公告)号：US20160131620A1
公开(公告)日：2016-05-12
申请号：US14881395
申请日：2015-10-13
发明人： James P. Murphy , Angela Doneanu
CPC分类号： G01N30/7266 , B01L3/5027 , G01N30/06 , G01N30/32 , G01N30/34 , G01N30/6095 , G01N30/84 , G01N2030/326 , H01J49/167
摘要： A microfluidic liquid chromatography-electrospray ionization (LC-ESI) device is provided for enhancing the sensitivity of mass spectrometric detection of an analyte in a sample. The device is designed to drive effective intermixing of an analytical flow stream exiting a chromatographic stationary phase and a post-column modifier reagent. The mixed flow stream thus obtained is used for generating an electrospray containing analyte ions. Also provided are methods for enhanced sensitivity of detection of an analyte in a sample.
摘要翻译： 提供微流体液相色谱 - 电喷雾离子化（LC-ESI）装置，用于提高样品中分析物质谱检测的灵敏度。 该设备旨在驱动离开色谱固定相和柱后改性剂的分析流的有效混合。 由此获得的混合流动流用于产生含有分析物离子的电喷雾。 还提供了增强样品中分析物检测灵敏度的方法。
-
10.发明申请公开(公告)号：US20150122988A1
公开(公告)日：2015-05-07
申请号：US14594644
申请日：2015-01-12
CPC分类号： G01N30/6095 , B01D15/22 , B01D15/424 , B01L3/502715 , B01L2200/025 , B01L2200/027 , B01L2200/028 , B01L2300/0816 , B01L2400/0487 , G01N30/461 , G01N30/606 , G01N30/6091 , G01N30/7233 , G01N30/7266 , G01N2030/027 , G01N2030/085 , G01N2030/8881 , Y10T29/49826
摘要： An apparatus for chemical separations includes a first substantially rigid microfluidic substrate defining a first fluidic port; a second substantially rigid microfluidic substrate defining second fluidic port; and a coupler disposed between the first and second substrates, the coupler defining a fluidic path in fluidic alignment with the ports of the first and second substrates. The coupler includes a material that is deformable relative to a material of the first substrate and a material of the second substrate. The substrates are clamped together to compress the coupler between the substrates and form a fluid-tight seal.
摘要翻译： 一种用于化学分离的装置包括限定第一流体端口的第一基本上刚性的微流体衬底; 限定第二流体端口的第二基本上刚性的微流体衬底; 以及耦合器，设置在所述第一和第二基板之间，所述耦合器限定与所述第一和第二基板的端口流体对准的流体路径。 耦合器包括相对于第一基板的材料和第二基板的材料可变形的材料。 将基板夹在一起以压缩基板之间的耦合器并形成流体密封。
-
-
-
-
-
-
-
-
-
搜索结果
31 条记录 (耗时 0.024 秒)
