Transdermally absorbable Donepezil Preparation
    5.
    发明申请
    Transdermally absorbable Donepezil Preparation 审中-公开
    透皮吸收多奈哌齐制剂

    公开(公告)号:US20090175929A1

    公开(公告)日:2009-07-09

    申请号:US12227201

    申请日:2007-05-08

    Abstract: Disclosed is a donepezil-containing transdermally absorbable preparation which develops reduced adverse side effects and shows a satisfactory level of therapeutic effect. The preparation comprises an adhesive and a donepezil component (containing crystalline donepezil having type-B crystal polymorphism) and/or a salt thereof, wherein the donepezil component or the salt thereof is contained in an amount of 9 to 50% by mass relative to the total weight of the adhesive. The preparation (particularly, one having a non-aqueous adhesive layer) shows an excellent penetration of donepezil and/or a salt thereof into the skin, retains good stability of the active ingredient therein, and is remarkably reduced in local stimulation and adverse side effects.

    Abstract translation: 公开了一种含多奈哌齐的透皮吸收制剂,其具有减少的副作用,并显示令人满意的治疗效果。 该制剂包含粘合剂和多奈哌齐组分(含有具有B型晶体多晶型的结晶多奈哌齐)和/或其盐,其中所述多奈哌齐组分或其盐的含量相对于所述组合物为9〜50质量% 粘合剂的总重量。 该制剂(特别是具有非水性粘合剂层的制剂)显示出多奈哌齐和/或其盐对皮肤的渗透性优异,保持其中活性成分的良好稳定性,并且局部刺激和不良副作用显着降低 。

    Electrophoresis chip, electrophoresis apparatus, and method for analyzing a sample
    8.
    发明授权
    Electrophoresis chip, electrophoresis apparatus, and method for analyzing a sample 有权
    电泳芯片,电泳装置和样品分析方法

    公开(公告)号:US07790007B2

    公开(公告)日:2010-09-07

    申请号:US12094359

    申请日:2006-11-17

    Applicant: Wataru Hattori

    Inventor: Wataru Hattori

    CPC classification number: G01N27/44791

    Abstract: A sample which contains protein is stably maintained in a liquid state during electrophoresis. Electrophoresis chip 1 includes substrate 2, channels 5a to 5d which is provided on surface 3 of substrate 2 and which has openings 4a to 4d at the top thereof, wherein a sample solvent is adapted to be supplied to the channel, and evaporation inhibitor reservoirs 8a, 8b for storing an evaporation inhibitor for the sample solvent, the reservoir being provided independently of channel 5a to 5d and being spatially connected to opening 4a to 4d of channel 5a to 5d.

    Abstract translation: 含有蛋白质的样品在电泳过程中稳定地保持液态。 电泳芯片1包括基板2,设置在基板2的表面3上并且在其顶部具有开口4a至4d的通道5a至5d,其中样品溶剂适于供应到通道,并且蒸发抑制剂储存器8a ,8b用于储存用于样品溶剂的蒸发抑制剂,储存器独立于通道5a至5d设置并且空间连接到通道5a至5d的开口4a至4d。

    ELECTROPHORETIC CHIP AND METHOD OF USING THE SAME
    9.
    发明申请
    ELECTROPHORETIC CHIP AND METHOD OF USING THE SAME 审中-公开
    电泳芯片及其使用方法

    公开(公告)号:US20100108512A1

    公开(公告)日:2010-05-06

    申请号:US12448558

    申请日:2007-12-14

    Applicant: Wataru Hattori

    Inventor: Wataru Hattori

    CPC classification number: G01N27/44791

    Abstract: A chip 400 is composed of a substrate 401, and a frame component 402 provided on the surface of the substrate 401, so as to be brought into contact with the substrate 401. A flow path 102 which retains a liquid sample, and serves as a trench-type flow path allowing therethrough electrophoretic migration of a sample to be subjected to mass analysis, is configured to use the substrate 401 as the bottom surface, and to use the frame component 402 as the sidewall. The substrate 401 and the frame component 402 are configured to be separable.

    Abstract translation: 芯片400由基板401和设置在基板401的表面上的框架部件402构成,以与基板401接触。流路102,其保持液体样品,并且用作 通过允许进行质量分析的样品的电泳迁移的沟槽型流路被配置为使用基板401作为底面,并且使用框架部件402作为侧壁。 基板401和框架部件402被配置为可分离的。

    Stuctural Body, Chip Using The Same, And Method Of Controlling Lyophilic/Lyophobic Property
    10.
    发明申请
    Stuctural Body, Chip Using The Same, And Method Of Controlling Lyophilic/Lyophobic Property 审中-公开
    结构体,芯片使用相同,以及控制亲液/疏液性的方法

    公开(公告)号:US20080056945A1

    公开(公告)日:2008-03-06

    申请号:US11570675

    申请日:2005-06-15

    Applicant: Wataru Hattori

    Inventor: Wataru Hattori

    Abstract: The present invention provides a technique for precisely controlling the lyophilic/lyophobic property of a material surface using a simple construction, a method of utilizing this technique to make anisotropic the level of lyophilic or lyophobic property of a material surface having its lyophilic/lyophobic property controlled, and a method of applying the technique to retain a liquid in a predetermined region of the material surface. For example, liquid retaining portion 103 consists of a regular recess and protrusion structure, and flat part 104 consists of a flat surface surrounding the outer periphery of liquid retaining portion 103 are formed on a surface of substrate 101. The recess and protrusion structure is formed so that the surface area of recess and protrusion structure of liquid retaining portion 103 is larger than the area of the region in which liquid retaining portion 103 is formed and so that the multiplication factor of the surface area has a desired value.

    Abstract translation: 本发明提供了一种使用简单结构精确控制材料表面的亲液/疏液性能的技术,利用该技术使各向异性的具有其亲液/疏液性质的材料表面的亲液性或疏液性的水平受控制的方法 以及应用该技术以将液体保持在材料表面的预定区域中的方法。 例如,液体保持部103由规则的凹凸结构构成,在基板101的表面上形成由包围液体保持部103的外周的平面构成的平坦部104。 凹凸结构形成为使得液体保持部103的凹凸结构的表面积大于形成液体保持部103的区域的面积,因此表面积的倍增系数为 所需值。

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