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1.发明公开公开(公告)号：US20240342110A1
公开(公告)日：2024-10-17
申请号：US18293750
申请日：2022-08-22
发明人： Peng LIU , Ke LI , Youbin WU , Xia LIN , Jing YUAN , Jinliang LV , Luanyuan TIAN , Lie LI
IPC分类号： A61K9/70 , A61K31/4174 , A61K47/10 , A61K47/24 , A61P25/20
CPC分类号： A61K9/7061 , A61K31/4174 , A61K47/10 , A61K47/24 , A61P25/20
摘要： Disclosed in the present application are a dexmedetomidine transdermal composition, a transdermal patch and a preparation method therefor and the use thereof. The composition comprises dexmedetomidine, propylene glycol, and a metal chelate crosslinking agent, or dexmedetomidine, propylene glycol, a metal chelate crosslinking agent and a pressure-sensitive adhesive. In addition, according to the present application, propylene glycol is added to the dexmedetomidine transdermal composition as a solubilizer, which can reduce the generation of impurities and make the compatibility of raw materials and auxiliary materials better. Moreover, the skeleton structure of the product is constructed using the metal chelate crosslinking agent and the pressure-sensitive adhesive together, so that the adhesion performance is obviously improved, and patients can achieve an excellent fitting feeling. The product of the present application is good in stability and free from skin irritation, the safety of the product when applied to the human body is significantly improved, and a sustained-release effect over 2-5 days can be achieved.
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公开(公告)号：US20240216358A1
公开(公告)日：2024-07-04
申请号：US17915687
申请日：2021-03-29
发明人： Suresh BORSADIA , Kalpana PATEL , Hock S. TAN , Krunal RAVAL
IPC分类号： A61K31/485 , A61K9/70 , A61K47/14 , A61K47/32
CPC分类号： A61K31/485 , A61K9/7061 , A61K9/7069 , A61K47/14 , A61K47/32
摘要： Provided herein are novel transdermal delivery devices (or patches) comprising dextromethorphan, pharmaceutical compositions comprising dextromethorphan, methods of preparation thereof, and methods of administering dextromethorphan transdermally. Also provided herein are methods of treating various diseases and disorders such as neurological diseases or disorders (e.g., PBA) using the transdermal delivery devices and/or pharmaceutical compositions herein.
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公开(公告)号：US20240041791A1
公开(公告)日：2024-02-08
申请号：US18332194
申请日：2023-06-09
申请人： CORIUM, LLC
发明人： Amit K. Jain , Eun Soo Lee , Parminder Singh
IPC分类号： A61K9/70 , A61K31/445 , A61P25/28
CPC分类号： A61K9/7061 , A61K31/445 , A61K9/7053 , A61P25/28 , A61K47/12
摘要： Methods, compositions, and devices for transdermally administering an active agent such as donepezil are provided.
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公开(公告)号：US11752109B2
公开(公告)日：2023-09-12
申请号：US16071156
申请日：2017-07-17
发明人： Florian Hammes , René Eifler
IPC分类号： A61K9/70 , A61K9/00 , A61K31/485 , A61P25/04
CPC分类号： A61K9/7061 , A61K9/0014 , A61K31/485
摘要： The invention relates to systems formed from closed liquid-tight packaging and a preferably dimensionally stable aqueous composition which is sealed therein and which, upon activation, releases a liquid phase essentially composed of water in a time-delayed manner. The invention further relates to methods for manufacturing such systems and the use thereof during the production of self-decomposing transdermal therapeutic systems (TTS).
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公开(公告)号：US20230165723A1
公开(公告)日：2023-06-01
申请号：US17921774
申请日：2021-04-27
发明人： Adam S. Cantor , Daniel H. Carlson , John R. Fenton , John R. Hart , Glen A. Jerry , Gordon P. Knutson , Jonathan J. O'Hare , Mikhail L. Pekurovsky , Timothy A. Peterson , Karl K. Stensvad
CPC分类号： A61F13/00063 , A61F13/025 , A61F13/0253 , A61F13/0289 , A61K9/7061 , A61F2013/0071 , A61F2013/0296
摘要： Various embodiments of an adhesive article and a method of forming such article are disclosed. The adhesive article includes an active pharmaceutical ingredient; a substrate having a first surface and a second surface including a first area and a second area; and a first adhesive layer disposed on the first area of the second surface of the substrate. The active pharmaceutical ingredient is present in the first adhesive layer at a first concentration. The adhesive article also includes a second adhesive layer having a first portion that is in contact with the first adhesive layer and a second portion that is disposed in the second area of the substrate. The active pharmaceutical ingredient is present in the second adhesive layer at a second concentration. The second concentration is less than the first concentration.
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公开(公告)号：US20180325839A1
公开(公告)日：2018-11-15
申请号：US15777481
申请日：2016-11-22
IPC分类号： A61K9/70
CPC分类号： A61K9/7069 , A61K9/7053 , A61K9/7061 , A61K9/7084 , A61K31/445 , A61K31/485
摘要： The present invention relates to a transdermal patch comprising a pharmaceutical formulation, the formulation comprising ropivacaine or an opioid, a pharmaceutically-acceptable adhesive comprising up to 75% (w/w) of silicone or polyisobutylene and between 5 and 20 wt. % of an excipient mixture. The present invention also relates to methods of preparation of such a pharmaceutical formulation, as well as the use of such a transdermal patch in the treatment of pain (e.g. nociceptive and/or neuropathic pain).
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公开(公告)号：US20180311362A1
公开(公告)日：2018-11-01
申请号：US15935443
申请日：2018-03-26
发明人： Tomohito TAKITA , Kaiji FUJIWARA , Chie MATSUMOTO
IPC分类号： A61K47/32 , A61K9/70 , A61K31/137 , A61K31/135
CPC分类号： A61K9/7061 , A61K9/7053 , A61K31/135 , A61K31/137
摘要： Provided is a transdermal absorption preparation that shows superior skin permeability of a drug and that does not easily cause cold flow.A transdermal absorption preparation having a drug-containing layer containing a drug and a polymer, wherein 50-100 wt % of the polymer in the drug-containing layer is a polymer having a glass transition temperature of 30° C.-200° C., and the drug in the drug-containing layer is in an amorphous state.
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公开(公告)号：US20180235903A1
公开(公告)日：2018-08-23
申请号：US15557637
申请日：2016-03-11
发明人： Jay Audett , Chee Youb Won
IPC分类号： A61K9/70 , A61K9/00 , A61K31/4468 , A61F13/00 , A61F13/02
CPC分类号： A61K9/7069 , A61F13/00063 , A61F13/0253 , A61K9/0014 , A61K9/7053 , A61K9/7061 , A61K31/4468
摘要： Described is a transdermal device comprising a backing layer; an adhesive matrix comprising fentanyl as an active agent suspended on a plurality of pressure sensitive adhesives along with a cross-linked moisture absorbent comprising cross-linked polyvinylpyrrolidone; and a release layer. Also described is a method of relieving pain, which comprising applying said transdermal device to the skin of a patient in need thereof.
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公开(公告)号：US20180228739A1
公开(公告)日：2018-08-16
申请号：US15894432
申请日：2018-02-12
CPC分类号： A61K9/7084 , A61K9/7061 , A61K31/56 , A61K31/57 , A61K2300/00
摘要： A transdermal drug delivery device is disclosed. Over an extended wear period, the device causes cumulative moderate irritation plus significant irritation of less than 5% and/or achieves a meaningful degree of detachment over a seven day period of less than 20%.
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公开(公告)号：US20180207280A1
公开(公告)日：2018-07-26
申请号：US15827190
申请日：2017-11-30
发明人： Viet NGUYEN , Jun Liao , Prashant Patel
IPC分类号： A61K47/32 , A61K9/70 , A61K9/00 , A61K31/137 , A61L31/12
CPC分类号： A61K47/32 , A61K9/0014 , A61K9/7007 , A61K9/7053 , A61K9/7061 , A61K31/137 , A61L31/129
摘要： Described are transdermal drug delivery compositions comprising amphetamine, methods of making transdermal drug delivery compositions comprising amphetamine, and therapeutic methods of using them. In specific embodiments, the compositions are free of components with moieties that are reactive with amphetamine. In specific embodiments, the compositions are manufactured using solvents free of components with moieties that are reactive with amphetamine. Therapeutic methods using the compositions also are described.
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