公开(公告)号：US20250009653A1

公开(公告)日：2025-01-09

申请号：US18689579

申请日：2022-09-08

Applicant: KINDEVA DRUG DELIVERY L.P.

Inventor： Philip COCKS ,  Sarah WRIGGLESWORTH ,  Connor MCCORMACK ,  James LISTER ,  Lauren HARRISON ,  Chad HARALDSON ,  Joseph MILLER ,  James DRAKE ,  Stephen STEIN

IPC: A61K9/00 ,  A61K9/08 ,  A61K31/40 ,  A61K31/439 ,  A61K31/5386 ,  A61K47/06 ,  A61K47/10

Abstract: A composition comprising a solution comprising an active pharmaceutical ingredient comprising an anticholinergic agent, such as ipratropium bromide, and a propellant comprising HFA-152a, HFO-1234ze(E), or both. A metered dose inhaler comprising a metering valve a canister; and an actuator comprising an actuator nozzle; wherein the canister comprises said composition.

公开(公告)号：US20240382703A1

公开(公告)日：2024-11-21

申请号：US18694108

申请日：2022-09-21

Applicant: KINDEVA DRUG DELIVERY L.P.

Inventor： John P. BUNTING

IPC: A61M15/00

Abstract: An inhaler (100) has an actuator (118) configured to interact with a container (110) to selectively release a substance for inhalation. A controller (112) is provided and configured to switch the inhaler between a locked and an unlocked condition. A motion sensor (114) is attached to the inhaler. The controller (112) is configured to store a predetermined motion sequence, and upon detection of the predetermined motion sequence by the motion sensor, the controller is configured to switch the inhaler from the locked condition to the unlocked condition.

公开(公告)号：US11779716B2

公开(公告)日：2023-10-10

申请号：US16635657

申请日：2018-08-01

Applicant: KINDEVA DRUG DELIVERY L.P.

Inventor： Philip A. Jinks ,  Frans A. Audenaert

IPC: A61M15/00 ,  B05D7/14 ,  B05D7/00 ,  C08G65/336 ,  C08G75/20

CPC classification number: A61M15/0066 ,  B05D7/14 ,  B05D7/52 ,  C08G65/336 ,  C08G75/20 ,  A61M2205/0238 ,  B05D2202/15 ,  B05D2202/25 ,  B05D2506/10 ,  B05D2518/00 ,  C08G2650/48

Abstract: Methods of making components for a medicinal delivery device are described, in which a base composition comprising a polysulphone is applied to the surface of a component to create a base layer, a primer composition comprising a silane having two or more reactive silane groups separated by an organic linker group is applied to the base layer to create primed surface, and a coating composition comprising an at least partially fluorinated compound is applied to the primed surface. Corresponding coated components and a medicinal delivery device are disclosed.

公开(公告)号：US11771878B2

公开(公告)日：2023-10-03

申请号：US16909723

申请日：2020-06-23

Applicant: KINDEVA DRUG DELIVERY L.P.

Inventor： Scott A. Burton ,  Chin-Yee Ng ,  Michael J. Frits ,  Richard R. Mathias

IPC: A61M37/00 ,  A61M5/142 ,  A61M5/32

CPC classification number: A61M37/0015 ,  A61M5/14248 ,  A61M5/322 ,  A61M5/3297 ,  A61M2037/0023 ,  A61M2037/0061

Abstract: A microneedle injection and infusion apparatus, and a method of using same. The apparatus can include a housing, a microneedle array holder for holding a microneedle array, and a shuttle that holds a cartridge (e.g., that contains an active agent). The microneedle array holder can be movable between a retracted position and an extended position. The shuttle can be movable between a first position in which the cartridge is not in fluid communication with a fluid path and a second position in which the cartridge is in fluid communication with the fluid path. The apparatus can further include an actuator movable between a first position and a second position. The method can include moving the actuator to its second position to allow the shuttle to move toward its second position, wherein movement of the shuttle toward its second position allows the microneedle array holder to move to its extended position.

公开(公告)号：US20230285697A1

公开(公告)日：2023-09-14

申请号：US18018365

申请日：2021-07-28

Applicant: Andrew Robert Cooper ,  Christopher George Blatchford ,  Stephen Howgill ,  Barzin Gavtash ,  Benjamin James Myatt ,  Hendrik Versteeg ,  Kerry Ward ,  Lee Michael Hodges ,  Sam Oladele Apoola ,  John Paul Bunting ,  KINDEVA DRUG DELIVERY L.P.

Inventor： Andrew Robert Cooper ,  Christopher George Blatchford ,  Stephen Howgill ,  Barzin Gavtash ,  Benjamin James Myatt ,  Hendrik Versteeg ,  Kerry Ward ,  Lee Michael Hodges ,  Sam Oladele Apoola ,  John Paul Bunting

IPC: A61M15/08 ,  A61M15/00

CPC classification number: A61M15/08 ,  A61M15/0065 ,  A61M15/0086

Abstract: Various embodiments of a device for delivery of a medicament and a method of utilizing such device are disclosed. The device can include a canister and an actuator. The actuator includes a housing receiving the canister; a valve block receiving a metering valve of the canister, the valve block defining an expansion chamber for passage of propellant and medicament expelled from the canister; and a nosepiece for insertion into a user's nostril, the nosepiece including a fluid passage and a delivery opening for expulsion of the propellant and medicament into the user's nostril. A flow path is defined through the actuator for passage of propellant and medicament from the canister and includes the expansion chamber, the fluid passage and the delivery opening. Further, the cross-sectional area of the flow path is greater than the lowest cross-sectional area of the metering valve at all points along the flow path.

公开(公告)号：US20230165723A1

公开(公告)日：2023-06-01

申请号：US17921774

申请日：2021-04-27

Applicant: KINDEVA DRUG DELIVERY L.P.

Inventor： Adam S. Cantor ,  Daniel H. Carlson ,  John R. Fenton ,  John R. Hart ,  Glen A. Jerry ,  Gordon P. Knutson ,  Jonathan J. O'Hare ,  Mikhail L. Pekurovsky ,  Timothy A. Peterson ,  Karl K. Stensvad

IPC: A61F13/00 ,  A61F13/02 ,  A61K9/70

CPC classification number: A61F13/00063 ,  A61F13/025 ,  A61F13/0253 ,  A61F13/0289 ,  A61K9/7061 ,  A61F2013/0071 ,  A61F2013/0296

Abstract: Various embodiments of an adhesive article and a method of forming such article are disclosed. The adhesive article includes an active pharmaceutical ingredient; a substrate having a first surface and a second surface including a first area and a second area; and a first adhesive layer disposed on the first area of the second surface of the substrate. The active pharmaceutical ingredient is present in the first adhesive layer at a first concentration. The adhesive article also includes a second adhesive layer having a first portion that is in contact with the first adhesive layer and a second portion that is disposed in the second area of the substrate. The active pharmaceutical ingredient is present in the second adhesive layer at a second concentration. The second concentration is less than the first concentration.

公开(公告)号：US11577900B2

公开(公告)日：2023-02-14

申请号：US17420918

申请日：2020-01-07

Applicant: KINDEVA DRUG DELIVERY L.P.

Inventor： Peter P. Evanson

IPC: B65D77/00 ,  A61M37/00 ,  B65D75/00 ,  B65D75/42 ,  B65D81/26

Abstract: A packaging system for microarrays, such as microarrays of microneedles, comprising inner and outer pouches (500, 5000).

公开(公告)号：US11497866B2

公开(公告)日：2022-11-15

申请号：US16331213

申请日：2017-09-05

Applicant: KINDEVA DRUG DELIVERY L.P.

Inventor： Stephen J. Howgill

IPC: A61M15/00

Abstract: A breath-responsive metered dose inhaler having a trigger mechanism for triggering delivery of a medicament and a trigger mechanism chassis for locating the trigger mechanism within the inhaler, the trigger mechanism including a breath responsive member moveable upon inhalation of the user from a primed position in which the inhaler is prevented from delivering medicament, to a triggered position in which the medicament is delivered to the user, a spring which is flexible along its longitudinal axis, wherein the spring is configured to bias the breath responsive member from its triggered position to its primed position by flexure along its longitudinal axis.

公开(公告)号：US20220008352A1

公开(公告)日：2022-01-13

申请号：US17482871

申请日：2021-09-23

Applicant: KINDEVA DRUG DELIVERY L.P.

Inventor： Adam S. Cantor ,  Terrance W. Ocheltree ,  Cynthia A. Robles

IPC: A61K9/70 ,  A61K31/4468 ,  A61K9/00 ,  A61K31/44

Abstract: A transdermal drug delivery composition comprises an acrylate copolymer and from about 8% to about 30% by weight fentanyl. A transdermal fentanyl delivery composition comprising methyl laurate or tetraglycol as a permeation enhancer is also provided. The transdermal drug delivery compositions can be used to make a transdermal drug delivery device for the delivery of fentanyl.

公开(公告)号：US20210260310A1

公开(公告)日：2021-08-26

申请号：US16973863

申请日：2019-06-26

Applicant: KINDEVA DRUG DELIVERY L.P.

Inventor： Alexander D. Slowey ,  Philip M. Cocks ,  Neha A. Patel

IPC: A61M15/00 ,  A61K31/5386 ,  A61K47/10 ,  A61K47/12 ,  A61K9/00 ,  A61K47/24

Abstract: A metered dose inhaler equipped with a metering valve and having an aerosol canister containing a pharmaceutical composition comprising propellant, ethanol, citric acid, and tiotropium or a pharmaceutically acceptable salt or solvate thereof dissolved in the composition, wherein the aerosol canister has an internal surface that is a non-metal material that is in contact with the pharmaceutical composition.