公开(公告)号：US20180235903A1

公开(公告)日：2018-08-23

申请号：US15557637

申请日：2016-03-11

申请人： Amneal Pharmaceuticals LLC

发明人： Jay Audett ,  Chee Youb Won

IPC分类号： A61K9/70 ,  A61K9/00 ,  A61K31/4468 ,  A61F13/00 ,  A61F13/02

CPC分类号： A61K9/7069 ,  A61F13/00063 ,  A61F13/0253 ,  A61K9/0014 ,  A61K9/7053 ,  A61K9/7061 ,  A61K31/4468

摘要： Described is a transdermal device comprising a backing layer; an adhesive matrix comprising fentanyl as an active agent suspended on a plurality of pressure sensitive adhesives along with a cross-linked moisture absorbent comprising cross-linked polyvinylpyrrolidone; and a release layer. Also described is a method of relieving pain, which comprising applying said transdermal device to the skin of a patient in need thereof.

公开(公告)号：US20180256562A1

公开(公告)日：2018-09-13

申请号：US15758269

申请日：2016-09-09

申请人： Amneal Pharmaceuticals LLC

发明人： Sameer Sachdeva ,  Tarun Goswami ,  Jay Audett

IPC分类号： A61K31/485 ,  A61K9/00 ,  A61K9/70 ,  A61K47/12 ,  A61K47/14 ,  A61K47/32 ,  A61M35/00 ,  A61F13/02 ,  A61F13/00

CPC分类号： A61K31/485 ,  A61F13/00063 ,  A61F13/0253 ,  A61F13/0259 ,  A61F13/0289 ,  A61F2013/0296 ,  A61K9/0014 ,  A61K9/7061 ,  A61K9/7069 ,  A61K47/12 ,  A61K47/14 ,  A61K47/32 ,  A61M35/00 ,  A61M2207/00

摘要： Described is a transdermal device comprising a backing layer; a single layer adhesive matrix comprising buprenorphine or a salt thereof, a pressure sensitive adhesive including a silicone-type adhesive blended with an acrylate-type adhesive, a solubilizer, a permeation enhancer, and a crystallization inhibitor; and a release layer. Also described is a method of relieving pain and a method of preparing a transdermal delivery system.