公开(公告)号：US20180311363A1

公开(公告)日：2018-11-01

申请号：US15935568

申请日：2018-03-26

申请人： Nitto Denko Corporation

发明人： Tomohito TAKITA ,  Kaiji FUJIWARA

IPC分类号： A61K47/32 ,  A61K9/70 ,  A61K31/135

CPC分类号： A61K31/135 ,  A61K9/703 ,  A61K9/7061

摘要： A transdermal absorption preparation precursor 50 containing a release liner 10 containing one first valley fold part 1, one or two first mountain fold parts 2, and a first base line L1 and a second base line L2 on one side and the other side apart from the first valley fold part 1 as a line of demarcation and at an approximately equal distance from the first valley fold part 1, wherein at least one of the first base line L1 and the second base line L2 is a fold line of the first mountain fold part 2, and a drug-containing layer 3 having a center line laid on the first base line L1 and an adhesive layer 4 having a center line laid on the second base line L2 on the release liner 10.

公开(公告)号：US20190231712A1

公开(公告)日：2019-08-01

申请号：US16262391

申请日：2019-01-30

申请人： NITTO DENKO CORPORATION

发明人： Chie MATSUMOTO ,  Tomohito TAKITA ,  Kaiji FUJIWARA ,  Akinori SUGIYAMA ,  Tomoya TANAKA

IPC分类号： A61K9/70 ,  A61K47/12 ,  A61K47/18 ,  A61K31/197 ,  A61K47/32 ,  A61K47/38 ,  A61K47/36

CPC分类号： A61K9/7084 ,  A61K9/7023 ,  A61K31/197 ,  A61K47/12 ,  A61K47/18 ,  A61K47/32 ,  A61K47/36 ,  A61K47/38

摘要： Provided is a transdermal absorption preparation having superior drug skin permeability, which can uniformly disperse the drug in the preparation and maintain the uniform dispersion state of the drug.A transdermal absorption preparation having a plaster layer containing a drug, a polymer and a pH adjuster, in which the aforementioned polymer contains a polymer having a particular glass transition temperature of 30° C.-200° C., and the surface of the plaster layer has a pH of 6.7-10.0.

公开(公告)号：US20190290596A1

公开(公告)日：2019-09-26

申请号：US16354275

申请日：2019-03-15

申请人： NITTO DENKO CORPORATION

发明人： Tomohito TAKITA ,  Kaiji FUJIWARA ,  Chie MATSUMOTO ,  Akinori SUGIYAMA ,  Jyun ISAYAMA ,  Toshinari HONDA ,  Ai FUNASAKI

IPC分类号： A61K9/70 ,  A61K9/00 ,  A61K31/385

摘要： Provided are a production method of a pregabalin-containing composition, which suppresses crystallization of pregabalin, and a pregabalin-containing composition that shows suppressed crystallization of Pregabalin. The production method of the pregabalin-containing composition of the present invention contains steps of:(1) dissolving pregabalin in an aqueous solution of an acid to prepare an aqueous solution of a salt of pregabalin; (2) mixing the aqueous solution of pregabalin salt and a hydrophilic resin to prepare a mixture thereof; and (3) concentrating the mixture; wherein the acid has an acid dissociation constant lower than that of pregabalin.

公开(公告)号：US20180311362A1

公开(公告)日：2018-11-01

申请号：US15935443

申请日：2018-03-26

申请人： Nitto Denko Corporation

发明人： Tomohito TAKITA ,  Kaiji FUJIWARA ,  Chie MATSUMOTO

IPC分类号： A61K47/32 ,  A61K9/70 ,  A61K31/137 ,  A61K31/135

CPC分类号： A61K9/7061 ,  A61K9/7053 ,  A61K31/135 ,  A61K31/137

摘要： Provided is a transdermal absorption preparation that shows superior skin permeability of a drug and that does not easily cause cold flow.A transdermal absorption preparation having a drug-containing layer containing a drug and a polymer, wherein 50-100 wt % of the polymer in the drug-containing layer is a polymer having a glass transition temperature of 30° C.-200° C., and the drug in the drug-containing layer is in an amorphous state.

公开(公告)号：US20140066865A1

公开(公告)日：2014-03-06

申请号：US13951697

申请日：2013-07-26

申请人： NITTO DENKO CORPORATION

发明人： Tomohito TAKITA ,  Masahiro MITSUSHIMA ,  Hidetoshi KURODA ,  Yuji SAEKI

IPC分类号： A61K9/70

CPC分类号： A61K9/7061 ,  A61F13/023 ,  A61K9/7046

摘要： The present invention provides a patch preparation that has an extremely low moisture permeability, has a sufficient ODT effect, is excellent in drug releasability, and has a preferred handleability. The patch preparation of the present invention includes a support; and a pressure-sensitive adhesive layer containing an adherent polymer and a drug on one surface of the support, wherein: the support has a polyester base layer, an inorganic oxide layer, and a polyester nonwoven fabric layer in the stated order; the polyester base layer has a thickness of 1.0 μm to 16 μm; and the pressure-sensitive adhesive layer is laminated on the polyester base layer.

摘要翻译： 本发明提供了具有极低的透湿性，足够的ODT效果，药物释放性优异并且具有优选的可操作性的贴片制剂。 本发明的贴片制剂包括支持体; 以及在载体的一个表面上含有粘着性聚合物和药物的粘合剂层，其中：所述载体具有所述顺序的聚酯基层，无机氧化物层和聚酯无纺布层; 聚酯基层的厚度为1.0μm〜16μm; 并且将压敏粘合剂层层压在聚酯基层上。