公开(公告)号：US20180207280A1

公开(公告)日：2018-07-26

申请号：US15827190

申请日：2017-11-30

申请人： NOVEN PHARMACEUTICALS, INC.

发明人： Viet NGUYEN ,  Jun Liao ,  Prashant Patel

IPC分类号： A61K47/32 ,  A61K9/70 ,  A61K9/00 ,  A61K31/137 ,  A61L31/12

CPC分类号： A61K47/32 ,  A61K9/0014 ,  A61K9/7007 ,  A61K9/7053 ,  A61K9/7061 ,  A61K31/137 ,  A61L31/129

摘要： Described are transdermal drug delivery compositions comprising amphetamine, methods of making transdermal drug delivery compositions comprising amphetamine, and therapeutic methods of using them. In specific embodiments, the compositions are free of components with moieties that are reactive with amphetamine. In specific embodiments, the compositions are manufactured using solvents free of components with moieties that are reactive with amphetamine. Therapeutic methods using the compositions also are described.

公开(公告)号：US20180036319A1

公开(公告)日：2018-02-08

申请号：US15667216

申请日：2017-08-02

申请人： Noven Pharmaceuticals, Inc.

发明人： Viet NGUYEN

IPC分类号： A61K31/569 ,  A61K9/70 ,  A61K47/10

CPC分类号： A61K31/569 ,  A61K9/7053 ,  A61K9/7061 ,  A61K9/7069 ,  A61K47/10 ,  A61K47/14 ,  A61K47/32

摘要： Described are transdermal drug delivery systems for the transdermal administration of norethindrone acetate in the form of a flexible finite system for topical application, comprising a drug-in-adhesive polymer matrix comprising norethindrone acetate (NETA) as the only systemically active drug, an adhesive polymer selected from silicone adhesives and polyisobutylene (PIB) adhesives, a penetration enhancer, and a crystallization inhibitor. Methods of making and using the systems also are described.