公开(公告)号：US20080138388A1

公开(公告)日：2008-06-12

申请号：US11883672

申请日：2006-01-24

Applicant: Kazunosuke Aida ,  Yasunari Michinaka ,  Takaaki Terahara

Inventor： Kazunosuke Aida ,  Yasunari Michinaka ,  Takaaki Terahara

IPC: A61K9/70 ,  A61K31/445 ,  A61P43/00

CPC classification number: A61K9/7061 ,  A61K31/445 ,  A61K31/454

Abstract: It is intended to provide a transdermal absorption patch which is highly excellent in transdermal absorption properties and long-lasting drug effect even in the case where a drug-effect component contained in the transdermal absorption patch is a basic drug hardly soluble in a pressure-sensitive adhesive base, has a high stability of the drug contained therein with the passage of time and can achieve improvement in the compliance and simplification of the administration method. These problems can be solved by providing a transdermal absorption patch which contains a basic drug having an octanol/water partition coefficient (logarithm) in the free state of 3 or above, a pressure-sensitive adhesive base and a (meth)acrylic copolymer having carboxyl group.

Abstract translation: 旨在提供一种透皮吸收贴片，即使在经皮吸收贴剂中含有的药物作用成分是几乎不溶于压敏药物的碱性药物的情况下，其经皮吸收性能和持久的药物作用也非常优异 粘合剂基，随着时间的流逝，其中所含药物的稳定性高，并且可以提高施用方法的顺应性和简化性。 这些问题可以通过提供一种透皮吸收贴片来解决，该贴剂含有游离状态3以上的辛醇/水分配系数（对数），粘合剂基和具有羧基的（甲基）丙烯酸共聚物）的碱性药物 组。

公开(公告)号：US09155710B2

公开(公告)日：2015-10-13

申请号：US14123163

申请日：2012-05-23

Applicant: Yuka Takagi ,  Naoyuki Uchida ,  Yasunari Michinaka

Inventor： Yuka Takagi ,  Naoyuki Uchida ,  Yasunari Michinaka

IPC: A61K9/70 ,  A61K31/4045

CPC classification number: A61K9/7038 ,  A61K9/7053 ,  A61K31/4045

Abstract: A ropinirole-containing patch comprises an adhesive agent layer and a support layer, the adhesive agent layer containing ropinirole and/or a pharmaceutically acceptable salt thereof, wherein a content of the ropinirole and/or the pharmaceutically acceptable salt thereof in terms of free ropinirole in the adhesive agent layer is 5 to 13.2% by mass relative to a total mass of the adhesive agent layer.

Abstract translation: 含罗匹尼罗的贴剂包含粘合剂层和支持层，所述粘合剂层含有罗匹尼罗和/或其药学上可接受的盐，其中根据游离罗哌卡罗的罗匹尼罗和/或其药学上可接受的盐的含量 粘合剂层相对于粘合剂层的总质量为5〜13.2质量％。

公开(公告)号：US20110195109A1

公开(公告)日：2011-08-11

申请号：US12919743

申请日：2009-02-09

Applicant: Yasunari Michinaka ,  Yuka Ansai

Inventor： Yasunari Michinaka ,  Yuka Ansai

IPC: A61K9/70 ,  A61K31/4045 ,  A61P25/16

CPC classification number: A61K31/4045 ,  A61K9/7053 ,  A61K9/7076

Abstract: Provided is a patch 1 containing a backing layer 2 and a pressure-sensitive adhesive layer 3 formed on the backing layer 2, where the pressure-sensitive adhesive layer 3 contains (i) ropinirole and a metal salt produced by the reaction of a ropinirole acid adduct and a metal ion containing desalting agent in an equivalent mole or less to the acid adduct and (ii) an adhesive base free of a hydroxyl group and a carboxy group.

Abstract translation: 提供了一种贴片1，其包含形成在背衬层2上的背衬层2和压敏粘合剂层3，其中压敏粘合剂层3含有（i）罗哌尼罗和通过罗哌卡罗酸 加合物和含有脱盐剂的金属离子与酸加合物的摩尔当量摩尔以下，（ii）不含羟基和羧基的粘合剂基。

公开(公告)号：US09155725B2

公开(公告)日：2015-10-13

申请号：US12919743

申请日：2009-02-09

Applicant: Yasunari Michinaka ,  Yuka Ansai

Inventor： Yasunari Michinaka ,  Yuka Ansai

IPC: A61F13/02 ,  A61K31/40 ,  A61L15/16 ,  A61K31/4045 ,  A61K9/70

CPC classification number: A61K31/4045 ,  A61K9/7053 ,  A61K9/7076

Abstract: Provided is a patch 1 containing a backing layer 2 and a pressure-sensitive adhesive layer 3 formed on the backing layer 2, where the pressure-sensitive adhesive layer 3 contains (i) ropinirole and a metal salt produced by the reaction of a ropinirole acid adduct and a metal ion containing desalting agent in an equivalent mole or less to the acid adduct and (ii) an adhesive base free of a hydroxyl group and a carboxy group.

Abstract translation: 提供了一种贴片1，其包含形成在背衬层2上的背衬层2和压敏粘合剂层3，其中压敏粘合剂层3含有（i）罗哌尼罗和通过罗哌卡罗酸 加合物和含有脱盐剂的金属离子与酸加合物的摩尔当量摩尔以下，（ii）不含羟基和羧基的粘合剂基。

公开(公告)号：US20130053358A1

公开(公告)日：2013-02-28

申请号：US13643427

申请日：2011-04-27

Applicant: Kazunosuke Aida ,  Yasunari Michinaka ,  Kenji Atarashi ,  Yasunori Takada

Inventor： Kazunosuke Aida ,  Yasunari Michinaka ,  Kenji Atarashi ,  Yasunori Takada

IPC: A61K31/445 ,  A61P17/00 ,  A61P25/28 ,  A61K31/575

CPC classification number: A61K31/445 ,  A61K9/0014 ,  A61K9/7061

Abstract: Provided is a transdermal preparation having low skin irritation as well as a sufficient skin permeability rate of donepezil, which comprises one or more drugs selected from donepezil and pharmaceutically acceptable salts thereof. Also provided are a manufacturing method thereof, and a method for reducing skin irritation of a transdermally absorbable donepezil-containing preparation. An embodiment is a transdermal preparation comprising one or more drugs selected from donepezil and pharmaceutically acceptable salts thereof, and a skin irritation-reducing agent.

Abstract translation: 提供具有低皮肤刺激性和多奈哌齐的足够的皮肤渗透速率的透皮制剂，其包含一种或多种选自多奈哌齐和其药学上可接受的盐的药物。 还提供了其制造方法和减少透皮吸收性多奈哌齐制剂的皮肤刺激的方法。 一个实施方案是包含一种或多种选自多奈哌齐和其药学上可接受的盐的药物和皮肤刺激减少剂的透皮制剂。

公开(公告)号：US20090175929A1

公开(公告)日：2009-07-09

申请号：US12227201

申请日：2007-05-08

Applicant: Takaaki Terahara ,  Yasunari Michinaka ,  Kazunosuke Aida ,  Masaru Nakanishi ,  Wataru Hattori ,  Takao Kuroda

Inventor： Takaaki Terahara ,  Yasunari Michinaka ,  Kazunosuke Aida ,  Masaru Nakanishi ,  Wataru Hattori ,  Takao Kuroda

IPC: A61K9/70 ,  A61K31/4353

CPC classification number: A61K9/7053 ,  A61K9/7061 ,  A61K31/445 ,  A61K47/02 ,  A61K47/12 ,  A61K47/20 ,  C07D211/32

Abstract: Disclosed is a donepezil-containing transdermally absorbable preparation which develops reduced adverse side effects and shows a satisfactory level of therapeutic effect. The preparation comprises an adhesive and a donepezil component (containing crystalline donepezil having type-B crystal polymorphism) and/or a salt thereof, wherein the donepezil component or the salt thereof is contained in an amount of 9 to 50% by mass relative to the total weight of the adhesive. The preparation (particularly, one having a non-aqueous adhesive layer) shows an excellent penetration of donepezil and/or a salt thereof into the skin, retains good stability of the active ingredient therein, and is remarkably reduced in local stimulation and adverse side effects.

Abstract translation: 公开了一种含多奈哌齐的透皮吸收制剂，其具有减少的副作用，并显示令人满意的治疗效果。 该制剂包含粘合剂和多奈哌齐组分（含有具有B型晶体多晶型的结晶多奈哌齐）和/或其盐，其中所述多奈哌齐组分或其盐的含量相对于所述组合物为9〜50质量％ 粘合剂的总重量。 该制剂（特别是具有非水性粘合剂层的制剂）显示出多奈哌齐和/或其盐对皮肤的渗透性优异，保持其中活性成分的良好稳定性，并且局部刺激和不良副作用显着降低 。

公开(公告)号：US20140112974A1

公开(公告)日：2014-04-24

申请号：US14123163

申请日：2012-05-23

Applicant: Yuka Takagi ,  Naoyuki Uchida ,  Yasunari Michinaka

Inventor： Yuka Takagi ,  Naoyuki Uchida ,  Yasunari Michinaka

IPC: A61K9/70 ,  A61K31/4045

CPC classification number: A61K9/7038 ,  A61K9/7053 ,  A61K31/4045

Abstract: A ropinirole-containing patch comprises an adhesive agent layer and a support layer, the adhesive agent layer containing ropinirole and/or a pharmaceutically acceptable salt thereof, wherein a content of the ropinirole and/or the pharmaceutically acceptable salt thereof in terms of free ropinirole in the adhesive agent layer is 5 to 13.2% by mass relative to a total mass of the adhesive agent layer.

Abstract translation: 含罗匹尼罗的贴剂包含粘合剂层和支持层，所述粘合剂层含有罗匹尼罗和/或其药学上可接受的盐，其中根据游离罗哌卡罗的罗匹尼罗和/或其药学上可接受的盐的含量 粘合剂层相对于粘合剂层的总质量为5〜13.2质量％。