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公开(公告)号：US20240325601A1
公开(公告)日：2024-10-03
申请号：US18622029
申请日：2024-03-29
CPC分类号： A61L27/3608 , A61L27/025 , A61L2430/02
摘要： A bone growth composition may include a cancellous portion and a noncancellous portion. The cancellous portion may be processed with an antimicrobial agent contact step and subsequent contact with a cryopreservative solution. In an embodiment, the cryopreservative solution is glycerol. In an embodiment, the bone growth composition includes a mix of cancellous chip formed from the cancellous portion and demineralized fibers formed from the noncancellous portion.
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公开(公告)号：US20180250442A1
公开(公告)日：2018-09-06
申请号：US15974146
申请日：2018-05-08
IPC分类号： A61L27/36 , C08L75/04 , A61L27/54 , A61L27/58 , A61L27/46 , C08G18/79 , C08G18/77 , C08G18/73 , C08G18/64 , C08G18/38 , C08G18/10 , A61L27/18
CPC分类号： A61L27/3608 , A61L27/18 , A61L27/46 , A61L27/54 , A61L27/58 , A61L2300/414 , A61L2300/426 , A61L2430/02 , C08G18/10 , C08G18/36 , C08G18/3878 , C08G18/3882 , C08G18/6484 , C08G18/73 , C08G18/771 , C08G18/798 , C08G2230/00 , C08L75/04
摘要： Biological-based polyurethanes and methods of making the same. The polyurethanes are formed by reacting a biodegradable polyisocyanate (such as lysine diisocyanate) with an optionally hydroxylated biomolecule to form polyurethane. The polymers formed may be combined with ceramic and/or bone particles to form a composite, which may be used as an osteoimplant.
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公开(公告)号：US09993579B2
公开(公告)日：2018-06-12
申请号：US15643137
申请日：2017-07-06
IPC分类号： A61K31/74 , A61F13/00 , A61L27/36 , C08G18/10 , C08G18/38 , C08G18/64 , C08G18/73 , C08G18/77 , C08G18/79 , A61L27/46 , A61L27/58 , A61L27/54 , A61L27/18 , C08L75/04
CPC分类号： A61L27/3608 , A61L27/18 , A61L27/46 , A61L27/54 , A61L27/58 , A61L2300/414 , A61L2300/426 , A61L2430/02 , C08G18/10 , C08G18/36 , C08G18/3878 , C08G18/3882 , C08G18/6484 , C08G18/73 , C08G18/771 , C08G18/798 , C08G2230/00 , C08L75/04
摘要： Biological-based polyurethanes and methods of making the same. The polyurethanes are formed by reacting a biodegradable polyisocyanate (such as lysine diisocyanate) with an optionally hydroxylated biomolecule to form polyurethane. The polymers formed may be combined with ceramic and/or bone particles to form a composite, which may be used as an osteoimplant.
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公开(公告)号：US09789223B2
公开(公告)日：2017-10-17
申请号：US15144139
申请日：2016-05-02
IPC分类号： A61K31/74 , A61F13/00 , A61L27/36 , A61L27/18 , A61L27/46 , C08G18/10 , C08G18/36 , C08G18/38 , C08G18/64 , C08G18/73 , C08G18/77 , C08G18/79 , A61L27/54 , A61L27/58
CPC分类号： A61L27/3608 , A61L27/18 , A61L27/46 , A61L27/54 , A61L27/58 , A61L2300/414 , A61L2300/426 , A61L2430/02 , C08G18/10 , C08G18/36 , C08G18/3878 , C08G18/3882 , C08G18/6484 , C08G18/73 , C08G18/771 , C08G18/798 , C08G2230/00 , C08L75/04
摘要： Biological-based polyurethanes and methods of making the same. The polyurethanes are formed by reacting a biodegradable polyisocyanate (such as lysine diisocyanate) with an optionally hydroxylated biomolecule to form polyurethane. The polymers formed may be combined with ceramic and/or bone particles to form a composite, which may be used as an osteoimplant.
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公开(公告)号：US09308296B2
公开(公告)日：2016-04-12
申请号：US14269287
申请日：2014-05-05
CPC分类号： A61L27/3687 , A61F2/4644 , A61L27/3608 , A61L27/54 , A61L2430/02 , A61L2430/40
摘要： A tissue treatment apparatus and method for treating biologic tissue has a controller, an enclosure, a reagent supply system, a draining configuration, and a gas relief valve is controlled by the controller. Optionally provided is a gas evacuation assembly, a gas supply unit, a thermal unit for heating or cooling reagents or gases, a sonication unit, any or each operated by the controller. The method provides for programming controller to effect a treatment procedure. In an embodiment of the present application the tissue sample is bone material and the treatment procedure effects demineralization of the bone material.
摘要翻译： 用于处理生物组织的组织处理装置和方法具有控制器，外壳，试剂供应系统，排水构造和气体释放阀，由控制器控制。 任选地，提供气体排出组件，气体供应单元，用于加热或冷却试剂或气体的热单元，超声处理单元，由控制器操作的任何或每个。 该方法提供了编程控制器来实现治疗过程。 在本申请的一个实施方案中，组织样品是骨材料，并且处理过程影响骨材料的脱矿质。
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公开(公告)号：US20140277480A1
公开(公告)日：2014-09-18
申请号：US13801170
申请日：2013-03-13
发明人： Julien J. Prevost , Charles Britt , Kyle Hess , David R. Kaes , Kelly W. Schlachter , Guobao Wei
IPC分类号： A61F2/44
CPC分类号： A61F2/4465 , A61F2/44 , A61F2/4455 , A61F2002/2835 , A61F2002/30062 , A61F2002/30092 , A61F2002/30235 , A61F2002/30405 , A61F2002/3055 , A61F2002/30556 , A61F2002/30579 , A61F2002/30593 , A61F2002/30601 , A61F2002/30733 , A61F2002/30841 , A61F2002/4475
摘要： A spinal implant comprises a first member including a wall that defines a first cavity and a second member including a wall defining a second cavity. At least one first expandable bone graft is disposable within the second cavity. The second member is axially translatable relative to the first member between a first configuration and a second, expanded configuration such that at least a portion of the at least one first graft is disposed within the first cavity and the first cavity includes a substantially void portion. At least one second bone graft has a selective configuration and dimension for disposal within the substantially void portion. Systems and methods are disclosed.
摘要翻译： 脊柱植入物包括第一构件，其包括限定第一空腔的壁和包括限定第二空腔的壁的第二构件。 至少一个第一可膨胀骨移植物在第二腔内是一次性的。 第二构件相对于第一构件在第一构造和第二膨胀构造之间可轴向平移，使得至少一个第一移植物的至少一部分设置在第一空腔内，并且第一空腔包括基本上空隙部分。 至少一个第二骨移植物具有用于在基本上无空隙部分内处置的选择性构型和尺寸。 公开了系统和方法。
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公开(公告)号：US20200275963A1
公开(公告)日：2020-09-03
申请号：US16879347
申请日：2020-05-20
发明人： Kelly W. Schlachter , Daniel A. Shimko , Kerem N. Kalpakci , Erick Vasquez , David R. Kaes , Subhabrata Bhattacharyya
IPC分类号： A61B17/88 , A61F2/46 , A61F2/28 , A61F2/30 , A61L27/36 , A61L27/54 , B01F13/00 , B01F13/06 , B01F15/00 , B01F15/02
摘要： A device for mixing a bone material with a liquid is provided. The device comprises a chamber having a proximal end and a distal end, and the bone material disposed within the chamber, the bone material comprising a coherent mass of milled and lyophilized demineralized bone fibers; and a plunger having at least a portion slidably disposed within the proximal end of the chamber and configured to dispense the bone material mixed with liquid from the distal end of the chamber, when the plunger is in an extended position.
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公开(公告)号：US20190336191A1
公开(公告)日：2019-11-07
申请号：US16515905
申请日：2019-07-18
发明人： Kelly W. Schlachter , Daniel A. Shimko , Kerem Kalpakci , Erick Vasquez , David R. Kaes , Subhabrata Bhattacharyya
IPC分类号： A61B17/88 , A61L27/54 , A61L27/36 , A61F2/46 , A61F2/30 , A61F2/28 , B01F13/00 , B01F13/06 , B01F15/00 , B01F15/02
摘要： A bone material for hydration with a liquid is provided, the bone material comprising a coherent mass of milled and demineralized bone fibers, the coherent mass having no binder disposed in or on the coherent mass. In some embodiments, a bone material for hydration with a liquid is provided, the bone material comprising a coherent mass of cartridge milled, lyophilized and demineralized bone fibers, the coherent mass having no binder on the coherent mass. In some embodiments, a method of implanting a bone material is provided, the method comprising contacting the bone material with a liquid, the bone material comprising a coherent mass of cartridge milled, lyophilized and demineralized bone fibers, the coherent mass having no binder disposed in or on the coherent mass; molding the bone material into a shape to implant the bone material; and implanting the bone material at the target tissue site.
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公开(公告)号：US10322209B2
公开(公告)日：2019-06-18
申请号：US15974146
申请日：2018-05-08
IPC分类号： A61L27/18 , A61L27/36 , A61L27/46 , C08G18/10 , C08G18/36 , C08G18/38 , C08G18/64 , C08G18/73 , C08G18/77 , C08G18/79 , A61L27/54 , A61L27/58 , C08L75/04
摘要： Biological-based polyurethanes and methods of making the same. The polyurethanes are formed by reacting a biodegradable polyisocyanate (such as lysine diisocyanate) with an optionally hydroxylated biomolecule to form polyurethane. The polymers formed may be combined with ceramic and/or bone particles to form a composite, which may be used as an osteoimplant.
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公开(公告)号：US10194964B2
公开(公告)日：2019-02-05
申请号：US14941073
申请日：2015-11-13
发明人： Kelly W. Schlachter , Daniel A. Shimko , Kerem N. Kalpakci , Erick Vasquez , David R. Kaes , Subhabrata Bhattacharyya
IPC分类号： A61F2/46 , A61B17/88 , A61F2/28 , A61F2/30 , A61L27/36 , A61L27/54 , B01F13/00 , B01F13/06 , B01F15/00 , B01F15/02
摘要： A bone material comprising a coherent mass of cartridge milled and demineralized bone fibers is provided, the coherent mass having no binder disposed in or on the coherent mass. In some embodiments, a bone material comprising a lyophilized coherent mass of cartridge milled and demineralized bone fibers is provided, the lyophilized coherent mass having no binder disposed in or on the coherent mass. In some embodiments, a method of making an implantable bone material is provided, the method comprising drying a coherent mass of cartridge milled and demineralized bone fibers, the coherent mass having no binder disposed in or on the coherent mass.
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