A bone growth composition may include a cancellous portion and a noncancellous portion. The cancellous portion may be processed with an antimicrobial agent contact step and subsequent contact with a cryopreservative solution. In an embodiment, the cryopreservative solution is glycerol. In an embodiment, the bone growth composition includes a mix of cancellous chip formed from the cancellous portion and demineralized fibers formed from the noncancellous portion.