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公开(公告)号：US20230241350A1
公开(公告)日：2023-08-03
申请号：US18297913
申请日：2023-04-10
CPC分类号： A61M25/0084 , A61M25/065 , A61M29/00 , A61M5/32 , A61K9/06 , A61B17/1671 , A61M2202/10 , A61M2025/09183
摘要： A method of delivering a therapeutic agent to a nucleus pulposus of an intervertebral disc is provided. The method comprises inserting a delivery tool containing the therapeutic agent through an anterior portion, a lateral portion, or an anterolateral portion of an annulus fibrosus and into the nucleus pulposus of the intervertebral disc and delivering the therapeutic agent to the nucleus pulposus of the intervertebral disc. Devices and kits are also provided.
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公开(公告)号：US20160243284A1
公开(公告)日：2016-08-25
申请号：US15144139
申请日：2016-05-02
CPC分类号： A61L27/3608 , A61L27/18 , A61L27/46 , A61L27/54 , A61L27/58 , A61L2300/414 , A61L2300/426 , A61L2430/02 , C08G18/10 , C08G18/36 , C08G18/3878 , C08G18/3882 , C08G18/6484 , C08G18/73 , C08G18/771 , C08G18/798 , C08G2230/00 , C08L75/04
摘要： Biological-based polyurethanes and methods of making the same. The polyurethanes are formed by reacting a biodegradable polyisocyanate (such as lysine diisocyanate) with an optionally hydroxylated biomolecule to form polyurethane. The polymers formed may be combined with ceramic and/or bone particles to form a composite, which may be used as an osteoimplant.
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公开(公告)号：US20200338307A1
公开(公告)日：2020-10-29
申请号：US16394854
申请日：2019-04-25
摘要： A method of delivering a therapeutic agent to a nucleus pulposus of an intervertebral disc is provided. The method comprises inserting a delivery tool containing the therapeutic agent through an anterior portion, a lateral portion, or an anterolateral portion of an annulus fibrosus and into the nucleus pulposus of the intervertebral disc; and delivering the therapeutic agent to the nucleus pulposus of the intervertebral disc. Devices and kits are also provided.
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公开(公告)号：US09993579B2
公开(公告)日：2018-06-12
申请号：US15643137
申请日：2017-07-06
IPC分类号： A61K31/74 , A61F13/00 , A61L27/36 , C08G18/10 , C08G18/38 , C08G18/64 , C08G18/73 , C08G18/77 , C08G18/79 , A61L27/46 , A61L27/58 , A61L27/54 , A61L27/18 , C08L75/04
CPC分类号： A61L27/3608 , A61L27/18 , A61L27/46 , A61L27/54 , A61L27/58 , A61L2300/414 , A61L2300/426 , A61L2430/02 , C08G18/10 , C08G18/36 , C08G18/3878 , C08G18/3882 , C08G18/6484 , C08G18/73 , C08G18/771 , C08G18/798 , C08G2230/00 , C08L75/04
摘要： Biological-based polyurethanes and methods of making the same. The polyurethanes are formed by reacting a biodegradable polyisocyanate (such as lysine diisocyanate) with an optionally hydroxylated biomolecule to form polyurethane. The polymers formed may be combined with ceramic and/or bone particles to form a composite, which may be used as an osteoimplant.
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公开(公告)号：US09789223B2
公开(公告)日：2017-10-17
申请号：US15144139
申请日：2016-05-02
IPC分类号： A61K31/74 , A61F13/00 , A61L27/36 , A61L27/18 , A61L27/46 , C08G18/10 , C08G18/36 , C08G18/38 , C08G18/64 , C08G18/73 , C08G18/77 , C08G18/79 , A61L27/54 , A61L27/58
CPC分类号： A61L27/3608 , A61L27/18 , A61L27/46 , A61L27/54 , A61L27/58 , A61L2300/414 , A61L2300/426 , A61L2430/02 , C08G18/10 , C08G18/36 , C08G18/3878 , C08G18/3882 , C08G18/6484 , C08G18/73 , C08G18/771 , C08G18/798 , C08G2230/00 , C08L75/04
摘要： Biological-based polyurethanes and methods of making the same. The polyurethanes are formed by reacting a biodegradable polyisocyanate (such as lysine diisocyanate) with an optionally hydroxylated biomolecule to form polyurethane. The polymers formed may be combined with ceramic and/or bone particles to form a composite, which may be used as an osteoimplant.
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公开(公告)号：US10098681B2
公开(公告)日：2018-10-16
申请号：US14821191
申请日：2015-08-07
发明人： Guobao Wei , Todd M. Boyce , Robert Cohen , Cristy Richards , Lawrence A. Shimp
摘要： A covering for delivering a substance or material to a surgical site is provided. The covering, with substance provided therein, may be referred to as a delivery system. Generally, the covering may be a single or multi-compartment structure capable of at least partially retaining a substance provided therein until the covering is placed at a surgical site. Upon placement, the covering may facilitate transfer of the substance or surrounding materials. For example, the substance may be released (actively or passively) to the surgical site. The covering may participate in, control, or otherwise adjust the release of the substance. In various embodiments, the covering may be formed of a collagen material and is suitable for a variety of procedure specific uses.
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公开(公告)号：US20160038207A1
公开(公告)日：2016-02-11
申请号：US14821191
申请日：2015-08-07
发明人： Guobao Wei , Todd M. Boyce , Robert Cohen , Cristy Richards , Lawrence A. Shimp
IPC分类号： A61B17/88
CPC分类号： A61B17/8819 , A61B17/823 , A61B17/8825 , A61B2017/8813 , A61F2/30 , A61F2/4603 , A61F2002/0086 , A61F2002/2825 , A61F2002/2835 , A61F2002/30059 , A61F2002/30064 , A61F2002/3007 , A61F2002/30072 , A61F2002/30588 , A61F2002/30677 , A61F2002/3068 , A61F2002/3093 , A61F2002/30971 , A61F2002/4623 , A61F2002/4627 , A61F2250/0068 , A61F2310/00592 , A61F2310/00958 , A61F2310/0097
摘要： A covering for delivering a substance or material to a surgical site is provided. The covering, with substance provided therein, may be referred to as a delivery system. Generally, the covering may be a single or multi-compartment structure capable of at least partially retaining a substance provided therein until the covering is placed at a surgical site. Upon placement, the covering may facilitate transfer of the substance or surrounding materials. For example, the substance may be released (actively or passively) to the surgical site. The covering may participate in, control, or otherwise adjust the release of the substance. In various embodiments, the covering may be formed of a collagen material and is suitable for a variety of procedure specific uses.
摘要翻译： 提供了将物质或材料输送到手术部位的覆盖物。 其中提供的物质的覆盖物可以被称为递送系统。 通常，覆盖物可以是能够至少部分地保留其中提供的物质的单室或多室结构，直到覆盖物被放置在手术部位。 放置时，覆盖物可以促进物质或周围材料的转移。 例如，物质可以被主动地或被动地释放到手术部位。 覆盖物可以参与，控制或以其他方式调节物质的释放。 在各种实施方案中，覆盖物可以由胶原材料形成，并且适用于各种程序特异性用途。
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公开(公告)号：US20140121781A1
公开(公告)日：2014-05-01
申请号：US13972640
申请日：2013-08-21
发明人： Deger C. Tunc , John Winterbottom , David R. Kaes , Todd M. Boyce , David Knaack , James Russell , Subhabrata Bhattacharyya
IPC分类号： A61F2/28
CPC分类号： A61F2/28 , A61F2002/2835 , A61F2002/30062 , A61F2002/30677 , A61F2210/0004 , A61F2310/00293 , A61F2310/00359 , A61F2310/00365 , A61L27/446 , A61L27/46 , A61L27/48 , A61L27/56 , A61L27/58 , A61L2400/06 , A61L2400/08 , A61L2430/02
摘要： An osteoimplant composite comprising a plurality of particles of an inorganic material, a bone substitute material, a bone-derived material, or any combination thereof; and a polymer material with which the particles are combined. The composite is either naturally moldable or flowable, or it can be made moldable or settable. After implantation, the composite may be set to provide mechanical strength to the implant. The inventive composite have the advantage of being able to fill irregularly shape implantation site while at the same time being settable to provide the mechanical strength required for most orthopedic applications. The invention also provides methods of using and preparing the moldable and flowable composites.
摘要翻译： 一种植物复合材料，其包含多种无机材料颗粒，骨替代材料，骨衍生材料或其任何组合; 以及与颗粒结合的聚合物材料。 复合材料可以自然地模塑或流动，或者它可以是可模制的或可设定的。 植入后，可以将复合材料设置成为植入物提供机械强度。 本发明的复合材料具有能够填充不规则形状的植入部位的优点，同时可设置为提供大多数矫形应用所需的机械强度。 本发明还提供了使用和制备可模制和可流动的复合材料的方法。
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公开(公告)号：US20130236547A1
公开(公告)日：2013-09-12
申请号：US13867689
申请日：2013-04-22
IPC分类号： A61L27/18
CPC分类号： A61L27/3608 , A61L27/18 , A61L27/46 , A61L27/54 , A61L27/58 , A61L2300/414 , A61L2300/426 , A61L2430/02 , C08G18/10 , C08G18/36 , C08G18/3878 , C08G18/3882 , C08G18/6484 , C08G18/73 , C08G18/771 , C08G18/798 , C08G2230/00 , C08L75/04
摘要： Biological-based polyurethanes and methods of making the same. The polyurethanes are formed by reacting a biodegradable polyisocyanate (such as lysine diisocyanate) with an optionally hydroxylated biomolecule to form polyurethane. The polymers formed may be combined with ceramic and/or bone particles to form a composite, which may be used as an osteoimplant.
摘要翻译： 生物基聚氨酯及其制备方法。 聚氨酯通过可生物降解的多异氰酸酯（例如赖氨酸二异氰酸酯）与任选羟基化的生物分子反应形成聚氨酯而形成。 形成的聚合物可以与陶瓷和/或骨颗粒结合以形成可用作骨样植入物的复合物。
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公开(公告)号：US11690974B2
公开(公告)日：2023-07-04
申请号：US16394854
申请日：2019-04-25
CPC分类号： A61M25/0084 , A61B17/1671 , A61K9/06 , A61M5/32 , A61M25/065 , A61M29/00 , A61M2025/0091 , A61M2025/09183 , A61M2202/0415 , A61M2202/0427 , A61M2202/0468 , A61M2202/09 , A61M2202/10 , A61M2205/0266 , A61M2210/1003
摘要： A method of delivering a therapeutic agent to a nucleus pulposus of an intervertebral disc is provided. The method comprises inserting a delivery tool containing the therapeutic agent through an anterior portion, a lateral portion, or an anterolateral portion of an annulus fibrosus and into the nucleus pulposus of the intervertebral disc; and delivering the therapeutic agent to the nucleus pulposus of the intervertebral disc. Devices and kits are also provided.
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