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    SAMPLE CARRIER FOR DRIED BIOLOGICAL SAMPLES
    5.
    发明申请
    SAMPLE CARRIER FOR DRIED BIOLOGICAL SAMPLES 审中-公开
    用于干燥生物样品的样品载体

    公开(公告)号：US20150047441A1

    公开(公告)日：2015-02-19

    申请号：US14388274

    申请日：2013-03-04

    申请人： Waters Technologies Corporation

    发明人： Xin Zhang ,  Pamela C. Iraneta ,  Moon Chul Jung ,  Pamela J. Longenbach ,  Frank Marszalkowski, Jr.

    IPC分类号： G01N1/30 ,  G01N1/10

    CPC分类号： G01N1/30 ,  B01L3/5088 ,  B01L2300/126 ,  B01L2300/161 ,  G01N1/10 ,  G01N33/5436 ,  G01N33/96 ,  G01N2291/02466

    摘要： Described is a biological sample carrier based on a rigid hydrophilic object fabricated from a non-absorbing inert porous material. A biological fluid sample applied to the surface of the object is absorbed into the pores and constituents of the biological fluid sample remain in the pores after drying. Unlike a disc punched from a conventional dried blood spot (DBS) card, the object is easily handled. In contrast to DBS cards containing glass fiber structures that interact with basic analytes and other DBS card having adsorbing fibers that tend to separate blood constituents as the sample spreads through the fibers, the biological sample carrier is substantially inert to drug analytes.

    摘要翻译： 描述了基于由非吸收惰性多孔材料制造的刚性亲水物体的生物样品载体。 施加到物体表面的生物流体样品被吸收到孔中，并且干燥后生物流体样品的成分保留在孔中。 与传统的干血斑（DBS）卡片冲孔不同，该物体易于处理。 与含有与碱性分析物相互作用的玻璃纤维结构的DBS卡和具有吸附纤维的其它DBS卡相反，当样品扩散通过纤维时，其具有倾向于分离血液成分的生物样品载体对药物分析物基本上是惰性的。

    Immobilized enzymatic reactor
    6.
    发明授权
    Immobilized enzymatic reactor 有权

    公开(公告)号：US11905548B2

    公开(公告)日：2024-02-20

    申请号：US17881175

    申请日：2022-08-04

    申请人： Waters Technologies Corporation

    发明人： Joomi Ahn ,  Moon Chul Jung ,  Kevin D. Wyndham

    IPC分类号： C12Q1/37 ,  C12N11/06 ,  C12N11/14 ,  C12M1/40 ,  C12M1/34 ,  C12Q1/48

    CPC分类号： C12Q1/37 ,  C12M21/18 ,  C12M41/40 ,  C12N11/06 ,  C12N11/14 ,  C12Q1/48

    摘要： An immobilized enzymatic reactor can include a wall defining a chamber having an inlet and an outlet; a solid stationary phase covalently linked to an enzyme and disposed within the chamber; and a pressure modulator in a fluid communication with the chamber and adapted to support continuous flow of a liquid sample comprising a polymer analyte through the inlet, over the solid stationary phase, and out of the outlet under a pressure between about 2,500 and 35,000 psi. In one example, the solid stationary phase includes inorganic/organic hybrid particles in an ultra performance liquid chromatography system, the enzyme is a protease, and the polymer analyte is a polypeptide. The immobilized enzymatic reactor can prepare an analyte for applications such as for hydrogen deuterium exchange mass spectrometry.

    HIGH SURFACE AREA CHROMATOGRAPHIC DEVICE WITH LOW PRESSURE DROP
    7.
    发明申请
    HIGH SURFACE AREA CHROMATOGRAPHIC DEVICE WITH LOW PRESSURE DROP 审中-公开

    公开(公告)号：US20190277816A1

    公开(公告)日：2019-09-12

    申请号：US16292610

    申请日：2019-03-05

    申请人： Waters Technologies Corporation

    发明人： Abhijit Tarafder ,  Moon Chul Jung ,  Edouard S.P. Bouvier

    IPC分类号： G01N30/60 ,  B01L3/00

    摘要： A chromatographic device includes a primary channel having a cross-sectional area and characteristic length such that analyte travel within the primary channel is substantially convective. A plurality of secondary channels each having a cross-sectional area and characteristic length such that analyte flow into and out of a secondary channel is substantially diffusive, each of the plurality of secondary channels having an entrance in fluidic communication with the primary channel wherein the entrance intersects the primary channel.