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    METHOD FOR MATRIX EFFECT CORRECTION IN QUANTITATIVE MASS SPECTROMETRIC ANALYSIS OF ANALYTES IN COMPLEX MATRICES
    1.
    发明申请
    METHOD FOR MATRIX EFFECT CORRECTION IN QUANTITATIVE MASS SPECTROMETRIC ANALYSIS OF ANALYTES IN COMPLEX MATRICES 有权

    公开(公告)号：US20220003726A1

    公开(公告)日：2022-01-06

    申请号：US17293978

    申请日：2019-11-18

    Applicant: UNIVERSITEIT LEIDEN

    Inventor： Thomas HANKEMEIER ,  Anne Charlotte DUBBELMAN ,  Amy C. HARMS ,  Oskar GONZÁLEZ

    IPC: G01N30/72 ,  G01N30/86 ,  G01N30/04

    Abstract: The present invention relates to a method for quantifying one or more analytes in a sample by an analysis system comprising a separation unit (LC column), a means of adding a solution post-column (Connector), and a detection unit comprising a mass spectrometer coupled through an ionization source, the method comprising: ⋅ (i) inducing matrix effect on the analytes in the sample and on the post-column infused internal standards (PCI-ISs); ⋅ (ii) matching one or more post-column infused internal standard (PCI-IS) to each analyte that best matches the analyte's response to the matrix effect, and ⋅ (iii) storing the analyte-matched PCI-IS identification and, optionally, associated response data in a library; and ⋅ (iv) applying the analyte-matched PCI-IS to the analyte in other samples to correct the analyte peak responses for the matrix effect during ionization and to obtain (absolute) quantitation of the analyte using the response data.

    METHOD AND DEVICE FOR RECEIVING A DROPLET
    2.
    发明申请
    METHOD AND DEVICE FOR RECEIVING A DROPLET 有权
    用于接收滴液的方法和装置

    公开(公告)号：US20160139090A1

    公开(公告)日：2016-05-19

    申请号：US14898833

    申请日：2014-06-19

    Applicant: UNIVERSITEIT LEIDEN

    Inventor： Jan-Williem SCHOONEN ,  Peter LINDENBURG ,  Paul VULTO ,  Thomas HANKEMEIER

    IPC: G01N30/12 ,  G01N30/72 ,  G01N30/06 ,  G01N30/64

    CPC classification number: G01N30/12 ,  G01N1/28 ,  G01N1/34 ,  G01N1/4022 ,  G01N30/06 ,  G01N30/463 ,  G01N30/64 ,  G01N30/7233

    Abstract: The present invention relates to a droplet receiver, comprising a receptacle for receiving a droplet, a fluid conduit connected at a first end thereof to the droplet receptacle thereby providing a course within which the droplet received in the droplet receptacle moves, the conduit at its distal end in communication with a reservoir,and a fluid layer wetting the internal walls of the receptacle and conduit in such a way as permit reception of the droplet without loss of the received droplet due to wetting of the internal receptacle and conduit walls.

    Abstract translation: 本发明涉及一种液滴接收器，包括用于接收液滴的容器，在其第一端处连接到液滴容器的流体导管，从而提供容纳在液滴容器中的液滴移动的过程，其远端处的导管 与储存器连通，并且液体层以允许接收液滴而不会由于内部容器和导管壁的润湿而损失所接收的液滴的方式润湿容器和导管的内壁。

    TWO-PHASE ELECTROEXTRACTION FROM MOVING PHASES
    4.
    发明申请
    TWO-PHASE ELECTROEXTRACTION FROM MOVING PHASES 审中-公开
    来自移动相的两相电解质

    公开(公告)号：US20160114261A1

    公开(公告)日：2016-04-28

    申请号：US14898813

    申请日：2014-06-19

    Applicant: UNIVERSITEIT LEIDEN

    Inventor： Jan-Williem SCHOONEN ,  Peter LINDENBURG ,  Vincent VAN DUINEN ,  Amar OEDIT ,  Paul VULTO ,  Thomas HANKEMEIER

    IPC: B01D11/04 ,  G01N1/40

    CPC classification number: B01D11/0419 ,  B01D11/0496 ,  B01L3/502776 ,  B01L2200/0636 ,  B01L2300/0645 ,  G01N1/40 ,  G01N2001/4038 ,  G01N2001/4072

    Abstract: The present invention relates to a process for the electro extraction of molecules from a moving fluid donor phase into an acceptor phase, comprising the steps of: providing an electrically conductive donor phase moving at a first flow velocity and in electrically conductive contact with a first electrode, providing an electrically conductive acceptor phase in direct contact and immiscible with the donor phase, in electrically conductive contact with a second electrode; and providing a supporting or confining phase guide pattern to keep a defined interface between donor phase and acceptor phase, and (d) applying an electrical field between the first and the second electrode.

    Abstract translation: 本发明涉及一种将分子从移动的液体给体相电解提取到受体相中的方法，包括以下步骤：提供以第一流速移动并与第一电极导电接触的导电供体相 提供与供体相直接接触并不混溶的导电受体相，与第二电极导电接触; 以及提供支撑或约束相位导向图案以保持施主相位和受主相位之间的界定，以及（d）在第一和第二电极之间施加电场。

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