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公开(公告)号：US11690983B2
公开(公告)日：2023-07-04
申请号：US16879169
申请日：2020-05-20
Applicant: TERUMO KABUSHIKI KAISHA
Inventor： Yasuo Kurosaki , Hiroshi Goto , Yuno Kitagawa
CPC classification number: A61M25/1029 , A61M25/104 , A61L2420/02 , A61M2025/0019 , A61M2025/105 , A61M2025/1031
Abstract: Provided are a drug layer applying device and a method for forming a drug layer which can quickly and easily apply or provide an appropriate amount of a drug on a surface of a medical instrument such as a balloon. A drug layer applying device that applies a drug layer on a surface of a balloon to be inserted into a living body, includes: a deformable porous body capable of holding a coating solution containing a drug and a solvent; a removal unit that is flexibly deformable and arranged alongside the porous body; and a holding base that holds the porous body and the removal unit.
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公开(公告)号：US11660429B2
公开(公告)日：2023-05-30
申请号：US16800204
申请日：2020-02-25
Applicant: TERUMO KABUSHIKI KAISHA
Inventor： Yasuo Kurosaki , Yu Osawa
IPC: A61M25/10 , A61L29/08 , A61L29/14 , A61L29/16 , A61K9/16 , A61K31/337 , A61K31/436 , A61K31/4418
CPC classification number: A61M25/104 , A61K9/16 , A61K31/337 , A61K31/436 , A61K31/4418 , A61M2025/105 , A61M2025/1075 , A61M2025/1088
Abstract: A drug coating layer that prevents breakage of elongated drug crystals on a balloon surface while maintaining the drug crystals in an appropriate shape to act on the living body includes plural elongated bodies which are crystals of a water-insoluble drug each extending from the surface of the balloon at various lengths and angles, and a water-soluble additive layer provided in a space between an outer surface of an aggregate of the elongated bodies and the balloon surface to fill a space between the elongated bodies. The outer surface of the additive layer being located outside the aggregate, being uneven connecting a plurality of tip ends and side surfaces of the elongated bodies to each other. The tip ends of the elongated bodies slightly protrude from the additive layer, and the side surfaces and/or tip surfaces of the elongated body are exposed on the surface of the additive layer.
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公开(公告)号：US11446475B2
公开(公告)日：2022-09-20
申请号：US16127586
申请日：2018-09-11
Applicant: TERUMO KABUSHIKI KAISHA
Inventor： Yasuo Kurosaki , Katsumi Morimoto , Hiroshi Goto
IPC: A61M25/10 , A61L29/16 , A61K31/436 , A61K31/337
Abstract: A balloon catheter by which a drug can be effectively delivered to living body tissue and a method of manufacturing the balloon catheter, and a treatment method. The balloon catheter is provided on an outer surface of a balloon with a plurality of elongate bodies which are independent crystals of a water-insoluble drug that extend in an elongate form. The elongate bodies have long axes extending in directions along the outer surface of the balloon when the balloon is in a deflated state. Deformation, when the balloon is inflated from the deflated state, of portions on an outer surface side of the balloon to which end portions of the elongate bodies are fixed causes a force to act on the elongate bodies such that the long axes of the elongate bodies approach perpendicularity to the outer surface of the balloon.
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公开(公告)号：US10350394B2
公开(公告)日：2019-07-16
申请号：US15789592
申请日：2017-10-20
Applicant: TERUMO KABUSHIKI KAISHA
Inventor： Hiroshi Goto , Yasuo Kurosaki , Eisuke Furuichi
Abstract: A balloon coating method for forming a coating layer containing a water-insoluble drug on the outer surface of a balloon of a balloon catheter. The method includes applying a first rotation force to the balloon catheter proximal to the balloon of the balloon catheter and applying a second rotation force to the balloon catheter distal to the balloon of the balloon catheter. The first rotation speed is the same as the second rotation speed. The method includes applying a coating solution containing the drug to the outer surface of the balloon from a dispensing tube while gradually moving the dispensing tube in the axial direction and simultaneously applying the first and second rotation forces to rotate the balloon catheter around the longitudinal axis of the balloon catheter.
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公开(公告)号：US09993629B2
公开(公告)日：2018-06-12
申请号：US15188266
申请日：2016-06-21
Applicant: TERUMO KABUSHIKI KAISHA
Inventor： Hiroshi Goto , Eisuke Furuichi , Yasuo Kurosaki
CPC classification number: A61M25/1029 , A61M25/10 , A61M2025/1031 , A61M2025/105 , B05B12/00
Abstract: A balloon coating method and apparatus are disclosed which can perform coating while freely controlling, for example, the thickness of a coating layer and/or the morphological form of a drug. The balloon coating method and the balloon coating apparatus are for forming a coating layer on a surface of a balloon. The balloon coating method includes a pulling step of pulling the balloon in the direction of an axis of the balloon to thereby straighten a bend of the balloon, and a coating step of rotating the balloon about the axis of the balloon, with the balloon maintained in the bend-straightened state, and coating an outer surface of the balloon with a coating liquid containing a drug.
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Patent Agency Ranking
公开(公告)号：US11707609B2
公开(公告)日：2023-07-25
申请号：US16137016
申请日：2018-09-20
Applicant: TERUMO KABUSHIKI KAISHA
Inventor： Hiroshi Goto , Yu Murata , Ryosuke Suzuki , Yasuo Kurosaki , Katsumi Morimoto
IPC: A61M25/10 , A61L29/16 , A61K31/337 , A61K31/436
CPC classification number: A61M25/1027 , A61K31/337 , A61K31/436 , A61L29/16 , A61M25/10 , A61M25/1002 , A61L2300/41 , A61L2300/416 , A61L2420/06 , A61M2025/105 , A61M2025/1075
Abstract: A balloon catheter is disclosed that can effectively deliver a drug to living body tissue, a method of manufacturing a balloon catheter, and a treatment method. A balloon catheter is disclosed, the balloon catheter is provided on an outer surface of a balloon with a plurality of elongate bodies which are independent crystals of a water-insoluble drug extending in an elongate form. The elongate bodies include fixed-side elongate bodies which are fixed to the outer surface side of the balloon, and top-side elongate bodies which are bent or broken from the fixed-side elongate bodies and are continuous with or independent of the fixed-side elongate bodies.
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公开(公告)号：US11369776B2
公开(公告)日：2022-06-28
申请号：US15467002
申请日：2017-03-23
Applicant: TERUMO KABUSHIKI KAISHA
Inventor： Katsumi Morimoto , Yasuo Kurosaki , Katsunori Ebata
IPC: A61M25/10 , B05D1/42 , C30B29/58 , C30B29/62 , C30B7/06 , B05D1/00 , A61L29/08 , A61L29/16 , B05D1/26 , B05D3/00
Abstract: A balloon catheter that includes an elongated main body extending in an axial direction and a balloon connected to the distal portion of the elongated main body. The balloon includes an interior and is inflatable and deflatable. The balloon catheter also includes a plurality of elongate bodies extending radially away from the outer surface of the balloon. The elongate bodies are crystals of a water-insoluble drug. The elongate bodies each possess an independent longitudinal axis. Each of the elongate bodies includes a base portion at the proximal end of the elongate body. A plurality of elongate body proximal portions extend radially inwardly from the base portion of each of the elongate bodies toward the interior of the balloon. The elongate body proximal portions are continuous extensions of the crystal of the water-insoluble drug.
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公开(公告)号：US11104056B2
公开(公告)日：2021-08-31
申请号：US15928597
申请日：2018-03-22
Applicant: TERUMO KABUSHIKI KAISHA
Inventor： Yasuo Kurosaki , Hiroshi Goto
Abstract: A balloon wrapping apparatus and a balloon wrapping method are disclosed by which a balloon can be wrapped appropriately. The balloon wrapping apparatus for wrapping a balloon of a balloon catheter provided with the balloon at a distal portion of an elongated shaft includes: a pleating section that forms the balloon with wing shapes projecting in radial directions; a folding section that includes a plurality of blades aligned in a circumferential direction, and that folds the wing shapes formed in the balloon along the circumferential direction by moving rotationally the blades; and a rotational support portion that supports a portion of the shaft which portion is on a proximal side of the balloon, and that rotates the shaft in a direction opposite to a rotary movement direction of the blades in a state in which the balloon is positioned in relation to the folding section.
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公开(公告)号：US10646697B2
公开(公告)日：2020-05-12
申请号：US15136269
申请日：2016-04-22
Applicant: TERUMO KABUSHIKI KAISHA
Inventor： Hiroshi Gotou , Yasuo Kurosaki , Eisuke Furuichi
Abstract: A balloon coating method for forming a coating layer containing a water-insoluble drug on the outer surface of a balloon of a balloon catheter, wherein the balloon catheter includes an elongate shaft possessing a distal portion at which is provided the balloon which is inflatable. The balloon coating method includes: holding the shaft on a support part capable of rotating about an axis of the balloon; and moving a dispensing tube for supplying a coating liquid containing the drug relative to the balloon in an axial direction of the balloon, while rotating the balloon together with the support part, thereby to coat the outer surface of the balloon with the coating liquid.
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公开(公告)号：US10569061B2
公开(公告)日：2020-02-25
申请号：US15282087
申请日：2016-09-30
Applicant: TERUMO KABUSHIKI KAISHA
Inventor： Yasuo Kurosaki , Eisuke Furuichi
IPC: B05D1/16 , B41J3/44 , A61L29/08 , A61M25/10 , B05C5/02 , B05C13/02 , A61L29/16 , B05D7/04 , B05D1/00 , B05D1/26 , B05B13/04
Abstract: A balloon coating method is disclosed for forming a coating layer containing a water-insoluble drug on an outer surface of a balloon of a balloon catheter. The balloon coating method includes an application step in which, where a pipe-shaped dispensing tube formed from a polyolefin for supplying a coating solution containing the water-insoluble drug and a solvent is formed at its end portion with an opening portion for discharging the coating solution therethrough and when the end portion side of the dispensing tube is placed in contact with the outer surface of the balloon while the balloon is rotated about an axis of the balloon, the coating solution is discharged through the opening portion and applied to the outer surface of the balloon while the dispensing tube is moved relative to the balloon in an axial direction of the balloon.
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