公开(公告)号：US11207506B2

公开(公告)日：2021-12-28

申请号：US16127427

申请日：2018-09-11

Applicant: TERUMO KABUSHIKI KAISHA

Inventor： Yu Murata ,  Hiroshi Goto ,  Ryosuke Suzuki

IPC: A61M25/10 ,  A61L29/16 ,  A61K31/436 ,  A61K31/337

Abstract: A balloon catheter is disclosed capable of effectively delivering a drug to living body tissue and a manufacturing method of the balloon catheter, and a treatment method. The balloon catheter has a balloon at a distal portion of a catheter shaft, and is provided on a surface of the balloon with elongate bodies which are crystals of a water-insoluble drug extending in a longitudinal direction. The surface of the balloon is provided with crystal conjugates formed of a plurality of elongate bodies united to one another while being in a tilted state.

公开(公告)号：US10328245B2

公开(公告)日：2019-06-25

申请号：US15937429

申请日：2018-03-27

Applicant: TERUMO KABUSHIKI KAISHA

Inventor： Yasuo Kurosaki ,  Ryosuke Suzuki ,  Eisuke Furuichi

IPC: A61M25/10 ,  B05C5/02 ,  B05C13/02 ,  A61L29/08 ,  A61L29/16 ,  B05B13/04

Abstract: A method is disclosed for forming a coating layer on an outer surface of a balloon of a balloon catheter. The method includes supplying a coating solution containing a drug and a solvent through an end portion of a flexible dispensing tube with an opening portion for discharging the coating solution through the end portion of the flexible dispensing tube; keeping in contact an opening portion-formed end portion side of the dispensing tube with the outer surface of the balloon in such a manner as to be oriented in a direction opposite to a rotating direction of the balloon; rotating the balloon about an axis of the balloon; and discharging the coating solution through the opening portion and applying the coating solution to the outer surface of the balloon while the dispensing tube is moved relative to the balloon in an axial direction of the balloon.

公开(公告)号：US09937328B2

公开(公告)日：2018-04-10

申请号：US15282563

申请日：2016-09-30

Applicant: TERUMO KABUSHIKI KAISHA

Inventor： Yasuo Kurosaki ,  Ryosuke Suzuki ,  Eisuke Furuichi

IPC: A61M25/10 ,  B05C5/02 ,  B05C13/02 ,  A61L29/08 ,  A61L29/16 ,  B05B13/04

CPC classification number: A61M25/10 ,  A61L29/08 ,  A61L29/16 ,  A61L2300/416 ,  A61L2420/02 ,  A61M25/1029 ,  A61M2025/1031 ,  A61M2025/105 ,  A61M2207/10 ,  B05B13/0442 ,  B05C5/0208 ,  B05C13/025

Abstract: A positioning method for balloon coating by which the thickness and morphological form of a drug in a coating formed on a balloon can be suitably set. This method is a positioning method for balloon coating for forming a coating layer containing a water-insoluble drug on an outer surface of a balloon of a balloon catheter. The positioning method includes a positioning step in which a dispensing tube is moved, from a state of non-contact with the balloon, in a direction intersecting the extending direction of the dispensing tube, and an opening portion-formed end portion side of the dispensing tube formed at its end portion with an opening portion for discharging a coating solution is thereby placed in contact with the outer surface of the balloon.

公开(公告)号：US11707609B2

公开(公告)日：2023-07-25

申请号：US16137016

申请日：2018-09-20

Applicant: TERUMO KABUSHIKI KAISHA

Inventor： Hiroshi Goto ,  Yu Murata ,  Ryosuke Suzuki ,  Yasuo Kurosaki ,  Katsumi Morimoto

IPC: A61M25/10 ,  A61L29/16 ,  A61K31/337 ,  A61K31/436

CPC classification number: A61M25/1027 ,  A61K31/337 ,  A61K31/436 ,  A61L29/16 ,  A61M25/10 ,  A61M25/1002 ,  A61L2300/41 ,  A61L2300/416 ,  A61L2420/06 ,  A61M2025/105 ,  A61M2025/1075

Abstract: A balloon catheter is disclosed that can effectively deliver a drug to living body tissue, a method of manufacturing a balloon catheter, and a treatment method. A balloon catheter is disclosed, the balloon catheter is provided on an outer surface of a balloon with a plurality of elongate bodies which are independent crystals of a water-insoluble drug extending in an elongate form. The elongate bodies include fixed-side elongate bodies which are fixed to the outer surface side of the balloon, and top-side elongate bodies which are bent or broken from the fixed-side elongate bodies and are continuous with or independent of the fixed-side elongate bodies.

公开(公告)号：US09901720B2

公开(公告)日：2018-02-27

申请号：US15281860

申请日：2016-09-30

Applicant: TERUMO KABUSHIKI KAISHA

Inventor： Yasuo Kurosaki ,  Ryosuke Suzuki ,  Eisuke Furuichi

IPC: A61M25/10 ,  B05C5/02 ,  B05C13/02 ,  B05B13/04

CPC classification number: A61M25/1029 ,  A61M25/10 ,  A61M2025/1031 ,  B05B13/0442 ,  B05C5/02 ,  B05C5/0208 ,  B05C5/0216 ,  B05C5/0241 ,  B05C13/02 ,  B05C13/025 ,  B05D1/002 ,  B05D1/26

Abstract: A positioning method for balloon coating by which the thickness, morphological form and the like of a drug in a coating formed on a balloon can be suitably set. This method is a positioning method for balloon coating for forming a coating layer containing a water-insoluble drug on an outer surface of a balloon of a balloon catheter. The positioning method includes a positioning step in which the dispensing tube is positioned in such a manner that a virtual position at which an opening portion would be located if the dispensing tube is assumed to be non-flexible is located within the range of 0 degrees to 40 degrees from the reference plane toward the rotating direction side of the balloon, in a region extending from the reference plane in a direction opposite to the discharge direction of the dispensing tube.