公开(公告)号：US11426564B2

公开(公告)日：2022-08-30

申请号：US16802687

申请日：2020-02-27

Applicant: TERUMO KABUSHIKI KAISHA

Inventor： Yasuo Kurosaki ,  Hiroshi Goto ,  Yuno Kitagawa

IPC: A61M25/10 ,  A61L29/08 ,  A61L29/16

Abstract: A method and apparatus are disclosed for forming a drug coating layer capable of preventing breakage of elongated drug crystals on a surface of a balloon and maintaining the drug crystals in an appropriate shape in order to act on a living body. The method includes supplying a coating solution which contains the water-insoluble drug, a water-soluble additive, an organic solvent, and water to the surface of the balloon and evaporating the organic solvent and the water to form an additive layer containing the water-soluble additive and a protruding crystal having a tip end protruding from the additive layer, cutting a surplus portion protruding from the additive layer of the protruding crystal from a part surrounded by the additive layer and forming the part surrounded by the additive layer as the elongated body, and removing the cut-out surplus portion from the drug coating layer.

公开(公告)号：US11690983B2

公开(公告)日：2023-07-04

申请号：US16879169

申请日：2020-05-20

Applicant: TERUMO KABUSHIKI KAISHA

Inventor： Yasuo Kurosaki ,  Hiroshi Goto ,  Yuno Kitagawa

IPC: A61M25/10 ,  A61M25/00

CPC classification number: A61M25/1029 ,  A61M25/104 ,  A61L2420/02 ,  A61M2025/0019 ,  A61M2025/105 ,  A61M2025/1031

Abstract: Provided are a drug layer applying device and a method for forming a drug layer which can quickly and easily apply or provide an appropriate amount of a drug on a surface of a medical instrument such as a balloon. A drug layer applying device that applies a drug layer on a surface of a balloon to be inserted into a living body, includes: a deformable porous body capable of holding a coating solution containing a drug and a solvent; a removal unit that is flexibly deformable and arranged alongside the porous body; and a holding base that holds the porous body and the removal unit.