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1.发明授权公开(公告)号：US09358255B2
公开(公告)日：2016-06-07
申请号：US14049026
申请日：2013-10-08
发明人： Kevin Dunworth , Richard J. Kana , Theodore Sand , Matthew Murphy
IPC分类号： A61K35/12 , A61K35/35 , A61K35/14 , A61K35/28 , C12N5/0775
CPC分类号： A61K35/28 , A61K35/14 , A61K35/35 , C12N5/0663 , C12N5/0667 , C12N2502/1358 , C12N2502/1382 , A61K2300/00
摘要： The invention is directed to a method for isolating stromal cells to form a therapeutic composition; and administering said therapeutic composition to the subject. A further embodiment of the invention is directed to therapeutic compositions comprising isolated stromal cells.
摘要翻译： 本发明涉及分离基质细胞以形成治疗组合物的方法; 并将所述治疗组合物施用于受试者。 本发明的另一个实施方案涉及包含分离的基质细胞的治疗组合物。
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2.发明申请MESENCHYMAL CELL-BASED SOFT FUSION AS A BIOLOGICAL INTERVERTEBRAL DISC REPLACEMENT 有权基于细胞的细胞融合作为生物学的椎间盘置换公开(公告)号：US20140114419A1
公开(公告)日：2014-04-24
申请号：US14061617
申请日：2013-10-23
发明人： Kevin Dunworth , Matthew Murphy , Theodore Sand
IPC分类号： A61F2/44
CPC分类号： A61F2/4465 , A61F2/442 , A61F2002/2817 , A61F2002/2835 , A61F2002/2842 , A61F2002/2867 , A61F2002/30014 , A61F2002/30069 , A61F2002/30204 , A61F2002/4475 , A61F2310/00293
摘要： The invention comprises a combination of biological elements that will naturally remodel in vivo based on applied mechanical forces. The final composition will possess mechanical properties similar to cartilage or a disc, and significantly less stiff than bone or implants comprised of metals or plastics. The equilibrium stress conduction will minimize unnatural forces on neighboring healthy discs.
摘要翻译： 本发明包括基于所施加的机械力在体内自然改造的生物元素的组合。 最终的组合物将具有类似于软骨或椎间盘的机械性质，并且显着地比由金属或塑料构成的骨或植入物硬。 平衡应力传导将使相邻健康盘上的非自然力最小化。
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公开(公告)号：US20140110317A1
公开(公告)日：2014-04-24
申请号：US14061623
申请日：2013-10-23
CPC分类号： A61M1/34 , A61M1/0272 , A61M1/0281 , A61M1/3403 , A61M2205/3306 , B01D63/02
摘要： The invention is directed to a device for the concentration of fluids comprising a donor receptacle containing a fluid to be concentrated, the donor receptacle comprising a plunger; a receiving receptacle to receive the concentrated fluid, the receiving receptacle comprising a plunger; a concentrator device that is connected to the donor receptacle and the receiving receptacle; and a housing that encloses the donor and receiving receptacles and the concentrator device that the plungers of the donor and receiving receptacles are enclosed within chambers that are gas tight.
摘要翻译： 本发明涉及一种用于浓缩流体的装置，该装置包括供体容器，该供体容器包含待浓缩的流体，该供体容器包括柱塞; 接收容器以接收浓缩流体，所述接收容器包括柱塞; 集中器装置，其连接到供体容器和接收容器; 以及包围供体和接收容器以及集中器装置的壳体，使得供体和接收容器的柱塞被封闭在气密的室内。
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公开(公告)号：US09623148B2
公开(公告)日：2017-04-18
申请号：US14589779
申请日：2015-01-05
发明人： Colan Partee , John B. Rossman , Theodore Sand , Brian Burkinshaw
CPC分类号： A61L27/3608 , A61F2/28 , A61F2/44 , A61F2/4644 , A61F2002/2817 , A61F2002/2835 , A61F2002/30909 , A61F2002/4495 , A61F2310/00293 , A61F2310/00359 , A61L27/3616 , A61L27/365 , A61L27/3834 , A61L27/58 , A61L2400/06 , A61L2430/02 , A61L2430/38
摘要： A composite bone graft which comprises an allograft bone component; a synthetic bone substitute, wherein the synthetic bone substitute is in contact with the allograft bone component. The composite is arranged within a resorbable mesh casing.
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5.发明申请公开(公告)号：US20140099288A1
公开(公告)日：2014-04-10
申请号：US14049026
申请日：2013-10-08
发明人： Kevin Dunworth , Richard J. Kana , Theodore Sand , Matthew Murphy
IPC分类号： A61K35/12
CPC分类号： A61K35/28 , A61K35/14 , A61K35/35 , C12N5/0663 , C12N5/0667 , C12N2502/1358 , C12N2502/1382 , A61K2300/00
摘要： The invention is directed to a method for isolating stromal cells to form a therapeutic composition; and administering said therapeutic composition to the subject. A further embodiment of the invention is directed to therapeutic compositions comprising isolated stromal cells.
摘要翻译： 本发明涉及分离基质细胞以形成治疗组合物的方法; 并将所述治疗组合物施用于受试者。 本发明的另一个实施方案涉及包含分离的基质细胞的治疗组合物。
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6.发明授权公开(公告)号：US10751185B2
公开(公告)日：2020-08-25
申请号：US15168199
申请日：2016-05-30
发明人： Eileen Dawson , Kevin Dunworth , Theodore Sand , Matthew Murphy , John B. Rossman , Melissa Samano , Richard Suzuki , Kathryn Moncivais
IPC分类号： A61F2/28 , A61F2/44 , A61L27/56 , A61F2/30 , A61F2/46 , A61L27/38 , A61L27/22 , A61L27/20 , A61L27/24 , A61L27/12
摘要： The invention is directed to a bone void filler comprising a scaffold or matrix. The scaffold or matrix may include a porous inorganic matrix component and/or a 3D-printed implantable device. The bone void filler may include a cellular component containing cells, some of which are capable of making extracellular matrix resembling native bone tissue. The bone void filler may include an organic matrix, such as, an organic biopolymer that aids in cell retention and renders the scaffold or matrix moldable. The bone void filler may include growth factors and/or cytokines. The bone void filler may include a clotting agent.
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公开(公告)号：US20170197010A1
公开(公告)日：2017-07-13
申请号：US15469295
申请日：2017-03-24
发明人： Colan Partee , John B. Rossman , Theodore Sand , Brian Burkinshaw
CPC分类号： A61L27/3608 , A61F2/28 , A61F2/44 , A61F2/4644 , A61F2002/2817 , A61F2002/2835 , A61F2002/30909 , A61F2002/4495 , A61F2310/00293 , A61F2310/00359 , A61L27/3616 , A61L27/365 , A61L27/3834 , A61L27/58 , A61L2400/06 , A61L2430/02 , A61L2430/38
摘要： A composite bone graft which comprises an allograft bone component; a synthetic bone substitute, wherein the synthetic bone substitute is in contact with the allograft bone component. The composite is arranged within a resorbable mesh casing.
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8.发明申请公开(公告)号：US20160250259A1
公开(公告)日：2016-09-01
申请号：US15147586
申请日：2016-05-05
发明人： Kevin Dunworth , Richard J. Kana , Theodore Sand , Matthew Murphy
CPC分类号： A61K35/28 , A61K35/14 , A61K35/35 , C12N5/0663 , C12N5/0667 , C12N2502/1358 , C12N2502/1382 , A61K2300/00
摘要： The invention is directed to a therapeutic composition that includes a first cell preparation that includes isolated stromal cells of a first type and a second cell preparation that includes isolated stromal cells of a second type. The first and second cell preparations may include cultured cells. The stromal cells may include adipose stromal cells and bone marrow derived stromal cells. The therapeutic composition may include a blood component that includes one or more of platelet-poor plasma, concentrated platelet-poor plasma, platelet-rich plasma, and whole blood.
摘要翻译： 本发明涉及治疗组合物，其包括第一细胞制剂，其包括第一类型的分离的基质细胞和包含第二类型的分离的基质细胞的第二细胞制剂。 第一和第二细胞制剂可以包括培养的细胞。 基质细胞可以包括脂肪基质细胞和骨髓来源的基质细胞。 治疗组合物可以包括血液成分，其包含贫血小血浆，浓缩血小板血浆，富血小板血浆和全血中的一种或多种。
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公开(公告)号：US20140112969A1
公开(公告)日：2014-04-24
申请号：US14061628
申请日：2013-10-23
发明人： Theodore Sand
CPC分类号： A61L31/16 , A61L31/005 , A61L2300/252 , A61L2300/414 , A61L2300/64 , A61L2430/02 , A61L2430/10
摘要： The invention is directed to a method for therapeutic repair of an injury to bone or tissue comprising providing a structural component, wherein the structural component repairs the injury; and providing a therapeutic fluid, wherein the therapeutic fluid is located within the structural component.
摘要翻译： 本发明涉及用于治疗性修复骨或组织损伤的方法，包括提供结构组分，其中所述结构组分修复损伤; 以及提供治疗性流体，其中所述治疗性流体位于所述结构部件内。
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10.发明授权公开(公告)号：US10183095B2
公开(公告)日：2019-01-22
申请号：US14921826
申请日：2015-10-23
发明人： Eileen Dawson , Kevin Dunworth , Theodore Sand , Matthew Murphy , John B. Rossman , Melissa Samano , Richard Suzuki , Katy Moncivais
摘要： The invention is directed to a bone void filler comprising a scaffold or matrix. The scaffold or matrix may include a porous inorganic matrix component. The bone void filler may include a cellular component containing cells, some of which are capable of making extracellular matrix resembling native bone tissue. The bone void filler may include an organic matrix, such as, an organic biopolymer that aids in cell retention and renders the scaffold or matrix moldable. The bone void filler may include growth factors and/or cytokines. The bone void filler may include a clotting agent.
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