公开(公告)号：US10751185B2

公开(公告)日：2020-08-25

申请号：US15168199

申请日：2016-05-30

申请人： SpineSmith Partners, L.P.

发明人： Eileen Dawson ,  Kevin Dunworth ,  Theodore Sand ,  Matthew Murphy ,  John B. Rossman ,  Melissa Samano ,  Richard Suzuki ,  Kathryn Moncivais

IPC分类号： A61F2/28 ,  A61F2/44 ,  A61L27/56 ,  A61F2/30 ,  A61F2/46 ,  A61L27/38 ,  A61L27/22 ,  A61L27/20 ,  A61L27/24 ,  A61L27/12

摘要： The invention is directed to a bone void filler comprising a scaffold or matrix. The scaffold or matrix may include a porous inorganic matrix component and/or a 3D-printed implantable device. The bone void filler may include a cellular component containing cells, some of which are capable of making extracellular matrix resembling native bone tissue. The bone void filler may include an organic matrix, such as, an organic biopolymer that aids in cell retention and renders the scaffold or matrix moldable. The bone void filler may include growth factors and/or cytokines. The bone void filler may include a clotting agent.

公开(公告)号：US10183095B2

公开(公告)日：2019-01-22

申请号：US14921826

申请日：2015-10-23

申请人： SpineSmith Partners, L.P.

发明人： Eileen Dawson ,  Kevin Dunworth ,  Theodore Sand ,  Matthew Murphy ,  John B. Rossman ,  Melissa Samano ,  Richard Suzuki ,  Katy Moncivais

IPC分类号： A61L27/38 ,  A61L27/56 ,  A61L27/12 ,  A61L27/20 ,  A61L27/22 ,  A61L27/24

摘要： The invention is directed to a bone void filler comprising a scaffold or matrix. The scaffold or matrix may include a porous inorganic matrix component. The bone void filler may include a cellular component containing cells, some of which are capable of making extracellular matrix resembling native bone tissue. The bone void filler may include an organic matrix, such as, an organic biopolymer that aids in cell retention and renders the scaffold or matrix moldable. The bone void filler may include growth factors and/or cytokines. The bone void filler may include a clotting agent.

公开(公告)号：US20160270920A1

公开(公告)日：2016-09-22

申请号：US15168199

申请日：2016-05-30

申请人： SpineSmith Partners, L.P.

发明人： Eileen Dawson ,  Kevin Dunworth ,  Theodore Sand ,  Matthew Murphy ,  John B. Rossman ,  Melissa Samano ,  Richard Suzuki ,  Katy Moncivais

IPC分类号： A61F2/28 ,  A61F2/46 ,  A61L27/56 ,  A61L27/54 ,  A61L27/02 ,  A61L27/14 ,  A61L27/58 ,  A61F2/44 ,  A61L27/38

摘要： The invention is directed to a bone void filler comprising a scaffold or matrix. The scaffold or matrix may include a porous inorganic matrix component and/or a 3D-printed implantable device. The bone void filler may include a cellular component containing cells, some of which are capable of making extracellular matrix resembling native bone tissue. The bone void filler may include an organic matrix, such as, an organic biopolymer that aids in cell retention and renders the scaffold or matrix moldable. The bone void filler may include growth factors and/or cytokines. The bone void filler may include a clotting agent.

摘要翻译： 本发明涉及包含支架或基质的骨空隙填料。 支架或基质可以包括多孔无机基质组分和/或3D印刷的可植入装置。 骨空隙填料可以包括含有细胞的细胞组分，其中一些细胞能够制备类似天然骨组织的细胞外基质。 骨空隙填料可以包括有机基质，例如有助于细胞保留的有机生物聚合物，并使支架或基质成型。 骨空隙填料可包括生长因子和/或细胞因子。 骨空隙填料可包括凝血剂。

公开(公告)号：US20160114078A1

公开(公告)日：2016-04-28

申请号：US14921826

申请日：2015-10-23

申请人： SpineSmith Partners, L.P.

发明人： Eileen Dawson ,  Kevin Dunworth ,  Theodore Sand ,  Matthew Murphy ,  John B. Rossman ,  Melissa Samano ,  Richard Suzuki ,  Katy Moncivais

IPC分类号： A61L27/36 ,  A61L27/12 ,  A61L27/22 ,  A61L27/20 ,  A61L27/24

CPC分类号： A61L27/12 ,  A61L27/20 ,  A61L27/22 ,  A61L27/222 ,  A61L27/225 ,  A61L27/227 ,  A61L27/24 ,  A61L27/3834 ,  A61L27/3847 ,  A61L27/56 ,  A61L2430/02

摘要： The invention is directed to a bone void filler comprising a scaffold or matrix. The scaffold or matrix may include a porous inorganic matrix component. The bone void filler may include a cellular component containing cells, some of which are capable of making extracellular matrix resembling native bone tissue. The bone void filler may include an organic matrix, such as, an organic biopolymer that aids in cell retention and renders the scaffold or matrix moldable. The bone void filler may include growth factors and/or cytokines. The bone void filler may include a clotting agent.

摘要翻译： 本发明涉及包含支架或基质的骨空隙填料。 支架或基质可以包括多孔无机基质组分。 骨空隙填料可以包括含有细胞的细胞组分，其中一些细胞能够制备类似天然骨组织的细胞外基质。 骨空隙填料可以包括有机基质，例如有助于细胞保留的有机生物聚合物，并使支架或基质成型。 骨空隙填料可包括生长因子和/或细胞因子。 骨空隙填料可包括凝血剂。