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29 条记录 (耗时 0.017 秒)

    Process for thermoformed articles
    2.
    发明授权
    Process for thermoformed articles 失效
    热成型制品的工艺

    公开(公告)号：US4673539A

    公开(公告)日：1987-06-16

    申请号：US735379

    申请日：1985-05-17

    申请人： W. James Hammar ,  Ronald F. Ofstead

    发明人： W. James Hammar ,  Ronald F. Ofstead

    IPC分类号： C08L31/02 ,  G02B1/04 ,  B29D11/00

    CPC分类号： G02B1/043 ,  C08L31/02

    摘要： A process for preparing shaped articles and shaped hydrogel articles including ophthalmic devices comprises the steps of preparing a polymer or copolymer comprising units derived from an ethylenically-unsaturated monomer bearing at least one trihaloacetoxy-substituent group, thermoforming said polymer by heating in a mold or in sheet-form at a temperature in the range of 100.degree. to 400.degree. C. for about 5 seconds to 15 minutes, and then cooling said polymer, to provide a shaped article, optionally, solvolyzing the resulting shaped article to provide a hydroxy-substituted polymeric shaped article, and optionally hydrating said hydroxy-substituted polymeric shaped article to provide a shaped hydrogel article.

    摘要翻译： 一种用于制备成型制品和包括眼科装置的成形水凝胶制品的方法包括以下步骤：制备聚合物或共聚物，其包含衍生自具有至少一个三卤代乙酰氧基取代基的烯属不饱和单体的单元，通过在模具中或在模具中加热 在100-400℃的温度下加热约5秒至15分钟，然后冷却所述聚合物，以提供成形制品，任选地将所得的成形制品溶剂化以提供羟基取代的 并且任选地使所述羟基取代的聚合物成形制品水合以提供成形的水凝胶制品。

    Method of sealing a gelatin capsule
    5.
    发明授权
    Method of sealing a gelatin capsule 失效
    密封胶囊的方法

    公开(公告)号：US5188688A

    公开(公告)日：1993-02-23

    申请号：US556816

    申请日：1990-07-20

    申请人： James R. Boardman ,  Ronald F. Ofstead

    发明人： James R. Boardman ,  Ronald F. Ofstead

    IPC分类号： A61J3/07

    CPC分类号： A61J3/072

    摘要： A gelatin capsule sealant of a water soluble, amide-containing polymer adhesive in a volatile, essentially non-aqueous solvent is used to seal gelatin capsule sections together at less than the entire circumference of overlap between the capsule sections. The sealant may also adhere a pharmaceutical caplet within the capsule to the internal wall of the capsule. The method of applying the sealant to the capsule sections and possibly also the pharmaceutical caplet uses a drop of the sealant spread at the junction of an eccentric arcuate portion of the sections and the pharmaceutical caplet. The solvent evaporates from the sealant through the portion of the capsule section overlap not sealed. The sealant may use "generally regarded as safe" (GRAS) solvents and may also include a GRAS dye for visual indication tha that the capsule is eccentrically sealed to resist manually forced separation of the capsule sections.

    摘要翻译： 在挥发性基本上非水溶剂中的水溶性含酰胺聚合物粘合剂的明胶胶囊密封剂用于在不到胶囊部分之间的重叠的整个圆周处密封明胶胶囊部分。 密封剂还可以将胶囊内的药物囊片粘附到胶囊的内壁。 将密封剂施加到胶囊部分以及可能的药物帽片上的方法使用一层密封剂，其在部分的偏心弧形部分和药物囊片的接合处扩展。 溶剂从密封胶中蒸发通过胶囊部分的重叠不密封。 密封剂可以使用“通常被认为是安全的”（GRAS）溶剂，并且还可以包括用于视觉指示的GRAS染料，使得胶囊被偏心地密封以防止手动强制分离胶囊部分。

    Article having non-crosslinked crystallized polymer coatings
    6.
    发明授权
    Article having non-crosslinked crystallized polymer coatings 失效
    具有非交联结晶聚合物涂层的物品

    公开(公告)号：US4977901A

    公开(公告)日：1990-12-18

    申请号：US505411

    申请日：1990-04-06

    申请人： Ronald F. Ofstead

    发明人： Ronald F. Ofstead

    IPC分类号： A61L27/34 ,  A61L29/08 ,  A61L31/10 ,  A61L33/00

    CPC分类号： A61L33/0029 ,  A61L27/34 ,  A61L29/085 ,  A61L31/10 ,  Y10T428/294 ,  Y10T428/31678 ,  Y10T428/31699

    摘要： A non-crosslinked crystallized polymer or polymer blending coating is disclosed for articles that come into contact with bodily fluids. The polymer or polymer blend to be used is crystallizable and is stable in the presence of water at temperatures of up to about 60.degree. C. when in the crystalline state. The polymer or polymer blend is dissolved in a solvent, such as water or dimethyl sulfoxide (DMSO), and is coated on the article. The polymer coating is then crystallized, generally by heat treatment, providing both toughness and increased adherence of the coating to the article without ready dissolution when the article comes into contact with fluids.

    摘要翻译： 公开了与体液接触的制品的非交联结晶聚合物或聚合物共混涂层。 要使用的聚合物或聚合物共混物是可结晶的，并且在结晶状态下在高达约60℃的温度下在水的存在下是稳定的。 将聚合物或聚合物共混物溶解在溶剂如水或二甲基亚砜（DMSO）中，并涂覆在制品上。 然后通常通过热处理使聚合物涂层结晶，当制品与流体接触时，提供涂层的韧性和增加的涂层对制品的粘附，而不会立即溶解。

    Copolymers of poly(vinyl trifluoroacetate) or poly(vinyl alcohol)
    7.
    发明授权
    Copolymers of poly(vinyl trifluoroacetate) or poly(vinyl alcohol) 失效
    聚（乙烯基三氟乙酸酯）或聚（乙烯醇）的共聚物

    公开(公告)号：US4528325A

    公开(公告)日：1985-07-09

    申请号：US500785

    申请日：1983-06-03

    申请人： Ronald F. Ofstead

    发明人： Ronald F. Ofstead

    IPC分类号： B29C39/02 ,  B29C43/02 ,  B29D11/00 ,  B29K31/00 ,  B29L11/00 ,  C08F8/12 ,  C08F18/02 ,  C08F218/00 ,  C08F218/02 ,  C08F218/04 ,  C08F218/08 ,  G02B1/04 ,  C08F32/00

    CPC分类号： G02B1/043 ,  C08F218/04 ,  C08F8/44 ,  C08J5/18 ,  C08F2810/50

    摘要： Novel, non-crosslinked copolymers of vinyl trifluoroacetate (VTA) and up to 5 weight percent of the VTA of certain comonomers, such as vinyl esters or disubstituted ethylene monomers, are disclosed. Solvolysis of these copolymers provides novel water-insoluble, non-crosslinked, poly(vinyl alcohol) copolymers which can be hydrated to copolymers having controllably variable hydrogel properties and high strength. Such poly(vinyl alcohol) copolymers are particularly desirable as optical devices such as contact lenses.

    摘要翻译： 公开了三乙酸乙烯酯（VTA）和高达5重量％的VTA某些共聚单体如乙烯基酯或二取代的乙烯单体的新型非交联共聚物。 这些共聚物的溶剂分解提供了新的水不溶性，非交联的聚（乙烯醇）共聚物，其可以水合成具有可控制的可变水凝胶性质和高强度的共聚物。 作为诸如隐形眼镜的光学装置，这种聚（乙烯醇）共聚物是特别理想的。

    Bioactive agent release coating and controlled humidity method
    8.
    发明授权
    Bioactive agent release coating and controlled humidity method 有权
    生物活性剂释放涂层和受控湿度法

    公开(公告)号：US07833548B2

    公开(公告)日：2010-11-16

    申请号：US11207380

    申请日：2005-08-19

    申请人： Ralph A. Chappa ,  Robert W. Hergenrother ,  Aron B. Anderson ,  Linh V. Tran ,  Laurie R. Lawin ,  Ronald F. Ofstead

    发明人： Ralph A. Chappa ,  Robert W. Hergenrother ,  Aron B. Anderson ,  Linh V. Tran ,  Laurie R. Lawin ,  Ronald F. Ofstead

    IPC分类号： A61K9/14

    CPC分类号： A61L31/16 ,  A61L29/085 ,  A61L29/16 ,  A61L31/10 ,  A61L2300/602 ,  A61L2300/606

    摘要： A coating composition in the form of a one or multi-part system, and method of applying such a composition under conditions of controlled humidity, for use in coating device surfaces to control and/or improve their ability to release bioactive agents in aqueous systems. The coating composition is particularly adapted for use with medical devices that undergo significant flexion and/or expansion in the course of their delivery and/or use, such as stents and catheters. The composition includes the bioactive agent in combination with a first polymer component such as polyalkyl(meth)acrylate, polyaryl(meth)acrylate, polyaralkyl(meth)acrylate, or polyaryloxyalkyl(meth)acrylate and a second polymer component such as poly(ethylene-co-vinyl acetate).

    摘要翻译： 一种或多种制剂形式的涂料组合物，以及在受控湿度条件下施用这种组合物的方法，用于涂覆装置表面以控制和/或提高其在水性体系中释放生物活性剂的能力。 涂料组合物特别适用于在其递送和/或使用过程中经历显着弯曲和/或膨胀的医疗装置，例如支架和导管。 组合物包括与第一聚合物组分如（甲基）丙烯酸聚烷基酯，（甲基）丙烯酸聚芳酯，（甲基）丙烯酸聚烷基酯或（甲基）丙烯酰基烷基酯）和第二聚合物组分如聚（乙烯 - 共 - 乙酸乙烯酯）。