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公开(公告)号：US20220277441A1
公开(公告)日：2022-09-01
申请号：US17637480
申请日：2020-08-31
Applicant: LEICA MICROSYSTEMS CMS GMBH
Inventor： Falk SCHLAUDRAFF , Markus SCHECHTER , Frank SIECKMANN , Oliver SCHLICKER
Abstract: An image processing apparatus for determining a focused output image in a passive autofocus system is configured to retrieve a set of input images and compute a baseline estimate for at least one input image. The baseline estimate represents image structures in the input image. The image structures have a length scale larger than a predetermined image feature length scale. The image processing apparatus is further configured to compute a set of output images, wherein each output image of the set of output images is computed based on one of a different input image of the set of input images and the at least one baseline estimate for the different input image and the at least one baseline estimate for a respective different input image. The image processing apparatus is further configured to determine one output image of the set of output images as the focused output image.
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2.发明公开公开(公告)号：US20240280798A1
公开(公告)日：2024-08-22
申请号：US18443399
申请日：2024-02-16
Applicant: LEICA MICROSYSTEMS CMS GMBH
Inventor： Falk SCHLAUDRAFF , Sam STEBLAU , Eugen NORDHEIMER , Bernd WIDZGOWSKI
CPC classification number: G02B21/365 , H04N23/76 , H04N23/81
Abstract: An apparatus for data processing for a digital imaging device is provided. The digital imaging device is configured to generate a digital image of a recording region by reading out, raster-element-by-raster-element, a multidimensional complete raster. The complete raster includes a plurality of raster elements. The apparatus is part of a control unit of the imaging device or is configured to be controllable by the control unit of the imaging device. The apparatus is configured to process raw image data from at least one sub-region of the complete raster that has already been read out during the reading out, generate processed image data in at least one processing step as a function of the raw image data, and make the processed image data available for display for access from outside the apparatus.
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3.发明申请LASER MICRODISSECTION SYSTEM AND EXAMINATION METHOD FOR SAMPLES CONTAINING NUCLEIC ACID 有权激光微观检测系统和含有核酸的样品检测方法公开(公告)号：US20160370315A1
公开(公告)日：2016-12-22
申请号：US14901727
申请日：2014-07-01
Applicant: LEICA MICROSYSTEMS CMS GMBH
Inventor： Falk SCHLAUDRAFF
IPC: G01N27/447 , G02B21/18 , G02B21/00 , G01N1/28
CPC classification number: G01N27/44721 , C12N15/1003 , G01N1/2813 , G01N1/286 , G01N27/44743 , G01N27/44782 , G01N2001/284 , G01N2001/2886 , G02B21/0016 , G02B21/0028 , G02B21/0048 , G02B21/18 , G02B21/26 , G02B21/32
Abstract: A laser microdissection includes a microscope having an incident-light device, a microscope objective, and a laser unit operable to produce a laser beam having a beam path extending through the incident-light device and through the microscope objective and intersecting an object plane of the microscope objective at an adjustable intersection point. The laser microdissection systems further includes an electrophoresis unit located below the object plane and containing an electrophoresis gel including one or more gel pockets, and a positioning device operable to position the electrophoresis gel in parallel with the object plane of the microscope objective and relative to a defined reference position such that dissectates of a sample that can be arranged in the object plane can be collected in the one or more gel pockets. The electrophoresis unit is operable to be attached by a coupling device. The dissectates are obtained via the laser beam.
Abstract translation: 激光显微切割包括具有入射光装置的显微镜，显微镜物镜和可操作以产生具有延伸穿过入射光装置的光束路径并通过显微镜物镜并与物镜平面相交的激光束的激光单元 显微镜物镜在可调交点。 激光显微解剖系统还包括位于物平面下方并含有包含一个或多个凝胶袋的电泳凝胶的电泳单元，以及可操作以将电泳凝胶与显微镜物镜的物平面相对定位的定位装置， 定义的参考位置，使得可以布置在物平面中的样品的解剖可以被收集在一个或多个凝胶袋中。 电泳单元可操作以通过联接装置附接。 解剖通过激光束获得。
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公开(公告)号：US20230296483A1
公开(公告)日：2023-09-21
申请号：US18178573
申请日：2023-03-06
Applicant: LEICA MICROSYSTEMS CMS GMBH
Inventor： Falk SCHLAUDRAFF
IPC: G01N1/30 , G01N33/483 , G01N1/31
CPC classification number: G01N1/30 , G01N33/4833 , G01N1/312 , G01N2001/305 , G01N2001/317
Abstract: A method includes applying a liquid cover to a microscopic sample to obtain a processed microscopic sample, generating at least one marker for a part of the processed microscopic sample using an imaging system, removing at least a part of the liquid cover from the processed microscopic sample to obtain an uncovered microscopic sample, and extracting a part of the uncovered microscopic sample, based on the at least one marker, to obtain an extracted part.
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公开(公告)号：US20230161146A1
公开(公告)日：2023-05-25
申请号：US17909451
申请日：2021-03-15
Applicant: LEICA MICROSYSTEMS CMS GMBH
Inventor： Falk SCHLAUDRAFF
CPC classification number: G02B21/367 , G02B21/0004 , G06V40/12 , G01N2035/00821
Abstract: A device for examining microscope specimens includes a microscope, wherein the microscope specimens include an object to be examined by the microscope and a specimen carrier holding the object, and wherein the device is configured to calculate a digital identification code of the microscope specimen by fingerprinting the microscope specimen using at least one optical marker in at least one digital image of at least a part of the object.
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Patent Agency Ranking
公开(公告)号：US20200309648A1
公开(公告)日：2020-10-01
申请号：US16310825
申请日：2017-06-27
Applicant: LEICA MICROSYSTEMS CMS GMBH
Inventor： Falk SCHLAUDRAFF , Andrew K. LEE
Abstract: A method for performing a laser microdissection for cutting a dissectate from a specimen using a laser includes the step of providing the specimen in a light path of an illumination system. The specimen is illuminated by the illumination system. A detector detects light emanating from the specimen. The light detected by the detector is analyzed. It is determined, based on the analysis of the light detected by the detector, whether a receptacle for collecting the dissectate is disposed in a predetermined collection position, at which the dissectate is to be collected in the receptacle after it is cut from the specimen. Laser cutting of the dissectate from the specimen is initiated based on it having been determined that the receptacle is in the predetermined collection position.
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公开(公告)号：US20240393244A1
公开(公告)日：2024-11-28
申请号：US18673388
申请日：2024-05-24
Applicant: Leica Microsystems CMS GmbH
Inventor： Falk SCHLAUDRAFF , Oliver SCHLICKER , Soeren ALSHEIMER
Abstract: A method for generating at least a first control area for a biological analysis includes depositing on a surface a solution comprising a first control analyte in order to generate the first control area. A system is configured to carry out the method. A method is also provided for analysing a biological sample including at least one first target analyte.
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公开(公告)号：US20240004179A1
公开(公告)日：2024-01-04
申请号：US18337098
申请日：2023-06-19
Applicant: LEICA MICROSYSTEMS CMS GMBH
Inventor： Falk SCHLAUDRAFF , Florian HOFFMANN
CPC classification number: G02B21/32 , G02B21/008 , G02B21/0036 , G02B21/0032
Abstract: A sample manipulation device includes a manipulation light source configured to emit manipulation light, an objective configured to focus the manipulating light onto the sample to form a manipulation light beam, a scanning unit configured to move the manipulation light beam within a field of view of the objective, a sample positioning unit configured to move the sample relative to an optical axis of the objective, and a controller configured to receive manipulation data comprising at least one manipulation path, upon determining that the manipulation path is entirely outside the predetermined area, control the manipulation light source and the scanning unit such that the sample is manipulated along the manipulation path, and upon determining that at least a part of the manipulation path is inside the predetermined area, control the sample positioning unit to move the sample such that the manipulation path is entirely outside the predetermined area.
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公开(公告)号：US20220411842A1
公开(公告)日：2022-12-29
申请号：US17844780
申请日：2022-06-21
Applicant: LEICA MICROSYSTEMS CMS GMBH
Inventor： Falk SCHLAUDRAFF
IPC: C12P19/34 , C12Q1/6844 , C12Q1/6874 , C12Q1/6853
Abstract: A method for generating region-specific amplification templates of a biological sample includes adding first oligonucleotide constructs and second oligonucleotide constructs to the biological sample. Each first or second oligonucleotide construct comprises a first or a second photoremovable cage molecule. The method further includes synthesising a complementary first strand from a template bound to target binding regions of each first oligonucleotide construct or each second oligonucleotide construct, scanning a first region of interest of the biological sample with a first focused light beam and a second region of interest of the biological sample with a second focused light beam to form uncaged first oligonucleotide constructs in the first region of interest and uncaged second oligonucleotide constructs in the second region of interest, synthesising a complementary second strand to form first amplification templates originating from the first region of interest and second amplification templates originating from the second region of interest.
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公开(公告)号：US20220136936A1
公开(公告)日：2022-05-05
申请号：US17424521
申请日：2020-01-23
Applicant: LEICA MICROSYSTEMS CMS GMBH
Inventor： Florian HOFFMANN , Falk SCHLAUDRAFF
Abstract: A method for laser microdissection includes: processing a microscopic examination object by a laser beam using tuples of coordinate values which respectively indicate positions of target points on the examination object at least in a first spatial direction and a second spatial direction orthogonal to the first spatial direction, positions of at least three reference points being ascertained beforehand in each case in the first and second spatial directions and also in a third spatial direction orthogonal to the first and second spatial directions; defining a reference plane based on the positions of the reference points; and determining, for the target points, further coordinate values indicating an expected position of the target points on the examination object in the third spatial direction in each case, as determined further coordinate values, the determining of the further coordinate values being performed depending on the defined reference plane.
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