公开(公告)号：US20180180864A1

公开(公告)日：2018-06-28

申请号：US15566729

申请日：2016-04-18

Applicant: LEICA MICROSYSTEMS CMS GMBH

Inventor： Werner KNEBEL ,  Frank SIECKMANN ,  Florian FAHRBACH

IPC: G02B21/00 ,  G02B21/24 ,  G02B21/18

CPC classification number: G02B21/006 ,  G02B21/0032 ,  G02B21/18 ,  G02B21/248 ,  G02B21/367

Abstract: A method for analyzing a microscopic sample with a microscope includes illuminating at least a sub-region of the microscopic sample by illumination light. Detection light emanating from the microscopic sample is guided on a detection beam path, which includes at least one focusing optical element and which has a plurality of detection beam path branches, each with at least one detector element. The detector elements are parts of the same surface detector. By art adjusting element in at least a first one of the detection beam path branches, an optical path length of the first detection beam path branch is adjusted in such a way that the portion of the detection light guided on the first detection beam path branch is focused on the detector element of the first detection beam path branch.

公开(公告)号：US20150338625A1

公开(公告)日：2015-11-26

申请号：US14410263

申请日：2013-06-20

Applicant: Leica Microsystems CMS GmbH

Inventor： Frank SIECKMANN ,  Stefan HUBER

IPC: G02B21/00

CPC classification number: G02B21/008 ,  G02B21/00 ,  G02B21/002

Abstract: A microscope for investigating a microscopic sample is disclosed, the microscope comprising a receiving apparatus that furnishes primary signals which contain at least one information item regarding at least one property of the sample, and the microscope comprising an output apparatus that generates, from the primary signals, secondary signals perceptible by the user. Provision is made that the output apparatus furnishes secondary signals perceptible auditorily and/or perceptible olfactorily and/or perceptible gustatorily and/or perceptible tactilely and/or perceptible by thermoreception; and/or that the microscope comprises a feedback apparatus with which the user can control the receiving apparatus in real time during the sensing of information regarding at least one property of the sample.

Abstract translation: 公开了一种用于研究微观样品的显微镜，显微镜包括接收装置，其提供关于样品的至少一个性质的至少一个信息项的主信号，并且显微镜包括输出装置，其从主信号 ，用户可以看到的次要信号。 规定，输出设备可以通过热观察来触觉地和/或可感觉地感知地感觉到和/或可感知的嗅觉和/或可感知的气味和/或可感知的辅助信号; 和/或显微镜包括反馈装置，用户可以在感测关于样本的至少一个属性的信息的过程中实时地控制接收装置。

公开(公告)号：US20220011867A1

公开(公告)日：2022-01-13

申请号：US17305335

申请日：2021-07-06

Applicant: Leica Microsystems CMS GmbH

Inventor： Frank SIECKMANN

IPC: G06F3/01 ,  G06F3/039 ,  G06F3/0354 ,  G06F3/0488 ,  G02B21/36

Abstract: An auxiliary appliance for a user interface device having a touch sensitive screen includes at least one haptic control element configured to be manually operated by a user. An attachment portion is configured to be attached to the user interface device such that the haptic control element is superimposed on the touch sensitive screen of the user interface device in a predetermined screen area where a touch control element is provided on the touch sensitive screen. The touch control element is operable by touching the touch sensitive screen in the predetermined screen area. The haptic control element comprises a touch portion configured to touch the touch sensitive screen in the predetermined screen area to operate the touch control element in response to a manual user operation of the haptic control element in a state in which the attachment portion is attached to the user interface device.

公开(公告)号：US20180149851A1

公开(公告)日：2018-05-31

申请号：US15566728

申请日：2016-04-18

Applicant: LEICA MICROSYSTEMS CMS GMBH

Inventor： Werner KNEBEL ,  Frank SIECKMANN ,  Florian FAHRBACH

IPC: G02B21/18 ,  G02B21/36 ,  G02B21/00 ,  G01N21/47

CPC classification number: G02B21/18 ,  G01N21/47 ,  G02B21/0052 ,  G02B21/0064 ,  G02B21/06 ,  G02B21/10 ,  G02B21/362 ,  G02B21/367

Abstract: A method for single plane illumination microscopy (SPIM) analysis of a sample includes simultaneously illuminating multiple sample layers by a single sheet of light. Detection light emanating from the individual sample layers is detected at different times and/or at different positions in a detection beam path. The detection beam path is branched using beam splitters and an effective refractive power of the individual beam splitters is zero.

公开(公告)号：US20160153892A1

公开(公告)日：2016-06-02

申请号：US14899157

申请日：2014-06-18

Applicant: Leica Microsystems CMS GmbH

Inventor： Werner KNEBEL ,  Wernher FOUQUET ,  Frank SIECKMANN

IPC: G01N21/13 ,  G02B21/26 ,  G02B21/00 ,  G02B21/06

CPC classification number: G01N21/13 ,  G01N2021/135 ,  G02B21/0024 ,  G02B21/0032 ,  G02B21/0076 ,  G02B21/06 ,  G02B21/26 ,  G02B21/34 ,  G02B21/367

Abstract: The invention relates to a method for microscopic investigation of a plurality of samples. The method contains the step of arranging the samples in a sample holder that is movable, in particular in motorized and/or automatic fashion, relative to a sample illumination position in such a way that at least one of the samples is respectively successively positionable in the sample illumination position, a clearance for a deflection means respectively remaining adjacent to the sample that is currently located in the sample illumination position; the step of focusing a light stripe with an illumination objective; the step of deflecting the light stripe, once it has passed through the illumination objective, with the deflection means in such a way that the light stripe propagates at an angle different from zero degrees with respect to the optical axis of the illumination objective and has a focus in the sample illumination position; and the step of successively positioning the samples, retained with the sample holder, in the sample illumination position, and detecting the detected light emerging from the sample respectively located in the sample illumination position. The invention furthermore relates to an optical apparatus having a sample holder that holds a plurality of samples and is supported movably, in particular in motorized and/or automatic fashion, relative to a sample illumination position in such a way that at least one of the samples is respectively successively positionable in the sample illumination position.

Abstract translation: 本发明涉及一种用于多个样品的微观研究的方法。 该方法包括将样品布置在样品保持器中，该样品保持器相对于样品照射位置，特别是以电动和/或自动的方式是可移动的，使得至少一个样品分别可连续定位在 样本照明位置，分别保持与当前位于样本照明位置的样本相邻的偏转装置的间隙; 将光条与照明物体对焦的步骤; 一旦透过照明物镜，偏转装置以使光条以相对于照明物镜的光轴为零度的角度传播的方式偏转光条的步骤，并且具有 聚焦在样品照明位置; 以及将样本保持器保留的样本连续定位在样本照射位置的步骤，以及检测从分别位于样本照明位置的样品出射的检测到的光。 本发明还涉及一种光学装置，其具有保持多个样品的样品保持器，并且以相对于样品照射位置可移动地尤其以机动和/或自动的方式被支撑，使得至少一个样品 分别连续定位在样本照明位置。

公开(公告)号：US20210342569A1

公开(公告)日：2021-11-04

申请号：US17285478

申请日：2019-09-25

Applicant: LEICA MICROSYSTEMS CMS GMBH

Inventor： Frank SIECKMANN ,  Constantin KAPPEL

IPC: G06K9/00 ,  G06K9/62 ,  G06N20/00 ,  G06N5/04

Abstract: An apparatus for optimizing workflows of one or more microscopes and/or microscope systems includes one or more processors and one or more computer-readable storage media. The one or more computer-readable storage media have stored therein computer-executable instructions, which, when executed by the one or more processors cause execution of the following steps: implementing, by one or more components of the one or more microscopes and/or microscope systems, a workflow comprising a capture of first data; applying one or more trained models to the captured first data; and making at least one decision in relation to the workflow based on the application of the one or more trained models to the captured first data.

公开(公告)号：US20200379230A1

公开(公告)日：2020-12-03

申请号：US16884069

申请日：2020-05-27

Applicant: Leica Microsystems CMS GmbH

Inventor： Frank SIECKMANN

IPC: G02B21/06 ,  G02B21/26

Abstract: An optical setup for a microscope includes a first optical arrangement having a first optical axis and facing a sample volume from a first side of the sample volume, and a second optical arrangement having a second optical axis and facing the sample volume from a second side of the sample volume, the first side of the sample volume lying opposite the second side of the sample volume. The first optical axis and the second optical axis pass through the sample volume. The first optical axis and the second optical axis are disposed in nonparallel fashion with respect to one another in the sample volume.

公开(公告)号：US20160320301A1

公开(公告)日：2016-11-03

申请号：US15104997

申请日：2014-12-17

Applicant: LEICA MICROSYSTEMS CMS GMBH

Inventor： Werner KNEBEL ,  Wernher FOUQUET ,  Frank SIECKMANN

IPC: G01N21/59 ,  G01N21/64 ,  G02B21/00 ,  G01N21/47

Abstract: The invention relates to a method for tomographic investigation of a sample (9), in which method a sample (9) is illuminated with an illuminating light bundle (3) and in which a transmitted light bundle (10) that contains the light of the illuminating light bundle (3) transmitted through the sample (9) is detected with a transmission detector (13). The invention further relates to an apparatus for tomographic investigation of a sample (9). Provision is made that the illuminating light bundle (3) and the transmitted light bundle (10) pass in opposite propagation directions through the same objective (7).

Abstract translation: 本发明涉及一种用于样品（9）的断层摄影研究的方法，其中样品（9）用照明光束（3）照射，并且其中包含所述样品（9）的光的透射光束（10） 用透射检测器（13）检测通过样品（9）透射的照明光束（3）。 本发明还涉及一种用于样品（9）的层析成像研究的装置。 设置照明光束（3）和透射光束（10）通过相同的物镜（7）在相反的传播方向上通过。

公开(公告)号：US20240142933A1

公开(公告)日：2024-05-02

申请号：US18279632

申请日：2022-02-24

Applicant: LEICA MICROSYSTEMS CMS GMBH

Inventor： Frank SIECKMANN

IPC: G05B19/042

CPC classification number: G05B19/0426 ,  G05B2219/25084

Abstract: A device for providing functionalities includes at least one storage unit providing a first parameter set and a second parameter set. The first parameter set indicates which functionalities are to be made available by the device to other devices. The second parameter set indicates which functionalities are to be made available by the other devices to the device. The device further includes a communication interface configured to obtain a third parameter set from a second device. The third parameter set indicates which functionalities are to be made available by the second device. The device further includes a processing unit configured to compare the third parameter set with the second parameter set, to select one or more functionalities made available by the second device for use, and to establish a payload connection with the second device if at least one functionality has been selected for use.

公开(公告)号：US20220277441A1

公开(公告)日：2022-09-01

申请号：US17637480

申请日：2020-08-31

Applicant: LEICA MICROSYSTEMS CMS GMBH

Inventor： Falk SCHLAUDRAFF ,  Markus SCHECHTER ,  Frank SIECKMANN ,  Oliver SCHLICKER

IPC: G06T7/00 ,  G06F17/15 ,  G06T5/00 ,  G06F17/13 ,  G06V10/42

Abstract: An image processing apparatus for determining a focused output image in a passive autofocus system is configured to retrieve a set of input images and compute a baseline estimate for at least one input image. The baseline estimate represents image structures in the input image. The image structures have a length scale larger than a predetermined image feature length scale. The image processing apparatus is further configured to compute a set of output images, wherein each output image of the set of output images is computed based on one of a different input image of the set of input images and the at least one baseline estimate for the different input image and the at least one baseline estimate for a respective different input image. The image processing apparatus is further configured to determine one output image of the set of output images as the focused output image.