公开(公告)号：US07507837B2

公开(公告)日：2009-03-24

申请号：US11295847

申请日：2005-12-07

申请人： Kevin D. Moeller ,  Eden Tesfu ,  Karl Maurer

发明人： Kevin D. Moeller ,  Eden Tesfu ,  Karl Maurer

IPC分类号： C07D311/08

CPC分类号： G01N33/54353

摘要： There is disclosed a process for performing an isolated Pd(II) mediated oxidation reaction electrochemically. The inventive process is performed on an electrode array device having a plurality of separately addressable electrodes. Preferably, the Pd(II) mediated oxidation is a Wacker reaction. Specifically, there is disclosed a process for conducting an isolated Pd(II) mediated oxidation on a plurality of electrodes, comprising providing an electrode array device having a plurality of electrodes with a conductive electrode surface and a matrix or coating material over the electrodes surfaces; providing a solution bathing the electrode array matrix or coating material and electrode surfaces, wherein the solution comprises a transition metal species and a confining agent; and biasing one or a plurality of electrodes (“selected electrode or electrodes”) with a voltage or current to regenerate the transition metal species required for the isolated Pd(II) mediated oxidation, whereby the confining agent limits diffusion of the transition metal species to a volume surrounding each selected electrode surface.

摘要翻译： 公开了一种用电化学方法进行分离的Pd（II）介导的氧化反应的方法。 本发明的方法在具有多个单独可寻址电极的电极阵列器件上进行。 优选地，Pd（II）介导的氧化是Wacker反应。 具体地，公开了在多个电极上进行分离的Pd（II）介导的氧化的方法，其特征在于，在所述电极表面上设置具有导电电极表面的多个电极和基体或涂层材料的电极阵列器件; 提供洗涤电极阵列基质或涂层材料和电极表面的溶液，其中所述溶液包含过渡金属物质和约束剂; 并用电压或电流偏压一个或多个电极（“所选择的电极或电极”）以再生分离的Pd（II）介导的氧化所需的过渡金属物质，由此限制剂限制过渡金属物质的扩散 围绕每个所选电极表面的体积。

公开(公告)号：US20060151335A1

公开(公告)日：2006-07-13

申请号：US11326717

申请日：2006-01-07

申请人： Jun Tian ,  Karl Maurer ,  Kevin Moeller ,  Eden Tesfu

发明人： Jun Tian ,  Karl Maurer ,  Kevin Moeller ,  Eden Tesfu

IPC分类号： C25B1/00

CPC分类号： C25B11/02 ,  B01J19/0046 ,  B01J2219/00527 ,  B01J2219/00585 ,  B01J2219/00596 ,  B01J2219/00599 ,  B01J2219/00653 ,  B01J2219/00659 ,  B01J2219/00713 ,  B01J2219/0072 ,  B01J2219/0075 ,  C25B3/00 ,  C25B11/04 ,  Y02P20/584

摘要： There is disclosed a process for performing an isolated Pd(0) catalyzed reaction electrochemically on an electrode array device. Preferably the Pd(0) catalyzed reaction is a Heck reaction. Specifically, there is disclosed a process for conducting an isolated Pd(0) catalyzed reaction on a plurality of electrodes, comprising providing an electrode array device having a matrix or coating material over metallic or conductive electrodes surfaces and a plurality of electrodes; providing a solution bathing the electrode array device, wherein the solution comprises a transition metal catalyst and a confining agent; and biasing one or a plurality of electrodes on the electrode array device with a voltage or current to regenerate the transition metal catalyst required for the isolated Pd(0) catalyzed reaction, whereby the confining agent limits diffusion of the transition metal catalyst to a volume surrounding each selected electrode surface.

摘要翻译： 公开了一种在电极阵列器件上进行电化学分离的Pd（O）催化反应的方法。 优选地，Pd（O）催化的反应是Heck反应。 具体地，公开了在多个电极上进行分离的Pd（O）催化反应的方法，其包括在金属或导电电极表面和多个电极上提供具有基体或涂层材料的电极阵列器件; 提供洗涤电极阵列器件的溶液，其中所述溶液包含过渡金属催化剂和限制剂; 并用电压或电流对电极阵列器件上的一个或多个电极进行偏置以再生分离的Pd（0）催化反应所需的过渡金属催化剂，由此限制剂限制过渡金属催化剂扩散到周围的体积 每个选择的电极表面。

公开(公告)号：US20060205959A1

公开(公告)日：2006-09-14

申请号：US11295847

申请日：2005-12-07

申请人： Kevin Moeller ,  Eden Tesfu ,  Karl Maurer

发明人： Kevin Moeller ,  Eden Tesfu ,  Karl Maurer

IPC分类号： C07D311/00

CPC分类号： G01N33/54353

摘要： There is disclosed a process for performing an isolated Pd(II) mediated oxidation reaction electrochemically. The inventive process is performed on an electrode array device having a plurality of separately addressable electrodes. Preferably, the Pd(II) mediated oxidation is a Wacker reaction. Specifically, there is disclosed a process for conducting an isolated Pd(II) mediated oxidation on a plurality of electrodes, comprising providing an electrode array device having a plurality of electrodes with a conductive electrode surface and a matrix or coating material over the electrodes surfaces; providing a solution bathing the electrode array matrix or coating material and electrode surfaces, wherein the solution comprises a transition metal species and a confining agent; and biasing one or a plurality of electrodes (“selected electrode or electrodes”) with a voltage or current to regenerate the transition metal species required for the isolated Pd(II) mediated oxidation, whereby the confining agent limits diffusion of the transition metal species to a volume surrounding each selected electrode surface.

公开(公告)号：US20060189166A1

公开(公告)日：2006-08-24

申请号：US11063402

申请日：2005-02-22

申请人： Eden Tesfu ,  Karl Maurer ,  Kevin Moeller

发明人： Eden Tesfu ,  Karl Maurer ,  Kevin Moeller

IPC分类号： H01L21/31

CPC分类号： G01N33/54353

摘要： There is disclosed a process for performing an isolated Pd(II) mediated oxidation reaction electrochemically. The inventive process is performed on an electrode array device having a plurality of separately addressable electrodes. Preferably, the Pd(II) mediated oxidation is a Wacker reaction. Specifically, there is disclosed a process for conducting an isolated Pd(II) mediated oxidation on a plurality of electrodes, comprising providing an electrode array device having a plurality of electrodes with a conductive electrode surface and a matrix or coating material over the electrodes surfaces; providing a solution bathing the electrode array matrix or coating material and electrode surfaces, wherein the solution comprises a transition metal species and a confining agent; and biasing one or a plurality of electrodes (“selected electrode or electrodes”) with a voltage or current to regenerate the transition metal species required for the isolated Pd(II) mediated oxidation, whereby the confining agent limits diffusion of the transition metal species to a volume surrounding each selected electrode surface.

公开(公告)号：US20090124517A1

公开(公告)日：2009-05-14

申请号：US11985386

申请日：2007-11-14

申请人： Melissae Stuart ,  Karl Maurer ,  Kevin D. Moeller

发明人： Melissae Stuart ,  Karl Maurer ,  Kevin D. Moeller

IPC分类号： C40B40/10 ,  C40B50/18 ,  C40B40/00 ,  C40B40/04

CPC分类号： C40B60/08 ,  B01J19/0046 ,  B01J2219/00527 ,  B01J2219/00576 ,  B01J2219/00596 ,  B01J2219/00605 ,  B01J2219/00626 ,  B01J2219/00637 ,  B01J2219/00639 ,  B01J2219/00644 ,  B01J2219/00653 ,  B01J2219/00659 ,  B01J2219/00713 ,  B01J2219/0072 ,  B01J2219/00725 ,  C40B50/18

摘要： A microarray and a process for making the microarray having a library of chemical compounds are disclosed herein. Each member of the library is attached at a known location. The microarray has a plurality of addressable electrodes and a porous reaction layer attached to each electrode. The porous reaction layer has reactive hydroxyl groups. Michael acceptors are attached to the porous reaction layer of selected electrodes. The Michael acceptors are attached at the hydroxyl groups using electrochemically-generated base that is generated by the selected electrodes and confined to the selected electrodes with the use of excess activated ester. At least one of a plurality of chemical compounds from a library of compounds is attached to the olefin of the plurality of Michael acceptors. Attachment occurs only at the selected electrodes having Michael acceptors with unreacted olefin. Each member of the library of compounds is attached to the known locations.

摘要翻译： 本文公开了微阵列和用于制备具有化学化合物文库的微阵列的方法。 图书馆的每个成员都附在一个已知的位置。 微阵列具有多个可寻址电极和连接到每个电极的多孔反应层。 多孔反应层具有反应性羟基。 迈克尔受体附着在选定电极的多孔反应层上。 使用由所选择的电极产生并使用过量的活化酯限制在所选择的电极上的电化学生成的碱，迈克尔受体与羟基连接。 来自化合物文库的多种化合物中的至少一种与多个迈克尔受体的烯烃连接。 附着仅在具有具有未反应烯烃的迈克尔受体的选定电极处发生。 化合物库的每个成员都连接到已知的位置。

公开(公告)号：US20070034513A1

公开(公告)日：2007-02-15

申请号：US11090096

申请日：2005-03-25

申请人： Karl Maurer ,  John Cooper ,  Michael Strathmann

发明人： Karl Maurer ,  John Cooper ,  Michael Strathmann

IPC分类号： C12Q1/68

CPC分类号： C25B3/00 ,  B01J19/0046 ,  B01J2219/00653 ,  C07B41/02 ,  C07B41/06 ,  C07C50/00 ,  C07C309/30 ,  C07D213/16 ,  C07H21/02 ,  C07H21/04 ,  C25B3/02 ,  C25B3/04 ,  C25B3/10 ,  Y02P20/55

摘要： There is disclosed an electrochemical deblocking solution for use on an electrode microarray. There is further disclosed a method for electrochemical synthesis on an electrode array using the electrochemical deblocking solution. The solution and method are for removing acid-labile protecting groups for synthesis of oligonucleotides, peptides, small molecules, or polymers on a microarray of electrodes while substantially improving isolation of deblocking to active electrodes. The method comprises applying a voltage or a current to at least one electrode of an array of electrodes. The array of electrodes is covered by the electrochemical deblocking solution.

摘要翻译： 公开了一种用于电极微阵列的电化学去块解决方案。 还公开了使用电化学去块溶液在电极阵列上进行电化学合成的方法。 该解决方案和方法是用于在电极的微阵列上除去用于合成寡核苷酸，肽，小分子或聚合物的酸不稳定保护基团，同时基本上改善了去活化对活性电极的分离。 该方法包括向电极阵列的至少一个电极施加电压或电流。 电极阵列被电化学去块溶液覆盖。

公开(公告)号：US07075187B1

公开(公告)日：2006-07-11

申请号：US10008547

申请日：2001-11-09

申请人： Karl Maurer

发明人： Karl Maurer

IPC分类号： H01L23/28 ,  H01L23/29

CPC分类号： H01L23/293 ,  H01L23/3171 ,  H01L2924/0002 ,  Y10S438/958 ,  H01L2924/00

摘要： There is disclosed a coating material formulation for layering a plurality of electrodes to provide a substrate for the electrochemical synthesis of organic oligomers. Specifically, there is disclosed a coating layer of from about 0.5 to about 100 microns thick and is composed of a mixture of controlled porosity glass (CPG) particles having an average particle size of from about 0.25 to about 25 microns, and a thickening agent.

摘要翻译： 公开了一种用于层叠多个电极以提供用于电化学合成有机低聚物的基底的涂料配方。 具体地，公开了约0.5至约100微米厚的涂层，并且由平均粒径为约0.25至约25微米的受控多孔玻璃（CPG）颗粒和增稠剂的混合物组成。

公开(公告)号：US20060102471A1

公开(公告)日：2006-05-18

申请号：US10992252

申请日：2004-11-18

申请人： Karl Maurer ,  John Cooper ,  Michael Strathmann ,  Andrei Gindilis

发明人： Karl Maurer ,  John Cooper ,  Michael Strathmann ,  Andrei Gindilis

IPC分类号： B23H3/04 ,  B08B6/00 ,  C23F1/00

CPC分类号： B01J19/0046 ,  B01J2219/00596 ,  B01J2219/00605 ,  B01J2219/00612 ,  B01J2219/00617 ,  B01J2219/00621 ,  B01J2219/00626 ,  B01J2219/00628 ,  B01J2219/00637 ,  B01J2219/00641 ,  B01J2219/00653 ,  B01J2219/00659 ,  B01J2219/00722 ,  B01J2219/00725 ,  B08B3/08 ,  C23C26/00 ,  C23F4/00 ,  C25F1/00 ,  C25F7/00

摘要： There is disclosed an electrode array device having an adsorbed porous reaction layer for improved synthesis quality. The array comprises a plurality of electrodes on a substrate, wherein the electrodes are electronically connected to a computer control system. The array has an adsorbed porous reaction layer on the plurality of electrodes, wherein the adsorbed porous reaction layer comprises a chemical species having at least one hydroxyl group. In the preferred embodiment, the reaction layer is sucrose. A method for preparing an electrode array for improved synthesis quality is disclosed. The method comprises a cleaning method and a method of attachment of a reaction layer. The cleaning method comprises a plasma cleaning method and a chemical cleaning method. The reaction layer is attached after cleaning by exposing the microarray to a solution containing the chemical species having at least one hydroxyl group.

摘要翻译： 公开了具有吸附的多孔反应层的电极阵列器件，以提高合成质量。 阵列包括在基底上的多个电极，其中电极电连接到计算机控制系统。 阵列在多个电极上具有吸附的多孔反应层，其中吸附的多孔反应层包含具有至少一个羟基的化学物质。 在优选的实施方案中，反应层是蔗糖。 公开了一种制备电极阵列以提高合成质量的方法。 该方法包括清洁方法和连接反应层的方法。 清洗方法包括等离子体清洗方法和化学清洗方法。 通过将微阵列暴露于含有具有至少一个羟基的化学物质的溶液，将反应层附着在清洁之后。

公开(公告)号：US5970626A

公开(公告)日：1999-10-26

申请号：US008008

申请日：1998-01-16

申请人： Manfred Schmidt ,  Karl Maurer ,  Gerhard Lehn ,  Friedrich Bahner ,  Klaus Hentschel ,  Karl-Friedrich Lang

发明人： Manfred Schmidt ,  Karl Maurer ,  Gerhard Lehn ,  Friedrich Bahner ,  Klaus Hentschel ,  Karl-Friedrich Lang

IPC分类号： F26B13/10 ,  F26B15/12 ,  F26B21/02 ,  F26B9/00

CPC分类号： F26B13/10 ,  F26B15/12 ,  F26B21/028

摘要： A drier for broad articles such as plasterboard has a conveyor in entraining the plasterboard along a drying path in a transport plane and the nozzle boxes for contacting the plasterboard with the drying air have their orifice surfaces inclined to the plasterboard to achieve uniformity of drying in terms of residual moisture content.

摘要翻译： 用于广泛物品如石膏板的干燥器具有沿输送平面中的干燥路径夹带石膏板的输送机，并且用于使石膏板与干燥空气接触的喷嘴箱的孔口表面倾斜于石膏板以实现干燥的均匀性 的残留水分含量。

公开(公告)号：US09394167B2

公开(公告)日：2016-07-19

申请号：US11108078

申请日：2005-04-15

申请人： Karl Maurer ,  John J. Cooper, Jr. ,  H. Sho Fujii ,  Joseph Leonetti

发明人： Karl Maurer ,  John J. Cooper, Jr. ,  H. Sho Fujii ,  Joseph Leonetti

IPC分类号： B01J19/00 ,  C25B11/02 ,  B82Y30/00 ,  C25B3/10

CPC分类号： B01J19/0046 ,  B01J2219/00527 ,  B01J2219/00529 ,  B01J2219/00576 ,  B01J2219/00585 ,  B01J2219/00596 ,  B01J2219/00641 ,  B01J2219/00653 ,  B01J2219/00659 ,  B01J2219/00675 ,  B01J2219/00713 ,  B01J2219/00722 ,  B01J2219/00725 ,  B01J2219/00731 ,  B01J2219/00736 ,  B82Y30/00 ,  C25B3/10 ,  C25B9/06 ,  C25B11/02

摘要： There is disclosed an electrode array architecture employing continuous and discontinuous circumferential electrodes. There is further disclosed a process for the neutralization of acid generated at anode(s) by base generated at cathode(s) circumferentially located to each other so as to confine a region of pH change. The cathodes can be displayed as concentric rings (continuous) or as counter electrodes in a cross pattern (discontinuous). In this way reagents, such as acid, generated in a center electrode are countered (neutralized) by reagents, such as base, generated at the corners or at the outer ring.