公开(公告)号：US20070034513A1

公开(公告)日：2007-02-15

申请号：US11090096

申请日：2005-03-25

Applicant: Karl Maurer ,  John Cooper ,  Michael Strathmann

Inventor： Karl Maurer ,  John Cooper ,  Michael Strathmann

IPC: C12Q1/68

CPC classification number: C25B3/00 ,  B01J19/0046 ,  B01J2219/00653 ,  C07B41/02 ,  C07B41/06 ,  C07C50/00 ,  C07C309/30 ,  C07D213/16 ,  C07H21/02 ,  C07H21/04 ,  C25B3/02 ,  C25B3/04 ,  C25B3/10 ,  Y02P20/55

Abstract: There is disclosed an electrochemical deblocking solution for use on an electrode microarray. There is further disclosed a method for electrochemical synthesis on an electrode array using the electrochemical deblocking solution. The solution and method are for removing acid-labile protecting groups for synthesis of oligonucleotides, peptides, small molecules, or polymers on a microarray of electrodes while substantially improving isolation of deblocking to active electrodes. The method comprises applying a voltage or a current to at least one electrode of an array of electrodes. The array of electrodes is covered by the electrochemical deblocking solution.

Abstract translation: 公开了一种用于电极微阵列的电化学去块解决方案。 还公开了使用电化学去块溶液在电极阵列上进行电化学合成的方法。 该解决方案和方法是用于在电极的微阵列上除去用于合成寡核苷酸，肽，小分子或聚合物的酸不稳定保护基团，同时基本上改善了去活化对活性电极的分离。 该方法包括向电极阵列的至少一个电极施加电压或电流。 电极阵列被电化学去块溶液覆盖。

公开(公告)号：US20060102471A1

公开(公告)日：2006-05-18

申请号：US10992252

申请日：2004-11-18

Applicant: Karl Maurer ,  John Cooper ,  Michael Strathmann ,  Andrei Gindilis

Inventor： Karl Maurer ,  John Cooper ,  Michael Strathmann ,  Andrei Gindilis

IPC: B23H3/04 ,  B08B6/00 ,  C23F1/00

CPC classification number: B01J19/0046 ,  B01J2219/00596 ,  B01J2219/00605 ,  B01J2219/00612 ,  B01J2219/00617 ,  B01J2219/00621 ,  B01J2219/00626 ,  B01J2219/00628 ,  B01J2219/00637 ,  B01J2219/00641 ,  B01J2219/00653 ,  B01J2219/00659 ,  B01J2219/00722 ,  B01J2219/00725 ,  B08B3/08 ,  C23C26/00 ,  C23F4/00 ,  C25F1/00 ,  C25F7/00

Abstract: There is disclosed an electrode array device having an adsorbed porous reaction layer for improved synthesis quality. The array comprises a plurality of electrodes on a substrate, wherein the electrodes are electronically connected to a computer control system. The array has an adsorbed porous reaction layer on the plurality of electrodes, wherein the adsorbed porous reaction layer comprises a chemical species having at least one hydroxyl group. In the preferred embodiment, the reaction layer is sucrose. A method for preparing an electrode array for improved synthesis quality is disclosed. The method comprises a cleaning method and a method of attachment of a reaction layer. The cleaning method comprises a plasma cleaning method and a chemical cleaning method. The reaction layer is attached after cleaning by exposing the microarray to a solution containing the chemical species having at least one hydroxyl group.

Abstract translation: 公开了具有吸附的多孔反应层的电极阵列器件，以提高合成质量。 阵列包括在基底上的多个电极，其中电极电连接到计算机控制系统。 阵列在多个电极上具有吸附的多孔反应层，其中吸附的多孔反应层包含具有至少一个羟基的化学物质。 在优选的实施方案中，反应层是蔗糖。 公开了一种制备电极阵列以提高合成质量的方法。 该方法包括清洁方法和连接反应层的方法。 清洗方法包括等离子体清洗方法和化学清洗方法。 通过将微阵列暴露于含有具有至少一个羟基的化学物质的溶液，将反应层附着在清洁之后。

公开(公告)号：US20070224613A1

公开(公告)日：2007-09-27

申请号：US11676302

申请日：2007-02-18

Applicant: Michael Strathmann

Inventor： Michael Strathmann

IPC: C12Q1/68

CPC classification number: C12Q1/6869 ,  C12Q2563/179 ,  C12Q2537/143

Abstract: The present invention provides multiplexed methods for analyzing polynucleotides associated with sample tags. The multiplexed information is deconvoluted by single-molecule and more generally single-particle detection methods. In particular, a method for determining nucleic acid sequence information is provided.

Abstract translation: 本发明提供了用于分析与样品标签相关的多核苷酸的多重方法。 多重信息通过单分子和更一般的单粒子检测方法去卷积。 特别地，提供了确定核酸序列信息的方法。

公开(公告)号：US5681068A

公开(公告)日：1997-10-28

申请号：US639278

申请日：1996-04-25

Applicant: Frank Kleefeldt ,  Michael Strathmann ,  Gerhard Zimmermann

Inventor： Frank Kleefeldt ,  Michael Strathmann ,  Gerhard Zimmermann

IPC: E05B13/00 ,  E05B53/00 ,  E05B65/19 ,  E05B65/20 ,  E05B3/00

CPC classification number: E05B83/36 ,  E05B13/005 ,  E05B79/20 ,  E05B85/12 ,  E05B85/13 ,  E05B77/265 ,  E05B77/30 ,  E05B83/16 ,  Y10S292/31 ,  Y10T292/57

Abstract: A motor-vehicle door latch having an element settable in locked, unlocked, and open positions, has an actuating assembly having a pivot defining a pivot axis remote from the latch. An inside locking lever mounted on the pivot has an outer end to one side of the pivot and an inner end to the opposite side of the pivot and a bowden cable is connected between the outer end and the latch element and connects the latch element with the inside lever for joint pivoting between the locked, unlocked, and open positions. An inside actuating lever is mounted on the pivot coaxial with the locking lever. A coupling between the levers is displaceable between a coupling position for displacing the locking lever and bowden cable and thereby setting the element in the open position on pivoting of the actuating lever and a decoupling position for pivoting of the actuating lever without pivoting of the locking lever.

Abstract translation: 具有可设置在锁定，解锁和打开位置的元件的机动车门闩具有致动组件，该致动组件具有限定远离闩锁的枢轴的枢轴。 安装在枢轴上的内侧锁定杆具有位于枢轴的一侧的外端和枢轴的相反侧的内端，并且弓形缆线连接在外端和闩锁元件之间，并将闩锁元件与 内部杠杆，用于锁定，解锁和打开位置之间的关节枢转。 内部致动杆安装在与锁定杆同轴的枢轴上。 杠杆之间的联接件可在用于移动锁定杆和弓形缆索的联接位置之间移位，从而在致动杆的枢转时将元件设置在打开位置，以及用于枢转致动杆而不使锁定杆枢转的解耦位置 。

公开(公告)号：US6085558A

公开(公告)日：2000-07-11

申请号：US307489

申请日：1999-05-10

Applicant: Michael Strathmann

Inventor： Michael Strathmann

IPC: E05B9/08 ,  E05B17/00 ,  E05B17/04 ,  E05B83/36

CPC classification number: E05B83/36 ,  E05B17/04 ,  E05B9/084 ,  E05B17/0012 ,  Y10T292/0957 ,  Y10T292/1091 ,  Y10T70/5518 ,  Y10T70/5889 ,  Y10T70/7655 ,  Y10T70/7706 ,  Y10T70/7712

Abstract: A motor-vehicle latch assembly has a door latch displaceable between a locked and unlocked position, a housing forming a seat, a lever pivoted on the housing, and a linkage connected between the lever and the door latch for displacement of the latch between its positions by the lever. A lock cylinder can fit in the seat and with the lever and interengaging formations on the lever, housing, and cylinder retain the lever in a predetermined angular position on the housing except when the cylinder is fitted in the seat. The housing is centered on an axis and has an elastically deformable and axially rearwardly projecting tongue having a radially inwardly directed ramp surface. The lever projects radially from the housing and is formed with a radially outwardly open notch receiving the tongue in a predetermined angular position of the lever on the housing. The lock cylinder engages the ramp surface when fitted fully in the seat to deflect the tongue radially outward out of the notch so that until the cylinder is fitted to the seat the lever is prevented from rotating.

Abstract translation: 机动车辆闩锁组件具有可在锁定和解锁位置之间移动的门闩，形成座椅的壳体，枢转在壳体上的杠杆以及连接在杠杆和门闩之间的连杆，用于使闩锁在其位置之间移位 通过杠杆。 锁定缸可以装配在座椅中，并且杠杆和相互接合的构件在杠杆，壳体和气缸上将锁定杆保持在壳体上的预定角度位置，除非当气缸安装在座椅中时。 外壳以轴为中心，并具有可弹性变形且轴向向后突出的舌片，具有径向向内的斜面。 杠杆从壳体径向突出并且形成有径向向外开口的凹口，其将杠杆接合在壳体上的杠杆的预定角度位置。 当完全安装在座椅中时，锁定圆筒与斜面接合，以使舌头径向向外偏离凹口，使得直到气缸装配到座位上，才能防止杠杆旋转。

公开(公告)号：US06234548B1

公开(公告)日：2001-05-22

申请号：US09430260

申请日：1999-10-29

Applicant: Stephan Mittelbach ,  Michael Strathmann ,  Stefan Uecker

Inventor： Stephan Mittelbach ,  Michael Strathmann ,  Stefan Uecker

IPC: E05B300

CPC classification number: E05B85/16 ,  E05B79/06 ,  Y10S292/53 ,  Y10T292/57 ,  Y10T292/85

Abstract: A motor-vehicle door-latch handle assembly has a mounting plate, an elongated handle having a rear end pivoted in the mounting plate and a front end formed with a horizontally and transversely projecting actuation arm having a hook end. The handle is pivotal on the plate between an inner position with the front end resting against the door and an outer position with the front end pulled horizontally out of the door. A coupling element is pivoted on the door about a horizontal axis and has one radially projecting coupling arm engageable with the hook end of the handle, another radially projecting coupling arm, and a radially projecting abutment formation. A link extends vertically between the other coupling arm and the latch so that when the handle is displaced into the outer position the element is pivoted and the link is displaced vertically to actuate the latch. A spring rotationally urges the coupling element such that the one coupling arm bears on the hook end and biases the handle into the inner position. A lever pivotal on the plate has one lever arm movable into and out of a blocking position angularly engaging the abutment formation and blocking rotation of the coupling element and inward movement of the one coupling arm and another lever arm. A holding pin displaceable on the door is engageable with the other lever arm for displacing the one lever arm into the freeing position.

Abstract translation: 机动车门闩锁手柄组件具有安装板，细长手柄具有枢转在安装板中的后端，前端形成有具有钩端的水平和横向突出的致动臂。 手柄在板之间枢转，内部位置与前端抵靠门之间，外部位置与前端水平地拉出门外。 耦合元件在门上围绕水平轴线枢转并且具有可与手柄的钩端接合的一个径向突出的联接臂，另一个径向突出的联接臂和径向突出的邻接结构。 连杆在另一个连接臂和闩锁之间垂直延伸，使得当手柄移动到外部位置时，元件枢转并且连杆垂直移位以致动闩锁。 弹簧旋转地推动联接元件，使得一个联接臂承载在钩端上并将把手偏压到内部位置。 在板上枢转的杠杆具有一个杠杆臂，其能够进入和离开与该邻接构件成角度地接合的阻挡位置并阻止联接元件的旋转并且一个联接臂和另一个杠杆臂的向内运动。 可移动到门上的保持销可与另一个杠杆臂接合，以将一个杠杆臂移动到释放位置。

公开(公告)号：US5997055A

公开(公告)日：1999-12-07

申请号：US281180

申请日：1999-03-30

Applicant: Michael Strathmann

Inventor： Michael Strathmann

IPC: E05B17/04 ,  E05B53/00 ,  E05B65/12 ,  E05B65/20 ,  E05C3/06

CPC classification number: E05B81/06 ,  E05B77/28 ,  E05B81/16 ,  E05B81/38 ,  E05B53/008 ,  Y10S292/27 ,  Y10S292/62 ,  Y10T292/1079 ,  Y10T292/1082 ,  Y10T70/65 ,  Y10T70/7107

Abstract: A motor-vehicle door latch has a latching element movable between a latched position retaining a door bolt and an unlatched position releasing the door bolt, and a locking pawl engageable with the element and displaceable between a locked position retaining the latching element and an unlocked position freeing the element. A planetary-gear drive has a reversible electric motor, a sun gear rotatable by the motor, a planet carrier, at least one planet gear meshing with the sun gear and carried on the carrier, and a ring gear meshing with the planet gear. A locking lever is displaceable by a locking element and by the planet carrier between a locked position and an unlocked position and a coupling element is displaceable between a coupling position engaged between the locking pawl and locking lever for coupling the locking pawl and lever together. An antitheft element is displaceable by the ring gear between an antitheft-on position engageable with the coupling element and retaining same in the uncoupling position and an antitheft-off position. Structure coupled to the antitheft element arrests the planet carrier in the antitheft-on position of the antitheft element. A releasable coupling is provided between the antitheft element and the ring gear for joint movement of the antitheft element and ring gear. The locking lever coupled to the antitheft element displaces of the antitheft element from the antitheft-on position to the antitheft-off position by the locking lever when the locking lever is actuated with sufficient force to release the coupling.

Abstract translation: 机动车门闩具有可在保持门螺栓的闩锁位置和释放门螺栓的解锁位置之间移动的闩锁元件，以及可与该元件接合并可在保持闩锁元件的锁定位置和解锁位置之间移位的锁定爪 释放元素 行星齿轮传动装置具有可逆电动机，可由电动机旋转的太阳齿轮，行星架，至少一个与太阳齿轮啮合并承载在行星架上的行星齿轮，以及与行星齿轮啮合的齿圈。 锁定杆可通过锁定元件和行星架在锁定位置和解锁位置之间移动，并且联接元件可在接合在锁定爪和锁定杆之间的联接位置之间移动，以将锁定爪和杠杆联接在一起。 防盗元件可以通过环形齿轮在可与联接元件接合的防盗位置位置之间移动，并将其保持在解耦位置和防盗位置。 耦合到防盗元件的结构将行星架停止在防盗元件的防盗位置。 在防盗元件和环形齿轮之间设置有可拆卸的联轴器，用于防盗元件和环形齿轮的关节运动。 当锁定杆以足够的力致动以释放联接器时，联锁到防盗元件的锁定杆通过锁定杆将防盗元件从防盗位置移动到防盗位置。

公开(公告)号：US5921595A

公开(公告)日：1999-07-13

申请号：US933687

申请日：1997-09-19

Applicant: Horst Brackmann ,  Michael Strathmann

Inventor： Horst Brackmann ,  Michael Strathmann

IPC: E05B13/00 ,  E05B53/00 ,  E05B65/20 ,  E05C3/06

CPC classification number: E05B83/36 ,  E05B79/20 ,  E05B13/005 ,  E05B77/30 ,  E05B85/10 ,  Y10S292/23 ,  Y10T292/1047 ,  Y10T292/1082

Abstract: A motor-vehicle door latch has a housing, a latching fork pivotal on the housing, and a release pawl pivotal on the housing between a latched position retaining the fork in a latched position engaged around a bolt and securing a motor-vehicle door closed and an unlatched position in which the fork can release the bolt and allow the door to open. An inside door handle can move between a center rest position, an end open position, and an end lock position. A bowden cable has a sheath fixed to the housing and a core having a pair of ends one of which is attached to the handle for displacement of another end of the core jointly with the door handle. A locking lever can pivot between a locked position and an unlocked position. A first actuating lever pivotal on the locking lever offset from its axis has one end connected to the other end of the cable core and an opposite end and a second actuating lever pivotal on the housing between an actuated and an unactuated position has a formation engageable with the opposite end of the actuating lever only in the unlocked position of the locking lever. Mechanism between the second actuating lever and the pawl displaces the pawl into the unlatched position on displacement of the second actuating lever into the actuated position.

Abstract translation: 机动车门闩具有壳体，在壳体上枢转的闭锁叉和在壳体上枢转的释放爪，该释放爪位于锁定位置处，该闩锁位置将叉保持在锁定位置，并且将机动车门闭合并且 解锁位置，其中叉可以释放螺栓并允许门打开。 内门把手可以在中心静止位置，端部打开位置和端部锁定位置之间移动。 弓形电缆具有固定到壳体的护套和具有一对端部的芯部，其中一个端部附接到手柄，用于与门把手一起移动芯部的另一端。 锁定杆可以在锁定位置和解锁位置之间枢转。 枢转在锁定杆上的第一致动杆从其轴线偏移，其一端连接到电缆芯的另一端，并且在致动和未致动位置之间在壳体上枢转的相对端和第二致动杆具有可与 驱动杆的相对端仅在锁定杆的解锁位置。 当第二致动杆移动到致动位置时，第二致动杠杆和棘爪之间的机构将棘爪移动到解锁位置。

公开(公告)号：US09109380B2

公开(公告)日：2015-08-18

申请号：US13583704

申请日：2011-01-14

Applicant: Stephan Mittelbach ,  Rolf Siemensmeyer ,  Dirk Eichel ,  Michael Strathmann

Inventor： Stephan Mittelbach ,  Rolf Siemensmeyer ,  Dirk Eichel ,  Michael Strathmann

IPC: E05C3/06 ,  E05B77/06

CPC classification number: E05B77/06 ,  Y10T292/1078

Abstract: A motor vehicle door lock is provided with a catch with an actuating-lever mechanism which acts on the catch. There is also a locking lever which, together with the actuating lever, renders the actuating-lever mechanism inactive when accelerating forces of predetermined magnitude occur, for example in the event of a crash. The actuating lever and locking lever disable the actuating-lever mechanism mechanically, as a result of the accelerating forces occurring, by associated deflection. Following dissipation of the accelerating forces, the actuating lever and locking lever reconnect the actuating-lever mechanism.

Abstract translation: 机动车门锁具有一个带有作用在捕捉器上的致动杠杆机构的卡扣。 还有一个锁定杆，其与致动杆一起使致动杆机构在例如在发生碰撞的情况下发生预定大小的加速的力时使其不起作用。 致动杆和锁定杆通过相关的偏转由于加速力的机械而机械地禁用致动杆机构。 在消散加速力之后，致动杆和锁定杆重新连接致动杆机构。

公开(公告)号：US20080105541A1

公开(公告)日：2008-05-08

申请号：US11863097

申请日：2007-09-27

Applicant: Michael Strathmann

Inventor： Michael Strathmann

IPC: B23H3/04 ,  B05D5/00 ,  B08B7/00

CPC classification number: B01J19/0046 ,  B01J2219/00596 ,  B01J2219/00605 ,  B01J2219/00612 ,  B01J2219/00617 ,  B01J2219/00621 ,  B01J2219/00626 ,  B01J2219/00628 ,  B01J2219/00637 ,  B01J2219/00641 ,  B01J2219/00653 ,  B01J2219/00659 ,  B01J2219/00722 ,  B01J2219/00725 ,  B08B3/08 ,  C23C26/00 ,  C23F4/00 ,  C25F1/00 ,  C25F7/00

Abstract: There is disclosed an electrode array device having an adsorbed porous reaction layer for improved synthesis quality. The array comprises a plurality of electrodes on a substrate, wherein the electrodes are electronically connected to a computer control system. The array has an adsorbed porous reaction layer on the plurality of electrodes, wherein the adsorbed porous reaction layer comprises a chemical species having at least one hydroxyl group. In the preferred embodiment, the reaction layer is sucrose. A method for preparing an electrode array for improved synthesis quality is disclosed. The method comprises a cleaning method and a method of attachment of a reaction layer. The cleaning method comprises a plasma cleaning method and a chemical cleaning method. The reaction layer is attached after cleaning by exposing the microarray to a solution containing the chemical species having at least one hydroxyl group.

Abstract translation: 公开了具有吸附的多孔反应层的电极阵列器件，以提高合成质量。 阵列包括在基底上的多个电极，其中电极电连接到计算机控制系统。 阵列在多个电极上具有吸附的多孔反应层，其中吸附的多孔反应层包含具有至少一个羟基的化学物质。 在优选的实施方案中，反应层是蔗糖。 公开了一种制备电极阵列以提高合成质量的方法。 该方法包括清洁方法和连接反应层的方法。 清洗方法包括等离子体清洗方法和化学清洗方法。 通过将微阵列暴露于含有具有至少一个羟基的化学物质的溶液，将反应层附着在清洁之后。