公开(公告)号：US20070215502A1

公开(公告)日：2007-09-20

申请号：US11675755

申请日：2007-02-16

申请人： Kenneth Babcock ,  James Coffey

发明人： Kenneth Babcock ,  James Coffey

IPC分类号： B65D85/04 ,  B65H49/08

CPC分类号： B65H55/046 ,  Y10T29/49826

摘要： An adapter for inserting into a carton containing a non-reel coil of filamentary material or wire has a shaft-receiving sleeve supported by a box structure. The adapter's structure has top, front, bottom and back walls reinforced by side gussets. The underside of the top wall, the interior of the back wall, and the top of the bottom wall of the adapter define a channel. The channel is oriented such that it may receive a shaft or rod of a wire pulling rack. The adapter may be assembled from a blank of foldable material. The adapter blank may be manufactured as a detachable element of a carton blank which is also used to construct a carton to hold a non-reel coil of filamentary material.

摘要翻译： 用于插入包含丝线材料或线材的非卷轴线圈的纸板的适配器具有由盒结构支撑的轴接收套筒。 适配器的结构具有通过侧面角撑板加强的顶部，前部，底部和后部壁。 顶壁的下侧，后壁的内部和适配器的底壁的顶部限定了通道。 通道定向成使得其可以接收导线架的轴或杆。 适配器可以由可折叠材料的坯料组装。 适配器坯件可以制造成纸箱坯件的可拆卸元件，其也用于构造纸箱以保持非卷轴盘管的丝状材料。

公开(公告)号：US20070075171A1

公开(公告)日：2007-04-05

申请号：US11375727

申请日：2006-03-15

申请人： Kenneth Babcock ,  James Coffey

发明人： Kenneth Babcock ,  James Coffey

IPC分类号： B65H55/00

CPC分类号： B65H55/046 ,  Y10T29/49826

摘要： An adapter for inserting into a carton containing a non-reel coil of filamentary material or wire has a shaft-receiving sleeve supported by a box structure. The adapter's box structure has top and back walls joined at right angles and reinforced by side walls. Knobs extend outwardly from the side walls and have openings therethrough. Ribs on the underside of the top wall define a channel which is aligned with the openings in the knobs. The ribs, top wall and knobs define a sleeve which is oriented such that it may receive a shaft or rod of a wire pulling rack. Alternatively, said adapter having a box structure with walls only in two perpendicular planes. At least two of said walls forming a channel extending outwardly that may receive a shaft or rod.

摘要翻译： 用于插入包含丝线材料或线材的非卷轴线圈的纸板的适配器具有由盒结构支撑的轴接收套筒。 适配器的盒子结构具有直角连接的顶壁和后壁，并由侧壁加强。 旋钮从侧壁向外延伸并具有穿过其中的开口。 在顶壁的下侧上的肋限定了与旋钮中的开口对准的通道。 肋，顶壁和旋钮限定了套筒，其被定向成使得其可以容纳拉线架的轴或杆。 或者，所述适配器具有仅具有两个垂直平面的壁的盒结构。 至少两个所述壁形成向外延伸的通道，其可以接收轴或杆。

公开(公告)号：US09027388B2

公开(公告)日：2015-05-12

申请号：US13310776

申请日：2011-12-04

申请人： Kenneth Babcock ,  Thomas Burg ,  Michel Godin ,  Scott Manalis

发明人： Kenneth Babcock ,  Thomas Burg ,  Michel Godin ,  Scott Manalis

IPC分类号： G01N15/00 ,  G01N5/00 ,  G01N9/00 ,  G01N15/10 ,  G01N15/02

CPC分类号： G01N15/00 ,  G01N5/00 ,  G01N9/002 ,  G01N15/0255 ,  G01N15/10 ,  G01N15/1012 ,  G01N2015/003 ,  G01N2015/1043 ,  G01N2015/1087

摘要： Method for measuring a target particle property. A suspended microchannel resonator is calibrated to determine the relationship between a detected mass and a resonance frequency shift of the resonator. The target particle is suspended in a fluid and introduced into the resonator, and the resonator frequency shift due to the particle is measured. Target particle mass is calculated from the resonator frequency shift, the target particle density, and the fluid density. A target particle property such as size or volume is determined from the calculated target particle mass.

摘要翻译： 测量目标粒子性质的方法。 校准悬浮微通道谐振器以确定检测到的质量和谐振器的谐振频率偏移之间的关系。 目标颗粒悬浮在流体中并被引入到谐振器中，并且测量由于颗粒引起的谐振器频率偏移。 目标粒子质量由共振器频率偏移，目标粒子密度和流体密度计算。 从计算出的目标粒子质量确定目标粒子性质如尺寸或体积。

公开(公告)号：US08722419B2

公开(公告)日：2014-05-13

申请号：US12305733

申请日：2007-06-15

申请人： Scott R. Manalis ,  Thomas P. Burg ,  Michel Godin ,  Kenneth Babcock

发明人： Scott R. Manalis ,  Thomas P. Burg ,  Michel Godin ,  Kenneth Babcock

IPC分类号： G01N24/00 ,  G01N33/543 ,  G01N35/08 ,  G01N31/00

CPC分类号： G01N33/56966 ,  C12Q1/04 ,  G01N2015/1413 ,  G01N2015/1486 ,  G01N2333/70514 ,  Y10T436/101666 ,  Y10T436/117497 ,  Y10T436/24

摘要： Mass cytometry method. In one aspect, the method includes providing a sample having at least one cell type and mixing the sample with material such as nanoparticles functionalized with affinity molecules for the at least one cell type. The sample is transported through a suspended microchannel resonator to record a mass histogram and a cell count for the at least one cell type is determined from the histogram.

摘要翻译： 质谱法 在一个方面，该方法包括提供具有至少一种细胞类型的样品，并将样品与诸如用于至少一种细胞类型的亲和分子官能化的纳米粒子的材料混合。 样品通过悬浮的微通道谐振器传输以记录质量直方图，并且从直方图确定至少一种细胞类型的细胞计数。

公开(公告)号：US20120174657A1

公开(公告)日：2012-07-12

申请号：US13348809

申请日：2012-01-12

申请人： Kenneth Babcock ,  Scott R. Manalis

发明人： Kenneth Babcock ,  Scott R. Manalis

IPC分类号： G01N29/00

CPC分类号： G01N29/036 ,  G01N29/022 ,  G01N2291/0256 ,  G01N2291/0427

摘要： Methods for improving measurements of bacterial growth, such as mass, in Suspended Microchannel Resonators (SMR's). Methods include techniques to provide for bacterial growth over time in response to changing fluid environment to aid in determining parameters such as drug resistance and drug susceptibility. In particular the methods include trapping multiple bacteria in the SMR for a time period and varying the fluid to include sequences of nutrients and antibiotics, and measuring the rate of mass change of the bacteria in response to the changes in fluid composition.

摘要翻译： 用于改善悬浮微通道谐振器（SMR）中细菌生长测量的方法，如质量。 方法包括随着时间的推移提供细菌生长以响应于改变的流体环境以帮助确定诸如耐药性和药物敏感性的参数的技术。 特别地，所述方法包括在SMR中捕获多种细菌一段时间并且改变流体以包括营养物和抗生素的序列，以及响应于流体组成的变化来测量细菌的质量变化速率。

公开(公告)号：US20100227310A1

公开(公告)日：2010-09-09

申请号：US12305733

申请日：2007-06-15

申请人： Scott Manalis ,  Thomas Burg ,  Kenneth Babcock ,  Michel Godin

发明人： Scott Manalis ,  Thomas Burg ,  Kenneth Babcock ,  Michel Godin

IPC分类号： C12Q1/70 ,  C12Q1/06 ,  G01N33/53 ,  G01N33/569 ,  G01N31/00

CPC分类号： G01N33/56966 ,  C12Q1/04 ,  G01N2015/1413 ,  G01N2015/1486 ,  G01N2333/70514 ,  Y10T436/101666 ,  Y10T436/117497 ,  Y10T436/24

摘要： Mass cytometry method. In one aspect, the method includes providing a sample having at least one cell type and mixing the sample with material such as nanoparticles functionalized with affinity molecules for the at least one cell type. The sample is transported through a suspended microchannel resonator to record a mass histogram and a cell count for the at least one cell type is determined from the histogram.

摘要翻译： 质谱法 在一个方面，该方法包括提供具有至少一种细胞类型的样品，并将样品与诸如用于至少一种细胞类型的亲和分子官能化的纳米粒子的材料混合。 样品通过悬浮的微通道谐振器传输以记录质量直方图，并且从直方图确定至少一种细胞类型的细胞计数。

公开(公告)号：US20090044608A1

公开(公告)日：2009-02-19

申请号：US12087495

申请日：2007-10-11

申请人： Kenneth Babcock ,  Thomas Burg ,  Michel Godin ,  Scott Manalis

发明人： Kenneth Babcock ,  Thomas Burg ,  Michel Godin ,  Scott Manalis

IPC分类号： G01N29/22

CPC分类号： G01N15/00 ,  G01N5/00 ,  G01N9/002 ,  G01N15/0255 ,  G01N15/10 ,  G01N15/1012 ,  G01N2015/003 ,  G01N2015/1043 ,  G01N2015/1087

摘要： Method for measuring a target particle property. A suspended microchannel resonator is calibrated to determine the relationship between a detected mass and a resonance frequency shift of the resonator. The target particle is suspended in a fluid and introduced into the resonator, and the resonator frequency shift due to the particle is measured. Target particle mass is calculated from the resonator frequency shift, the target particle density, and the fluid density. A target particle property such as size or volume is determined from the calculated target particle mass.

摘要翻译： 测量目标粒子性质的方法。 校准悬浮微通道谐振器以确定检测到的质量和谐振器的谐振频率偏移之间的关系。 目标颗粒悬浮在流体中并被引入到谐振器中，并且测量由于颗粒引起的谐振器频率偏移。 目标粒子质量由共振器频率偏移，目标粒子密度和流体密度计算。 从计算出的目标粒子质量确定目标粒子性质如尺寸或体积。

公开(公告)号：US20050145021A1

公开(公告)日：2005-07-07

申请号：US11075019

申请日：2005-03-08

申请人： Ami Chand ,  Kevin Kjoller ,  Kenneth Babcock ,  Michael Harris

发明人： Ami Chand ,  Kevin Kjoller ,  Kenneth Babcock ,  Michael Harris

IPC分类号： G01B11/00 ,  G01B5/28 ,  G01B21/30 ,  G01D5/26 ,  G01Q10/02 ,  G01Q10/04 ,  G01Q10/06 ,  G01Q30/20 ,  G01Q60/00 ,  G01Q70/02 ,  G01Q70/08 ,  G01Q70/16 ,  G01Q80/00 ,  G01Q90/00 ,  G12B21/20 ,  G01N13/10

CPC分类号： G01Q70/16 ,  G01B5/28 ,  G01D5/26 ,  G01Q10/02 ,  G01Q10/04 ,  G01Q10/06 ,  G01Q70/02 ,  G01Q70/08 ,  G01Q80/00

摘要： A method and apparatus for manipulating the surface of a sample including a cantilever, a first tip mounted on the cantilever, and a second tip mounted on the cantilever, the first and the second tip being configured to combine to form an imaging probe and to separate to form a manipulation probe. The first and second tips are configured to form a first position characterized in that the tips combine to form an imaging tip and the first and the second tip are configured to form a second position characterized in that the tips separate to manipulate particles on a surface of a sample. The tips can be configured to form the first position when a voltage is applied across the tips, and preferable extend downwardly from the cantilever substantially perpendicular thereto.

摘要翻译： 一种用于操纵样品表面的方法和装置，包括悬臂，安装在悬臂上的第一尖端和安装在悬臂上的第二尖端，第一和第二尖端构造成组合以形成成像探针并分离 以形成操纵探针。 第一和第二尖端被配置成形成第一位置，其特征在于，所述尖端组合以形成成像尖端，并且所述第一和第二末端被配置成形成第二位置，其特征在于，所述尖端分离以操纵颗粒在 一个样品。 当跨越尖端施加电压时，尖端可被配置成形成第一位置，并且优选地从基本垂直于其的悬臂向下延伸。

公开(公告)号：US20050121615A1

公开(公告)日：2005-06-09

申请号：US10975792

申请日：2004-10-28

申请人： Craig Prater ,  Charles Meyer ,  Chanmin Su ,  James Massie ,  Kenneth Babcock ,  Mary Turner

发明人： Craig Prater ,  Charles Meyer ,  Chanmin Su ,  James Massie ,  Kenneth Babcock ,  Mary Turner

IPC分类号： G01N9/00 ,  G01Q70/00 ,  G02B7/182 ,  G01N21/35

CPC分类号： G02B7/1821 ,  G01N9/002 ,  G01N2291/0427

摘要： An integrated cantilever sensor array system that accurately detects and measures the presence of target substances in various environmental conditions. The integrated cantilever sensor array system comprises a cantilever sensor measurement head, a cantilever sensor system for measuring the oscillatory properties of the cantilevers and a measurement chamber. The measurement head includes a cantilever array having at least one cantilever, a light source and a detector positioned to detect incoming light reflected by the cantilevers within the cantilever array. The cantilever sensor system measures the oscillatory properties generated by the cantilevers within the cantilever array. The system includes the cantilever array and a detection system that measures a signal related to the bending of the cantilever. In addition, optional components such as a high frequency clock, Q-Control, may be added to more accurately measure the oscillation of the cantilevers within the cantilever array. The measurement chamber includes a flow cell, a cantilever sensor array mounted within the flow cell. The flow cell is designed to minimize dead volume and unwanted air bubbles within the cell, which may reduce accuracy of measurement.

摘要翻译： 集成的悬臂传感器阵列系统，能够准确地检测和测量各种环境条件下目标物质的存在。 集成的悬臂传感器阵列系统包括悬臂传感器测量头，用于测量悬臂的振荡特性的悬臂传感器系统和测量室。 测量头包括悬臂阵列，其具有至少一个悬臂，光源和检测器，定位成检测由悬臂阵列内的悬臂反射的入射光。 悬臂传感器系统测量由悬臂阵列内的悬臂产生的振荡特性。 该系统包括悬臂阵列和测量与悬臂弯曲有关的信号的检测系统。 此外，可以添加诸如高频时钟Q-Control等可选组件以更准确地测量悬臂阵列内的悬臂的振荡。 测量室包括流动池，安装在流动池内的悬臂传感器阵列。 流动池被设计成使细胞内的死体积和不需要的气泡最小化，这可能降低测量精度。

公开(公告)号：US09581569B2

公开(公告)日：2017-02-28

申请号：US13348809

申请日：2012-01-12

申请人： Kenneth Babcock ,  Scott R. Manalis

发明人： Kenneth Babcock ,  Scott R. Manalis

IPC分类号： G01N29/036 ,  G01N29/02

CPC分类号： G01N29/036 ,  G01N29/022 ,  G01N2291/0256 ,  G01N2291/0427

摘要： Methods for improving measurements of bacterial growth, such as mass, in Suspended Microchannel Resonators (SMR's). Methods include techniques to provide for bacterial growth over time in response to changing fluid environment to aid in determining parameters such as drug resistance and drug susceptibility. In particular the methods include trapping multiple bacteria in the SMR for a time period and varying the fluid to include sequences of nutrients and antibiotics, and measuring the rate of mass change of the bacteria in response to the changes in fluid composition.

摘要翻译： 用于改善悬浮微通道谐振器（SMR）中细菌生长测量的方法，如质量。 方法包括随着时间的推移提供细菌生长以响应于改变的流体环境以帮助确定诸如耐药性和药物敏感性的参数的技术。 特别地，所述方法包括在SMR中捕获多种细菌一段时间并且改变流体以包括营养物和抗生素的序列，以及响应于流体组成的变化来测量细菌的质量变化速率。