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    Polypeptide binding to extracellular domain of epidermal growth factor receptor
    4.
    发明授权
    Polypeptide binding to extracellular domain of epidermal growth factor receptor 有权

    公开(公告)号：US10364293B2

    公开(公告)日：2019-07-30

    申请号：US15310585

    申请日：2015-05-21

    Applicant: KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY

    Inventor： Hak-Sung Kim ,  Joong-Jae Lee

    IPC: C07K14/46 ,  C07K14/71 ,  C12N15/62 ,  C07K14/195 ,  C12P21/02 ,  C07K16/30 ,  C07K19/00

    Abstract: The present invention relates to a polypeptide capable of binding specifically to the extracellular domain of epidermal growth factor receptor, a polynucleotide that encodes the polypeptide, an expression vector comprising the polynucleotide, a recombinant microorganism having the expression vector introduced therein, and a method of producing the polypeptide using the recombinant microorganism. The polypeptide according to the present invention can bind to the extracellular domain of epidermal growth factor receptor with a high binding affinity comparable to those of existing monoclonal antibodies that are widely used as targeted therapeutic agents, thereby inhibiting the activity of the epidermal growth factor receptor. The polypeptide is useful for the development of agents for the prevention or diseases associated with overexpression of epidermal growth factor receptor.

    Polypeptide for binding to complement protein C5A, and use of same
    5.
    发明授权
    Polypeptide for binding to complement protein C5A, and use of same 有权

    公开(公告)号：US10287342B2

    公开(公告)日：2019-05-14

    申请号：US15500921

    申请日：2015-08-03

    Applicant: Korea Advanced Institute of Science and Technology

    Inventor： Hak-Sung Kim ,  Da Eun Hwang ,  Jung-Min Choi ,  Joong-Jae Lee ,  Woosung Heu

    IPC: A61K39/00 ,  A61K39/02 ,  C07H21/04 ,  C07K16/18 ,  C12N15/62 ,  C07K14/725 ,  C07K14/34 ,  A61K38/00

    Abstract: The present invention relates to novel polypeptide for binding to a complement protein C5a. More particularly, the present invention relates to polypeptide which can be bound to a complement protein C5a and inhibit the activation of same, polynucleotide which codes for the polypeptide, a recombinant vector which comprises the polynucleotide, a recombinant microorganism to which the recombinant vector has been introduced, a method for producing the polypeptide by means of the recombinant microorganism, and a pharmaceutical composition, for treating immune diseases or sepsis, containing the polypeptide. A polypeptide, according to the present invention, can be bound to a complement protein C5a, with higher affinity compared to being bound to a complement protein C5a receptor which is present in nature, and inhibits the activation of same, thus being widely utilized for development of formulation for preventing or treating diseases related to a complement protein C5a.

    REPEBODY AGAINST IMMUNOGLOBULIN G AND USES THEREOF
    9.
    发明申请
    REPEBODY AGAINST IMMUNOGLOBULIN G AND USES THEREOF 有权
    重复免疫球蛋白G及其用途

    公开(公告)号：US20150018533A1

    公开(公告)日：2015-01-15

    申请号：US14322864

    申请日：2014-07-02

    Applicant: Korea Advanced Institute of Science and Technology

    Inventor： Hak-Sung Kim ,  Woosung Heu ,  Joong-Jae Lee ,  Seong-Min Jo

    IPC: C07K14/195

    CPC classification number: C07K14/195 ,  C07K14/705 ,  C07K16/065 ,  C07K2319/70

    Abstract: The present invention relates to a polypeptide (repebody) selectively bound to an immunoglobulin G, a polynucleotide which encodes the repebody, a vector containing the polynucleotide, a recombinant microorganism in which the polynucleotide is introduced, a method for producing the repebody using the recombinant microorganism, and a method for immobilizing or purifying an immunoglobulin G using the repebody. The repebody according to the present invention is useful as utilized for immobilization of an immunoglobulin G, purification of an immunoglobulin G, and production of an immunosensor, since the repebody selectively bound to an immunoglobulin G.

    Abstract translation: 本发明涉及选择性结合免疫球蛋白G的多肽（重组体），编码重组体的多核苷酸，含有多核苷酸的载体，引入多核苷酸的重组微生物，使用重组微生物产生重组体的方法 ，以及使用该重复体固定或纯化免疫球蛋白G的方法。 根据本发明的重组体可用于固定免疫球蛋白G，免疫球蛋白G的纯化和免疫传感器的产生，因为选择性结合免疫球蛋白G的重组体。

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