-
Patent Agency Ranking
公开(公告)号：US10287342B2
公开(公告)日：2019-05-14
申请号：US15500921
申请日：2015-08-03
Inventor： Hak-Sung Kim , Da Eun Hwang , Jung-Min Choi , Joong-Jae Lee , Woosung Heu
Abstract: The present invention relates to novel polypeptide for binding to a complement protein C5a. More particularly, the present invention relates to polypeptide which can be bound to a complement protein C5a and inhibit the activation of same, polynucleotide which codes for the polypeptide, a recombinant vector which comprises the polynucleotide, a recombinant microorganism to which the recombinant vector has been introduced, a method for producing the polypeptide by means of the recombinant microorganism, and a pharmaceutical composition, for treating immune diseases or sepsis, containing the polypeptide. A polypeptide, according to the present invention, can be bound to a complement protein C5a, with higher affinity compared to being bound to a complement protein C5a receptor which is present in nature, and inhibits the activation of same, thus being widely utilized for development of formulation for preventing or treating diseases related to a complement protein C5a.
-
公开(公告)号：US10995153B2
公开(公告)日：2021-05-04
申请号：US16074530
申请日：2016-09-20
Inventor： Hak-Sung Kim , Sukyo Jeong , Woosung Heu , Jong-Won Kim , Joong-Jae Lee
IPC: C07K16/46 , C07K14/195 , C12N15/62 , C12N15/63 , G01N33/531 , G01N33/543 , C12N15/70 , G01N33/532 , C07K14/705 , G01N33/544
Abstract: The present invention relates to a novel polypeptide that binds selectively to mouse or rabbit immunoglobulin G. More specifically, the present invention relates to a polypeptide that binds to mouse or rabbit immunoglobulin G, a polynucleotide encoding the polypeptide, an expression vector comprising the polynucleotide, a transformant introduced with the expression vector, a method of producing the polypeptide using the transformant, and a composition for immunoassay comprising the polypeptide. The novel peptide according to the present invention binds specifically to mouse or rabbit immunoglobulin G, can replace conventional expensive secondary immunoglobulin G, and can be used in various biological immunoassays. In addition, a conjugate of the polypeptide of the present invention and immunoglobulin G is useful for fabrication of various immunosensors/immunochips and for drug screening.
-
公开(公告)号：US09777046B2
公开(公告)日：2017-10-03
申请号：US14322864
申请日：2014-07-02
Inventor： Hak-Sung Kim , Woosung Heu , Joong-Jae Lee , Seong-Min Jo
IPC: C07K14/195 , C07K14/705 , C07K16/06
CPC classification number: C07K14/195 , C07K14/705 , C07K16/065 , C07K2319/70
Abstract: The present invention relates to a polypeptide (repebody) selectively bound to an immunoglobulin G, a polynucleotide which encodes the repebody, a vector containing the polynucleotide, a recombinant microorganism in which the polynucleotide is introduced, a method for producing the repebody using the recombinant microorganism, and a method for immobilizing or purifying an immunoglobulin G using the repebody. The repebody according to the present invention is useful as utilized for immobilization of an immunoglobulin G, purification of an immunoglobulin G, and production of an immunosensor, since the repebody selectively bound to an immunoglobulin G.
-
4.发明申请公开(公告)号：US20190040157A1
公开(公告)日：2019-02-07
申请号：US16074530
申请日：2016-09-20
Inventor： Hak-Sung Kim , Sukyo Jeong , Woosung Heu , Jong-Won Kim , Joong-Jae Lee
IPC: C07K16/46 , C07K14/195 , C12N15/62 , C12N15/70 , G01N33/532 , G01N33/544
Abstract: The present invention relates to a novel polypeptide that binds selectively to mouse or rabbit immunoglobulin G. More specifically, the present invention relates to a polypeptide that binds to mouse or rabbit immunoglobulin G, a polynucleotide encoding the polypeptide, an expression vector comprising the polynucleotide, a transformant introduced with the expression vector, a method of producing the polypeptide using the transformant, and a composition for immunoassay comprising the polypeptide. The novel peptide according to the present invention binds specifically to mouse or rabbit immunoglobulin G, can replace conventional expensive secondary immunoglobulin G, and can be used in various biological immunoassays. In addition, a conjugate of the polypeptide of the present invention and immunoglobulin G is useful for fabrication of various immunosensors/immunochips and for drug screening.
-
公开(公告)号：US20150018533A1
公开(公告)日：2015-01-15
申请号：US14322864
申请日：2014-07-02
Inventor： Hak-Sung Kim , Woosung Heu , Joong-Jae Lee , Seong-Min Jo
IPC: C07K14/195
CPC classification number: C07K14/195 , C07K14/705 , C07K16/065 , C07K2319/70
Abstract: The present invention relates to a polypeptide (repebody) selectively bound to an immunoglobulin G, a polynucleotide which encodes the repebody, a vector containing the polynucleotide, a recombinant microorganism in which the polynucleotide is introduced, a method for producing the repebody using the recombinant microorganism, and a method for immobilizing or purifying an immunoglobulin G using the repebody. The repebody according to the present invention is useful as utilized for immobilization of an immunoglobulin G, purification of an immunoglobulin G, and production of an immunosensor, since the repebody selectively bound to an immunoglobulin G.
Abstract translation: 本发明涉及选择性结合免疫球蛋白G的多肽（重组体），编码重组体的多核苷酸，含有多核苷酸的载体，引入多核苷酸的重组微生物，使用重组微生物产生重组体的方法 ，以及使用该重复体固定或纯化免疫球蛋白G的方法。 根据本发明的重组体可用于固定免疫球蛋白G，免疫球蛋白G的纯化和免疫传感器的产生，因为选择性结合免疫球蛋白G的重组体。
-
-
-
-
Search Results
5
records
(took 0.042 seconds)
