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公开(公告)号：US20250057767A1
公开(公告)日：2025-02-20
申请号：US18807111
申请日：2024-08-16
Inventor： Ji Soo Ryu , A Reum Jang , Jae Yong Seo , Hyun Dae Cho , Hee Cheol Kang , Mi Jung Kim , En Young Jeong , Hye Sun Park , Kwan Soo Hong , Hyunseung Lee
IPC: A61K9/127 , A61K8/14 , A61K8/9789 , A61K9/50
Abstract: The present invention relates to hybrid exosomes, a use of the same, and a preparation method of the same, and the hybrid exosomes provided from the present invention have excellent skin inflammation amelioration, skin wrinkle amelioration, skin moisturization efficacy, and skin regeneration efficacy compared to using hydrangea-derived exosomes and liposomes alone, and thus can be effectively utilized as a cosmetic composition containing the same as an active ingredient. In addition, the hybrid exosomes have better stability and biocompatibility compared to existing exosomes.
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公开(公告)号：US20250012747A1
公开(公告)日：2025-01-09
申请号：US18711550
申请日：2022-11-03
Applicant: KOREA BASIC SCIENCE INSTITUTE
Inventor： Dong Uk Kim , Ki Soo Chang , Chan Bae Jeong , II Kyu Han
Abstract: A device and a method for measuring a time-resolved thermal image. An embodiment comprises an optical imaging unit comprising a camera and a probe light source, the optical imaging unit emitting a probe optical signal from the probe light source to a sample during a time-resolution time; a control unit for outputting a first trigger signal to the camera, outputting a driving signal to the probe light source such that the probe light source emits the probe light source to the sample during the time-resolution time, outputting a second trigger signal to a bias unit in an turn-on interval, and outputting no second trigger signal to the bias unit in a turn-off interval; and a bias unit for applying a bias signal generated on the basis of the second trigger signal in the turn-on interval to the sample, and applying no bias signal to the sample in the turn-off interval.
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公开(公告)号：US20240331967A1
公开(公告)日：2024-10-03
申请号：US18407388
申请日：2024-01-08
Applicant: KOREA BASIC SCIENCE INSTITUTE
Inventor： Myoung Choul Choi , Woo Jun Byeon , Byeong Jun Cha
IPC: H01J37/08
CPC classification number: H01J37/08 , H01J2237/032 , H01J2237/0805 , H01J2237/208
Abstract: A liquid metal ion source device for using bismuth and an alloy of the bismuth is provided. The liquid metal ion source device includes a base formed of an electrically insulating material, two electrodes connected to the base and configured to supply current, a needle mounted on the base and configured to pass through the base, a filament including a pair of connection rods connected to the two electrodes, respectively, a pair of support rods formed to be extended from the pair of connection rods, respectively, and provided in a direction away from the base and towards the needle, and a filament head connecting the pair of support rods to one another and having a shape curved toward the base, and a reservoir configured to accommodate at least a portion of the filament head inside the reservoir and store a liquid metal.
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公开(公告)号：US12016936B2
公开(公告)日：2024-06-25
申请号：US17262503
申请日：2019-07-24
Applicant: KOREA BASIC SCIENCE INSTITUTE
Inventor： Ki-Yuk Chang , Chan-Woo Kim , Kwan-Soo Hong , Hyun-Seung Lee , Hyun-Min Kim
IPC: A61K51/10
CPC classification number: A61K51/1027
Abstract: The present invention relates to a neovascular-targeting contrast medium composition and a method for preparing same. The neovascular-targeting contrast medium composition according to the present invention exhibits high binding force to neovascularization-associated αvβ3 integrin, excellent tissue permeability and biostability, enables simple measurement in vitro, in vivo, or ex vivo, and thus is effective in the detection of neovascularization and in diagnosing diseases associated therewith, and therefore may be usefully employed in the relevant industries.
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5.发明授权公开(公告)号：US11947104B2
公开(公告)日：2024-04-02
申请号：US17641770
申请日：2020-09-09
Applicant: KOREA BASIC SCIENCE INSTITUTE , INSTITUTE FOR BASIC SCIENCE , GWANGJU INSTITUTE OF SCIENCE AND TECHNOLOGY
Inventor： I Jong Kim , Ji Yong Bae , Hong Seung Kim , Geon Hee Kim , Ki Soo Chang , Cheonha Jeon , Il Woo Choi , Chang Hee Nam
CPC classification number: G02B26/06 , G02B26/0825 , G02B27/0068
Abstract: A spiral phase plate, according to one embodiment, for generating a Laguerre Gaussian beam by reflecting an incident beam emitted from a light source, may comprise: a first quadrant area in which the step height increase rate per unit angle decreases progressively in one direction from the point with the lowest step height to the point with the highest step height; and a second quadrant area in which the step height increase rate per unit angle increases progressively in the one direction.
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Patent Agency Ranking
6.发明授权公开(公告)号：US11821956B2
公开(公告)日：2023-11-21
申请号：US17352799
申请日：2021-06-21
Applicant: KOREA BASIC SCIENCE INSTITUTE , THE INDUSTRY & ACADEMIC COOPERATION IN CHUNGNAM NATIONAL UNIVERSITY (IAC) , KOREA RESEARCH INSTITUTE OF STANDARDS AND SCIENCE
Inventor： Joonhee Moon , Cheolho Jeon , Jouhahn Lee , Kyoung Soon Choi , Chunjoong Kim , Jae Yong Song , Hosun Shin , Sun Hwa Park
CPC classification number: G01R31/385 , G01N21/47 , G01N21/84 , H01M10/4285 , H01M10/44 , H01M10/48
Abstract: A battery cell measurement module includes a lower housing having a connection part and a fixing part connected to the lower housing. An upper portion of the fixing part has a battery cell accommodation space accommodating a battery cell. The fixing part includes a connection hole that is in communication with the battery cell accommodation space and has the connection part arranged therein. Module includes a height control part that extends from the battery cell accommodation space to the connection part via the connection hole. Module includes an upper housing detachably attached to the lower housing, arranged to surround the fixing part and the height control part, and provided with a transparent window. The battery cell has an opening in an upper surface of the battery cell and is accommodated in the battery cell accommodation space such that the opening is located at a position vertically overlapping the transparent window.
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公开(公告)号：US11260488B2
公开(公告)日：2022-03-01
申请号：US15995018
申请日：2018-05-31
Applicant: KOREA BASIC SCIENCE INSTITUTE
Inventor： Hwan Hur , Geon-Hee Kim , Ji Yong Bae , Hee-Seok Kweon
IPC: B24B3/36 , G01N1/06 , B23K26/364
Abstract: Provided is a method of manufacturing a diamond knife for an ultra-microtome, including determining a shape and size of a knife, performing a multiphase flow analysis on movement of a droplet at a fore-end of the knife with the determined shape and size, processing a fine pattern to ensure hydrophobic property according to a result of the flow analysis, and grinding a blade of the knife after the processing of the fine pattern to minimize an interval between the pattern and the blade and, thus, a knife blade is always maintained in a wet state due to a droplet movement between a hydrophobic fine pattern and a hydrophilic surface to continuously generate ultrathin slices.
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公开(公告)号：US10699868B2
公开(公告)日：2020-06-30
申请号：US16185527
申请日：2018-11-09
Applicant: KOREA BASIC SCIENCE INSTITUTE
Inventor： Chang Min Choi , Myoung Choul Choi , Sang Ju Lee , Ji Young Baek , Jeong Jin Kim
IPC: H01J37/08 , G01N29/44 , H01J37/244
Abstract: Disclosed is a device for generating an organic molecular cluster ion beam, the device including a receiver configured to accommodate an organic material, a cluster generator configured to generate a cluster by supersonic expanding the organic material accommodated in the receiver at a high speed, a photo-ionizer configured to temporarily accommodate the cluster that is generated through the cluster generator, an ultraviolet (UV) light source configured to irradiate an UV pulse to the photo-ionizer to ionize the cluster, and entrance electrodes disposed at both sides of the photo-ionizer and configured to provide a potential difference to the photo-ionizer to generate a cluster ion beam.
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9.发明申请公开(公告)号：US20200152410A1
公开(公告)日：2020-05-14
申请号：US16663341
申请日：2019-10-25
Applicant: KOREA BASIC SCIENCE INSTITUTE
Inventor： Myoung Choul Choi , Boo Ki Min , Sang Ju Lee , Chang Min Choi , Ji Young Baek , Jae yeong Eo , Il Hee Kim
IPC: H01J37/08
Abstract: An ion beam generating device includes a liquid metal ion source configured to melt metal and emit an ion beam, and an extractor disposed under the liquid metal ion source and configured to extract the ion beam emitted from the liquid metal ion source. The liquid metal ion source includes a storage configured to accommodate the metal, an emitter configured to receive the metal from the storage and emit the ion beam, and a heater configured to heat the emitter or the storage. The heater is configured to directly heat the metal accommodated in the storage to melt the metal into a liquid state, and an amount of the ion beam to be extracted is controlled by a voltage difference that changes based on a distance between the emitter and the extractor.
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10.发明申请公开(公告)号：US20190324015A1
公开(公告)日：2019-10-24
申请号：US16169020
申请日：2018-10-24
Applicant: Korea Basic Science Institute
Inventor： Gun H. Kim , Edmond C. Park , Seung I. Kim , Sang-Yeop Lee
Abstract: The present invention relates to a biomarker for diagnosis of overactive bladder (OAB) disease, and a method for screening a drug using the biomarker. The markers described in the present invention can effectively detect or diagnose the onset of OAB by distinguishing them from normal populations. In particular, OAB-specific protein markers released into urine enable simple and rapid OAB diagnosis in a non-invasive manner. In addition, by selecting an agent that changes, particularly normalizes the expression and activity of the markers selected in the present invention, more effective preventative or therapeutic agents of OAB disease can be screened.
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