公开(公告)号：US20250015992A1

公开(公告)日：2025-01-09

申请号：US18516691

申请日：2023-11-21

Applicant: INSTITUTE FOR BASIC SCIENCE

Inventor： Kyung Ah SHIM

IPC: H04L9/30 ,  H04L9/08

Abstract: Embodiments of the present disclosure may include a key generation device of a lattice-based public key cryptosystem. In some embodiments, the key generation device may include a communication unit, a storage unit, and a processor that may be configured to control the key generation device to perform operations. In some embodiments, the operations may include generating a public key by using a public key polynomial, where the public key polynomial may belong to a first polynomial ring. In some embodiments, the operations may additionally include generating a secret key that may correspond to the public key. In some embodiments, the secret key may be generated by using a secret key polynomial that may belong to a second polynomial ring. In some embodiments, the operations may additionally include storing the public key and the secret key.

公开(公告)号：US12161662B2

公开(公告)日：2024-12-10

申请号：US17285253

申请日：2019-07-29

Applicant: INSTITUTE FOR BASIC SCIENCE ,  POSTECH ACADEMY-INDUSTRY FOUNDATION

Inventor： Sin-Hyeog Im ,  Verma Ravi ,  Changhon Lee

IPC: A61K31/736 ,  A23L33/125 ,  A23L33/145 ,  A61K31/715 ,  A61K31/716 ,  A61K36/06 ,  A61K39/00 ,  A61P1/00 ,  A61P29/00 ,  A61P37/02 ,  C08B37/00 ,  C12N5/0783

Abstract: The present invention relates to a yeast-derived polysaccharide inducing Treg cells and a use thereof and, more particularly, to a polysaccharide comprising mannan and β-glucan, an composition for immunomodulation comprising the polysaccharide as an active ingredient, a pharmaceutical composition or food comprising the polysaccharide as an active ingredient for prevention or treatment of immune disease or inflammatory disease, a method for preparation of regulatory T cells by using the polysaccharide, a cell therapeutic agent comprising the regulatory T cells prepared by the preparation method as an active ingredient, and a treatment method using same. Even at a low dose, the novel polysaccharide according to the present invention allows the production of tolerogenic antigen presenting cells through the β-glucan and mannan structure retained therein, whereby the novel polysaccharide can induce the differentiation or production of antigen-specific regulatory T cells (Treg cells) to modulate the target immune system with low adverse effects. Therefore, MGCP and the Treg cells induced by the polysaccharide are effective for preventing or treating immune disease or inflammatory disease.

公开(公告)号：US20240383863A1

公开(公告)日：2024-11-21

申请号：US18692655

申请日：2022-09-19

Applicant: INSTITUTE FOR BASIC SCIENCE ,  KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Sukbok CHANG ,  Won Seok HAM ,  Jianbo ZHANG ,  Hoonchul CHOI

IPC: C07D239/42 ,  B01J23/42 ,  B01J31/22 ,  C07D239/48 ,  C07D401/04 ,  C07D403/04 ,  C07D405/04 ,  C07D417/04 ,  C07D487/04 ,  C07F7/18

Abstract: The present invention relates to a preparation method for pyrimidine-2-amine and, more specifically, to a method for preparing a pyrimidine-2-amine compound via a pyrimidine-2-iminium salt intermediate by using a nucleophilic imine-type reagent, in which various amino functional groups are selectively introduced at position No. 2 of pyrimidine.

公开(公告)号：US12139519B2

公开(公告)日：2024-11-12

申请号：US17293568

申请日：2019-11-13

Applicant: INSTITUTE FOR BASIC SCIENCE

Inventor： Wondo Heo ,  Sungsoo Kim ,  Sang Kyu Lee ,  Taeyoon Kyung

IPC: C07K14/47 ,  C07K14/705 ,  C12N15/86

Abstract: Provided is a CRY2 variant in which E279 and/or E281 having a negative charge in a N277SEGE281 sequence of SEQ ID NO: 1 is substituted with any one selected from the neutral amino acid group of alanine (A), isoleucine (I), leucine (L), valine (V), phenylalanine (F), methionine (M) and tryptophan (W), or in which S278 or G280 of a N277SEGE281 sequence of SEQ ID NO: 1 is substituted with any one selected from the bulky amino acid group of tryptophan (W) and phenylalanine (F).

公开(公告)号：US12024562B2

公开(公告)日：2024-07-02

申请号：US17111413

申请日：2020-12-03

Applicant: INSTITUTE FOR BASIC SCIENCE

Inventor： Gou Young Koh ,  Jeomil Bae ,  Jaeryung Kim

IPC: C07K16/28 ,  A61K31/713 ,  A61K39/395 ,  A61K45/06 ,  A61P27/06 ,  C12N5/10 ,  C12N15/63 ,  A61K39/00

CPC classification number: C07K16/2863 ,  A61K31/713 ,  A61K39/3955 ,  A61K45/06 ,  A61P27/06 ,  C12N5/10 ,  C12N15/63 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2317/34 ,  C07K2317/565 ,  C07K2317/92 ,  C07K2317/94

Abstract: The present invention refers to an antibody against Tie-2 or antigen-binding fragment thereof, a nucleic acid encoding the same, a vector comprising the nucleic acid, a cell transformed with the vector, a manufacturing method of the antibody or antigen-binding fragment thereof, and a composition for preventing or treating angiogenic diseases, which comprises the antibody or antigen-binding fragment thereof.

公开(公告)号：US11947104B2

公开(公告)日：2024-04-02

申请号：US17641770

申请日：2020-09-09

Applicant: KOREA BASIC SCIENCE INSTITUTE ,  INSTITUTE FOR BASIC SCIENCE ,  GWANGJU INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： I Jong Kim ,  Ji Yong Bae ,  Hong Seung Kim ,  Geon Hee Kim ,  Ki Soo Chang ,  Cheonha Jeon ,  Il Woo Choi ,  Chang Hee Nam

IPC: G02B26/06 ,  G02B26/08 ,  G02B27/00

CPC classification number: G02B26/06 ,  G02B26/0825 ,  G02B27/0068

Abstract: A spiral phase plate, according to one embodiment, for generating a Laguerre Gaussian beam by reflecting an incident beam emitted from a light source, may comprise: a first quadrant area in which the step height increase rate per unit angle decreases progressively in one direction from the point with the lowest step height to the point with the highest step height; and a second quadrant area in which the step height increase rate per unit angle increases progressively in the one direction.

公开(公告)号：US11879183B2

公开(公告)日：2024-01-23

申请号：US17354104

申请日：2021-06-22

Applicant: INSTITUTE FOR BASIC SCIENCE ,  UNIST(ULSAN NATIONAL INSTITUTE OF SCIENCE AND TECHNOLOGY)

Inventor： Rodney S. Ruoff ,  Sunghwan Jin

IPC: C30B1/02 ,  C22F1/08 ,  C22F1/00 ,  C30B25/14 ,  C22F1/10 ,  C30B25/18 ,  C30B29/02

CPC classification number: C30B1/02 ,  C22F1/00 ,  C22F1/08 ,  C22F1/10 ,  C30B25/14 ,  C30B25/18 ,  C30B29/02

Abstract: The present invention relates to a manufacturing method for single crystalline metal foil including: thermally treating poly-crystalline metal foil positioned to be spaced apart from a base to manufacture single crystalline metal foil, and a single crystalline metal foil manufactured thereby. According to the present invention, single crystalline metal foil having a large area may be obtained by thermally treating the poly-crystalline metal foil under a condition at which stress applied to the poly-crystalline metal foil is minimized.

公开(公告)号：US20240007298A1

公开(公告)日：2024-01-04

申请号：US17978147

申请日：2022-10-31

Applicant: INSTITUTE FOR BASIC SCIENCE

Inventor： Kyung Ah SHIM

IPC: H04L9/32 ,  H04L9/08 ,  G06F17/12 ,  G06F17/16 ,  H04L9/00

CPC classification number: H04L9/3247 ,  H04L9/0861 ,  G06F17/12 ,  G06F17/16 ,  H04L9/50

Abstract: Disclosed is an electronic device for computing a solution to a linear system using a block matrix. The electronic device includes a memory configured to store data, and a processor configured to perform a plurality of operations by executing instructions. The electronic device computes the solution to the linear system without directly computing an inverse matrix R−1 of a block matrix R, using an inverse matrix of at least one of a plurality of sub-blocks matrices A, B, C, and D that constitute a block matrix R representing the linear system, and an inverse matrix of at least one of combinations of the plurality of sub-block matrices A, B, C, and D. According, the solution to the linear system can be efficiently computed.

公开(公告)号：US20230406812A1

公开(公告)日：2023-12-21

申请号：US18036847

申请日：2021-11-12

Applicant: INSTITUTE FOR BASIC SCIENCE ,  KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Chang Jun LEE ,  Heejung CHUN ,  Woojin WON ,  Ki Duk PARK ,  Jong Hyun PARK ,  Ae Nim PAE ,  Ji Won CHOI ,  Elijah LEE ,  Sun Jun PARK ,  Hyeon Jeong KIM ,  Yoowon KIM ,  Byung Eun KIM ,  Siwon KIM

IPC: C07C211/53 ,  A23L33/10 ,  A61P25/28

CPC classification number: C07C211/53 ,  A61P25/28 ,  A23L33/10

Abstract: The present invention provides a novel aminoaromatic compound or a pharmaceutically acceptable salt thereof, a pharmaceutical composition that is for preventing or treating neurodegenerative diseases and comprises same as an active ingredient, and a health functional food composition for preventing or ameliorating neurodegenerative diseases.

公开(公告)号：US20230323562A1

公开(公告)日：2023-10-12

申请号：US18193483

申请日：2023-03-30

Applicant: SEOUL NATIONAL UNIVERSITY R&DB FOUNDATION ,  INSTITUTE FOR BASIC SCIENCE

Inventor： Jungwon PARK ,  Kunwoo PARK

IPC: C30B29/16 ,  C30B1/02 ,  C30B29/68

CPC classification number: C30B29/16 ,  C30B29/68 ,  C30B1/026

Abstract: A ferroelectric thin film and a forming method thereof are provided. The method of forming a ferroelectric thin film according to embodiments of the present invention comprises forming a sacrificial seed layer on a first substrate, forming a ferroelectric thin film on the sacrificial seed layer, and transferring the ferroelectric thin film to a second substrate. The ferroelectric thin film according to embodiments of the present invention is formed by the method.