公开(公告)号：US20240060890A1

公开(公告)日：2024-02-22

申请号：US18500236

申请日：2023-11-02

Applicant: Illumina, Inc.

Inventor： Hod Finkelstein ,  Cheng Frank Zhong ,  Eliane H. Trepagnier

IPC: G01N21/64 ,  G01N21/77 ,  G01N21/05 ,  H01L31/107 ,  G01S7/4863 ,  H01L31/055 ,  G01S7/4865 ,  B01L3/00 ,  C12Q1/6869

CPC classification number: G01N21/6408 ,  G01N21/648 ,  G01N21/6452 ,  G01N21/7703 ,  G01N21/6454 ,  G01N21/05 ,  H01L31/107 ,  G01S7/4863 ,  H01L31/055 ,  G01S7/4865 ,  B01L3/502715 ,  C12Q1/6869 ,  G01N21/6428 ,  G01N2201/06113 ,  G01N2201/10

Abstract: An integrated detection, flow cell and photonics (DFP) device is provided that comprises a substrate having an array of pixel elements that sense photons during active periods. The substrate and pixel elements form an IC photon detection layer. At least one wave guide is formed on the IC photo detection layer as a photonics layer. An optical isolation layer is formed over at least a portion of the wave guide. A collection of photo resist (PR) walls patterned to define at least one flow cell channel that is configured to direct fluid along a fluid flow path. The wave guides align to extend along the fluid flow path. The flow cell channel is configured to receive samples at sample sites that align with the array of pixel elements.

公开(公告)号：US11841322B2

公开(公告)日：2023-12-12

申请号：US17135595

申请日：2020-12-28

Applicant: ILLUMINA, INC.

Inventor： Hod Finkelstein ,  Cheng Frank Zhong ,  Eliane H. Trepagnier

IPC: G01N21/64 ,  B01L3/00 ,  H01L31/107 ,  G01N21/77 ,  G01N21/05 ,  G01S7/4863 ,  H01L31/055 ,  G01S7/4865 ,  C12Q1/6869

CPC classification number: G01N21/6408 ,  B01L3/502715 ,  C12Q1/6869 ,  G01N21/05 ,  G01N21/648 ,  G01N21/6428 ,  G01N21/6452 ,  G01N21/6454 ,  G01N21/7703 ,  G01S7/4863 ,  G01S7/4865 ,  H01L31/055 ,  H01L31/107 ,  G01N2201/06113 ,  G01N2201/10

Abstract: An integrated detection, flow cell and photonics (DFP) device is provided that comprises a substrate having an array of pixel elements that sense photons during active periods. The substrate and pixel elements form an IC photon detection layer. At least one wave guide is formed on the IC photo detection layer as a photonics layer. An optical isolation layer is formed over at least a portion of the wave guide. A collection of photo resist (PR) walls patterned to define at least one flow cell channel that is configured to direct fluid along a fluid flow path. The wave guides align to extend along the fluid flow path. The flow cell channel is configured to receive samples at sample sites that align with the array of pixel elements.

公开(公告)号：US20230358678A1

公开(公告)日：2023-11-09

申请号：US18339185

申请日：2023-06-21

Applicant: ILLUMINA, INC.

Inventor： Cheng Frank Zhong ,  Hod Finkeslstien ,  Boyan Boyanov ,  Dietrich Dehlinger ,  Darren Segale

IPC: G01N21/64 ,  H01L27/146 ,  H01L27/00 ,  H01L27/088 ,  B01L3/00 ,  G01N33/543 ,  G01N27/414 ,  C12Q1/6874 ,  G01N21/05

CPC classification number: G01N21/645 ,  G01N21/6454 ,  H01L27/14623 ,  H01L27/00 ,  H01L27/088 ,  B01L3/502707 ,  G01N33/54373 ,  G01N21/6452 ,  G01N27/4145 ,  G01N21/6428 ,  B01L3/502715 ,  G01N2021/6482 ,  C12Q1/6874 ,  G01N2021/6441 ,  G01N21/05 ,  G01N2201/061 ,  G01N2201/0642

Abstract: Biosensor including a device base having a sensor array of light sensors and a guide array of light guides. The light guides have input regions that are configured to receive excitation light and light emissions generated by biological or chemical substances. The light guides extend into the device base toward corresponding light sensors and have a filter material. The device base includes device circuitry electrically coupled to the light sensors and configured to transmit data signals. A passivation layer extends over the device base and forms an array of reaction recesses above the light guides. The biosensor also includes peripheral crosstalk shields that at least partially surround corresponding light guides of the guide array to reduce optical crosstalk between adjacent light sensors.

公开(公告)号：US11579336B2

公开(公告)日：2023-02-14

申请号：US16093070

申请日：2017-04-21

Applicant: ILLUMINA, INC.

Inventor： Juraj Topolancik ,  Cheng Frank Zhong

IPC: H01L27/146 ,  G02B1/00 ,  G02B1/02 ,  G01N21/64 ,  B82Y20/00

Abstract: A device for luminescent imaging includes an array of imaging pixels, a photonic structure over the array of imaging pixels, and an array of features over the photonic structure. A first feature of the array of features is over a first pixel of the array of imaging pixels, and a second feature of the array of features is over the first pixel and spatially displaced from the first feature. A first luminophore is within or over the first feature, and a second luminophore is within or over the second feature. The device includes a radiation source to generate first photons having a first characteristic at a first time, and generate second photons having a second characteristic at a second time. The first pixel selectively receives luminescence emitted by the first and second luminophores responsive to the first photons at the first time and second photons at the second time, respectively.

公开(公告)号：US20210238673A1

公开(公告)日：2021-08-05

申请号：US16949821

申请日：2020-11-16

Applicant: Illumina, Inc.

Inventor： Dietrich Dehlinger ,  Cheng Frank Zhong ,  Juraj Topolancik

IPC: C12Q1/6874 ,  G01N21/64 ,  G02B5/20 ,  B01L3/00 ,  G02B21/00 ,  G02B21/18 ,  G02B21/36 ,  G01N21/77

Abstract: Under one aspect, a device is provided for use in luminescent imaging. The device can include a photonic superlattice including a first material, the first material having a first refractive index. The first material can include first and second major surfaces and first and second pluralities of features defined through at least one of the first and second major surfaces, the features of the first plurality differing in at least one characteristic from the features of the second plurality. The photonic superlattice can support propagation of a first wavelength and a second wavelength approximately at a first angle out of the photonic superlattice, the first and second. wavelengths being separated from one another by a first non.-propagating wavelength that does not selectively propagate at the first angle out of the photonic superlattice.

公开(公告)号：US12140541B2

公开(公告)日：2024-11-12

申请号：US18500236

申请日：2023-11-02

Applicant: Illumina, Inc.

Inventor： Hod Finkelstein ,  Cheng Frank Zhong ,  Eliane H. Trepagnier

IPC: H01L31/107 ,  B01L3/00 ,  C12Q1/6869 ,  G01N21/05 ,  G01N21/64 ,  G01N21/77 ,  G01S7/4863 ,  G01S7/4865 ,  H01L31/055

Abstract: An integrated detection, flow cell and photonics (DFP) device is provided that comprises a substrate having an array of pixel elements that sense photons during active periods. The substrate and pixel elements form an IC photon detection layer. At least one wave guide is formed on the IC photo detection layer as a photonics layer. An optical isolation layer is formed over at least a portion of the wave guide. A collection of photo resist (PR) walls patterned to define at least one flow cell channel that is configured to direct fluid along a fluid flow path. The wave guides align to extend along the fluid flow path. The flow cell channel is configured to receive samples at sample sites that align with the array of pixel elements.

公开(公告)号：US10472675B2

公开(公告)日：2019-11-12

申请号：US16035208

申请日：2018-07-13

Applicant: Illumina, Inc.

Inventor： Dietrich Dehlinger ,  Cheng Frank Zhong ,  Juraj Topolancik

IPC: C12Q1/6874 ,  B01L3/00 ,  G01N21/64 ,  G02B21/00 ,  G02B21/18 ,  G02B21/36 ,  G01N21/77 ,  G02B5/20 ,  G01N21/03 ,  G01N21/25

Abstract: Under one aspect, a device is provided for use in luminescent imaging. The device can include a photonic superlattice including a first material, the first material having a first refractive index. The first material can include first and second major surfaces and first and second pluralities of features defined through at least one of the first and second major surfaces, the features of the first plurality differing in at least one characteristic from the features of the second plurality. The photonic superlattice can support propagation of a first wavelength and a second wavelength approximately at a first angle out of the photonic superlattice, the first and second wavelengths being separated from one another by a first non-propagating wavelength that does not selectively propagate at the first angle out of the photonic superlattice.

公开(公告)号：US11181478B2

公开(公告)日：2021-11-23

申请号：US16295973

申请日：2019-03-07

Applicant: Illumina, Inc.

Inventor： Cheng Frank Zhong ,  Hod Finkelstein ,  Boyan Boyanov ,  Dietrich Dehlinger ,  Darren Segale

IPC: H01L27/146 ,  H01L27/00 ,  G01N27/414 ,  G01N33/543 ,  G01N21/64 ,  B01L3/00 ,  H01L27/088 ,  C12Q1/6874 ,  H01L29/78 ,  G01N21/05

Abstract: Biosensor including a device base having a sensor array of light sensors and a guide array of light guides. The light guides have input regions that are configured to receive excitation light and light emissions generated by biological or chemical substances. The light guides extend into the device base toward corresponding light sensors and have a filter material. The device base includes device circuitry electrically coupled to the light sensors and configured to transmit data signals. A passivation layer extends over the device base and forms an array of reaction recesses above the light guides. The biosensor also includes peripheral crosstalk shields that at least partially surround corresponding light guides of the guide array to reduce optical crosstalk between adjacent light sensors.

公开(公告)号：US20210116372A1

公开(公告)日：2021-04-22

申请号：US17135595

申请日：2020-12-28

Applicant: ILLUMINA, INC.

Inventor： Hod Finkelstein ,  Cheng Frank Zhong ,  Eliane H. Trepagnier

IPC: G01N21/64 ,  G01N21/77 ,  G01N21/05 ,  H01L31/107 ,  G01S7/4863 ,  H01L31/055 ,  G01S7/4865 ,  B01L3/00 ,  C12Q1/6869

Abstract: An integrated detection, flow cell and photonics (DFP) device is provided that comprises a substrate having an array of pixel elements that sense photons during active periods. The substrate and pixel elements form an IC photon detection layer. At least one wave guide is formed on the IC photo detection layer as a photonics layer. An optical isolation layer is formed over at least a portion of the wave guide. A collection of photo resist (PR) walls patterned to define at least one flow cell channel that is configured to direct fluid along a fluid flow path. The wave guides align to extend along the fluid flow path. The flow cell channel is configured to receive samples at sample sites that align with the array of pixel elements.

公开(公告)号：US20190024163A1

公开(公告)日：2019-01-24

申请号：US16035208

申请日：2018-07-13

Applicant: Illumina, Inc.

Inventor： Dietrich Dehlinger ,  Cheng Frank Zhong ,  Juraj Topolancik

IPC: C12Q1/6874 ,  G02B21/36 ,  G02B21/18 ,  B01L3/00 ,  G01N21/64 ,  G01N21/77 ,  G02B5/20 ,  G02B21/00 ,  G01N21/03 ,  G01N21/25

Abstract: Under one aspect, a device is provided for use in luminescent imaging. The device can include a photonic superlattice including a first material, the first material having a first refractive index. The first material can include first and second major surfaces and first and second pluralities of features defined through at least one of the first and second major surfaces, the features of the first plurality differing in at least one characteristic from the features of the second plurality. The photonic superlattice can support propagation of a first wavelength and a second wavelength approximately at a first angle out of the photonic superlattice, the first and second wavelengths being separated from one another by a first non-propagating wavelength that does not selectively propagate at the first angle out of the photonic superlattice.