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    METHOD AND SYSTEM FOR FLUORESCENCE LIFETIME BASED SEQUENCING
    4.
    发明申请
    METHOD AND SYSTEM FOR FLUORESCENCE LIFETIME BASED SEQUENCING 审中-公开
    基于荧光寿命的测序方法与系统

    公开(公告)号：US20150293021A1

    公开(公告)日：2015-10-15

    申请号：US14619287

    申请日：2013-03-08

    Applicant: ILLUMINA, INC.

    Inventor： Hod Finkelstein ,  Cheng Frank Zhong ,  Eliane H. Trepagnier

    IPC: G01N21/64 ,  C12Q1/68

    CPC classification number: G01N21/6408 ,  C12Q1/6869 ,  G01N21/05 ,  G01N21/6428 ,  G01N21/6452 ,  G01N21/6454 ,  G01N21/648 ,  G01N21/7703 ,  G01N2201/06113 ,  G01N2201/10

    Abstract: An integrated detection, flow cell and photonics (DFP) device is provided that comprises a substrate having an array of pixel elements that sense photons during active periods. The substrate and pixel elements form an IC photon detection layer. At least one wave guide is formed on the IC photo detection layer as a photonics layer. An optical isolation layer is formed over at least a portion of the wave guide. A collection of photo resist (PR) walls patterned to define at least one flow cell channel that is configured to direct fluid along a fluid flow path. The wave guides align to extend along the fluid flow path. The flow cell channel is configured to receive samples at sample sites that align with the array of pixel elements.

    Abstract translation: 提供了一种集成的检测，流动池和光子学（DFP）装置，其包括具有在活动时段期间感测光子的像素元件阵列的衬底。 衬底和像素元件形成IC光子检测层。 在IC光检测层上形成至少一个波导作为光子层。 在波导的至少一部分上形成光隔离层。 图案化的光致抗蚀剂（PR）壁的集合，以限定至少一个流动池通道，其构造成沿着流体流动路径引导流体。 波导对准沿着流体流动路径延伸。 流动池通道被配置为在与像素元件阵列对准的采样点处接收采样。

    BIOSENSORS FOR BIOLOGICAL OR CHEMICAL ANALYSIS AND METHODS OF MANUFACTURING THE SAME
    7.
    发明申请
    BIOSENSORS FOR BIOLOGICAL OR CHEMICAL ANALYSIS AND METHODS OF MANUFACTURING THE SAME 审中-公开
    生物化学或化学分析生物传感器及其制备方法

    公开(公告)号：US20160356715A1

    公开(公告)日：2016-12-08

    申请号：US15175489

    申请日：2014-12-09

    Applicant: Illumina, Inc.

    Inventor： Cheng Frank Zhong ,  Hod Finkelstein ,  Boyan Boyanov ,  Dietrich Dehlinger ,  Darren Segale

    IPC: G01N21/64 ,  G01N21/05

    CPC classification number: G01N21/645 ,  B01L3/502707 ,  B01L3/502715 ,  G01N21/05 ,  G01N21/6428 ,  G01N21/6454 ,  G01N33/54373 ,  G01N2021/6441 ,  G01N2021/6482 ,  G01N2201/061 ,  G01N2201/0642

    Abstract: Biosensor including a device base having a sensor array of light sensors and a guide array of light guides. The light guides have input regions that are configured to receive excitation light and light emissions generated by biological or chemical substances. The light guides extend into the device base toward corresponding light sensors and have a filter material. The device base includes device circuitry electrically coupled to the light sensors and configured to transmit data signals. The biosensor also includes a shield layer having apertures that are positioned relative to the input regions of corresponding light guides such that the light emissions propagate through the apertures into the corresponding input regions. The shield layer extends between adjacent apertures and is configured to block the excitation light and the light emissions incident on the shield layer between the adjacent apertures.

    Abstract translation: 生物传感器包括具有光传感器的传感器阵列的装置基座和光导的引导阵列。 光导具有被配置为接收由生物或化学物质产生的激发光和发光的输入区域。 光导件延伸到装置底座中朝向相应的光传感器并具有过滤材料。 器件基底包括电耦合到光传感器并被配置为传输数据信号的器件电路。 生物传感器还包括具有相对于相应光导的输入区域定位的孔的屏蔽层，使得光发射通过孔径传播到相应的输入区域。 屏蔽层在相邻的孔之间延伸并且被配置为阻挡入射在相邻孔之间的屏蔽层上的激发光和发光。

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