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    Biochemical analysis cartridge having improved operability
    1.
    发明授权
    Biochemical analysis cartridge having improved operability 有权
    生化分析盒具有改进的可操作性

    公开(公告)号：US09316655B2

    公开(公告)日：2016-04-19

    申请号：US14608564

    申请日：2015-01-29

    申请人： I-SENS, INC.

    发明人： Geun Sig Cha ,  Hakhyun Nam ,  Dongxuan Shen ,  Joo Young Cho ,  Jihoon Kim

    IPC分类号： C12M1/34 ,  C12M3/00 ,  G01N33/72 ,  G01N33/543 ,  B01L3/00

    CPC分类号： G01N33/726 ,  B01L3/502 ,  B01L2300/045 ,  B01L2300/047 ,  B01L2300/0672 ,  B01L2300/0816 ,  B01L2300/0835 ,  B01L2300/0867 ,  B01L2400/0409 ,  B01L2400/0457 ,  B01L2400/0683 ,  G01N33/54366 ,  G01N33/723

    摘要： The present invention relates to a biochemical analysis cartridge having improved operability. More particularly, the present invention provides a biochemical analysis cartridge including an insertion-type sample cartridge and a reaction cartridge receiving the insertion-type sample cartridge, in which, as the sample cartridge is inserted into the reaction cartridge, a reaction solution chamber moves toward a broken part of a covertape so as to automatically supply the reaction solution stored in the chamber. The biochemical analysis cartridge having improved operability according to the present invention can induce the mixing between a sample and a reaction solution by simply inserting them into the reaction cartridge and a reaction thereafter, thereby minimizing the process of a measurer to intervene in the assay, and subsequently improving user convenience and operability.

    摘要翻译： 本发明涉及具有改善的可操作性的生化分析盒。 更具体地说，本发明提供了一种生物化学分析盒，其包括插入型样品盒和容纳插入型样品盒的反应盒，其中当样品盒插入反应盒中时，反应溶液室朝向 虹膜的断裂部分，以便自动地供应存储在腔室中的反应溶液。 根据本发明的具有改进的可操作性的生物化学分析盒可以通过简单地将样品和反应溶液插入反应筒中并且随后进行反应来诱导样品和反应溶液之间的混合，由此最小化测定者介入测定的过程，并且 从而提高用户的便利性和可操作性。

    Apparatus and method for measuring concentration of an analyte in whole blood samples
    2.
    发明授权
    Apparatus and method for measuring concentration of an analyte in whole blood samples 有权

    公开(公告)号：US10690619B2

    公开(公告)日：2020-06-23

    申请号：US14564002

    申请日：2014-12-08

    申请人： I-SENS, INC.

    发明人： Geun Sig Cha ,  Hakhyun Nam ,  Seok-Won Lee ,  Sung Hyuk Choi ,  Youngjea Kang ,  Myeongho Lee ,  Ho Dong Park ,  Sung Pil Cho

    IPC分类号： G01N27/327 ,  G01N33/49 ,  G01N33/487 ,  C12Q1/00 ,  G01N33/543 ,  A61B5/1468 ,  G01N33/53 ,  B01L3/00 ,  A61B5/1495 ,  A61B5/145 ,  G01N27/49 ,  G01N33/26 ,  G01N33/52 ,  G01N27/48 ,  G01N27/42

    摘要： A method for measuring a concentration of an analyte in a bio-sample using an electrochemical bio-sensor according to an exemplary embodiment of the present invention is characterized by a step of obtaining predetermined features from induced currents obtained by applying a DC voltage according to chronoamperometry in which, after a whole blood sample is injected to the electrochemical bio-sensor, a concentration of an analyte is obtained from an induced current obtained by applying a DC voltage for a certain time and from all induced currents obtained by further applying several step-ladder perturbation potentials for a short time subsequent to the DC voltage for the certain time, and is also characterized by minimization of a measurement error caused by a hindering material by forming a calibration equation by combining the at least one feature in a function and optimizing various conditions of the bio-sample through DeletedTextsmultivariable analysis. With this configuration, a perturbation potential application method added to a conventional measurement method can maintain a bio-sensor and a measuring apparatus already used, a line used in the measuring apparatus, and calibration of amperometry as they are, improve accuracy in measurement by effectively minimizing a matrix interference effect of a background material in a bio-sample, particularly an inaccuracy caused by a change in hematocrit, and also remarkably improve accuracy in measurement by simply upgrading a measurement program of a conventional measuring apparatus.

    BIOCHEMICAL ASSAY CARTRIDGE
    3.
    发明申请
    BIOCHEMICAL ASSAY CARTRIDGE 审中-公开
    生物化学测定盒

    公开(公告)号：US20150044764A1

    公开(公告)日：2015-02-12

    申请号：US14523698

    申请日：2014-10-24

    申请人： I-SENS, INC.

    发明人： Guen Sig Cha ,  Hakhyun Nam ,  Dongxuan Shen ,  Joo Young Cho ,  Kap Soo Park ,  Jihoon Kim

    IPC分类号： C12Q1/28 ,  G01N33/53

    CPC分类号： C12Q1/28 ,  A61B5/14532 ,  A61B5/14546 ,  A61B5/1455 ,  A61B5/150022 ,  A61B5/150343 ,  A61B5/150755 ,  A61B2560/0443 ,  B01L3/502715 ,  B01L3/50273 ,  B01L3/52 ,  B01L2200/025 ,  B01L2200/04 ,  B01L2200/10 ,  B01L2300/044 ,  B01L2300/0816 ,  B01L2400/0457 ,  G01N33/5304 ,  G01N2333/805

    摘要： The present invention relates to a biochemical assay cartridge. More particularly, the present invention provides a biochemical assay cartridge including an insertion-type solution cartridge and a reaction cartridge receiving the insertion-type solution cartridge, in which the solution cartridge is inserted into the reaction cartridge to catch a protruding protection film inducement unit by a latch in the reaction cartridge and thus break the protection film inducement unit and a protection film for sealing a reaction solution storage unit attached to the solution cartridge is automatically detached to discharge the reaction solution from the solution cartridge to the reaction cartridge. The biochemical assay cartridge according to the present invention is automatically injected into the reaction cartridge while a sample to be subjected to assay is inserted, through the insertion-type solution cartridge, into the reaction cartridge, and thus user convenience and operability of the assay cartridge are improved.

    摘要翻译： 本发明涉及生化测定盒。 更具体地，本发明提供一种生物化学测定盒，其包括插入型溶液盒和接收插入型溶液盒的反应盒，其中将溶液盒插入反应盒中以通过以下步骤捕获突出的保护膜诱导单元： 反应盒中的闩锁并因此破坏保护膜诱导单元，并且自动分离用于密封附接到溶液盒的反应溶液存储单元的保护膜，以将反应溶液从溶液滤芯排出到反应盒。 根据本发明的生物化学分析盒被自动注射到反应盒中，同时待测试的样品通过插入型溶液盒插入反应盒中，因此用户方便和可操作性的测定盒 改进了

    HEMOLYSIS REAGENT COMPOSITION FOR HEMOGLOBIN A1C QUANTITATIVE ANALYSIS USING ENZYMATIC METHOD
    4.
    发明申请
    HEMOLYSIS REAGENT COMPOSITION FOR HEMOGLOBIN A1C QUANTITATIVE ANALYSIS USING ENZYMATIC METHOD 有权
    HEMOGLOBIN A1C定量分析的化学试剂组合物使用酶法

    公开(公告)号：US20140370539A1

    公开(公告)日：2014-12-18

    申请号：US14373977

    申请日：2012-11-16

    申请人： I-Sens, Inc.

    发明人： Dongxuan Shen ,  Joo Young Cho ,  Kap Soo Park ,  Geun Sig Cha ,  Hakhyun Nam

    IPC分类号： G01N33/50

    CPC分类号： G01N33/5091 ,  C07C309/14 ,  C12Q1/26 ,  G01N33/721 ,  G01N2333/805

    摘要： Disclosed is a hemolysis reagent composition for the quantitative analysis of glycated hemoglobin (HbAlc) via an enzymatic method. The hemolysis reagent compositions of the present invention containing a zwitterionic surfactant and a nitrous compound considerably accelerate hemolysis rate due to the presence of the zwitterionic surfactant, and also induce the N-terminal β-chain of hemoglobin released by hemolysis to be exposed to the outside of the hemoglobin molecule and assists the participation of a greater number of molecules in the reaction, thereby improving reaction sensitivity and reaction rate of the glycated hemoglobin, and the nitrous compound makes the protein structure of the hemoglobin flexibly modified so that the amino acid sequence of the N-terminal β-chain of hemoglobin can be readily cut off, thereby significantly reducing the entire time required for the measurement and improving the accuracy of the measurement.

    摘要翻译： 公开了通过酶法定量分析糖化血红蛋白（HbAlc）的溶血试剂组合物。 含有两性离子表面活性剂和亚硝基化合物的本发明的溶血试剂组合物由于两性离子表面活性剂的存在而显着加速溶血速率，并且还诱导通过溶血释放的血红蛋白的N末端和末端被暴露于 在血红蛋白分子之外，有助于反应中更多的分子的参与，从而提高糖化血红蛋白的反应灵敏度和反应速率，并且亚硝基化合物使得血红蛋白的蛋白质结构被灵活地修饰，使得氨基酸序列 的血红蛋白的N-末端和链长可以容易地切断，从而显着减少测量所需的整个时间并提高测量的精度。

    BLOOD GLUCOSE MONITORING SYSTEM HAVING WIRELESS COMMUNICATION MODULE TO WHICH TIME SYNCHRONIZATION METHOD IS APPLIED
    5.
    发明申请
    BLOOD GLUCOSE MONITORING SYSTEM HAVING WIRELESS COMMUNICATION MODULE TO WHICH TIME SYNCHRONIZATION METHOD IS APPLIED 有权
    具有应用时间同步方法的无线通信模块的血液葡萄糖监测系统

    公开(公告)号：US20140241338A1

    公开(公告)日：2014-08-28

    申请号：US14273405

    申请日：2014-05-08

    申请人： i-SENS, Inc.

    发明人： Chang Woo Ryu ,  Dae Kag Choi ,  Geun Sig Cha ,  Hakhyun Nam

    IPC分类号： H04J3/06

    CPC分类号： H04J3/0638 ,  A61B5/002 ,  A61B5/1411 ,  A61B5/14532 ,  A61B5/150022 ,  A61B5/150854 ,  A61B5/157 ,  G04G7/00 ,  G04G9/0076 ,  G04G21/025 ,  G04G21/04 ,  G06F19/00 ,  G06Q50/24

    摘要： The present disclosure relates to a blood sugar meter system with a wireless communication module, and more particularly, to a time synchronization method between a blood sugar meter system with a wireless communication module synchronized with a cellular network such as a global system for mobile communication (GSM)/code division multiple access (CDMA) network and the cellular network. The present invention provides a blood sugar meter system with a wireless communication module applying a time synchronization scheme including: a global system for mobile communication (GSM)/code division multiple access (CDMA) network transmitting network identity and time zone (NITZ) information; and a blood sugar meter metering user's blood sugar data, wherein the blood sugar meter synchronizes a network time according to the NITZ information with an internal time of the metered data and transmits the metered blood sugar data to a server connected to the GSM/CDMA network.

    摘要翻译： 本公开涉及一种具有无线通信模块的血糖计系统，更具体地，涉及在与诸如全球移动通信系统之类的蜂窝网络同步的无线通信模块的血糖仪系统之间的时间同步方法 GSM）/码分多址（CDMA）网络和蜂窝网络。 本发明提供了一种具有应用时间同步方案的无线通信模块的血糖计系统，包括：全球移动通信系统（GSM）/码分多址（CDMA）网络传输网络身份和时区（NITZ）信息; 和血糖计计量用户的血糖数据，其中血糖仪根据NITZ信息与计量数据的内部时间同步网络时间，并将计量的血糖数据发送到连接到GSM / CDMA网络的服务器 。

    CONNECTOR FOR CONNECTING BIO-SENSOR AND MEASURING INSTRUMENT THEREOF
    9.
    发明申请
    CONNECTOR FOR CONNECTING BIO-SENSOR AND MEASURING INSTRUMENT THEREOF 审中-公开
    连接生物传感器和测量仪器的连接器

    公开(公告)号：US20150014162A1

    公开(公告)日：2015-01-15

    申请号：US14371218

    申请日：2012-11-16

    申请人： I-SENS, INC.

    发明人： Moon Hwan Kim ,  Geun Sig Cha ,  Hakhyun Nam

    IPC分类号： H01R24/62 ,  G01N27/327

    CPC分类号： H01R24/62 ,  G01N27/3273 ,  G01N33/4875 ,  H01R12/714 ,  H01R12/721 ,  H01R13/631 ,  H01R2107/00 ,  H01R2201/12 ,  H01R2201/20

    摘要： Disclosed herein is a connector for connecting a biosensor and a measuring device thereof. The connector includes an insertion guide to prevent a connection electrode from being damaged due to a mis-insertion of the biosensor when the biosensor is inserted into the connector, and also may further include an integrated photo reflector for emitting and detecting an infrared ray to identify production lot information of the biosensor, so that production information of the biosensor may be simply opened, and as a result, the connector may be used as a connector for connecting the biosensor and the measuring device thereof.

    摘要翻译： 这里公开了用于连接生物传感器及其测量装置的连接器。 连接器包括插入引导件，以防止连接电极在生物传感器插入连接器时由于生物传感器的插入而被损坏，并且还可以包括用于发射和检测红外线的集成光反射器以识别 生物传感器的生产批次信息，从而可以简单地打开生物传感器的生产信息，结果可以将连接器用作用于连接生物传感器及其测量装置的连接器。