知搜-全球专利检索

  1. Login
  2. Sign Up

Search Results

27 records (took 0.052 seconds)

    Polymorphic repeats in human genes
    2.
    发明授权
    Polymorphic repeats in human genes 失效
    人类基因中的多态重复序列

    公开(公告)号：US06472154B1

    公开(公告)日：2002-10-29

    申请号：US09475947

    申请日：1999-12-31

    Applicant: Harold R. Garner ,  Jonathan D. Wren ,  John D. Minna ,  John W. Fondon, III

    Inventor： Harold R. Garner ,  Jonathan D. Wren ,  John D. Minna ,  John W. Fondon, III

    IPC: C12Q168

    CPC classification number: G06F19/22 ,  C12Q1/6876 ,  C12Q2600/156

    Abstract: The invention provides computational methods and compositions for identifying polymorphic repeats in genes. Candidate polymorphic repeats are identified by detecting tandem repeats in a target coding sequence, scoring the repeats for polymorphic probability, and generating a dataset correlating the repeats with polymorphic probability. Actual polymorphic repeat are identified by further detecting the candidate polymorphic repeat in each of a population of different coding sequences, and determining whether the candidate polymorphic repeat is polymorphic in the population. Computationally derived polymorphic repeats are validated with phenotypic variations and these correlates are used to detect the presence or absence of such phenotypic variation in test genes. Variances at polymorphic repeats are identified by detecting in a test gene or coding region the presence or absence of variance at a disclosed unconventional polymorphic repeat.

    Abstract translation: 本发明提供用于鉴定基因中多态性重复序列的计算方法和组合物。 通过检测目标编码序列中的串联重复序列来鉴定候选多态性重复序列，对重复序列进行多态概率评分，并生成将重复与多态概率相关联的数据集。 通过进一步检测不同编码序列的群体中的候选多态性重复，并确定候选多态性重复是否在群体中是多态性，来鉴定实际多态性重复。 计算得到的多态性重复序列用表型变异验证​​，这些相关性用于检测测试基因中这种表型变异的存在或不存在。 通过在测试基因或编码区域中检测在所公开的非常规多态性重复序列中存在或不存在差异来鉴定多态性重复序列的差异。

    Automatic sequencer/genotyper having extended spectral response
    3.
    发明授权
    Automatic sequencer/genotyper having extended spectral response 失效
    自动定序器/ genotyper具有扩展的光谱响应

    公开(公告)号：US06427126B1

    公开(公告)日：2002-07-30

    申请号：US09227720

    申请日：1999-01-08

    Applicant: Ali Dabiri ,  Harold R. Garner

    Inventor： Ali Dabiri ,  Harold R. Garner

    IPC: G06E100

    CPC classification number: G01N27/44721 ,  B01J2219/00702

    Abstract: An advanced imaging spectrograph system and method are provided for very high throughput identification, sequencing and/or genotyping of DNA and other molecules. The system is based on the integration of improved electrophoresis structures with an imaging spectrophotometer that records the entire emission spectra along an imaging line across a sequencing gel (or capillary array). The system includes spectral shape matching to improve dye identification allowing the use of dyes having nearly any emission spectra and allowing greater than four dye multiplexing.

    Abstract translation: 提供先进的成像光谱仪系统和方法，用于DNA和其他分子的非常高的通量鉴定，测序和/或基因分型。 该系统基于改进的电泳结构与成像分光光度计的整合，其通过测序凝胶（或毛细管阵列）沿着成像线记录整个发射光谱。 该系统包括光谱形状匹配以改善染料鉴定，允许使用具有几乎任何发射光谱并允许大于四种染料复合的染料。

    Coated capillary tube for the controlled release of reagent
    4.
    发明授权
    Coated capillary tube for the controlled release of reagent 失效
    涂层毛细管用于控释试剂

    公开(公告)号：US5387526A

    公开(公告)日：1995-02-07

    申请号：US030445

    申请日：1993-03-30

    Applicant: Harold R. Garner ,  Orenda F. Tuason ,  Larry S. Peranich

    Inventor： Harold R. Garner ,  Orenda F. Tuason ,  Larry S. Peranich

    IPC: B01L3/00 ,  B01L3/02 ,  G01N21/03 ,  G01N21/29 ,  G01N21/59 ,  G01N21/64 ,  G01N21/77 ,  G01N33/52 ,  G01N33/543 ,  G01N35/00 ,  G01N35/10

    CPC classification number: B01L3/508 ,  B01L3/502 ,  G01N21/03 ,  G01N33/52 ,  G01N33/54373 ,  B01L2200/16 ,  B01L2300/0838 ,  B01L2300/087 ,  B01L3/021 ,  G01N2021/0346 ,  G01N2035/00237 ,  G01N2035/1062 ,  G01N21/29 ,  Y10S436/81 ,  Y10T436/143333

    Abstract: A hollow, elongated, micropipette, which is specially adapted for use in spectrometers and which has an inner wall on which a coating containing a reagent has been deposited, is provided. The reagent is selected from among those that interact with one or more compounds in a sample solution, which is introduced into the micropipette, in order to permit the compounds to be detected by virtue of light absorption or emission by the complexes formed upon interaction of the reagent with the compound of interest in the sample.Upon introduction of the sample solution into the micropipette, a sufficient amount of the reagent in the coating dissolves in the solution and reacts, either directly or indirectly with a compound or compounds of interest in the solution to render such compound detectable and to permit quantification of the concentration of the compound in the sample. The resulting solution is held in the micropipette for analysis of the light absorption or light emission characteristics of the solution to determine the composition of the solution or the concentration of a particular constituent of the solution.In preferred embodiments, the coating on the inner surface of the micropipette includes a binding agent or adhesive that delays, preferably for about 5 to 15 sec, the dissolution of the reagent in the solution.

    Abstract translation: PCT No.PCT / US91 / 06567 Sec。 371日期1993年3月30日 102（e）1993年3月30日PCT 1991年9月11日PCT。一种中空的细长的微量移液器，其特别适用于分光计，并且其内壁上已经沉积了含有试剂的涂层， 被提供。 该试剂选自与引入微量吸管中的样品溶液中的一种或多种化合物相互作用的试剂，以便允许通过在相互作用下形成的络合物的光吸收或发射来检测化合物 试剂与样品中感兴趣的化合物。 当将样品溶液引入微量移液管中时，涂层中的足量的试剂溶解在溶液中，直接或间接地与溶液中的化合物或化合物直接或间接反应，以使该化合物可检测并允许定量 样品中化合物的浓度。 将所得溶液保持在微量移液管中，以分析溶液的光吸收或发光特性，以确定溶液的组成或溶液的特定成分的浓度。 在优选的实施方案中，微量移液管内表面上的涂层包括粘合剂或粘合剂，其优选延长试剂溶解在溶液中约5至15秒。

    Coaxial microwave asborption diagnostic
    5.
    发明授权
    Coaxial microwave asborption diagnostic 失效
    同轴微波加固诊断

    公开(公告)号：US4990858A

    公开(公告)日：1991-02-05

    申请号：US357333

    申请日：1989-05-25

    Applicant: Harold R. Garner

    Inventor： Harold R. Garner

    IPC: G01N22/00

    CPC classification number: G01N22/00

    Abstract: A coaxial microwave absorption diagnostic device comprises a hollow cylindrical outer layer conductor with a coaxially aligned conductor rod extending therethrough and a dielectric material which interconnects the outer layer to the conductor rod. The device is formed with a passageway which is directed perpendicular to the longitudinal axis of the device and which passed through the outer layer, the conductor rod and the dielectric material. As so formed, the passageway is positioned for receiving a sample holder, such as a small capillary tube holding a sample solution. A variable or fixed frequency oscillator is electrically connected to an input end of the conductor rod for sending microwave power through the device and a diode senses the output portion of this microwave power which has passed through the device. The absorbed power, i.e. the input microwave power less the output microwave power, is determined by a comparator and used to analyze the sample.

    Computer-based method for creating collections of sequences from a dataset of sequence identifiers corresponding to natural complex biopolymer sequences and linked to corresponding annotations
    7.
    发明授权
    Computer-based method for creating collections of sequences from a dataset of sequence identifiers corresponding to natural complex biopolymer sequences and linked to corresponding annotations 失效
    基于计算机的方法，用于从对应于天然复合生物聚合物序列的序列标识符的数据集创建序列集合并链接到相应的注释

    公开(公告)号：US07065451B2

    公开(公告)日：2006-06-20

    申请号：US09865090

    申请日：2001-05-24

    Applicant: Harold R. Garner ,  Amit Kulkarni

    Inventor： Harold R. Garner ,  Amit Kulkarni

    IPC: G06F19/00 ,  G06F17/30 ,  G05B15/00

    CPC classification number: G06F19/28 ,  G06F19/20 ,  G06F19/22 ,  Y10S707/99933

    Abstract: The invention relates to computer-based systems and methods for the design, comparison and analysis of genetic and proteomic databases. In a particular embodiment, the recited systems and methods have been implemented in a computer tool called ARROGANT. ARROGANT, in the analysis mode, is a comprehensive tool for providing annotation to large gene and protein collections. ARROGANT takes in a large collection of sequence identifiers and associates it with other information collected from many sources like sequence annotations, pathways, homology, polymorphisms, artifacts, etc. The simultaneous annotation for a large assembly of genes makes the collection of genomic/EST sequences truly informative.

    Abstract translation: 本发明涉及用于遗传和蛋白质组学数据库的设计，比较和分析的基于计算机的系统和方法。 在特定实施例中，所述系统和方法已经在称为ARROGANT的计算机工具中实现。 ARROGANT在分析模式下，是为大型基因和蛋白质集合提供注释的综合工具。 ARROGANT收集了大量的序列标识符，并将其与从诸如序列注释，途径，同源性，多态性，伪像等的许多来源收集的其他信息相关联。大量基因组的同时注释使得基因组/ EST序列的收集 真正的信息。

    Optical correlator using spatial light modulator illumination
    8.
    发明授权
    Optical correlator using spatial light modulator illumination 有权
    光相关器使用空间光调制器照明

    公开(公告)号：US06819807B2

    公开(公告)日：2004-11-16

    申请号：US09933778

    申请日：2001-08-20

    Applicant: Harold R. Garner ,  Richard O. Gale

    Inventor： Harold R. Garner ,  Richard O. Gale

    IPC: G02F101

    CPC classification number: G06E3/003 ,  G02B6/262 ,  G02B6/3516

    Abstract: An optical correlator (10) that uses a spatial light modulator (11) to illuminate a pattern of on and off pixels into a length of an optical fiber (12). The spatial light modulator (11) is optically coupled to the length of fiber (12) so that the illumination enters the fiber along that length. The optical fiber (12) also carries light representing a bitstream of data. At the optical fiber, the illumination from the spatial light modulator interacts with the illumination of the optical bitstream. A detector (14) is optically coupled to the same length of fiber (12) and detects the resulting optical response to determine if a correlation exists.

    Abstract translation: 一种光学相关器（10），其使用空间光调制器（11）将开/关像素的图案照射成光纤（12）的长度。 空间光调制器（11）光纤耦合到光纤（12）的长度，使得照明沿着该长度进入光纤。 光纤（12）还承载代表数据比特流的光。 在光纤中，来自空间光调制器的照明与光比特流的照明相互作用。 检测器（14）光学耦合到相同长度的光纤（12），并检测所得到的光学响应以确定是否存在相关性。

    Assembly for converting a spectrophotometer to a fluorometer
    10.
    发明授权
    Assembly for converting a spectrophotometer to a fluorometer 失效
    用于将分光光度计转换到荧光计的组件

    公开(公告)号：US5166743A

    公开(公告)日：1992-11-24

    申请号：US746855

    申请日：1991-08-19

    Applicant: Harold R. Garner

    Inventor： Harold R. Garner

    IPC: G01J3/02 ,  B01L3/02 ,  B01L7/00 ,  G01J3/443 ,  G01N21/01 ,  G01N21/03 ,  G01N21/64 ,  G01N35/00 ,  G01N35/10 ,  G05D23/22

    CPC classification number: B01L3/021 ,  B01L7/00 ,  G01N21/01 ,  G01N21/0332 ,  G01N21/645 ,  G05D23/22 ,  G01N2021/0346 ,  G01N2021/6463 ,  G01N2035/00237 ,  G01N2035/1062 ,  G01N2201/0245

    Abstract: A conversion assembly for converting a spectrophotometer to a fluorometer which utilizes the light source and light detector of the spectrophotometer. The assembly has a conversion adaptor which is positionable in the spectrophotometer between the light source and the light detector. The adaptor is an enclosure having a receptacle for holding a sample container filled with the sample being analyzed and having openings formed therein to provide a light path for excitation light from the light source to the sample container and further to provide a light path for emitted luminescent light from the sample container to the light detector. In one embodiment the excitation light is centered on an optical shield on the front of the enclosure while light receiving openings at the edges of the front of the enclosure are positioned to receive off center excitation light. In another embodiment a light receiving opening is formed in the side of the enclosure and excitation light centered on the front of the enclosure is reflected around to the opening in the side of the enclosure by a plurality of reflectors.

    Abstract translation: 用于将分光光度计转换成利用分光光度计的光源和光检测器的荧光计的转换组件。 该组件具有可在光源和光检测器之间的分光光度计中定位的转换适配器。 适配器是具有用于容纳填充有待分析的样品的样品容器的容器的容器，并且具有形成在其中的开口，以提供用于从光源到样品容器的激发光的光路，并且还提供用于发射的发光的光路 从样品容器到光检测器的光。 在一个实施例中，激发光在外壳的前部上的光学屏蔽上居中，而外壳前部边缘的光接收开口定位成接收偏心的激发光。 在另一个实施例中，光接收开口形成在外壳的侧面，并且围绕外壳的前部的中心的激发光由多个反射器反射到外壳侧面的开口。

Patent Agency Ranking