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    Dyes and labeled molecules
    1.
    发明授权
    Dyes and labeled molecules 有权
    染料和标记分子

    公开(公告)号：US08530195B2

    公开(公告)日：2013-09-10

    申请号：US12820983

    申请日：2010-06-22

    Applicant: Fei Mao ,  Wai-Yee Leung ,  Xing Xin

    Inventor： Fei Mao ,  Wai-Yee Leung ,  Xing Xin

    IPC: C12P19/34 ,  C12Q1/68 ,  C07H21/04

    CPC classification number: C12Q1/6876 ,  C07D209/08 ,  C07D213/38 ,  C07D221/10 ,  C07D417/06 ,  C07D417/14 ,  C07D491/147 ,  C07H21/00 ,  C09B15/00 ,  C12Q1/6851 ,  C12Q1/686 ,  C12Q2563/173

    Abstract: Dimeric and trimeric nucleic acid dyes, and associated systems and methods are provided. Such a dye may form a hairpin-like structure that enables it to stain nucleic acids via a release-on-demand mechanism, for example. Such a dye may have low background fluorescence in the absence of nucleic acids and high fluorescence in the presence of nucleic acids, upon binding therewith, for example. A dye provided herein may be useful in a variety of applications, such as in DNA quantitation in real-time PCR, for example.

    Abstract translation: 提供二聚和三聚体核酸染料以及相关系统和方法。 这样的染料可以形成发夹状结构，使其能够通过例如按需释放机制来染色核酸。 在不存在核酸的情况下，这样的染料可能具有低的背景荧光，并且例如在与核酸的结合时在核酸存在下具有高荧光。 本文提供的染料可用于各种应用，例如在实时PCR中的DNA定量中。

    DYES AND LABELED MOLECULES
    4.
    发明申请
    DYES AND LABELED MOLECULES 有权
    染色体和标签分子

    公开(公告)号：US20100317016A1

    公开(公告)日：2010-12-16

    申请号：US12820983

    申请日：2010-06-22

    Applicant: Fei Mao ,  Wai-Yee Leung ,  Xing Xin

    Inventor： Fei Mao ,  Wai-Yee Leung ,  Xing Xin

    IPC: C12Q1/68 ,  G01N33/566 ,  C07H21/00

    CPC classification number: C12Q1/6876 ,  C07D209/08 ,  C07D213/38 ,  C07D221/10 ,  C07D417/06 ,  C07D417/14 ,  C07D491/147 ,  C07H21/00 ,  C09B15/00 ,  C12Q1/6851 ,  C12Q1/686 ,  C12Q2563/173

    Abstract: Dimeric and trimeric nucleic acid dyes, and associated systems and methods are provided. Such a dye may form a hairpin-like structure that enables it to stain nucleic acids via a release-on-demand mechanism, for example. Such a dye may have low background fluorescence in the absence of nucleic acids and high fluorescence in the presence of nucleic acids, upon binding therewith, for example. A dye provided herein may be useful in a variety of applications, such as in DNA quantitation in real-time PCR, for example.

    Abstract translation: 提供二聚和三聚体核酸染料以及相关系统和方法。 这样的染料可以形成发夹状结构，使其能够通过例如按需释放机制来染色核酸。 在不存在核酸的情况下，这样的染料可能具有低的背景荧光，并且例如在与核酸的结合时在核酸存在下具有高荧光。 本文提供的染料可用于各种应用，例如在实时PCR中的DNA定量中。

    Dimeric and trimeric nucleic acid dyes, and associated systems and methods
    5.
    发明申请
    Dimeric and trimeric nucleic acid dyes, and associated systems and methods 有权
    二聚体和三聚体核酸染料，以及相关系统和方法

    公开(公告)号：US20060211028A1

    公开(公告)日：2006-09-21

    申请号：US11377253

    申请日：2006-03-16

    Applicant: Fei Mao ,  Wai-Yee Leung ,  Xing Xin

    Inventor： Fei Mao ,  Wai-Yee Leung ,  Xing Xin

    IPC: C12Q1/68 ,  C07D401/02

    CPC classification number: C12Q1/6876 ,  C07D209/08 ,  C07D213/38 ,  C07D221/10 ,  C07D417/06 ,  C07D417/14 ,  C07D491/147 ,  C07H21/00 ,  C09B15/00 ,  C12Q1/6851 ,  C12Q1/686 ,  C12Q2563/173

    Abstract: Dimeric and trimeric nucleic acid dyes, and associated systems and methods are provided. Such a dye may form a hairpin-like structure that enables it to stain nucleic acids via a release-on-demand mechanism, for example. Such a dye may have low background fluorescence in the absence of nucleic acids and high fluorescence in the presence of nucleic acids, upon binding therewith, for example. A dye provided herein may be useful in a variety of applications, such as in DNA quantitation in real-time PCR, for example.

    Abstract translation: 提供二聚和三聚体核酸染料以及相关系统和方法。 这样的染料可以形成发夹状结构，使其能够通过例如按需释放机制来染色核酸。 在不存在核酸的情况下，这样的染料可能具有低的背景荧光，并且例如在与核酸的结合时在核酸存在下具有高荧光。 本文提供的染料可用于各种应用，例如在实时PCR中的DNA定量中。

    Substituted anthraquinone dyes for cellular stains and enzyme detection
    6.
    发明授权
    Substituted anthraquinone dyes for cellular stains and enzyme detection 有权
    取代的蒽醌染料用于细胞染色和酶检测

    公开(公告)号：US08790892B2

    公开(公告)日：2014-07-29

    申请号：US13439821

    申请日：2012-04-04

    Applicant: Fei Mao ,  Wai-Yee Leung ,  Ching-Ying Cheung ,  Lori Michelle Roberts

    Inventor： Fei Mao ,  Wai-Yee Leung ,  Ching-Ying Cheung ,  Lori Michelle Roberts

    IPC: G01N1/30

    CPC classification number: C09B1/516 ,  A61K49/0052 ,  C09B1/501 ,  C09B1/51 ,  C09B1/5155 ,  G01N1/30 ,  G01N21/6428

    Abstract: The invention discloses new substituted anthraquinone dyes that may be useful as cellular stains. In some aspect of the invention, the nuclear stains are useful for staining the nuclei of dead or fixed cells. Another aspect of the invention relates to substituted anthraquinone dyes comprising an enzyme substrate moiety that is transformable or cleavable by an enzyme such that the transformation or cleavage of the substrate moiety causes a detectable change in the functionality or spectral properties of the dye.

    Abstract translation: 本发明公开了可用作细胞污渍的新的取代的蒽醌染料。 在本发明的某些方面，核染料可用于染色死细胞或固定细胞的细胞核。 本发明的另一方面涉及包含酶底物部分的取代的蒽醌染料，其可由酶转化或切割，使得底物部分的转化或切割导致染料的官能度或光谱性质的可检测变化。

    Methods of using dyes in association with nucleic acid staining or detection and associated technology
    7.
    发明授权
    Methods of using dyes in association with nucleic acid staining or detection and associated technology 有权
    使用染料与核酸染色或检测及相关技术相结合的方法

    公开(公告)号：US08232050B2

    公开(公告)日：2012-07-31

    申请号：US12854436

    申请日：2010-08-11

    Applicant: Fei Mao ,  Wai-Yee Leung

    Inventor： Fei Mao ,  Wai-Yee Leung

    IPC: C12Q1/68 ,  C07H21/00 ,  C07H19/04

    CPC classification number: C09B15/00 ,  C09B11/28 ,  C09B23/04 ,  C12Q1/6818 ,  G01N1/30 ,  G01N21/6486 ,  Y10S435/81 ,  Y10T436/143333 ,  C12Q2525/301

    Abstract: Methods of using dyes and associated technology are provided. A dye, such as a monomeric dye or a dimeric dye, may be used in a nucleic acid gel staining application and/or a nucleic acid detection application. Such a dye and a salt that comprises an anion that is associated with a strong acid and a cation that is associated with a strong base may be used in such an application. A dimeric dye, such as a dimeric dye capable of forming a hairpin-like structure, may be used to stain and/or detect nucleic acids via a release-on-demand mechanism. A dimeric dye having low background fluorescence in the absence of nucleic acids and high fluorescence in the presence of nucleic acids, upon binding therewith, may be used to stain and/or detect nucleic acids.

    Abstract translation: 提供了使用染料和相关技术的方法。 可以在核酸凝胶染色应用和/或核酸检测应用中使用染料，例如单体染料或二聚染料。 这种染料和包含与强酸相关的阴离子和与强碱相关的阳离子的盐可用于这种应用中。 可以使用二聚染料，例如能够形成发夹状结构的二聚染料，以通过按需释放机制对核酸进行染色和/或检测。 在存在核酸时具有低背景荧光的二聚染料和在存在核酸时与核酸存在时的高荧光可用于染色和/或检测核酸。

    Sulfonated derivatives of 7-aminocoumarin
    10.
    发明授权
    Sulfonated derivatives of 7-aminocoumarin 失效
    7-氨基香豆素的磺化衍生物

    公开(公告)号：US5696157A

    公开(公告)日：1997-12-09

    申请号：US749753

    申请日：1996-11-15

    Applicant: Hui-Ying Wang ,  Wai-Yee Leung ,  Fei Mao

    Inventor： Hui-Ying Wang ,  Wai-Yee Leung ,  Fei Mao

    IPC: C07D311/16 ,  C07D405/12 ,  A61K31/37 ,  C07D311/18

    CPC classification number: C07D405/12 ,  C07D311/16

    Abstract: The present invention describes 7-aminocoumarin dyes that are substituted one or more times at the 3-, 6- and/or 8-positions by a sulfonic acid or a salt of a sulfonic acid, said dyes being useful as fluorescent probes or in the preparation of enzyme substrates, caged probes, or adducts with reducing sugars. The dyes of the invention optionally possess a reactive group useful for preparing fluorescent conjugates, which conjugates and methods for their preparation are described herein.

    Abstract translation: 本发明描述了在3-，6-和/或8位被磺酸或磺酸盐取代一次或多次的7-氨基香豆素染料，所述染料可用作荧光探针或在 酶底物的制备，笼式探针或与还原糖的加合物。 本发明的染料任选地具有可用于制备荧光共轭物的反应性基团，其缀合物及其制备方法在本文中描述。

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