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公开(公告)号：US11698582B2
公开(公告)日：2023-07-11
申请号：US16239272
申请日：2019-01-03
IPC分类号： H01J37/05 , H01J37/317 , H01L21/265 , H01L21/311 , H01L21/02 , H05H3/02 , G03F1/80 , G03F1/82 , H01J37/147 , H01L29/36 , B24B37/04
CPC分类号： G03F1/80 , G03F1/82 , H01J37/05 , H01J37/147 , H01J37/317 , H01J37/3171 , H01L21/02115 , H01L21/02274 , H01L21/26506 , H01L21/26513 , H01L21/26566 , H01L21/31105 , H01L21/31111 , H05H3/02 , B24B37/04 , H01J2237/0041 , H01J2237/0812 , H01J2237/15 , H01L29/36 , Y10T428/24355 , Y10T428/24479 , Y10T428/30
摘要： A method for preparing a biological material for implanting provides irradiating at least a portion of the surface of the material with an accelerated Neutral Beam.
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2.发明申请公开(公告)号：US20150038899A1
公开(公告)日：2015-02-05
申请号：US14238503
申请日：2012-08-22
CPC分类号： A61F2/30771 , A61C8/0013 , A61C19/06 , A61F2/30942 , A61F2/3607 , A61F2002/2835 , A61F2002/30028 , A61F2002/3068 , A61L27/047 , A61L27/06 , A61L27/306 , A61L27/32 , A61L27/50 , A61L27/54 , A61L31/08 , A61L31/16 , A61L2300/414 , A61L2300/426 , A61L2300/606 , A61L2400/18 , A61L2420/02 , A61L2420/06 , A61L2430/02 , B05D3/068
摘要： A bone implantable medical device made from a biocompatible material, preferably comprising titania or zirconia, has at least a portion of its surface modified to facilitate improved integration with bone. The implantable device may incorporate a surface infused with osteoinductive agent and/or may incorporate holes loaded with a therapeutic agent. The infused surface and/or the holes may be patterned to determine the distribution of and amount of osteoinductive agent and/or therapeutic agent incorporated. The rate of release or elution profile of the therapeutic agent may be controlled. Methods for producing such a bone implantable medical device are also disclosed and employ the use of accelerated Neutral Beam irradiation, wherein the Neutral Beam is derived from an accelerated gas cluster ion beam irradiation for improving bone integration.
摘要翻译： 由生物相容性材料（优选包含二氧化钛或氧化锆）制成的骨可植入医疗装置具有至少部分其表面改性以便于改进与骨的整合。 可植入装置可以包含注入骨诱导剂的表面和/或可以掺入装有治疗剂的孔。 输注的表面和/或孔可以被图案化以确定引入的骨诱导剂和/或治疗剂的分布和量。 可以控制治疗剂的释放或洗脱曲线的速率。 还公开了用于生产这种骨可植入医疗装置的方法，并且采用加速中性束照射的方法，其中中性束源自用于改善骨整合的加速气体簇离子束照射。
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公开(公告)号：US09839723B2
公开(公告)日：2017-12-12
申请号：US15130354
申请日：2016-04-15
CPC分类号： A61L27/38 , A61L27/06 , A61L27/16 , A61L27/18 , A61L27/50 , A61L2300/64 , A61L2400/18 , C12N13/00 , C08L27/18
摘要： A method for improving bioactivity of a surface of an implantable object comprising titania, titanium, an alloy of titanium, and/or polytetrafluoroethylene (PTFE) and implantable objects prepared thereby provides forming an accelerated neutral beam derived from an accelerated gas-cluster ion-beam (GCIB) in a reduced-pressure chamber, introducing an implantable object into the reduced-pressure chamber, and irradiating at least a first portion of the surface of said implantable object with a GCIB-derived neutral beam.
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4.发明申请公开(公告)号：US20130138213A1
公开(公告)日：2013-05-30
申请号：US13746795
申请日：2013-01-22
CPC分类号： A61F2/28 , A61C8/0012 , A61C8/0018 , A61F2/30771 , A61F2002/30677 , A61F2002/3068 , A61F2002/30795 , A61F2250/0068 , A61F2310/00796 , A61L27/10 , A61L27/50 , A61L27/54 , A61L2300/406 , A61L2300/414 , A61L2300/426 , A61L2300/45 , A61L2300/602 , A61L2300/606 , A61L2400/18 , B05D3/068 , C23C14/221 , C23C14/48
摘要： A method of modifying a surface of implantable medical device provides coating at least a first portion of the surface of the medical device with a therapeutic agent to form a coated surface region; and irradiating at least a portion of the coated surface region with a gas cluster ion beam infusing the therapeutic agent into the at least a portion of the coated surface region.
摘要翻译： 修改可植入医疗装置的表面的方法提供用医疗装置的表面的至少第一部分涂覆治疗剂以形成涂覆的表面区域; 以及将所述涂覆的表面区域的至少一部分用喷射所述治疗剂的气体团簇离子束照射到所述涂覆的表面区域的至少一部分中。
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