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1.发明授权Compositions and systems for forming high strength medical sealants, and associated methods of preparation and use 有权用于形成高强度医用密封剂的组合物和系统，以及相关的制备和使用方法公开(公告)号：US06495127B1
公开(公告)日：2002-12-17
申请号：US09649337
申请日：2000-08-28
IPC分类号： A61K3174
CPC分类号： A61L24/0031 , A61L24/0015 , A61L24/0026 , A61L24/046 , A61L2300/406 , A61L2300/414 , A61L2300/418 , C08G65/329 , C08G75/045 , C08G75/26 , C08L71/02 , C08L81/02 , Y10S977/914 , C08L89/06 , C08L71/00
摘要： The present invention relates generally to synthetic polymer compositions that form interpenetrating polymer networks. In a preferred embodiment, the compositions comprise two multifunctionally activated synthetic polymers, along with a tensile strength enhancer. Such compositions form matrices that exhibit superior cohesive strength and in many instances can serve as adequate replacements for surgical means of attaching tissues, such as sutures and medical staples.
摘要翻译： 本发明一般涉及形成互穿聚合物网络的合成聚合物组合物。 在优选的实施方案中，组合物包含两种多功能活化的合成聚合物以及拉伸强度增强剂。 这样的组合物形成表现出优异的内聚强度的基质，并且在许多情况下可以作为用于连接组织的手术装置如缝合线和医用缝钉的适当替代物。
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公开(公告)号：US6083522A
公开(公告)日：2000-07-04
申请号：US4550
申请日：1998-01-08
申请人： George H. Chu , Jeff E. Yeung , Jacqueline Anne Schroeder , Vivek N. Shenoy , Melissa K. C. Brown , James J. Cassidy , John Rice
发明人： George H. Chu , Jeff E. Yeung , Jacqueline Anne Schroeder , Vivek N. Shenoy , Melissa K. C. Brown , James J. Cassidy , John Rice
IPC分类号： A61F2/00 , A61F2/08 , A61L27/24 , A61L27/46 , A61L27/48 , A61L31/04 , A61L31/12 , B29C47/70 , A61F2/02 , A61F2/28
CPC分类号： B29C47/702 , A61B17/0401 , A61L27/24 , A61L27/46 , A61L27/48 , A61L31/044 , A61L31/127 , A61L31/129 , B29C47/0023 , B29C47/003 , A61B2017/00526 , A61B2017/00898 , A61B2017/0404 , A61B2017/0409 , A61B2017/0414 , A61B2017/0445 , A61F2/0811 , A61F2310/00365 , A61L2430/02
摘要： Disclosed herein are uniformly shaped swellable devices comprising polymeric materials, as well as apparatuses and processes for their manufacture. In one embodiment, the present invention relates to load bearing implant devices for use in tissue repair. The implants consist of a resorbable, swellable implant body which is formed from a dehydrated crosslinked biocompatible polymer. As such, the implants are capable of swelling after insertion to become anchored in place. The implants function to enhance the structural integrity of the hard tissue into which they are placed, and thereby improve the load bearing capacity of such tissues. The implants are particularly well suited for use in attaching a second (hard or soft) tissue to the first (hard) tissue into which the implant is inserted. They may also be used as a site for attachment of a surgical device such as a screw, rod or pin.
摘要翻译： 本文公开了包括聚合材料的均匀形状的可溶胀装置，以及用于其制造的装置和方法。 在一个实施例中，本发明涉及用于组织修复的承载植入装置。 植入物由可再吸收的，可溶胀的植入体组成，其由脱水交联的生物相容性聚合物形成。 因此，植入物在插入后能够膨胀以锚定到位。 植入物起到提高其放置于其中的硬组织的结构完整性的作用，从而提高这些组织的承载能力。 植入物特别适合用于将第二（硬的或软的）组织附着到植入物插入的第一（硬）组织中。 它们也可以用作用于附接诸如螺钉，杆或销的外科装置的部位。
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公开(公告)号：US08617584B2
公开(公告)日：2013-12-31
申请号：US12787304
申请日：2010-05-25
申请人： Louis C. Sehl , Olof Mikael Trollsas , Donald G. Wallace , David Toman , Frank A. DeLustro , Jacqueline A. Schroeder , George H. Chu
发明人： Louis C. Sehl , Olof Mikael Trollsas , Donald G. Wallace , David Toman , Frank A. DeLustro , Jacqueline A. Schroeder , George H. Chu
IPC分类号： A61F13/00
CPC分类号： A61L24/043 , A61F2/0063 , A61L24/08 , A61L24/102 , A61L27/24 , A61L27/26 , A61L31/041 , A61L31/044 , C08B37/0075 , C08F283/00 , C08F283/04 , C08F283/06 , C08G65/329 , C08G75/045 , C08G75/26 , C08H1/00 , C08H1/06 , C08L51/003 , C08L53/00 , C08L67/06 , C08L71/02 , C08L81/02 , C09D167/02 , C09J151/003 , C09J153/00 , C09J189/06 , C08L89/06 , C08L5/16 , C08L91/06 , C08L2666/26 , C08L71/00
摘要： The present invention relates generally to synthetic polymer compositions that form interpenetrating polymer networks. In a preferred embodiment, the compositions comprise two multifunctionally activated synthetic polymers, along with a tensile strength enhancer. Such compositions form matrices that exhibit superior cohesive strength and in many instances can serve as adequate replacements for surgical means of attaching tissues, such as sutures, sponges and medical staples.
摘要翻译： 本发明一般涉及形成互穿聚合物网络的合成聚合物组合物。 在优选的实施方案中，组合物包含两种多功能活化的合成聚合物以及拉伸强度增强剂。 这样的组合物形成表现出优异的内聚强度的基质，并且在许多情况下可用作适当的替代物，用于附接组织例如缝合线，海绵和医用缝钉的外科手段。
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公开(公告)号：US20100233246A1
公开(公告)日：2010-09-16
申请号：US12787304
申请日：2010-05-25
申请人： Louis C. Sehl , Olof Mikael Trollsas , Donald G. Wallace , David Toman , Frank A. DeLustro , Jacqueline A. Schroeder , George H. Chu
发明人： Louis C. Sehl , Olof Mikael Trollsas , Donald G. Wallace , David Toman , Frank A. DeLustro , Jacqueline A. Schroeder , George H. Chu
IPC分类号： A61K9/70 , A61K38/00 , A61K38/39 , A61K38/38 , A61K31/726
CPC分类号： A61L24/043 , A61F2/0063 , A61L24/08 , A61L24/102 , A61L27/24 , A61L27/26 , A61L31/041 , A61L31/044 , C08B37/0075 , C08F283/00 , C08F283/04 , C08F283/06 , C08G65/329 , C08G75/045 , C08G75/26 , C08H1/00 , C08H1/06 , C08L51/003 , C08L53/00 , C08L67/06 , C08L71/02 , C08L81/02 , C09D167/02 , C09J151/003 , C09J153/00 , C09J189/06 , C08L89/06 , C08L5/16 , C08L91/06 , C08L2666/26 , C08L71/00
摘要： The present invention relates generally to synthetic polymer compositions that form interpenetrating polymer networks. In a preferred embodiment, the compositions comprise two multifunctionally activated synthetic polymers, along with a tensile strength enhancer. Such compositions form matrices that exhibit superior cohesive strength and in many instances can serve as adequate replacements for surgical means of attaching tissues, such as sutures, sponges and medical staples.
摘要翻译： 本发明一般涉及形成互穿聚合物网络的合成聚合物组合物。 在优选的实施方案中，组合物包含两种多功能活化的合成聚合物以及拉伸强度增强剂。 这样的组合物形成表现出优异的内聚强度的基质，并且在许多情况下可用作适当的替代物，用于附接组织例如缝合线，海绵和医用缝钉的外科手段。
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公开(公告)号：US06833408B2
公开(公告)日：2004-12-21
申请号：US10262640
申请日：2002-09-30
申请人： Louis C. Sehl , Olof Mikael Trollsas , Donald G. Wallace , David Toman , Frank A. DeLustro , Jacqueline A. Schroeder , George H. Chu
发明人： Louis C. Sehl , Olof Mikael Trollsas , Donald G. Wallace , David Toman , Frank A. DeLustro , Jacqueline A. Schroeder , George H. Chu
IPC分类号： C08F28300
CPC分类号： A61L24/043 , A61F2/0063 , A61L24/08 , A61L24/102 , A61L27/24 , A61L27/26 , A61L31/041 , A61L31/044 , C08B37/0075 , C08F283/00 , C08F283/04 , C08F283/06 , C08G65/329 , C08G75/045 , C08G75/26 , C08H1/00 , C08H1/06 , C08L51/003 , C08L53/00 , C08L67/06 , C08L71/02 , C08L81/02 , C09D167/02 , C09J151/003 , C09J153/00 , C09J189/06 , C08L89/06 , C08L5/16 , C08L91/06 , C08L2666/26 , C08L71/00
摘要： A method of tissue repair is provided using a biocompatible nonimmunogenic adhesive composition. The adhesive composition comprises collagen and a plurality of crosslinkable components having reactive functional groups thereon, with the functional groups selected so as to enable inter-reaction between the components, i.e., crosslinking. Kits for use in carrying out the method of the invention are also provided, as are pretreated surgically acceptable patches that have been coated with the aforementioned adhesive composition.
摘要翻译： 使用生物相容性非免疫原性粘合剂组合物提供组织修复的方法。 粘合剂组合物包含胶原和多个在其上具有反应性官能团的可交联组分，其中官能团被选择以使得组分之间能够进行交联，即交联。 还提供了用于实施本发明的方法的试剂盒，以及已经用上述粘合剂组合物涂覆的预处理的外科手术可接受的贴剂。
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6.发明申请COMPOSITIONS AND SYSTEMS FOR FORMING CROSSLINKED BIOMATERIALS AND METHODS OF PREPARATION AND USE 审中-公开用于形成交联的生物材料的组合物和系统及其制备和使用方法公开(公告)号：US20110159075A1
公开(公告)日：2011-06-30
申请号：US12979215
申请日：2010-12-27
申请人： Louis C. Sehl , Olof Mikael Trollsas , Donald G. Wallace , David Toman , Frank A. DeLustro , Jacqueline A. Schroeder , George H. Chu
发明人： Louis C. Sehl , Olof Mikael Trollsas , Donald G. Wallace , David Toman , Frank A. DeLustro , Jacqueline A. Schroeder , George H. Chu
IPC分类号： A61F2/00 , A61K38/43 , A61K38/22 , A61K38/18 , A61K35/28 , A61K39/395 , A61K35/00 , A61K48/00
CPC分类号： A61L17/145 , A61F2/0063 , A61L24/043 , A61L24/046 , A61L24/08 , A61L24/102 , A61L27/24 , A61L27/26 , A61L27/34 , A61L27/54 , A61L31/041 , A61L31/044 , A61L31/10 , A61L31/16 , C08B37/0075 , C08F283/00 , C08F283/04 , C08F283/06 , C08G65/329 , C08G65/33306 , C08G65/33337 , C08G75/045 , C08G75/26 , C08G2650/50 , C08H1/00 , C08H1/06 , C08L5/00 , C08L51/003 , C08L53/00 , C08L67/06 , C08L71/02 , C08L81/02 , C09D167/02 , C09J151/003 , C09J153/00 , C09J189/06 , C08L91/06 , C08L2666/26 , C08L89/06 , C08L5/16 , C08L71/00
摘要： Crosslinkable compositions are provided that readily crosslink in situ to provide biocompatible, nonimmunogenic crosslinked materials that may be used as adhesive compositions. The compositions comprise collagen and a plurality of crosslinkable components having reactive functional groups thereon, with the functional groups selected so as to enable inter-reaction between the components, i.e., crosslinking. Methods for preparing and using the compositions are also provided. Exemplary uses include tissue augmentation, biologically active agent delivery, bioadhesion, prevention of adhesions following surgery or injury, and coating of surgically acceptable patches and solid implants, the latter including sutures.
摘要翻译： 提供可交联的组合物，其易于原位交联以提供可用作粘合剂组合物的生物相容性，非免疫原性交联材料。 所述组合物包含胶原和多个在其上具有反应性官能团的可交联组分，其中所述官能团被选择以使组分之间的相互反应，即交联。 还提供了制备和使用组合物的方法。 示例性用途包括组织增加，生物活性剂递送，生物粘附，预防手术或损伤后的粘连以及手术可接受的贴剂和固体植入物的涂覆，后者包括缝线。
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公开(公告)号：US08377466B2
公开(公告)日：2013-02-19
申请号：US10971684
申请日：2004-10-22
申请人： Louis C. Sehl , Olof Mikael Trollsas , Donald G. Wallace , David Toman , Frank A. DeLustro , Jacqueline A. Schroeder , George H. Chu
发明人： Louis C. Sehl , Olof Mikael Trollsas , Donald G. Wallace , David Toman , Frank A. DeLustro , Jacqueline A. Schroeder , George H. Chu
IPC分类号： A61F13/00
CPC分类号： A61L24/043 , A61F2/0063 , A61L24/08 , A61L24/102 , A61L27/24 , A61L27/26 , A61L31/041 , A61L31/044 , C08B37/0075 , C08F283/00 , C08F283/04 , C08F283/06 , C08G65/329 , C08G75/045 , C08G75/26 , C08H1/00 , C08H1/06 , C08L51/003 , C08L53/00 , C08L67/06 , C08L71/02 , C08L81/02 , C09D167/02 , C09J151/003 , C09J153/00 , C09J189/06 , C08L89/06 , C08L5/16 , C08L91/06 , C08L2666/26 , C08L71/00
摘要： A method of tissue repair is provided using a biocompatible nonimmunogenic adhesive composition. The adhesive composition comprises collagen and a plurality of crosslinkable components having reactive functional groups thereon, with the functional groups selected so as to enable inter-reaction between the components, i.e., crosslinking. Kits for use in carrying out the method of the invention are also provided, as are pretreated surgically acceptable patches that have been coated with the aforementioned adhesive composition.
摘要翻译： 使用生物相容性非免疫原性粘合剂组合物提供组织修复的方法。 粘合剂组合物包含胶原和多个在其上具有反应性官能团的可交联组分，其中官能团被选择以使得组分之间能够进行交联，即交联。 还提供了用于实施本发明的方法的试剂盒，以及已经用上述粘合剂组合物涂覆的预处理的外科手术可接受的贴剂。
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8.发明授权Compositions and systems for forming crosslinked biomaterials and methods of preparation of use 有权用于形成交联生物材料的组合物和系统及其制备和使用方法公开(公告)号：US07883693B2
公开(公告)日：2011-02-08
申请号：US11344752
申请日：2006-01-31
申请人： Louis C. Sehl , Olof Mikael Trollsas , Donald G. Wallace , David Toman , Frank A. DeLustro , Jacqueline A. Schroeder , George H. Chu
发明人： Louis C. Sehl , Olof Mikael Trollsas , Donald G. Wallace , David Toman , Frank A. DeLustro , Jacqueline A. Schroeder , George H. Chu
IPC分类号： A61K31/785
CPC分类号： A61L17/145 , A61F2/0063 , A61L24/043 , A61L24/046 , A61L24/08 , A61L24/102 , A61L27/24 , A61L27/26 , A61L27/34 , A61L27/54 , A61L31/041 , A61L31/044 , A61L31/10 , A61L31/16 , C08B37/0075 , C08F283/00 , C08F283/04 , C08F283/06 , C08G65/329 , C08G65/33306 , C08G65/33337 , C08G75/045 , C08G75/26 , C08G2650/50 , C08H1/00 , C08H1/06 , C08L5/00 , C08L51/003 , C08L53/00 , C08L67/06 , C08L71/02 , C08L81/02 , C09D167/02 , C09J151/003 , C09J153/00 , C09J189/06 , C08L91/06 , C08L2666/26 , C08L89/06 , C08L5/16 , C08L71/00
摘要： Crosslinkable compositions are provided that readily crosslink in situ to provide biocompatible, nonimmunogenic crosslinked materials that may be used as adhesive compositions. The compositions comprise collagen and a plurality of crosslinkable components having reactive functional groups thereon, with the functional groups selected so as to enable inter-reaction between the components, i.e., crosslinking. Methods for preparing and using the compositions are also provided. Exemplary uses include tissue augmentation, biologically active agent delivery, bioadhesion, prevention of adhesions following surgery or injury, and coating of surgically acceptable patches and solid implants, the latter including sutures.
摘要翻译： 提供可交联的组合物，其易于原位交联以提供可用作粘合剂组合物的生物相容性，非免疫原性交联材料。 所述组合物包含胶原和多个在其上具有反应性官能团的可交联组分，其中所述官能团被选择以使组分之间的相互反应，即交联。 还提供了制备和使用组合物的方法。 示例性用途包括组织增加，生物活性剂递送，生物粘附，预防手术或损伤后的粘连以及手术可接受的贴剂和固体植入物的涂覆，后者包括缝线。
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公开(公告)号：US5786421A
公开(公告)日：1998-07-28
申请号：US853045
申请日：1997-05-06
申请人： Woonza M. Rhee , Prema R. Rao , George H. Chu , Frank A. DeLustro , Carol F. H. Harner , Naomi Sakai , Jacqueline A. Schroeder
发明人： Woonza M. Rhee , Prema R. Rao , George H. Chu , Frank A. DeLustro , Carol F. H. Harner , Naomi Sakai , Jacqueline A. Schroeder
IPC分类号： A61L24/00 , A61F2/00 , A61F2/06 , A61K38/00 , A61K47/48 , A61L24/10 , A61L26/00 , A61L27/18 , A61L27/20 , A61L27/24 , A61L27/26 , A61L27/34 , A61L27/44 , A61L27/54 , A61L29/04 , A61L29/06 , A61L29/16 , A61L31/04 , A61L31/10 , A61L31/12 , C07K14/495 , C07K14/78 , C08B37/08 , C08H1/06 , C08L89/06 , C09J189/06 , A61F13/00 , A61B17/07
CPC分类号： A61L31/044 , A61K47/48215 , A61K47/4823 , A61L24/102 , A61L26/0033 , A61L27/24 , A61L27/26 , A61L27/34 , A61L27/44 , A61L27/54 , A61L31/041 , A61L31/10 , A61L31/125 , C07K14/495 , C07K14/78 , C08B37/0069 , C08B37/0072 , C08H1/06 , C08L89/06 , C09J189/06 , A61F2/07 , A61F2310/00365 , A61K38/00 , A61L2300/414 , A61L2430/16 , Y10S530/84 , Y10S602/904
摘要： Collagen-based compositions useful in the attachment of tissues, or the attachment of tissues to synthetic implant materials, are disclosed. The compositions comprise collagen crosslinked using a multifunctionally activated synthetic hydrophilic polymer. A particularly preferred composition comprises fibrillar collagen, a fiber disassembly agent, and a multifunctionally activated synthetic hydrophilic polymer. Methods are disclosed for using the compositions to effect the attachment of a native tissue to the surface of another native tissue, a non-native tissue, or a synthetic implant. Also disclosed are methods of using the compositions to prevent the formation of surgical adhesions.
摘要翻译： 公开了可用于组织附着的基于胶原的组合物，或将组织附着于合成植入材料。 组合物包括使用多功能活化的合成亲水性聚合物交联的胶原蛋白。 特别优选的组合物包括纤维胶原，纤维分解剂和多功能活化的合成亲水性聚合物。 公开了使用组合物来实现天然组织附着到另一天然组织，非天然组织或合成植入物的表面的方法。 还公开了使用该组合物来防止手术粘连形成的方法。
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10.发明授权Clear, chemically modified collagen-synthetic polymer conjugates for ophthalmic applications 失效透明的化学改性胶原蛋白合成聚合物共轭物用于眼科应用
公开(公告)号：US5565519A
公开(公告)日：1996-10-15
申请号：US147227
申请日：1993-11-03
申请人： Woonza M. Rhee , Prema R. Rao , George H. Chu , Frank A. DeLustro
发明人： Woonza M. Rhee , Prema R. Rao , George H. Chu , Frank A. DeLustro
IPC分类号： A61L27/00 , A61F2/00 , A61F2/06 , A61K38/00 , A61K47/48 , A61L24/10 , A61L26/00 , A61L27/18 , A61L27/20 , A61L27/24 , A61L27/26 , A61L27/34 , A61L27/44 , A61L27/54 , A61L29/04 , A61L29/06 , A61L29/16 , A61L31/04 , A61L31/10 , A61L31/12 , C07K14/495 , C07K14/78 , C08B37/08 , C08H1/00 , C08H1/06 , C08L89/06 , C09J189/06 , C08G63/48 , C08G63/91
CPC分类号： A61K47/48215 , A61K47/4823 , A61L24/102 , A61L26/0033 , A61L27/18 , A61L27/20 , A61L27/24 , A61L27/26 , A61L27/34 , A61L27/44 , A61L27/54 , A61L29/043 , A61L29/045 , A61L29/06 , A61L29/16 , A61L31/041 , A61L31/044 , A61L31/10 , A61L31/125 , C07K14/495 , C07K14/78 , C08B37/0069 , C08B37/0072 , C08H1/06 , C08L89/06 , C09J189/06 , A61F2/07 , A61F2310/00365 , A61K38/00 , A61L2300/414 , A61L2300/426 , A61L2300/802 , A61L2430/16
摘要： Various forms of chemically modified collagen are covalently crosslinked with activated synthetic hydrophilic polymers to form optically clear biocompatible conjugates useful in a variety of medical applications, particularly in ophthalmic devices. The chemically modified collagen is in substantially nonfibrillar form at pH 7 and is preferably succinylated or methylated collagen. The synthetic hydrophilic polymer is preferably an activated polymeric glycol, most preferably, a di- or multifunctionally activated polyethylene glycol. Materials and devices formed with the chemically modified collagen-synthetic polymer conjugates have good optical clarity, mechanical strength, and moldability.
摘要翻译： 各种形式的化学修饰的胶原与活化的合成亲水性聚合物共价交联以形成用于各种医学应用的光学透明的生物相容性缀合物，特别是在眼科装置中。 化学修饰的胶原蛋白在pH7下基本上非原纤维形式，优选琥珀酰化或甲基化胶原蛋白。 合成的亲水性聚合物优选为活化的聚合二醇，最优选为二官能或多功能活化的聚乙二醇。 用化学改性的胶原 - 合成聚合物共轭物形成的材料和装置具有良好的光学透明度，机械强度和成型性。
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